Custom immune cells take on multiple cancers in early trial

NCT ID NCT05973487

Ongoing Disease control Sponsor: TScan Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new treatment called T-Plex for people with advanced solid tumors (like head and neck, cervical, or melanoma) that haven't responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The main goals are to check if it's safe and to find the best dose.

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Conditions

The condition(s) this trial relates to.

anal carcinoma anal squamous cell carcinoma anogenital human papillomavirus infection cervical adenocarcinoma cervical cancer cutaneous melanoma endocervical adenocarcinoma head and neck cancer Head and Neck Neoplasms human papillomavirus-related penile squamous cell carcinoma human papillomavirus-related squamous cell carcinoma melanoma non-small cell lung carcinoma oropharynx squamous cell carcinoma ovarian cancer reproductive system cancer squamous cell carcinoma of rectum Uterine Cervical Neoplasms vaginal adenocarcinoma vulvar squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Allegheny Hospitals Network

Pittsburgh, Pennsylvania, 15224, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Columbia University Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
HonorHealth Research and Innovation Institute

Scottsdale, Arizona, 85258, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Memorial Healthcare System

Hollywood, Florida, 33021, United States
Norton Cancer Institute

Louisville, Kentucky, 40202, United States
OU Health Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104, United States
Oncology Hematology Care

Cincinnati, Ohio, 45242, United States
Orlando Health

Orlando, Florida, 32806, United States
Providence Cancer Institute Franz Clinic

Portland, Oregon, 97213, United States
Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
The Cleveland Clinic

Cleveland, Ohio, 44195, United States
University of California San Diego

San Diego, California, 92037, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Miami, Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
University of Minnesota Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of South Florida

Tampa, Florida, 33606, United States
Yale Cancer Center

New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.