Can diet, exercise, and pills tame metabolic syndrome?
NCT ID NCT06271200
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a strict lifestyle program—eating only during an 8-hour window, walking 10,000 steps daily, and cutting 500 calories—can help obese adults with metabolic syndrome lose weight and improve heart health. After 24 weeks, participants also receive either Rybelsus or Forxiga, two weight-loss medications, for another 26 weeks. The goal is to see if these approaches work together to reduce metabolic risks and sustain weight loss over a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lifestyle intervention (time-restricted eating, walking, calorie reduction) and weight-loss medications (Rybelsus or Forxiga)
What this could lead to
If successful, this could show that combining lifestyle changes with medication helps obese adults with metabolic syndrome lose weight and reduce heart disease risk.
What could go wrong
This is a mid-stage trial with 200 participants, so results may not apply to everyone. The lifestyle program is demanding, and medications can have side effects like nausea or dehydration.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institute of Molecular and Genomic Medicine, National Health Resesarch Institutes
RECRUITINGZhunan, Miaoli County, 350, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••