DIABETES

This study is evaluating the health results of a 12-week intensive program for adults with type 2 diabetes and obesity. The program focuses on helping participants lose weight and better control their diabetes. Researchers are measuring changes in body weight, blood sugar levels,…

This study is testing if a new weekly insulin injection (GZR4) works as well and is as safe as the standard daily insulin (glargine) for people with type 2 diabetes who haven't started insulin yet. It will involve about 580 participants and will compare how well each treatment co…

This study is testing a new way of running a diabetes clinic for children under 10. It focuses on using play, teaching calmness during daily care tasks, promoting healthy lifestyles, and connecting families for support. The goal is to see if this more family-friendly approach imp…

This study provides continued access to the drug metreleptin for people with partial lipodystrophy, a rare condition that causes severe diabetes and high blood fats. It is for patients who have already benefited from the drug in past NIH studies but cannot get it through regular …

This study is testing whether providing hospital-level medical care in a patient's own home is a safe and effective alternative to a traditional hospital stay. It will involve nearly 10,000 adults with conditions like heart failure, infections, or COPD who qualify for hospital ad…

This study is testing if a new, once-weekly insulin injection called GZR4 is as effective and safe as a standard daily insulin for adults with type 2 diabetes. It will involve about 620 people who are already using a long-acting insulin. The main goal is to see which treatment be…

This study is testing if a new experimental insulin called GZR4, given just once a week, works as well and is as safe as the standard daily insulin injections for people with type 2 diabetes. It will involve about 580 adults who are already using a combination of long-acting and …

This study is testing whether a concentrated extract from yerba mate, a traditional tea, can improve health markers in overweight adults. 80 participants will take either the extract or a placebo pill daily for 90 days. Researchers will measure changes in weight, body fat, blood …

This study provides continued access to the drug metreleptin for people with a rare condition called generalized lipodystrophy who have previously received it through NIH research and cannot get it through normal channels in their home country. It aims to monitor the long-term sa…

This study tests a new program designed to improve teamwork between cancer specialists and primary care doctors (PCPs) for patients who have both cancer and a heart-related condition like high blood pressure or diabetes. The goal is to see if better coordination helps manage the …

This study is testing if giving people with both obesity and diabetes a monthly grocery subsidy for fruits and vegetables, along with support using an online delivery service, helps them buy and eat healthier foods. About 214 participants are assigned to different groups that rec…

This study is testing whether adding a specific long-acting insulin (detemir) to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight than dieting alone. Researchers want to see if the insulin works by changing brain activity related to pleasure and r…

This study is testing if a newer combination treatment (a GLP-1 drug plus a long-acting insulin) works better than standard insulin therapy alone for people who develop diabetes from taking steroid medications. It will involve about 100 adults who need steroids for conditions lik…

This study is testing whether using a fast, in-clinic blood test for key diabetes markers helps doctors better manage the disease and protect patients' kidney health over time. It involves 222 adults with diabetes who are receiving regular care. The goal is to see if getting test…

This study is testing whether a new nutritional drink for people with diabetes works as well as an existing one. About 100 adults with diabetes or prediabetes who are at risk for poor nutrition will drink one of the two formulas daily for 90 days. Researchers will check if the ne…

This study is evaluating a home blood collection kit that lets people with diabetes test their blood sugar levels without visiting a clinic. Researchers are testing whether the kit is accurate compared to standard lab tests and whether patients find it convenient to use. The goal…

This study is testing whether pharmacists can help people lower their risk of heart disease. Over 1,000 adults with conditions like high blood pressure, diabetes, or who smoke will work with pharmacists for up to six months. The goal is to see if this support leads to better bloo…

This study tested whether giving extra, personalized help to people who weren't losing weight early in a standard diabetes prevention program could help them succeed. It involved 403 Black adults at high risk for diabetes who were part of community programs, mainly in churches. R…

This study is testing a counseling and support program designed to help Chinese and Korean American family members caring for a loved one with dementia. The program includes individual counseling, family sessions, and online chat groups to provide emotional support and health inf…

This study is testing whether mindfulness training and yoga can help teenagers with type 1 diabetes. Researchers want to see if these practices can lower stress, improve quality of life, and potentially help with blood sugar control. The study involves 90 teens aged 13 to 18 who …

This small pilot study is testing whether a word game-based workbook can help people with type 2 diabetes learn how to better manage their condition. Researchers developed a workbook with puzzles and games that teach diabetes management concepts, focusing first on carbohydrate co…

This study aims to understand why African diaspora populations have higher rates of obesity, type 2 diabetes, and heart disease by examining their genetic makeup. Researchers will collect health information and blood samples from about 1,100 adults who identify as African America…

This long-term study follows a diverse group of 3,720 adults in Baltimore over many years. Its main goal is to understand why health differences exist between racial and income groups as people get older. Researchers use mobile medical vans and regular check-ups to collect health…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This research aims to understand how weight loss surgery helps improve diabetes and metabolism by studying tissue samples from patients. Researchers will collect small samples of fat, muscle, liver, and intestine during scheduled medical procedures like endoscopies and surgeries.…

This study is testing whether it's practical to use a Fitbit activity tracker and a continuous glucose monitor together to track daily exercise patterns. It involves 35 adults who are either cancer survivors or at risk for diabetes but do not have diabetes. The main goal is to se…

This study aims to better understand how having diabetes affects the health and daily life of adults with cystic fibrosis. Researchers will compare the quality of life, lung function, and nutritional status of patients with and without diabetes. They will also look at how newer c…

This study aims to understand why some people with diabetes develop serious heart and kidney problems while others do not. Researchers are collecting detailed health information and blood samples from 48,000 people with diabetes in Hong Kong to look for genetic and other biologic…

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This study aimed to understand if diabetic patients have food or liquid left in their stomachs before scheduled surgery, even after following standard fasting rules. Researchers planned to use a simple, non-invasive ultrasound scan to compare the stomachs of diabetic and non-diab…

This study aims to understand how type 1 diabetes affects young athletes' bodies during exercise. Researchers will compare 40 young soccer players—half with diabetes and half without—measuring their fitness, body composition, and temperature changes during workouts. By monitoring…

This project is not a new treatment trial, but a large-scale analysis of past research. Researchers are compiling and reviewing results from many existing diet studies to understand if replacing animal protein (like meat and dairy) with plant protein (like beans and nuts) leads t…

This study aims to understand how part of the immune system, called the complement system, contributes to kidney damage in people with diabetes. Researchers will measure specific proteins in the blood and urine of 90 participants with diabetic kidney disease to see if immune syst…

This early-stage study aims to understand how a potential diabetes drug, GZR4 Injection, is processed by the body in people with varying degrees of liver impairment. It will enroll 36 adults, including those with mild, moderate, or severe liver damage, as well as people with norm…