Just 5 days of fatty food can mess with your muscles

NCT ID NCT02328235

Completed Knowledge-focused Sponsor: Kevin Davy Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how eating a high fat diet for just 5 days changes the way muscles handle sugar and fat. Researchers fed 11 healthy men a diet with 50-60% fat and measured muscle flexibility and gut health. The goal was to understand why muscles in people with diabetes become 'metabolically inflexible' and whether gut bacteria play a role.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High saturated fat diet
What this could lead to: If successful, this research could help explain how diet contributes to metabolic inflexibility and insulin resistance, pointing toward dietary strategies to prevent diabetes.
What could go wrong: This is a small, early-stage study with only 11 healthy men, so results may not apply to women, older adults, or people with existing health conditions. It focuses on understanding mechanisms, not testing a treatment.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES

Contacts and locations

Locations

Virginia Polytechnic and State University

Blacksburg, Virginia, 24061, United States

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