Can a stem cell spray stop radiation mouth pain?

NCT ID NCT07312656

Not yet recruiting Prevention Sponsor: First Affiliated Hospital of Guangxi Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an oral spray made from stem cell exosomes to prevent severe mouth sores in head and neck cancer patients undergoing radiation. 200 participants will use the spray three times daily, starting a week before radiation and continuing for two weeks after. The goal is to see if it reduces the number of patients who develop painful, high-grade mouth ulcers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mesenchymal stem cell-derived exosomes
What this could lead to: If it works, this could provide a new way to prevent painful mouth sores caused by radiation therapy, improving quality of life for head and neck cancer patients.
What could go wrong: This is a Phase 2 trial, so it is still early. The treatment may not reduce severe mouth sores more than standard care, and side effects from the exosome spray are not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer stomatitis ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORAL MUCOSITIS (ULCERATIVE) DUE TO RADIATION

Contacts and locations

Locations

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, 530021, China

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