Could a diabetes drug shield the brains of HIV patients?

This pilot study tested whether metformin, a common diabetes drug, can reduce blood vessel damage in the brain of people living with HIV who also have metabolic syndrome (a cluster of conditions like high blood pressure and cholesterol). The study enrolled 30 adults in South Africa and measured changes in brain blood flow and blood vessel function over 12 weeks. The goal was to see if metformin could help prevent long-term brain problems in this high-risk group.