Throat cancer radiation trial targets saliva ducts to stop dry mouth

NCT ID NCT06276946

Terminated Symptom relief Sponsor: UNC Lineberger Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study aimed to see if using MRI scans to guide radiation away from the main saliva ducts could reduce dry mouth in people with oropharynx cancer. The trial planned to compare standard radiation with a new approach that spares these ducts. However, the study was withdrawn before any patients were enrolled, so no data was collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiotherapy
What this could lead to: If successful, this approach could reduce long-term dry mouth after radiation for oropharynx cancer, improving quality of life.
What could go wrong: The trial was withdrawn before enrolling any participants, so no results are available. The approach is still experimental and unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms oropharynx cancer Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER OROPHARYNX CANCER XEROSTOMIA

Contacts and locations

Locations

University of North Carolina at Chapel Hill, Department of Radiation Oncology

Chapel Hill, North Carolina, 27599, United States

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