DIABETES

This study looks at whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and specialized nutrition. About 80 adults with diabetes will be randomly assigned to eithe…

This study looks at whether sending reminders by text, email, or patient portal messages helps people with heart disease or diabetes refill their statin prescriptions. About 22,000 adults will receive different types of outreach or usual care, and researchers will track who refil…

This study tests a 6-week program where older adults with diabetes and mild memory issues work with their caregivers to improve diabetes self-care and thinking skills. About 309 participants will attend weekly sessions and provide feedback. The goal is to see if this team-based a…

This study tests whether an AI-powered tool can help community doctors better manage patients with high blood pressure plus diabetes or high cholesterol. About 6,800 adults will be split into two groups: one gets standard care, the other gets AI-assisted care. The goal is to see …

This study tests whether group care—where patients meet together with healthcare providers for education and check-ups—can help control high blood pressure and diabetes in Nepal. About 1,110 adults from 37 health facilities will take part. The goal is to see if group visits impro…

This study looks at whether adding a supplement called HMB to an exercise program can improve muscle mass, strength, and blood sugar control in older adults (ages 60-80) with type 2 diabetes and low muscle mass. Participants will be randomly assigned to exercise, HMB, both, or pl…

This study looks at whether a GLP-1 RA drug (used for diabetes and weight loss) can improve fat levels in the liver and blood of people with MASLD (fatty liver disease). About 30 adults with MASLD, diabetes, and obesity will take the drug and have liver biopsies and blood tests t…

This study tests Mobili®, a portable digital dispenser that gives the right pills at the right time, to help people with multiple chronic diseases stick to their medication schedule. About 96 adults with diabetes or heart disease who take at least two daily oral medications will …

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card of either $80 or $120. Researchers want to see if the extra grocery support helps people control their blood sugar and blood pressure, and reduces food insecurity. The goal is to find o…

This study will test whether using a continuous glucose monitor (CGM) helps people with severe obesity better control their blood sugar after weight-loss surgery. Twenty participants will be randomly assigned to use either a CGM or standard finger-stick testing before and after s…

This study looks at how safe and effective the Endogenex System is for people with type 2 diabetes. It includes 50 adults who previously received a sham (fake) treatment in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This study looks at whether a tighter blood sugar target (70-140 mg/dL) is better than the current standard (70-180 mg/dL) for children and teens with Type 1 Diabetes who use automated insulin pumps. About 120 participants across three countries will be randomly assigned to one o…

This study tests a program called PINPOINT that helps women with diabetes or obesity get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether empagliflozin, a diabetes drug, can improve blood sugar control in people who have had islet transplants but still have partial pancreas function. About 40 adults will take either a placebo or one of two doses of the drug for 3 months. The goal is to see …

This study tests a 12-week home-based exercise program for adults aged 60+ with type 2 diabetes and early muscle weakness (probable sarcopenia). Participants will do short bouts of aerobic and resistance exercises to see if it improves their physical activity levels and muscle st…

This study tests if a mild electrical pulse to the ear can stimulate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis (delayed stomach emptying). Researchers will enroll 60 adults who have had gastroparesis for at least…

This study looks at whether it is safe and practical for pregnant people with type 1 or type 2 diabetes to keep using their insulin pump during labor, instead of switching to IV insulin. About 30 participants who already use an insulin pump will be allowed to continue using it wh…

This study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function in people with diabetes and in healthy volunteers. About 30 adults aged 18 to 60 will take part. The goal is to see if NaPB can help ease blood vessel problems link…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—the goal is to better understand how diabetes affects hear…

This study collects blood samples from 30,000 adults in the UK who have various health conditions, such as blood clots, infections, heart disease, diabetes, and liver disease. The samples are used to develop and fine-tune new diagnostic tests that can be done right at the patient…

This study is testing a new, noninvasive device called the Argus CGM that uses light and AI to estimate blood sugar levels without needles. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to im…

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …

This study compares two ways of making treatment decisions for people with severe blockages in all three main heart arteries who also have diabetes. One group gets a real-time online discussion among heart specialists during their procedure, while the other gets usual care. The g…

This study tests whether giving primary care doctors regular feedback on how well they follow treatment guidelines can improve care for patients with high blood pressure and diabetes. About 324 healthcare providers in Nepal, Mozambique, Tanzania, and China will be randomly assign…

This study looks at whether a special mobile app can reliably send blood sugar readings from continuous glucose monitors (CGMs) used by children with diabetes in the hospital to a central database. The goal is to make it easier for doctors and nurses to see the data live, which c…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides guidance on adjusting doses and handling side effects. The study involves 16 participants and focuses on gathering feedback t…

This study looks at how to make it easier for doctors to screen patients who don't get enough physical activity and refer them to local exercise programs. Researchers will work with 35 clinics and track how many patients get referred and whether their health improves. The goal is…

This study looks at whether a simple ultrasound test can help predict how well people recover after a stroke caused by a large blood clot. Researchers will measure blood flow in the brain using transcranial Doppler (TCD) ultrasound in 100 adults who had a stroke and received endo…

This study aims to collect health information and biological samples from 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic issues. Researchers will follow participants for up to 30 years to learn how diabetes and obesity develop and change over ti…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand how the drug boosts insulin release after drinking sugar. About 400 healthy volunteers from the Old Order Amish community will take …

This study will collect health information from 10,000 adults with diabetes, metabolic disorders, or related conditions like high blood pressure and fatty liver. Researchers will track patients over at least 10 years to find better ways to diagnose, monitor, and treat these disea…

This pilot study tests whether a program of education, motivation, and social support can help adults with diabetes and early-stage chronic kidney disease (CKD) keep their kidneys healthier. Researchers will enroll 50 people and compare those who receive the program to those who …

This registry will follow 500 people with type 2 diabetes who have already been treated with the Endogenex System. The goal is to collect long-term safety data by tracking any device- or procedure-related side effects. Participants must agree to share their medical records and at…

This study looks at how meals with different amounts of fat, carbs, and protein change fat levels in the blood. Researchers will study 100 adults with conditions like diabetes, metabolic syndrome, or kidney disease, plus healthy volunteers. Participants will eat two different bre…