Could a few big doses of radiation before surgery beat head and neck cancer?
NCT ID NCT05538533
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study is testing whether giving a shorter, more intense course of radiation before surgery is safe for people with head and neck cancer. The trial involves 12 adults with HPV-negative, surgically removable tumors. The main goal is to see if this condensed radiation schedule causes severe side effects or prevents surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy (hypofractionated)
What this could lead to
If successful, this could lead to a shorter, more convenient radiation schedule before surgery for head and neck cancer, potentially reducing treatment time.
What could go wrong
This is a very early phase 1 study with only 12 participants, so safety and feasibility are still being tested. It may not lead to better outcomes or could cause unexpected side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States