Could less radiation be just as effective for HPV throat cancer?

This study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 participants will receive either reduced radiation to low-risk lymph nodes, a lower dose to the tumor itself, or both, based on their individual risk factors and a blood test. The study aims to keep cancer control rates high while making treatment easier to tolerate.