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Could less radiation be just as effective for HPV throat cancer?

NCT ID NCT07418034

Not yet recruiting Symptom relief Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 participants will receive either reduced radiation to low-risk lymph nodes, a lower dose to the tumor itself, or both, based on their individual risk factors and a blood test. The study aims to keep cancer control rates high while making treatment easier to tolerate.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma human papilloma virus infection human papillomavirus-related squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER HEAD AND NECK SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CARCINOMA HPV (HUMAN PAPILLOMAVIRUS)-ASSOCIATED CARCINOMA HPV 16 POSITIVE OROPHARYNGEAL TUMORS (OPC) HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA OROPHARYNGEAL CANCER OROPHARYNGEAL CARCINOMA OROPHARYNGEAL HUMAN PAPILLOMAVIRUS-POSITIVE SQUAMOUS CELL CARCINOMA OROPHARYNGEAL SQUAMOUS CELL CANCER OROPHARYNGEAL SQUAMOUS CELL CARCINOMA OROPHARYNGEAL SQUAMOUS CELL CARCINOMA (OPSCC) OROPHARYNGEAL SQUAMOUS CELL CARCINOMA (OPSCCA) OROPHARYNGEAL SQUAMOUS CELL CARCINOMA (SCC)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••