Can adding chemo to radiation stop salivary gland cancer from coming back?

NCT ID NCT01220583

Ongoing Disease control Sponsor: Radiation Therapy Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding chemotherapy (cisplatin) to standard radiation therapy after surgery helps people with high-risk salivary gland tumors live longer without the cancer returning. About 252 adults whose tumors were removed took part. The goal is to see if the combination treatment is better than radiation alone.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms salivary gland cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER

Contacts and locations

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Locations

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, 93301, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003, United States
Arizona Breast Cancer Specialists

Scottsdale, Arizona, 85251, United States
Arizona Breast Cancer Specialists-Gilbert

Gilbert, Arizona, 85297, United States
Arizona Breast Cancer Specialists-Phoenix

Phoenix, Arizona, 85027, United States
Arizona Breast Cancer Specialists-Scottsdale

Scottsdale, Arizona, 85258, United States
Arizona Center for Cancer Care-Peoria

Peoria, Arizona, 85381, United States
Arizona Center for Cancer Care-Surprise

Surprise, Arizona, 85374, United States
Arizona Oncology Services Foundation

Scottsdale, Arizona, 85260, United States
Arizona Oncology-Deer Valley Center

Phoenix, Arizona, 85027, United States
Ascension Saint John Hospital

Detroit, Michigan, 48236, United States
Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601, United States
Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States
Aurora Health Center-Fond du Lac

Fond du Lac, Wisconsin, 54937, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Bixby Medical Center

Adrian, Michigan, 49221, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Boulder Community Hospital

Boulder, Colorado, 80301, United States
Bozeman Deaconess Hospital

Bozeman, Montana, 59715, United States
Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
CHUM - Hopital Notre-Dame

Montreal, Quebec, H2L 4M1, Canada
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
Cancer Treatment Center

Wooster, Ohio, 44691, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Compass Oncology Vancouver

Vancouver, Washington, 98684, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States
Dixie Medical Center Regional Cancer Center

St. George, Utah, 84770, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory Proton Therapy Center

Atlanta, Georgia, 30308, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Fremont - Rideout Cancer Center

Marysville, California, 95901, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Goshen Center for Cancer Care

Goshen, Indiana, 46526, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, 54301-3526, United States
Health Sciences North

Greater Sudbury, Ontario, P3E 5J1, Canada
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Highland Hospital

Rochester, New York, 14620, United States
Hoag Memorial Hospital

Newport Beach, California, 92663, United States
IU Health North Hospital

Carmel, Indiana, 46032, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States
Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States
King Faisal Specialist Hospital and Research Centre

Riyadh, 11211, Saudi Arabia
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lenox Hill Hospital

New York, New York, 10021, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Logan Regional Hospital

Logan, Utah, 84321, United States
London Regional Cancer Program

London, Ontario, N6A 4L6, Canada
Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Los Angeles County-USC Medical Center

Los Angeles, California, 90033, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
MD Anderson League City

League City, Texas, 77573, United States
MD Anderson West Houston

Houston, Texas, 77079, United States
MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States
MD Anderson in The Woodlands

Conroe, Texas, 77384, United States
Maimonides Medical Center

Brooklyn, New York, 11219, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic PC - Ames

Ames, Iowa, 50010, United States
McGill University Department of Oncology

Montreal, Quebec, H2W 1S6, Canada
McKee Medical Center

Loveland, Colorado, 80539, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Memorial Medical Center

Modesto, California, 95355, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Sleepy Hollow

Sleepy Hollow, New York, 10591, United States
Memorial Sloan Kettering Westchester

East White Plains, New York, 10604, United States
Mercy Cancer Center-Elyria

Elyria, Ohio, 44035, United States
Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Miami Cancer Institute

Miami, Florida, 33176, United States
Mills-Peninsula Medical Center

Burlingame, California, 94010, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Mount Sinai Chelsea

New York, New York, 10011, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Mount Sinai Union Square

New York, New York, 10003, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, 05819, United States
North Suburban Medical Center

Thornton, Colorado, 80229, United States
Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rutgers New Jersey Medical School

Newark, New Jersey, 07101, United States
SSM Health Saint Louis University Hospital

St Louis, Missouri, 63104, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint John's Hospital

Springfield, Illinois, 62702, United States
Saint Joseph Hospital - Orange

Orange, California, 92868, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106, United States
Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341, United States
Saint Mary Mercy Hospital

Livonia, Michigan, 48154, United States
Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States
Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States
Seattle Cancer Care Alliance at Northwest Hospital

Seattle, Washington, 98133, United States
Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, 23666, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, 23454, United States
Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, 46202, United States
Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Sparta Cancer Treatment Center

Sparta, New Jersey, 07871, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Summa Health Medina Medical Center

Medina, Ohio, 44256, United States
Summa Health System - Akron Campus

Akron, Ohio, 44304, United States
Summa Health System - Barberton Campus

Barberton, Ohio, 44203, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, 95687, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
The Kirklin Clinic at Acton Road

Birmingham, Alabama, 35243, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Touro Infirmary

New Orleans, Louisiana, 70115, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, 44870, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UH Seidman Cancer Center at Salem Regional Medical Center

Salem, Ohio, 44460, United States
UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States
UPMC Jameson

New Castle, Pennsylvania, 16105, United States
UPMC Jefferson Regional Radiation Oncology

Pittsburgh, Pennsylvania, 15236, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States
UPMC-Coraopolis/Heritage Valley Radiation Oncology

Moon Township, Pennsylvania, 15108, United States
UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243, United States
UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Colorado Hospital

Aurora, Colorado, 80045, United States
University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610, United States
University of Florida Health Science Center - Jacksonville

Jacksonville, Florida, 32209, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Missouri - Ellis Fischel

Columbia, Missouri, 65212, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Tennessee - Knoxville

Knoxville, Tennessee, 37920, United States
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Toledo, Ohio, 43614, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States
Utah Valley Regional Medical Center

Provo, Utah, 84604, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

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Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States
William Backus Hospital

Norwich, Connecticut, 06360, United States