METABOLIC SYNDROME

This study looks at whether taking a yerba mate extract can help improve health markers in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researchers will measure changes in weight, blood sugar, cholesterol, and inflammation to …

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study looks at whether eating almonds every day for 12 weeks can improve gut health and lower inflammation in people with metabolic syndrome. About 80 adults aged 35-60 with conditions like high blood pressure, high blood sugar, or unhealthy cholesterol levels will participa…

This study tests a 6-month home-based program called FIT Families, designed to help African American teens with obesity and their caregivers lose weight. The program includes coaching sessions, family counseling, and small prizes for completing tasks. Researchers will measure cha…

This study tests whether a 6-week exercise program, done twice a week, can improve physical and mental health in 100 adults with severe mental illness. Participants are randomly assigned to either usual care or usual care plus the exercise program. The goal is to see if exercise …

This study tests whether maslinic acid, a natural compound found in olive skins, can improve metabolic health by activating brown fat—a type of fat that burns calories. Fifty adults with pre-metabolic syndrome or mild obesity will take maslinic acid or a placebo for 12 weeks. Res…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study looks at whether a 26-week behavioral weight loss program called 'Paso a Paso' is practical for Mexican and Central American adults with fatty liver disease and overweight. Researchers will track attendance, weight loss, liver stiffness, and diet changes in 50 particip…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This study tests whether a daily supplement containing inositol and alpha-lactalbumin can improve blood sugar, cholesterol, blood pressure, and heart health in people with metabolic syndrome who are at risk for cardiac fibrosis. Thirty participants will take the supplement for 18…

This study looks at whether eating 2 cups of frozen raspberries daily for 8 weeks can improve blood sugar, cholesterol, and gut health in overweight or obese adults with early signs of metabolic syndrome. Researchers want to see if the berries' natural compounds help by changing …

This study tests whether taking 50 grams of blueberry powder daily for 8 weeks can improve gut bacteria and metabolic health in overweight or obese adults. Researchers will measure changes in blood sugar, cholesterol, and gut microbes. The goal is to see if blueberries can help m…

This study looks at whether a protein supplement called carnitine can reduce hardening of the arteries in teenagers at high risk for future heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. Researchers will measure artery stiffness…

This study looks at whether a very-low-calorie ketogenic diet (VLCKD) helps people with severe obesity and metabolic syndrome lose more weight and improve heart health over three years compared to a standard Mediterranean diet. About 100 adults aged 55-75 will be randomly assigne…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study is testing a digital health platform called STELA that creates personalized lifestyle plans to reduce risk factors for heart disease, like obesity, high cholesterol, and insulin resistance. About 100 adults without existing heart disease will use the platform for a yea…

This study tests whether coaching for Latino mothers on how to feed and put their babies to sleep can prevent obesity in the first two years of life. About 256 mothers and their healthy full-term infants will receive either group coaching or text-based support. The goal is to hel…

This study tests whether a home-based walking program can improve blood sugar, cholesterol, and body measurements in people living with HIV who also have metabolic syndrome. Fifty participants will gradually increase their walking over six months. The main goal is to see if the p…

This study looks at whether pretzels made with safflower oil and soy can help postmenopausal women with metabolic syndrome maintain a healthy weight. Twenty women will eat three different types of pretzels over 14 weeks, and researchers will measure how their bodies process the s…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study looks at how eating a diet rich in pulses—like beans, lentils, and peas—affects the gut microbiome, feelings of fullness, and appetite hormones. Researchers are enrolling 44 overweight or obese adults who will follow a high-pulse diet for four weeks. The goal is to see…

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study looked at 41 healthy adults who regularly drink sugary sodas. Researchers replaced their sugary drinks with either stevia-sweetened or aspartame-sweetened beverages for 10 weeks. The goal was to see how these alternatives affect metabolism and gut bacteria. The results…

This study looks at how dairy fat, especially a component called milk fat globule membrane, affects inflammation after a high-fat meal. Thirty-eight adults with metabolic syndrome or obesity will consume shakes with different fats, and researchers will measure inflammatory marker…

This study looks at how eating cheese, compared to a non-dairy cheese substitute, changes inflammation levels in the body over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand the shor…

This study looks at why storing fat around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to find better ways to treat diseases like diabetes and heart di…

This study looks at whether teenagers and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use advanced imaging and tests to measure liver fat, insulin resistance, and cholesterol problems in 80 participants…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…