DIABETES

This small pilot study is testing whether eating Greek bottarga, a type of fish roe, can improve markers of metabolic health like cholesterol and blood sugar. It will involve 20 adults in Massachusetts who have conditions like prediabetes, high cholesterol, or obesity. Participan…

This study aims to find the most effective way to help adults with uncontrolled type 2 diabetes manage their condition. Researchers are testing whether extra support from a pharmacist, a community health worker, or both, can help people better manage their medications and daily l…

This study is testing a new injectable diabetes drug, GZR4, against a once-weekly insulin. It aims to see which one better controls blood sugar levels, is safer, and affects weight in people with type 2 diabetes who are already using insulin. About 300 adults will participate to …

This study is testing whether providing free boxes of fruits and vegetables, along with nutrition education, can help improve health for people at risk for diabetes and heart disease in the Mississippi Delta. About 300 participants from local health clinics will be randomly assig…

This study is testing a comprehensive support program to help people better manage multiple chronic conditions like high blood pressure, diabetes, and kidney disease. It involves giving participants home blood pressure monitors and connecting them with a team including community …

This study tests a program to help low-income patients with diabetes or high blood pressure use telehealth tools more effectively. It provides digital coaching to patients and support to clinics to overcome barriers like limited tech access or skills. The goal is to see if this a…

This study is testing whether providing free continuous glucose monitors (CGMs) to low-income adults with poorly controlled type 2 diabetes helps improve their blood sugar levels and quality of life. Researchers will give CGMs to 17 participants who can't afford them and track th…

This study is testing if wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people who are new to insulin manage their diabetes better. Researchers will compare the CGM group to a group using traditional finger-prick blood sugar checks. The …

This study is observing how well the Omnipod 5 automated insulin delivery system works for people with type 1 diabetes in their everyday lives. It will follow 304 adults and children in France for one year to see how the system affects blood sugar control, quality of life, and sa…

This study has two main goals. First, it aims to find out how common memory and thinking problems are in older adults with type 2 diabetes. Second, it will test a 2-year personalized health program designed to slow down cognitive decline. The program combines medication managemen…

This study is testing whether a mobile health app, combined with check-ins from a nurse, can help older adults better manage their diabetes day-to-day. Researchers will compare this approach to usual care for 184 participants. The main goals are to see if it improves blood sugar …

This study aims to determine whether weight-loss surgeries provide better long-term control of type 2 diabetes and related health problems compared to standard medical care. Researchers will follow 408 obese patients with diabetes who receive either one of three surgical procedur…

This early-stage study is testing the safety of a new procedure for diabetes. Doctors implant insulin-producing cells into the front chamber of a patient's eye that already has very poor vision. The goal is to see if these cells can survive and function there, potentially helping…

This study is testing a new 'smart' bandage that delivers gentle electrical stimulation to help heal chronic, slow-healing wounds. It will involve 16 veterans with wounds related to diabetes or spinal cord injury. Researchers will compare the new bandage to standard wound care to…

This study is testing if a daily pill called semaglutide (Rybelsus) is a safe and effective way to control high blood sugar in people who have recently received a kidney transplant. It will compare the pill to a placebo (dummy pill) in 104 patients, with both groups also receivin…

This study is looking at whether starting an automated insulin delivery system very soon after a child is diagnosed with type 1 diabetes can help protect their brain development and thinking skills. Researchers will compare brain scans and thinking tests in 60 children, aged 5 to…

This study is testing a diabetes management program specifically designed for Lakota families in South Dakota. It involves adults with Type 2 diabetes and a young family member who acts as a support person. The goal is to see if this culturally relevant, family-focused approach h…

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This study is testing a smartphone app designed to help older adults with multiple chronic conditions like heart failure, diabetes, and kidney disease manage their care after leaving the hospital. The goal is to see if the app can reduce complications and readmissions by providin…

This study is testing if a weight loss program using the drug tirzepatide is practical and safe for men to use before prostate cancer surgery. It will enroll 30 overweight or obese men with intermediate-risk prostate cancer and type 2 diabetes. The main goal is to see if particip…

This study is testing whether a home device for monitoring a baby's heart rate is practical and acceptable for women with high-risk pregnancies. It aims to see if this remote monitoring can be a helpful addition to regular prenatal care, potentially reducing the need for frequent…

This study is testing whether drinking whole milk or nonfat milk for one year affects children's weight, body fat, and risk factors for heart disease and diabetes. Researchers will enroll 200 children aged 9-12 who are above average weight and randomly assign them to drink three …

This study is testing whether adding either empagliflozin or semaglutide to standard insulin therapy can help overweight adults with type 1 diabetes better control their blood sugar levels. The goal is to see if these medications can lower long-term blood sugar (HbA1c) without ca…

This study is testing whether a special adhesive patch can help keep continuous glucose monitor (CGM) sensors from falling off the skin. People with diabetes who use a CGM and have trouble keeping it attached will be randomly assigned to use the patch or not for four months. Rese…

This study tests a new support program for low-income patients with chronic diseases like diabetes and heart problems after they leave the hospital. It provides free medications, delivers them to the bedside and then to the home, and offers a coach to help with follow-up care. Re…

This study tests two different church-based programs to help reduce heart disease risk in Black adults in New Orleans. It will compare a program led by trained community health workers, which includes coaching and support, to a simpler group education program. The goal is to find…

This study is testing whether providing free boxes of fresh fruits and vegetables, along with nutrition education, can help people with diabetes or prediabetes better manage their condition. The 6-month program serves 400 participants in the Bronx who struggle with food insecurit…

This study is testing a 24-week lifestyle program called Inspire HER, designed specifically for Black women at risk for heart disease. The program provides health education, physical activity guidance, and social support resources. Researchers will compare the program's effective…

This study tests a community health worker program designed to improve heart health in young, low-income migrant farmworker women. The program provides peer support and helps connect women to local resources, aiming to reduce stress, social isolation, and risk factors like high b…

This study is testing if a simple text message program can help emergency room patients with diabetes. The texts provide educational materials and connect people to helpful resources. Researchers want to see if this support improves patients' knowledge, reduces their stress about…

This study is testing whether a device called the iLet Bionic Pancreas can help adults with type 1 or type 2 diabetes better manage their blood sugar when it is prescribed and monitored by their regular primary care doctor. Researchers will compare 13 weeks of using the automated…

This study is testing if providing free, healthy food boxes can help Veterans with moderate to advanced kidney disease. It aims to see if better access to nutritious food improves kidney function, blood pressure, and quality of life. The study will also ask Veterans about their e…

This study is testing if a new clinic program can help control chronic diseases like high blood pressure, diabetes, and asthma. The program screens patients for social needs like housing or food insecurity and works to reduce racial bias in care. Researchers will enroll 68,000 ad…

This study is testing whether a do-it-yourself oral glucose tolerance test (OGTT) at home, using a wearable continuous glucose monitor (CGM), is as accurate as the standard test done in a clinic. Researchers will compare the results from 75 adults with prediabetes who complete bo…

This study is testing a new, painless way to check blood sugar levels using a special light (Raman spectroscopy) instead of a finger prick. Researchers will compare the results from this new device to the traditional finger-prick method to see if it's just as accurate. They also …

This study is testing a new AI software tool designed to spot early signs of diabetic retinopathy, a serious eye disease that can lead to blindness. The software analyzes simple retinal photos taken in a doctor's office to see if it can identify the disease as accurately as exper…

This study aims to find the most accurate blood test to detect diabetes in people who need to take steroid medications long-term. It will enroll 75 non-diabetic adults starting a steroid treatment plan lasting more than three months. Researchers will compare several common blood …

This study is testing whether a new wearable sensor can detect high or low blood sugar events by analyzing chemicals in a person's breath. Researchers are recruiting 30 teens with type 1 diabetes in Indianapolis to wear the sensor for 3 days and compare its readings to standard f…

This study is testing a new automated ultrasound system designed to help doctors monitor a special type of blood vessel connection (an arteriovenous fistula) used for dialysis in people with kidney failure. The goal is to see if using this device regularly can help the connection…

This study is testing whether two different lifestyle programs can help prevent dementia and diabetes in older adults who are at risk. It will enroll 400 African American and non-Hispanic white adults over 60 in the San Francisco Bay Area. One program focuses on aerobic exercise,…

This study tests a family-focused health program designed to prevent type 2 diabetes in Black communities in Southwest Georgia. It adapts a proven diabetes prevention curriculum for both parents and children, focusing on healthy eating and increased physical activity. Researchers…

This study compares three different support programs to help pregnant women maintain a healthy weight during pregnancy and after giving birth. Researchers want to see which approach works best at helping women return to their pre-pregnancy weight by 12 months after delivery. The …

This study is testing whether a specific type of video-delivered talk therapy, combined with reviewing continuous glucose monitor data, can help young adults with type 1 diabetes feel less anxious and depressed and improve their blood sugar control. Researchers will compare this …

This study is testing a coaching and navigation program called enCompass Humana, designed to support family members who are unpaid caregivers for adults with both cancer and diabetes. The goal is to see if the program is practical and acceptable, and if it can help caregivers fee…

This study aims to see if using one common anesthesia drug (propofol) instead of another (sevoflurane) can lower the risk of post-surgery confusion, known as delirium, in older diabetic patients. It will involve 450 patients aged 60 and over having major non-heart surgery. The go…

This study is testing whether group counseling can help people who feel shame or stigma because of their health condition. Researchers are enrolling 195 adults with conditions like obesity, cancer, HIV, diabetes, or chronic pain who report feeling stigmatized. Participants will t…

This study aims to understand how fat buildup in the pancreas relates to the risk of developing type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat in 100 participants and see how it connects to their body's abilit…

This study aims to track the long-term health of over 4,000 adults in Shanghai to understand how heart, kidney, and metabolic conditions like diabetes and high blood pressure develop and interact over time. It is a follow-up to health data collected from the same group of people …

This study is testing a new type of heart scan to see if it can detect specific chemical changes in the hearts of people with aortic stenosis or diabetes. Researchers will compare scans from 96 participants—including healthy volunteers and people with these conditions—to understa…

This study aims to find biological markers in blood that could indicate how diabetes develops and worsens. Researchers are recruiting 165 people, including those with type 1 or type 2 diabetes, people with early blood sugar changes, and healthy volunteers. Participants will provi…

This study aims to check the accuracy and consistency of various laboratory tests and research procedures used to study chronic diseases like obesity, diabetes, and heart failure. It will enroll up to 100 adults, both healthy and with certain conditions, to perform tests multiple…

This study aims to follow 2000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress. Researchers will collect health data to identify which factors most influence the development of serious complications like heart disease and diabet…

This study is creating a collection of health information and DNA samples from 500 adults to help researchers better understand heart disease, high blood pressure, diabetes, and obesity. Participants provide their health data and biological samples, which will be stored for futur…

This study aims to create a powerful research tool to understand diabetes. Participants provide a single small skin, blood, or urine sample. Scientists will use these samples to create stem cells and then turn them into insulin-producing cells in the lab to study the disease.

This study aims to understand how the stress of long-term caregiving affects a person's health and well-being over many years. Researchers will follow 2,800 caregivers for up to five years, using surveys, interviews, and optional blood tests to track changes in their social life,…

This study aims to understand how small vessel disease in the brain develops and progresses, which can lead to memory problems and dementia. Researchers will follow 50 people who have had a stroke and have risk factors like high blood pressure or diabetes. Participants will have …

This early-stage study aims to see if stem cells can be taken from tiny taste buds on the tongue, grown in a lab, and turned into cells that produce insulin. Researchers will enroll 250 healthy adults to collect small tongue tissue samples and study how these cells change with ag…

This study aims to collect genetic and health information from 3,000 people to understand how genes affect medication responses. The goal is to help doctors prescribe the right drugs and doses to avoid harmful side effects, especially for people taking multiple medications. Resea…

This study is a partnership between the University of Colorado and community groups to better understand and improve health in specific Colorado communities. It aims to learn how to make health research more relevant and accessible by working directly with trusted local members. …

This study aims to understand how the pancreas changes size during pregnancy and how this relates to diabetes risk. Researchers will use MRI scans to track pancreas size in about 87 pregnant women and their developing babies from early pregnancy until one year after birth. The go…

This study is testing an online training program for primary care doctors working in community health centers across the U.S. The goal is to see if giving doctors specialized diabetes education and support through video calls improves care for their patients. Researchers will mea…

This study aims to understand how the brain uses a fuel called lactate, especially in people with obesity. Researchers will compare brain blood flow and lactate levels during exercise in 24 adults with and without obesity. They also want to see if a short exercise program changes…

This study aims to understand how obesity relates to heart disease risk in Black men and women, as past research shows the connection may be different than in other groups. Researchers will enroll 2000 healthy, non-diabetic Black adults to measure body fat, blood fats, and how th…

This study aims to understand why people with diabetes often have lower vitamin C levels in their blood. Researchers will compare vitamin C measurements in blood and urine from 5,000 people with and without diabetes. The goal is to determine if people with diabetes lose more vita…

This study aims to understand how weight loss and improved diabetes control after bariatric surgery affect brain function and thinking. Researchers will follow 120 participants, testing their memory and brain scans before surgery, after 12 weeks, and at 18 months. They will also …

This study aims to find biological markers in blood, wound fluid, and tissue that can predict whether a diabetic foot ulcer will heal or not. It will enroll 5000 adults with an open foot ulcer from diabetes to collect samples and track their healing over 78 weeks. The goal is to …

This study aims to create better formulas for measuring how the human body uses energy (metabolism). Researchers will compare 2000 healthy volunteers and people with conditions like diabetes or cancer. They will use detailed scans and breath tests during short hospital stays to u…

This study aims to understand how our environment and our genes work together to influence our risk for common diseases like diabetes, heart disease, and asthma. It will enroll 25,000 adults to collect detailed health, lifestyle, and genetic information to build a research resour…

This study aims to find out if certain proteins in the blood can help predict which older diabetic patients might develop confusion after surgery. Researchers will collect blood samples from 180 patients before their operation and measure specific protein levels. They will then t…

This study aims to develop better MRI scanning methods to see the heart and arteries in more detail without using radiation. Researchers will compare these new MRI techniques to standard heart tests in up to 4000 adults, including both healthy volunteers and people with or at ris…

This study aims to test new, high-tech eye imaging systems that can see microscopic details of the eye, like individual cells and blood flow, which are not visible with standard equipment. Researchers will enroll 1,200 participants, including people with various eye conditions an…

This study aims to understand how a person's weight and blood sugar levels affect gene activity in their body tissues. Researchers will collect tissue samples from 20,000 people undergoing abdominal surgery to see how genes are expressed differently in those with obesity, diabete…

This study aims to understand how common diabetes-related complications are in people with cystic fibrosis who have had diabetes for at least five years. Researchers will examine 200 adolescents and adults to check for eye, kidney, and nerve problems, as well as heart disease ris…

This study aims to discover the genetic factors that contribute to type 2 diabetes and related conditions like high blood pressure in people of African ancestry, particularly the Yoruba population in Nigeria. Researchers will collect health data and DNA samples from 10,000 partic…

This study is testing whether a new decision-making guide helps hospital doctors better manage chronic medications like those for diabetes and high blood pressure in older patients. Researchers will see if doctors using the guide feel more confident and make fewer unnecessary med…

This study aims to understand if ultrasound scans of leg nerves can help explain walking and balance problems in people with diabetic nerve damage. Researchers will compare ultrasound measurements with walking tests and balance assessments in 86 people, including those with and w…