Sitting less, moving more: new study reveals Body-Wide effects of activity changes
NCT ID NCT06377254
First seen Jan 11, 2026 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This study looks at how increasing or decreasing physical activity changes the way your body works. Forty overweight adults aged 50-65 will either become less active for 3 months then retrain, or become more active for 6 months. Researchers will measure fitness, muscle strength, brain function, and take tissue samples to understand the full-body impact.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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David Greenfield Human Physiology Unit
RECRUITINGNottingham, Notts, NG72UH, United Kingdom
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal how physical activity and inactivity impact multiple body systems, helping shape better public health advice for healthy aging.
What could go wrong
This is an early-stage observational intervention with only 40 participants. Results may not apply to everyone, and the study does not test a treatment or cure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.