DIABETES

This study tests a new way to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one heart-related condition will be enrolled. Their primary care doctors will work more cl…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to diabetes and high blood fats. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This study tests whether a natural substance called maslinic acid, found in olives, can safely improve health in 50 Chinese adults with excess weight or early signs of metabolic syndrome. Over 12 weeks, researchers will measure changes in blood sugar, body fat, energy use, and br…

This study tests whether giving free boxes of fruits and vegetables along with nutrition tips can help people with diabetes, high blood pressure, or obesity improve their health. About 300 adults in three Mississippi Delta counties will take part. The main goal is to see if blood…

This study gives the drug metreleptin to people with partial lipodystrophy, a rare condition that causes abnormal fat storage, high blood fats, and diabetes. Participants have already shown improvement from metreleptin in earlier studies and cannot get the drug elsewhere. The goa…

This study tests a new insulin called GZR4 that is taken once a week, compared to a standard daily insulin, in people with type 2 diabetes who already use insulin. About 580 adults will take part to see if the weekly shot controls blood sugar just as well, with fewer injections a…

This study tests a program where community paramedics visit adults with diabetes who have had severe low blood sugar (hypoglycemia). The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. About 150 people in southeast…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, hi…

This study tests whether giving people with obesity and diabetes a monthly $160 subsidy for fruits and vegetables helps them buy more healthy food. 214 participants will be split into groups, some receiving the subsidy and some not, for 3 months. Researchers will track how much p…

This study tests two treatment plans for people who develop diabetes from taking steroids. One plan uses a combination of a GLP-1 receptor agonist and long-acting insulin, while the other uses standard intensive insulin therapy. The goal is to see which approach better controls b…

This study tests a culturally tailored support program for Chinese and Korean American caregivers of relatives with dementia. The program combines counseling with online peer support groups to help reduce stress, depression, and health risks like diabetes and heart disease. Resea…

This study tests a new insulin called GZR4 that is given once a week, compared to a standard daily insulin, in people with type 2 diabetes who have never used insulin before. About 580 adults will take part to see if the weekly shot works as well or better at controlling blood su…

This study tests whether pharmacists can help people lower their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity will receive pharmacist-led support. The goal is to see if this approach reduces overall cardiovascular risk wi…

This study looks at whether adding the medication insulin detemir to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight and improve brain function related to food pleasure. About 240 adults aged 31-60 will be split into two groups: one on diet only,…

This study looks at how well the Joslin Why WAIT? program works for people with type 2 diabetes and a BMI over 35. The program aims to help participants lose at least 7% of their body weight and improve blood sugar and cholesterol levels. The study followed 110 participants to se…

This study compares two special nutritional drinks for people with diabetes who are at risk of malnutrition. About 100 adults with type 1, type 2, or prediabetes took one of the two drinks for 90 days. The goal was to see if the new drink works as well as the existing one in impr…

This study tests a new point-of-care platform that gives instant results for key diabetes markers (HbA1c and cystatin C) during clinic visits. Researchers want to see if this quick feedback helps improve kidney function and other outcomes in 222 adults with diabetes. The goal is …

This study tests a new insulin called GZR4 that is taken once a week, compared to a daily insulin (degludec), in adults with type 2 diabetes who already use basal insulin. The goal is to see if the weekly shot works as well or better at controlling blood sugar and is safe. About …

This study tests a home collection kit for people with diabetes to measure their HbA1c, a key blood sugar marker. 63 adults with Type 1 or Type 2 diabetes will use the kit and mail a dried blood spot to the lab. The goal is to see if the kit is accurate and easy to use, potential…

This study looks at whether giving extra support—like phone calls and resources—to people who don't lose weight early in a diabetes prevention program can help them succeed. About 400 Black adults without diabetes but at high risk took part in community settings like churches. Th…

This study looks at whether taking a daily extract of yerba mate can improve health markers like weight, blood sugar, and cholesterol in overweight adults. 80 people aged 40-65 will take either the extract or a placebo for 90 days. Researchers will measure changes in body fat, bl…

This study is testing a new way of running a diabetes clinic for children under 10. The clinic uses play, healthy lifestyle coaching, and parent support groups to help families manage diabetes with less stress. Researchers will measure if this approach improves quality of life fo…

This study tests whether fun challenges (gamification) and personal coaching can help older adults become more active after leaving the hospital. About 350 people aged 50+ with conditions like high blood pressure or heart failure will wear a Fitbit to track steps. The goal is to …

This study looks at whether a mindfulness-based stress reduction program and yoga can lower stress, improve quality of life, and help control blood sugar in teenagers with type 1 diabetes. About 90 teens aged 13 to 18 will take part. The goal is to see if these mind-body practice…

This study looks at how a single dose of the experimental drug GZR4 injection behaves in the body of people with mild, moderate, or severe liver impairment compared to those with normal liver function. The goal is to understand safety and how the drug is processed. 36 adults with…

This study looks at whether using a Fitbit and a continuous glucose monitor (CGM) is practical for people with cancer or diabetes who want to track their daily exercise. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if pe…

This study looks at differences in body composition, fitness, and how body temperature changes during exercise between young soccer players with type 1 diabetes and healthy ones. About 40 boys will be monitored with thermal cameras and continuous glucose sensors. The goal is to l…

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to track heart disease risks like high blood pressure, diabetes, and smoking. Researchers will measure how common these risks are and how they lead to heart attacks, strokes, or heart failure. The g…

This study looks at whether a 'Learning Health System' can help clinics in Thailand better manage high blood pressure, diabetes, and kidney disease. About 419 people from 16 primary care units will take part. The approach uses electronic health records to give care teams real-tim…

This study aims to collect genetic information and health data from 1,100 adults of African ancestry (including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa) to better understand why obesity, type 2 diabetes, and heart disease are common in these popul…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to see how memory, thinking, and daily activities change over time. Researchers will compare the two groups and look for risk factors that may lead to cognitive decline, dementia, or str…

This study is a review of many smaller studies that looked at what happens when people replace animal proteins (like meat, dairy, and eggs) with plant proteins (like beans, nuts, and seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressu…

This study follows thousands of Black and white adults in Baltimore over many years to understand how race and income differences lead to health problems like heart disease, diabetes, and memory loss as people age. Participants complete health exams, questionnaires, and some get …

This study tests different ways to invite adults with diabetes to meet with a pharmacist for medication support. About 590 participants will receive different letters and phone call schedules to see which approach works best. The goal is to find a simple, repeatable method that c…

This study looks at how certain immune proteins, called the complement system, may contribute to kidney damage in people with diabetes. Researchers will measure these proteins in blood and urine from 90 participants to see if they are linked to kidney disease stage and blood vess…

This study looks at whether treating patients at home, instead of in a hospital, can lead to better health outcomes and happier patients. About 9,654 adults with conditions like heart failure, infections, or diabetes will receive hospital-level care in their own homes. Researcher…

This study looks at how bariatric surgery affects the way the body handles sugar and fat. Researchers will collect tissue and blood samples from 500 people having weight-loss surgery or other procedures. The goal is to learn more about how the intestines signal other organs, whic…

This study looks at how COVID-19 may change organs like the heart, lungs, or kidneys in people who have diabetes and those who don't. Researchers will use scans to measure organ size and other changes in 35 adults who had COVID-19. The goal is to learn more about long-term effect…

This study is creating a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genes and other markers to better predict who is at risk for serious complications like kidney failure, heart disease, and stroke…

This study looks at how diabetes impacts the quality of life, breathing, and nutrition of adults with cystic fibrosis. Researchers will compare patients with and without diabetes using questionnaires and lung function tests. The goal is to better understand these connections to i…

This study aimed to see if people with diabetes have slower stomach emptying after fasting, which could raise the risk of complications during surgery. Researchers planned to use ultrasound to compare stomach contents between diabetic and non-diabetic patients before scheduled va…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs in tiny particles called exosomes. The goal is to better …