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New hope for tough lymphoma: drug combo plus stem cell transplant shows promise

NCT ID NCT06905509

Recruiting now Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests whether adding the drug epcoritamab to standard chemotherapy and a stem cell transplant can help people with large B-cell lymphoma that has come back or not responded to treatment. About 25 adults will receive the combination, followed by more epcoritamab after transplant. The goal is to see if this approach improves the chance of complete remission.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement Lymphoma, B-Cell, Marginal Zone nodal marginal zone B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS RECURRENT HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS RECURRENT HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT NODAL MARGINAL ZONE LYMPHOMA RECURRENT TRANSFORMED FOLLICULAR LYMPHOMA TO DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS REFRACTORY HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS REFRACTORY HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY NODAL MARGINAL ZONE LYMPHOMA REFRACTORY TRANSFORMED FOLLICULAR LYMPHOMA TO DIFFUSE LARGE B-CELL LYMPHOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of California Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••