DIABETES

This study tested an AI-based system called X-Life that gives personalized lifestyle advice to adults with type 2 diabetes. 124 participants used the system along with glucose monitors and activity trackers to improve their blood sugar control. The goal was to see if the AI guida…

This study looked at whether treating gum disease (periodontitis) can improve blood sugar control in people with diabetes. 91 adults with both conditions were randomly assigned to receive gum treatment either right away or after the study ended. The main goal was to see if the tr…

This study tested a new method called the inforatio technique to help heal diabetic foot ulcers. The technique involves making tiny cuts in the wound to trigger the body's natural healing response. The trial included 100 adults with diabetes and foot ulcers that had not healed fo…

This study tested a personalized lifestyle program for 232 overweight or obese Hispanic women during and after pregnancy. The goal was to help them gain a healthy amount of weight during pregnancy, lose weight after birth, and improve blood sugar and other health markers. The pro…

This study tested a program where community health workers helped young adults (ages 18-35) from underrepresented minority groups with type 1 diabetes start and continue using diabetes technology like continuous glucose monitors and insulin pumps. Over 9 months, 119 participants …

This early-stage study tested an experimental drug called CT-388 in 129 overweight or obese adults, some with type 2 diabetes. The goal was to check safety and how the drug affects body weight and blood sugar. Participants received either the drug or a placebo as a shot under the…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days. 247 adults with diabetes wore the sensor along with a standard continuous glucose monitor and took fingerstick tests. The goal was to see if the new se…

This study looked at whether community health workers can help low-income adults better manage chronic diseases like diabetes, high blood pressure, and obesity. About 200 people took part over 10 months. The goal was to see if working with a health worker improved health markers …

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. The goal was to see if these drugs could lower the risk of death or hospitalization due to worsening heart failure. Participants took either the drugs …

This study looked at whether getting blood sugar under control for a short time before major abdominal surgery can lower the risk of problems and death in adults with uncontrolled diabetes. Researchers enrolled 53 patients with high HbA1c levels (7.5% or higher) who were schedule…

This study tested whether a personalized program of diet, aerobic exercise, and balance training could improve autonomic nerve function and balance in people with prediabetes or early type 2 diabetes. 61 participants were assigned to either the program or standard care. The goal …

This small pilot study tested a closed-loop system that automatically adjusts insulin delivery for people with type 1 diabetes. Five adults who already use an insulin pump and continuous glucose monitor took part. The goal was to see if the system works reliably and helps keep bl…

This study tested whether people with type 2 diabetes and early kidney disease can manage their medications from home. Twelve participants took empagliflozin and, if needed, added finerenone to lower protein in their urine. They measured their own blood pressure, weight, and coll…

This study tested a program called Family Check-Up Heart, which helps new mothers and their babies improve heart health through home visits. About 117 low-income mothers in Allegheny County took part. The program focused on healthy weight, blood pressure, and lifestyle habits aft…

This study tested a weight maintenance program delivered through a patient portal. Adults who had already lost at least 5% of their body weight were randomly assigned to track their weight, diet, and activity with or without coaching from routine healthcare staff. The goal was to…

This early study tested a new device used during an endoscopy to regenerate the lining of the small intestine in people with type 2 diabetes. Twenty adults whose blood sugar was not well controlled with 2-3 non-insulin medications took part. The main goal was to see if the proced…

This study tested a virtual cooking and nutrition program for 89 adults with type 2 diabetes and high body mass index. Participants attended online culinary medicine classes to learn healthy cooking skills and improve their diet. The goal was to see if the program could help lowe…

This study tested a new type of education for people with type 2 diabetes. Instead of just giving instructions, the program focused on empowering patients to manage their own condition. 50 adults with diabetes took part, and researchers measured their blood sugar control and self…

This pilot study tested a 6-month program of healthy eating (plant-forward diet) and active living to help people with early Type 2 diabetes achieve remission. It involved 35 adults with diabetes and obesity from low-income Memphis neighborhoods. The program used health coaches a…

This study looked at whether adding the antibiotic rifampin to usual treatment can prevent foot or leg amputations in people with diabetes who have a bone infection. Over 800 adults took part. The goal was to see if the combination works better than standard care alone to keep pa…

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used the dual-hormone closed loop system or standard care. The goal was to see if the system helps people spen…

This study looked at whether bringing HIV and chronic disease care into the community and linking it with microfinance groups helps people with HIV stay in care and keep the virus under control. About 1,200 adults in rural Kenya took part. The goal was to see if this combined app…

This study tested whether the diabetes pill glyburide works as well as insulin shots for controlling gestational diabetes (high blood sugar during pregnancy). Over 900 pregnant women took either the pill or insulin. Researchers checked if babies had fewer problems like being very…

This study tested a program to help South Asian adults with uncontrolled diabetes lower their blood sugar (HbA1c). The program included health coaching, referrals to community resources, and better care coordination. 859 participants took part, and the main goal was to see if at …

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for diabetes and heart disease. Researchers compared normal-weight and overweight/obese South Asian adults who sit at least 7…

This study tested a new automated screening tool called OPTDR01 to detect diabetic retinopathy, an eye disease that can cause vision loss. The goal was to see if the tool is easy to use and works well in primary care settings, making screening more accessible. About 300 adults wi…

This study tested a new device that measures blood sugar without needles. It compared the device's readings to standard blood tests in 40 adults, including healthy people, those with prediabetes, and those with type 2 diabetes. The goal was to see if the non-invasive method is ac…

This study tested how well a new finger-prick blood glucose monitor works. Researchers compared its readings to those from a lab machine to see if it's accurate enough for people with diabetes to use at home. Over 200 adult volunteers with different blood sugar levels participate…

This study tested a program that gives people at risk for diabetes free healthy food and nutrition coaching. The goal was to help them stick with healthy habits and lower their chances of getting diabetes. 61 adults with high blood sugar took part. Researchers tracked how many cl…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), could reduce daily pain in adults with painful diabetic neuropathy and large blood sugar swings. 170 participants were randomly assigned to receive acarbose or a placebo for …

This study tested a program that sends text reminders and uses social support and game-like features to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults who own a smartphone took part. The goal was …

This study tested a personalized home exercise program for cancer survivors who also have diabetes or high blood pressure. Thirty-four participants chose from four exercise options (like walking or yoga) and used a wearable device to track their activity. The goal was to see if t…

This study looked at whether quercetin, a compound found in many foods, can change how the body absorbs sugar. Researchers gave 24 obese adults, some with type 2 diabetes, either quercetin or a placebo during a sugar-drink test. They measured blood sugar levels to see if querceti…

This study tested whether a 12-week foot-ankle exercise program could help adults with type 2 diabetes who have nerve pain in their feet. Researchers compared it to walking and to standard education alone. The main goal was to see if a larger study is possible, but early results …

This study tested a mobile health program designed to support family caregivers of people who have both dementia and diabetes. Sixty caregivers used the app for three months to get guidance and reduce their stress. The goal was to see if the app could lower caregiver burden and i…

This study looked at whether foot-ankle exercises or walking exercises can help people with type 2 diabetes who have nerve problems in their feet. 375 adults with diabetes were split into three groups: one did foot-ankle exercises, one did walking, and one received only standard …

This study looked at how often low blood sugar (hypoglycemia) happens in elderly diabetic patients living in nursing homes. Researchers used continuous glucose monitors to track blood sugar levels in 29 participants over 60 years old. The goal was to find out how common these eve…

This study tested a new workbook filled with word games to help people with diabetes learn how to manage their condition. 25 participants used the workbook during clinic visits or at home to learn about carbohydrate management and diabetes terms. The goal was to see if this appro…

This study tested a text-message program that sends diabetes education and resource referrals to patients in the emergency department. 50 adults with poorly controlled or new diabetes took part. The goal was to see if the program improved diabetes knowledge, reduced diabetes-rela…

This study looked at whether giving mothers a family health history package could help them teach their families about disease risks and encourage healthier eating and physical activity. About 310 adults with children took part, completing surveys and interviews. The goal was to …

This study examined 200 patients who had surgery to clear blocked neck arteries. Researchers looked for bacteria inside the removed plaque and tracked whether certain bacteria were linked to later problems like stroke or re-narrowing of the artery. The goal was to learn which bac…

This study looked at how vitamin E is absorbed and used by the body in normal-weight, overweight, and obese women, including those with type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after different meals and vitamin C doses. The goal was to better un…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from the same households to understand how culture and family ties help or hinder these conversations. The goal i…

This study looked at whether viruses in pregnant women with diabetes might increase the risk of congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect enteroviruses and other viruses. The goal was to gather knowledge for fu…

This study looked at medical records from over 740,000 older adults with diabetes to see if a drug called semaglutide (used for diabetes) might lower the risk of developing dementia or Alzheimer's disease. Researchers compared people taking semaglutide to those taking other diabe…

This study checked whether acetaminophen (Tylenol) interferes with a new continuous glucose monitor (CGM) called Biolinq. 31 adults with diabetes wore the Biolinq sensor and a standard CGM for three days. On the third day, they took acetaminophen and had their blood sugar measure…

This study looked at over 30,000 adults hospitalized in Maryland to understand why some patients wait in the emergency room after being admitted (called boarding) and how that affects costs and care. Researchers analyzed existing medical records to find patterns and financial imp…

This study looked at how the calories people burn through physical activity relate to body weight and diabetes risk. Researchers tracked 2,500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US over two years. They used activity monitors and special water test…

This study tested whether combining health information technology with practice facilitation (coaching for clinic staff) could increase referrals to diabetes self-management education. Twenty-two clinics participated. The goal was to see if these tools help clinics refer more pat…

This study tested a program that combined job placement support with health coaching to see if it could lower the risk of chronic diseases like diabetes and heart disease in unemployed, low-income adults. 455 people took part and were followed for a year. The goal was to see if t…

This study looked at whether a continuous glucose monitor (Freestyle Libre) can help track blood sugar levels in diabetic patients who are starting chemotherapy. About 103 adults with diabetes and cancer participated. The goal was to see how often blood sugar went too low or too …

This completed study looked at how lifestyle changes like diet and exercise affect blood sugar in 61 adults with diabetes. Researchers used advanced tests (genomics, proteomics, and more) to find the biological pathways involved. The goal was to build a model that could help pers…

This study looked at 120 people having hand or wrist surgery to see if kidney failure or diabetes changes how long a nerve block lasts. Researchers measured the time it took for feeling to return after the block. The goal was to understand how these metabolic conditions affect re…

This study looked at how family members talk about genetic health risks like sickle cell, diabetes, cancer, and heart disease. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand how sharing this information …

This study looked for rare forms of diabetes caused by a single gene, rather than the usual mix of many genes. Researchers studied 127 people with severe or unusual diabetes, along with their family members. The goal was to find new genes and better understand these genetic types…

This study looked at how well people with stable coronary artery disease handle fats (triglycerides) and sugar after a meal. Over 18 months, researchers tracked heart attacks, strokes, and deaths to see if a fat-tolerance test could identify those at higher risk. The goal was to …

This study looked at whether replacing sitting time with standing or walking can help control blood sugar in South Asian adults who are overweight or obese. Eighteen participants changed their daily routines to sit less and move more. The results showed that even small changes ca…

This study looked at 146 healthy women of African, African-American, and white backgrounds to see if risk factors for diabetes and heart disease differ by race. Participants completed several visits including blood tests, glucose tolerance tests, body fat measurements, and meal t…

This study looked at how different diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems after losing weight. Over 200 adults took part, and researchers measured their energy use by having them drink special water and trackin…

This study tested whether a personalized lifestyle program could help people with obesity and related conditions like prediabetes or high blood pressure improve their insulin resistance. Forty adults received either nutrition or exercise counseling first, and if they didn't impro…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors affects kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drugs helped preserve kidney function. The goal was to understa…

This study tested a new AI system called X Life that gives personalized lifestyle advice to people with type 2 diabetes or prediabetes. The system uses data from continuous glucose monitors and activity trackers to offer tailored health tips. Twenty participants used the system t…

This study tested whether a Fitbit activity tracker plus health coaching could help people with overweight or obesity who are already taking weight loss medications (GLP-1/GIP) become more active. Fifteen patients from a primary care clinic participated in a 12-week program where…

This study looked at how two diabetes medications, metformin and HRS-7535, affect each other in the body. It involved 18 healthy men aged 18 to 50. The goal was to measure drug levels and safety, not to treat any disease.

This study looked at a recently discovered protein called 26RFa, which may be linked to hunger, blood sugar, and obesity. Researchers measured its levels in 62 obese women (some with type 2 diabetes) before and after weight-loss surgery, and compared them to healthy volunteers. T…

This study looked at whether having a doctor send an online referral to a food program called WIC helps more pregnant women sign up. About 240 pregnant women on Medicaid or without insurance took part. Some got usual care, others got a direct referral, and some also spoke with a …

This early-phase study tested whether a natural substance called apelin can improve how the body responds to insulin in people with type 2 diabetes. Nine adults with type 2 diabetes received apelin to measure changes in insulin sensitivity. The goal was to gather initial data, no…

This study aimed to measure how often older adults with diabetes living in nursing homes experience dangerously low blood sugar levels. Researchers used continuous glucose monitors on 86 residents for 10 days to track blood sugar patterns. The goal was to better understand this h…