Can a simple fluoride treatment save teeth after cancer radiation?

NCT ID NCT07556367

Ongoing Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study looks at whether giving fluoride varnish during regular cancer checkups can help protect the teeth of head and neck cancer patients who have had radiation and lack easy access to a dentist. About 43 uninsured or underinsured adults will receive 4-5 fluoride treatments, complete surveys, and provide saliva samples. The goal is to see if this approach is practical and might improve dental health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluoride varnish treatment
What this could lead to: If successful, this could show that providing fluoride varnish during routine cancer visits is a practical way to improve dental health in underserved patients.
What could go wrong: This is a small pilot study with only 43 participants, so results may not apply broadly. It focuses on feasibility, not on proving the varnish prevents cavities.

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Conditions

The condition(s) this trial relates to.

head and neck cancer head and neck carcinoma head and neck neoplasm Head and Neck Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER HEAD AND NECK CARCINOMA HEAD AND NECK NEOPLASMS

Contacts and locations

Locations

Zuckerberg San Francisco General Hospital (ZSFG)

San Francisco, California, 94110, United States

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