Obesity disorder

This trial tests whether a newer surgical technique, which combines sleeve gastrectomy with a rerouting of the digestive tract, can control acid reflux as well as the standard gastric bypass in adults with obesity. The new approach aims to keep the entire digestive tract visible …

This large phase 3 trial is testing a new once-weekly injection called MET097 for weight loss in 3501 adults with obesity or overweight (but without diabetes). Participants will receive either the drug or a placebo for up to 84 weeks. The main goal is to see how much weight peopl…

This early-stage study will compare two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version for several weeks, and researchers will measure how the drug builds up in the body. The goal is to s…

This study tests a new daily pill, orforglipron, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea lose weight. About 3,100 participants will take either the pill or a placebo for 72 weeks, with some continui…

This pilot study tests whether a daily probiotic supplement containing L. acidophilus (strain TW01), originally isolated from fermented coffee grounds, can improve gut health, body composition, and markers of inflammation. Overweight or obese adults aged 18-60 will take either th…

This study looks at whether eating only during a set window each day combined with short, intense exercise can help overweight adults lose fat and improve health markers like blood sugar and cholesterol. One hundred participants will follow this routine remotely for 12 months, wi…

This study tests whether offering personalized financial incentives can help 80 adults with obesity stick to a weight-loss program. Participants attend virtual group classes, log their calories, and weigh themselves regularly. The goal is to see if tailored rewards improve diet t…

This study looks at whether a daily dose of milk polar lipids (a type of fat found in milk) can improve cholesterol levels, reduce inflammation, and support gut health in adults with high cholesterol and abdominal obesity. Researchers will measure changes in blood fats and other …

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests a program that teaches parents how to help their child, a childhood cancer survivor, eat healthy and exercise more. The goal is to prevent or reduce obesity, which is a major risk for heart disease in these children. About 520 families will take part in one of tw…

This pilot trial tests whether the timing of carbohydrates and protein across meals can improve glucose metabolism in people with prediabetes or type 2 diabetes who are overweight or obese. Participants follow two different isocaloric diets—one with a high-protein breakfast and h…

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps adults with obesity or overweight lose more weight over 48 weeks. About 285 participants without diabetes will receive either the combination or a placebo pl…

This study tests an experimental drug called CS060380, taken with the weight-loss drug semaglutide, in adults with both fatty liver disease (MASH) and obesity. About 120 participants will be randomly assigned to get either CS060380 or a placebo for 36 weeks, then everyone gets CS…

This early-stage study tests a new daily pill, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor…

This trial tests whether adding self-monitoring of breath acetone—a marker of fat burning—to an app-based lifestyle program helps overweight adults lose more weight. Participants will use the LIM-App for 12 months and report their weight. The study compares those who also monitor…

This study tests whether a once-weekly injection of semaglutide helps children and teenagers (ages 6 to 17) with obesity or overweight lose weight. About 210 participants will receive either the drug or a placebo for up to 2.5 years, along with healthy lifestyle counseling. The m…

This Phase 3 trial tests whether cagrilintide, a new injectable drug, helps people with overweight or obesity lose weight. About 300 adults will receive either cagrilintide or a placebo for up to 18 months, along with lifestyle counseling. The study measures weight change and wai…

This study is testing a minimally invasive weight loss procedure called endoscopic sleeve gastroplasty (ESG) in 12 people who have both obesity and ulcerative colitis and are planning or have had colon removal surgery. The procedure uses a suturing device to reduce stomach size b…

This study tests whether a brief, personalized online tool (MyHealthPath) can increase the number of adults with obesity who start a comprehensive behavioral weight loss program. Participants will be randomly assigned to receive either the tailored tool or informational material.…

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This two-year study will follow 1,250 people with obesity who are starting Wegovy (semaglutide) as part of their regular medical care. Researchers will track changes in weight, waist size, and quality of life to see how the drug performs outside of clinical trials. The goal is to…

This pilot trial tests whether tirzepatide, a drug used for diabetes and weight loss, can help people who still have obesity one year after gastric bypass surgery. Thirty participants will either receive the drug or standard care. The study tracks weight changes and any stomach-r…

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight. Participants must have already been on weekly injections of semaglutide or tirzepatide for at least 6 months. The goal is to find …

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This Phase 3 trial tests whether zovaglutide, given as a shot every 4 weeks, helps people with overweight or obesity lose weight. About 744 adults will receive either the drug or a placebo for 52 weeks. The study measures how much weight they lose and how many achieve at least 5%…

This trial tests whether a nutritional supplement, designed with the help of artificial intelligence to target the gut microbiome, can help adults with overweight or obesity lose weight. Eighty participants will receive either the active supplement or a placebo for 24 weeks, alon…

This early-stage trial tests an experimental drug called SYH2069, given as an injection under the skin, in healthy volunteers. The goal is to see if it is safe and how the body processes it at different doses. The study includes people who are overweight or obese, as the drug is …

This study tested whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 women with high stress levels took part. The goal was to see if a culturally-tailored approach could improve weight loss resul…

This Phase 1 trial tests whether a single dose of an experimental drug called SYH2082 is safe and tolerable in healthy adults aged 18 to 55 who are overweight or have obesity. Participants receive either the drug or a placebo injection, and researchers monitor for side effects an…

This early-stage study is testing a new medicine called LY4167586 in people who are overweight or have obesity but are otherwise healthy. The main goal is to see if the drug is safe and how the body processes it after a single dose. About 84 participants will be randomly assigned…

This study tests a web-based tool called the BMI-CDS (Weight Loss Wizard) in 40 primary care clinics. The tool gives doctors and patients with type 2 diabetes and obesity personalized estimates of the benefits and risks of treatments like weight-loss surgery or medication. Over 1…

This trial tests whether 16 weeks of supervised exercise, with or without daily taurine supplements, can reduce fat stored inside the muscles of women aged 60–75 with obesity. Researchers will use MRI scans, muscle biopsies, and blood tests to measure changes in muscle compositio…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This Phase 3 study tests CagriSema, a weekly injection combining two drugs (cagrilintide and semaglutide), for weight loss and long-term weight maintenance in 609 adults with obesity. Participants are randomly assigned to receive either CagriSema or a placebo for over 3 years. Th…

This study tests whether a home-visit program called PAT+HEALTH can help pregnant women with obesity in Nigeria improve their heart health and manage weight. About 1,000 women will be randomly assigned to receive the program or standard care. Researchers will track weight, lifest…

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This Phase 2 trial tests two experimental drugs, trevogrumab and garetosmab, added to the weight-loss drug semaglutide (Wegovy) in about 1,000 people with obesity. The goal is to see if the combination improves weight loss and body composition (more fat loss, less muscle loss) co…

This study investigates whether tirzepatide, a drug used for diabetes and weight loss, can reverse biological aging in people with HIV who are virally suppressed and have obesity. Participants receive tirzepatide for 25 weeks after a diet program. Researchers measure epigenetic a…

This phase 3 trial tests whether retatrutide is better than tirzepatide for weight loss in 800 adults with obesity. Participants receive one of the two drugs for about 89 weeks. The study measures changes in body weight, BMI, waist size, and other health markers.

This study tests whether using a pedal-assist electric bike for commuting can improve physical activity, fitness, and health in overweight or obese college students. Participants are randomly assigned to either use an e-bike for at least four trips per week for 12 weeks or to a c…

This study investigates whether GLP-1 receptor agonists (semaglutide or tirzepatide), combined with diet and exercise, can improve physical function, reduce biological aging, and enhance vascular health in postmenopausal women with obesity. Participants will take the medication a…

This study tests whether semaglutide, a drug already used for obesity and type 2 diabetes, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD). Participants are adults aged 40 to 80 who are overweight or have type 2 diabetes. The trial will also val…

This study looks at two types of programs—one focused on parents alone and another involving the whole family—to see which works better at reducing obesity risk in African American families. About 120 parent-child pairs will take part. The goal is to find ways to lower obesity an…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study tests whether parent and family support programs can help African American families lose weight. Obesity runs in families and raises cancer risk, so researchers are using health coaching, support groups, and educational materials with 81 parent-child pairs. The goal is…

This early-stage trial is testing a new drug called brenipatide in 150 healthy people with overweight or obesity. Participants receive different doses of the drug or a placebo as injections under the skin. The study lasts about 42 weeks and aims to see how well the drug works for…

This study tests a new medicine called KAI-9531 (ribupatide) given as a weekly shot to help people with obesity lose weight. It includes 250 adults who have a BMI of 35 or higher and have tried to lose weight before without success. Participants will receive either the drug or a …

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This trial tests a culturally adapted program called Health Without Barriers/Salud Sin Barreras for teens aged 11–19 and their families in Northern Colorado. The program combines mindfulness, nutrition education, physical activity, and parenting support over several sessions. Res…

This study looks at whether weight-loss surgery (sleeve gastrectomy) combined with lifestyle changes, or lifestyle changes alone, can help women who have had early-stage breast cancer and are obese. The goal is to see if losing weight might lower the chance of the cancer returnin…

This study tests a new medicine called CagriSema to help people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo for around one year. The main goal is to see how much weight they lose and check for any side effects.

This study tests whether a culturally tailored plant-based diet, guided by community health workers, can help Latino adults with obesity lose weight and improve metabolic health. Forty participants will be randomly assigned to either the plant-based diet program or standard healt…

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This pilot study tests a new approach to childhood obesity treatment: before starting a 12-week family weight management program, families work with a community health worker for three months to address social needs like food, housing, or healthcare access. The study enrolls 120 …

This study tests a procedure that reroutes part of the small intestine to help control type 2 diabetes and weight. About 15 adults with diabetes and obesity will be followed for a year to see if their blood sugar and weight improve. The goal is to reduce the need for diabetes med…

This study tests a program called SANOS that teaches Mexican adults how to eat healthy without spending a lot of money and how to be more active. About 1,785 overweight or obese participants will receive counseling and be followed for up to a year. The goal is to see if this appr…

This pilot study tests whether personalized herbal medicine can help obese adults with spinal or joint pain lose weight and reduce pain. Forty participants will receive either herbal treatment plus lifestyle guidance or lifestyle guidance alone. The study measures changes in BMI …

This trial tests whether an immersive virtual reality exercise program, done three times a week during school breaks, can improve body composition and fitness in children aged 12 to 16 with overweight or obesity. Participants wear a head-mounted display and play active video game…

This study tests three home-based programs—healthy eating, physical activity, and gardening—designed to prevent obesity in Hispanic children aged 3 to 4 living in rural West Texas. Over 24 months, researchers will measure changes in body mass index, waist-to-height ratio, and bod…

This study tests whether tirzepatide, a once-weekly injection, helps teenagers with obesity or overweight (with related health issues) lose weight. About 160 teens will receive either tirzepatide or a placebo for 72 weeks, alongside lifestyle advice. The main goal is to see if bo…

This study tests whether adding an AI chatbot to a 12-week smartphone weight loss program helps young adults with overweight or obesity lose more weight and stay engaged. Twenty participants will either get the standard program or the program plus a chatbot for extra support. Res…

This Phase 2a trial tests whether adding an oral drug called ECC4703 to the weekly injection semaglutide helps adults with obesity lose more weight and reduce liver fat. About 151 participants will take either ECC4703 or a placebo alongside semaglutide for 20 weeks. The study is …

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study tests a 4-month program called GOAL that helps 5th-8th graders eat healthier and be more active. It includes after-school clubs, parent meetings, and a website. About 935 teens and their parents from Michigan schools are taking part. The goal is to lower heart disease …

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study tests a new drug, olatorepatide, for weight loss in people who are overweight or obese but do not have diabetes. The drug works by targeting hormones that control appetite and blood sugar. Researchers will check how safe the drug is, how the body processes it, and how …

This study looks at whether sewing shut a specific incision site (the epigastric trocar) during sleeve gastrectomy can prevent hernias from forming later. People having their first sleeve gastrectomy for obesity are included, while those with prior stomach banding or repeat sleev…

This study tests whether a stepped-care program using digital tools like smart scales, activity trackers, and text messages, plus in-person counseling if needed, can help adults with obesity maintain at least 5% weight loss for a year. About 258 participants first lose weight thr…

This study aimed to see if blocking blood vessels to part of the stomach (bariatric embolization) could help super obese patients lose weight before sleeve gastrectomy surgery, potentially lowering surgical risks. It planned to enroll patients with a BMI over 50 and at least thre…

This Phase 2 study tests whether ZT006, a daily or weekly tablet, helps overweight and obese adults lose weight when combined with diet and exercise. About 184 participants will receive either ZT006 or a placebo for 28 weeks, with some continuing for an extra 12 weeks. The main g…

This study looks at whether adding Traditional Chinese Medicine (TCM) to standard weight-loss drugs helps people lose more weight. About 296 adults with obesity (BMI 27 or higher) in Taiwan are being followed for 6 to 12 months. Researchers are measuring weight loss, body fat, an…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study compares two digital weight loss programs for people with obesity. One program uses weekly live video meetings, while the other uses a private Facebook group that participants can access anytime. The goal is to see if the flexible, on-demand option works as well as the…

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a …

This study looks at whether taking a synbiotic supplement (a mix of probiotics and prebiotics) and eating more fruits and vegetables can lower the risk of obesity and related health problems in Hong Kong Chinese adults. One hundred overweight or obese participants will follow the…

This phase 3 trial is testing different ways to increase the dose of retatrutide, a new weight-loss drug, in 600 people with obesity or overweight who do not have type 2 diabetes. The study lasts about 113 weeks and measures weight loss, waist size, and other health markers. The …

This study looks at whether the diabetes drug metformin, combined with a low-calorie diet, helps overweight or obese adults with a large waistline lose weight. About 150 participants will take either metformin or a placebo for 24 weeks. The main goal is to see if at least 5% of b…

This study tests an online weight loss program for couples. It includes 762 married or cohabitating partners who are overweight or obese. The program adds four strategies—like joint goal setting and partner feedback—to a core behavioral weight loss plan. The goal is to see which …

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study tests a telehealth program for Latino families with children aged 5 to 12 who have overweight or obesity. The program helps caregivers support healthy changes, and is compared to standard health education. The goal is to see if this approach improves children's weight …

This study looks at whether children and teens being treated for acute lymphoblastic leukemia can follow a low-glycemic (low-sugar) diet for six months. The goal is to see if this diet is practical and helps manage weight during cancer treatment. About 88 participants will track …

This study tests a new drug called MET097, given as a shot, to help people with obesity or overweight lose weight. After 12 weekly doses, participants switch to monthly shots for up to 64 weeks. The trial compares four different dose schedules against a placebo to see which works…

This study tests a new drug called CRB-913 for weight loss in people with obesity. It involves 252 participants and has two parts: first, measuring how the drug works in healthy adults, then comparing three doses against a placebo over 12 weeks. The goal is to check safety and ho…

This study looks at whether taking a yerba mate extract can help improve health markers in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researchers will measure changes in weight, blood sugar, cholesterol, and inflammation to …

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study looks at a 12-week program called 'GameDay Ready' to help Black men living in rural South Carolina lose weight. About 29 men will take part, and their weight changes will be compared to a group that does walking and general health education. The goal is to see if the n…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This early-stage trial is testing a new drug called MD-18 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 54 participants will receive either MD-18 or a placebo by injection. The study is currently …

This study tests a special magnet system that creates a new connection between the stomach and intestine without traditional surgery. It is designed for adults with obesity (BMI 30-50) who also have type 2 diabetes or have regained weight after a previous sleeve gastrectomy. The …

This study tests a new magnetic device (MagDI System) that creates a connection between the duodenum and ileum, bypassing part of the small intestine. The goal is to help with weight loss and blood sugar control in 60 adults with obesity and type 2 diabetes. Researchers are check…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This study compares three treatments for severe obesity: two types of bariatric surgery (gastric bypass and sleeve gastrectomy) and two newer weekly injectable medications (semaglutide and tirzepatide). About 125 adults with a BMI of 35 or higher will be followed for one year to …

This study was designed to see if a dietary supplement called WM Formula could help people with obesity lose weight and improve blood sugar and fat levels. It planned to enroll adults with high body fat who were not taking weight-loss or diabetes drugs. However, the study was wit…

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests whether the drug liraglutide, combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight and improve heart function. Thirty children will receive either liraglutide injections plus lifestyle advice or lifestyle advice …

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study tests whether a new weekly injection called IBI362 works better than the existing drug semaglutide for weight loss and reducing liver fat in overweight or obese Chinese adults with metabolic dysfunction-associated fatty liver disease (MAFLD). About 479 participants wil…

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity from primary care clinics will take part. One group gets extra support and motivation to use these tools, while the other group gets basic informatio…

This early-phase trial tests the safety of a single dose of HRS-5817 in 40 obese adults aged 18-55. Participants receive either the drug or a placebo by injection. The study monitors side effects and how the drug moves through the body.

This study tests whether survodutide, a new weekly injection, helps people with obesity burn more energy and fat compared to the existing drug semaglutide (Wegovy). 64 adults aged 18-65 with a BMI between 30 and 45 will be randomly assigned to one of the two drugs. Researchers wi…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study looks at whether combining high-intensity interval training with recovery in low oxygen (hypoxia) and taurine supplements can improve body composition, metabolism, and mitochondrial function in women with obesity. Fifty women aged 25–45 with a BMI of 30–35 will exercis…

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This study tests whether a structured high-protein diet with meal replacements helps adults with overweight or obesity lose more weight than a standard low-calorie diet. About 60 participants will follow a calorie-restricted plan and attend visits for body measurements and blood …

This study tests a smartphone-based weight loss program (EVO) against the standard Diabetes Prevention Program (DPP) in 524 adults with obesity. Participants use an app to track diet, activity, and weight, with remote coaching. The goal is to see which approach leads to more weig…

This study tests a 6-month home-based program called FIT Families, designed to help African American teens with obesity and their caregivers lose weight. The program includes coaching sessions, family counseling, and small prizes for completing tasks. Researchers will measure cha…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This study tracks 30 adults with obesity who are starting anti-obesity medications like Wegovy or Mounjaro. Researchers will measure how these drugs affect 24-hour energy expenditure and body composition (fat vs. muscle) over 6 months using a metabolic chamber and DXA scans. The …

This study tests whether semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have excess fat around the midsection (lipohypertrophy). About 108 participants will receive either semaglutide or a placebo for 32 weeks. …

This study uses brain scans (fMRI) to see how the weight-loss drug lorcaserin changes activity in brain areas that control appetite and food intake. Forty obese adults will receive either lorcaserin or a placebo pill. Researchers will also measure changes in body composition. The…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite. Researchers will scan the brains of 28 obese adults to see how they respond to food cues after treatment. The goal is to understand the underlying mechanisms that help p…

This study is testing a new digital weight management program for adults with obesity who are referred to NHS Tier 3 services. The program uses a smartphone app to help people manage their weight. Researchers want to see if it improves health, saves money, and works well for pati…

This study tests whether semaglutide (Wegovy), a weekly injection for weight loss, can help people in secure mental health care who have gained weight from antipsychotic drugs like clozapine or olanzapine. About 20 adults with a BMI of 35 or higher will receive the drug along wit…

This study tests a new daily pill, aleniglipron, in 58 adults with type 2 diabetes who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure weight loss and blood sugar changes. The study is not yet …

This study tests whether a diet with more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose weight and reduce diabetes risk. Over 10 weeks at a lifestyle camp, one group eats a higher-protein diet while another eats a lower-protein diet, bot…

This study tests a 10-week program called Healthy Dads, Healthy Kids for Hispanic families in Houston. Dads aim to lose weight, while kids increase physical activity through group sessions and joint exercise. About 187 fathers and their children are taking part to see if the prog…

This study planned to test whether a virtual weight control program (WW, formerly Weight Watchers) could help adults with type 2 diabetes and obesity lower their blood sugar levels. Participants would have used the WW SmartPoints system and attended weekly online workshops. Howev…

This study tests whether giving people with obesity and diabetes a monthly $160 subsidy to buy fruits and vegetables online helps them eat healthier. 214 participants will be split into groups, some getting the subsidy and some not, to see if it increases their produce purchases …

This study follows 120 teenagers aged 13 to 18 with severe obesity to see if weight-loss surgery (gastric bypass) leads to better health than standard treatments like diet and exercise. Participants are tracked for up to 10 years, measuring weight loss, quality of life, and menta…

This study looks at whether a non-surgical stomach-reducing procedure called endoscopic sleeve gastroplasty (ESG) can help obese people with nonalcoholic fatty liver disease lose weight and improve liver health. Researchers will measure changes in liver fat and stiffness, as well…

This study tests a program called ROC+ to help people who are very responsive to food cues lose weight. It compares ROC+ to standard behavioral weight loss programs in 300 adults with overweight or obesity. The goal is to see if reducing reactions to food cues leads to lasting we…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study tests whether group nutrition education based on Brazil's dietary guidelines can help overweight adults eat better and lose weight. Sixty participants will attend monthly group sessions or receive individual counseling. Researchers will compare diet quality, BMI, and w…

This study planned to test a procedure called bariatric embolization for people with morbid obesity who cannot have standard weight-loss surgery. The procedure involves injecting tiny particles into blood vessels near the stomach to reduce blood flow, which may lower hunger hormo…

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 participants without type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if it is…

This study looks at whether adding a small bypass (gastroenteroanastomosis) to the standard sleeve gastrectomy can prevent or reduce acid reflux in people with obesity. Sixty patients will be split into two groups: one gets the added bypass, the other does not. Researchers will c…

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This study tests whether a new drug called XW003 works better than the existing drug semaglutide for weight loss in Chinese adults with obesity. About 163 participants with a BMI of 30 or higher will receive either drug, and researchers will measure changes in body weight, waist …

This study looks at whether eating oats for 6 weeks can improve cholesterol, blood pressure, and gut health in people who are overweight or have high cholesterol. Participants will follow a low-gluten diet rich in either oats or rice. Researchers will measure blood fats, inflamma…

This study looked at whether time-restricted eating (eating only during a set window each day) helps overweight or obese people with prediabetes return to normal blood sugar levels. Over 12 months, 142 participants either followed this eating pattern or received standard care. Th…

This study tests a 6-month online weight loss program designed for Arab adults in Saudi Arabia. Participants are randomly assigned to either the online program or standard hospital-based dietary care. The online program includes 12 Arabic educational sessions and dietitian suppor…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study tests whether a parent-only weight loss program followed by a family healthy lifestyles program works better than the family program alone. It involves 480 rural families with a child aged 6-11 who is overweight and a parent with a BMI between 25 and 50. The goal is to…

This study looks at whether the weight-loss medication Contrave (naltrexone/bupropion) increases the risk of serious heart problems like heart attacks, strokes, or heart-related death. About 8,600 obese or overweight adults with heart risk factors will be randomly assigned to tak…

This study tests whether the weight-loss drug phentermine, currently approved for only 12 weeks, can be safely used for up to 2 years. About 870 adults with obesity will take phentermine and receive online lifestyle coaching. Researchers will track weight loss, blood pressure, an…

This phase 3 trial tests whether VCT220, a daily pill that targets GLP-1 receptors, can help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo for 12 months. The main goals are to see how much weight they lose and ho…

This study tests whether a combination of medication (naltrexone/bupropion, also known as Contrave) and behavioral weight-loss counseling can help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy a…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to either early or late eating windows or standard daily calorie restriction for one …

This study tests whether a gamified mobile health program, including a neurotraining video game, can help overweight men lose weight. 228 men will use either a standard mHealth app or a fully gamified version with team competition and digital rewards. The goal is to see if gamifi…

This study tests whether limiting food intake to an 8-hour window each day (between 10am and 6pm) for 2 months helps children and teens with obesity lose weight. Researchers will also check if any benefits last and explore how the gut microbiome and body clock might play a role. …

This phase 2 trial tests different doses of tirzepatide in 414 adults with type 2 diabetes and obesity who already take metformin. The goal is to see if the drug helps with weight loss and blood sugar control. Participants receive either tirzepatide or a placebo for about 89 week…

This study tests a postbiotic supplement called ABB C3 in 70 children and teens with obesity. Half take the supplement and half take a placebo for 3 months, with an optional 3-month extension for all. Researchers will measure changes in body fat and blood sugar levels to see if t…

This study tests a new drug called taldefgrobep alfa (BHV-2000) to help adults with overweight or obesity lose weight. About 150 participants will receive either the drug or a placebo as a weekly or monthly injection for 24 weeks. The main goal is to see how much body weight chan…

This trial compares two versions of a procedure called TORe, which is used to help people who have regained weight after gastric bypass surgery. One version is the classic TORe, and the other is a newer version called ESD-TORe. The study will look at which one leads to more weigh…

This study will offer shared medical appointments (group visits) for obesity treatment to over 140,000 patients across 56 Cleveland Clinic primary care practices. About 3,600 adults aged 20-75 with a BMI of 30 or higher will take part. The goal is to see if offering these group v…

This study tests whether a Mediterranean diet adapted to use local Indonesian foods can help obese women lose weight and improve health markers like inflammation and gut bacteria. Fifty-four women will follow either this diet or a standard low-calorie diet for 4 weeks. Researcher…

This study looks at whether a very low-calorie diet (800-960 calories per day) can reduce fat and scarring in the liver for people with obesity and non-alcoholic fatty liver disease (NAFLD). Twenty participants will follow either the low-calorie diet or a standard lower-calorie d…

This study tests whether personalized nutrition coaching, delivered online, can help overweight or obese nurses at an Indonesian hospital lose weight, eat better, and become more active. Over 8 weeks, 44 nurses will receive individual guidance to make lasting lifestyle changes. T…

This study tests whether a probiotic supplement containing Bifidobacterium longum can help overweight or obese children aged 3 to 14 improve their body mass index (BMI). Sixty children will receive either the probiotic or a placebo for 8 weeks, along with lifestyle advice. Resear…

This study tests a procedure called Revita DMR, which uses a thin tube to treat the lining of the upper gut, to help people with obesity keep weight off after they stop taking the weight-loss drug tirzepatide. About 315 participants who lost at least 15% of their body weight on t…

This phase 3 study tests whether a new weekly injection called HRS9531 works better than semaglutide for weight loss in 572 adults with obesity. Participants receive either drug for 52 weeks, and researchers measure changes in body weight, waist size, and BMI. The trial is active…

This study tests whether taking Urolithin A daily for 6 months helps adults with obesity lose weight while keeping muscle mass and improving metabolism. About 100 participants aged 30-60 with a BMI over 30 will follow a structured diet and sleep program, with half receiving the s…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This study tests whether adding relationship skills training to a standard weight management program helps Mexican American mothers and adult daughters lose weight and keep it off. The program includes nutrition and physical activity education along with behavior change technique…

This study looks at whether giving tranexamic acid (a drug that helps blood clot) during weight-loss surgery can reduce dangerous bleeding. About 1000 adults having bariatric surgery will be split into two groups: one gets the drug, the other gets standard care. The goal is to se…

This study compares two weight loss surgeries for people with severe obesity: sleeve gastrectomy with transit bipartition (SG+TB) and Roux-en-Y gastric bypass (RYGB). About 320 participants will be followed for two years to see which surgery leads to greater weight loss and fewer…

This study compares an intensive weight loss program—using meal replacements, behavior coaching, and weight-loss medication—against standard care for 480 adults with obesity. The goal is to see if the intensive approach leads to greater weight loss, better quality of life, and is…

This study tests a supplement called Cornfit™, made from corn silk, to see if it helps reduce body fat and manage weight in adults who are overweight or obese. One hundred participants will take either Cornfit™ or a placebo for 12 weeks. Researchers will measure changes in body f…

This study tests whether the medication naltrexone/bupropion (Contrave) can help people who had bariatric surgery maintain control over eating and avoid weight regain. About 100 adults who previously responded to treatment for loss-of-control eating will receive either the medica…

This study is testing a smartphone app that uses artificial intelligence and cognitive behavior therapy to help people with obesity lose weight and improve their health. About 100 adults aged 18 to 65 with a BMI of 27 or higher will use the app for 12 months. The app tracks food …

This pilot study at Mayo Clinic is testing a special low-calorie, high-protein tube feeding formula called Peptamen Intense VHP in 12 obese patients who rely on tube feeding. The goal is to see if it helps them lose weight while maintaining muscle mass, and also improves blood pr…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study looks at whether adding the drug insulin detemir to a low-calorie diet helps obese adults with type 2 diabetes lose more weight and improve brain function related to food reward. About 240 people will be split into two groups: one on diet only, the other on diet plus d…

This early-stage trial is checking whether maridebart cafraglutide, a new weight-loss drug, affects the heart's electrical activity. About 81 adults with overweight or obesity will receive the drug or a placebo, and their heart rhythms will be closely monitored. The main goal is …

This 16-week study tests whether an avocado-based dietary supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo daily, and researchers will track changes in body weight, glucose levels, …

This study tests a new injectable drug called nimacimab, given weekly, to see if it helps overweight or obese adults lose weight. Some participants will receive nimacimab alone, others will get it together with semaglutide (a known weight-loss drug), and some will receive a place…

This study tests whether three culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in 198 African American adults. Participants attend weekly classes for 6 months, then bi-weekly for another 6 mon…

This study looks at how the source of protein in a high-protein ketogenic diet influences weight loss and inflammation in people with obesity. Sixty adults will follow a 12-week diet with either plant protein (pea/lupine) or animal protein (whey). Researchers will measure weight,…

This pilot study tests whether taking a daily probiotic supplement for 12 weeks can improve insulin resistance and asthma control in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and asthma symptoms. Only 7 people are enroll…

This study tests whether a device that gently stimulates the vagus nerve through the ear can improve how the body handles sugar and affect mood in people with obesity and prediabetes. Seventy participants will use the device for 45 minutes, three times a week for three months. Th…

This study tests whether adding a weekly injection of exenatide (Bydureon) to family-based behavioral treatment helps children aged 10-12 with obesity lose weight more effectively. The trial involves 63 children and their parents, with weekly sessions over 24 weeks. Researchers w…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This early study is testing a new magnetic device that creates a shortcut in the digestive system to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI between 30 and 35 will have the device placed using a scope, wit…

This was a planned phase 3 study to test a new combination of two drugs, sibutramine and topiramate, for weight loss in overweight and obese adults. The study aimed to see if the combination worked better than either drug alone or a placebo. However, the trial was withdrawn befor…

This study aimed to see if the weight-loss drug Wegovy (semaglutide) could help active-duty military personnel lose weight and improve body composition without harming physical performance. It planned to enroll 0 participants and was withdrawn before starting. No results are avai…

This study looks at whether high-intensity interval training (HIIT) can improve heart health and physical fitness in young adults with obesity. Forty participants will do HIIT three times a week for 12 weeks. Researchers will measure changes in fitness, body composition, and bloo…

This study tests a new drug called IBI362 in 98 Chinese adults with moderate to severe obesity (BMI ≥ 32.5). Participants receive weekly injections of IBI362, tirzepatide, or a placebo for several weeks. The main goals are to check safety, side effects, and how the drug behaves i…

This study tests a new drug called maridebart cafraglutide to help adults in Japan with obesity lose weight. About 279 participants will receive either the drug or a placebo for 72 weeks. The main goals are to see how much weight they lose and if at least 5% of body weight is los…

This study will follow 500 Korean adults with obesity who are starting Wegovy (semaglutide) as part of their normal care. Researchers will track how much weight they lose and any side effects over about 52 weeks. The goal is to see how effective and safe the drug is in real-world…

This study tests whether combining anti-obesity medications with a structured lifestyle program can help people with obesity lose weight and keep muscle. 150 participants will first take tirzepatide or semaglutide for 9 months, then switch to another oral medication for 12 months…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This pilot study is testing whether a procedure called endoscopic sleeve gastroplasty (ESG) is safe and helpful for weight loss in 10 obese adolescents aged 12-17. Instead of traditional weight-loss surgery, doctors use a device inserted through the mouth to stitch the stomach sm…

This study looks at whether a protein supplement called carnitine can reduce hardening of the arteries in teenagers at high risk for future heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. Researchers will measure artery stiffness…

This study tests whether a daily kefir peptide supplement can help obese children lose weight and improve related health issues like insulin resistance and fatty liver. Sixty children with a BMI above the 95th percentile will take either kefir or a placebo for 12 weeks. The goal …

This study compares two types of weight-loss surgery for people who have already had a sleeve gastrectomy but still have obesity. One surgery is the standard duodenal switch, and the other is a simpler single-loop version. Researchers want to see if the simpler surgery causes few…

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study looks at whether a non-surgical stomach reduction procedure (endoscopic sleeve gastroplasty) can improve liver health in people with obesity and advanced NASH (a severe form of fatty liver disease). Twenty adults with obesity and biopsy-confirmed NASH with advanced sca…

This study tests a probiotic called Streptococcus thermophilus (FX856) in 100 overweight or obese adults. The goal is to see if it can reduce mild gut inflammation and improve digestive symptoms. Participants will take the probiotic or a placebo in a crossover design, and researc…

This early-stage study tests a new drug called HCR-188 in 48 overweight or obese adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo as injections. The goal is to gather initial safety data, not to treat obesity at this poi…

This study tests whether eating more plant-based foods or taking polyphenol supplements (like green tea and berry extracts) can help overweight adults lose weight and improve heart health. 99 participants will follow a calorie-restricted diet for 12 weeks, with one group eating e…

This Phase 3 study tests an injection called GZR18 for weight loss in 630 adults who are obese or overweight with related health issues. Participants receive either the drug or a placebo, and researchers measure weight change over time. The goal is to see if GZR18 is safe and eff…

This phase III trial tests whether telephone-based Acceptance and Commitment Therapy (ACT) helps overweight or obese adults lose more weight than standard behavioral therapy. About 418 participants will receive coaching over the phone and use a Fitbit and scale to track progress.…

This study was designed to treat toddler obesity by improving the food environment at home. Parents would take part in a free online nutrition program and could also take weight-loss medication. The goal was to help both parent and child lose weight. However, the study was withdr…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This study follows 300 children aged 9 to 14 with obesity to see if ultrasound and MRI can detect early signs of liver disease. Researchers will compare imaging markers like liver fat and stiffness with standard tests. The goal is to improve diagnosis and monitoring without invas…

This study looks at whether two blood markers, PLIN2 and RAB14, can accurately diagnose NASH (a serious liver disease) and advanced scarring, without needing a liver biopsy. Researchers will test these markers in 828 adults with NASH, type 2 diabetes, or obesity. If successful, t…

This study tests whether a smartphone app that sets daily step goals can help middle-aged adults (30-70 years old) who are overweight walk more. Participants use a Fitbit and receive adaptive goals to increase light physical activity. The goal is to see if this simple approach ca…

This study looks at how to best bring MINISTOP 3.0, a mobile app for parents, into Swedish primary child healthcare. The app aims to help parents of 2.5- to 3-year-olds encourage healthy eating, physical activity, and less screen time. Researchers will compare two ways of rolling…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This study tests a culturally tailored healthy eating program for Hispanic mothers and their children aged 7–12 in rural Arkansas. The program includes home lessons and cooking workshops to improve diet and cooking habits. Researchers will compare 16 mother-child pairs who get th…

This study tests a program for children ages 3 to 6 that includes monthly health lessons and extra physical activity at school. The goal is to see if these activities help children maintain a healthy weight. About 1,500 children in Suzhou, China, are taking part.

This study compares time-restricted eating (eating only between 12pm-8pm) to daily calorie restriction for weight loss and colorectal cancer risk reduction in 193 obese adults aged 45-70. Participants follow their assigned diet for 6 months, then a maintenance phase for another 6…

This study tests a program called Healthy Eating for My Infant (HEMI) designed to prevent obesity in infants from low-income families. The program includes educational sessions and peer support to help mothers with feeding and mental health. Researchers will enroll 60 mother-infa…

This study tests whether a weight loss program for overweight or obese women (and their partners) before pregnancy can reduce the risk of their child becoming overweight. 240 couples are randomly assigned to either a very low-calorie diet and counseling or no intervention. The ma…

This study tests an 8-week online program called EatGrow, where parents and their preschool-aged children (ages 3-5) learn about nutrition, cook together, and taste new foods. The goal is to see if it helps kids eat more fruits and vegetables and become more willing to try new fo…

This study tests a program that uses kindergartens, families, and hospitals to prevent obesity in children aged 4-6. About 980 children in China will take part. The program includes teacher training, health lessons, parent education, and check-ups. Researchers will measure change…

This study is testing a digital health platform called STELA that creates personalized lifestyle plans to reduce risk factors for heart disease, like obesity, high cholesterol, and insulin resistance. About 100 adults without existing heart disease will use the platform for a yea…

This study tests whether a 16-week family-focused lifestyle program can reduce type 2 diabetes risk in Latino children aged 10-16 who have obesity. The program includes nutrition education, behavior change skills, and physical activity. Researchers will measure glucose tolerance …

This study tests a 2-year personalized program for overweight children aged 6-7 that includes diet advice, physical activity, psychology, and relaxation techniques. The goal is to reduce their body mass index (BMI) and prevent obesity. Researchers will compare results to a histor…

This study tests whether helping women with overweight or obesity adopt a healthy lifestyle before and during pregnancy can reduce the risk of their children developing obesity. About 360 women planning pregnancy will either receive a tailored program including a low-calorie diet…

This study tests a school-based lifestyle program to prevent obesity in children aged 4-7 in Karachi, Pakistan. The program encourages healthy eating, drinking water, physical activity, and less screen time. Researchers will measure changes in teachers' and parents' knowledge, at…

This study tests a mobile health program called Fit for Duty-mobile to help 350 active-duty Air Force members aged 18-39 prevent weight gain over 2 years. Participants use a smartphone app, get coaching calls, and wear a Fitbit. The goal is to see if this approach can stop unheal…

This study tests whether giving breastfeeding mothers a natural nutrient called betaine can help prevent rapid weight gain in babies, which is linked to later obesity. About 47 mothers with overweight or obesity will take betaine or a placebo for 3 months while exclusively breast…

This study tests whether adding a natural nutrient called betaine to infant formula can safely prevent excessive weight gain in babies at risk for childhood obesity. Researchers will compare growth and gut bacteria in 50 formula-fed infants whose mothers had a higher pre-pregnanc…

This study tests a program where Black mothers and their 9th- or 10th-grade daughters work together to increase physical activity and improve diet, aiming to prevent obesity. About 120 pairs will join, with daughters at higher risk due to weight. The program uses activity tracker…

This study tests a mobile app called 'Applícate por tu salud' that sends parents tips, recipes, and videos to encourage healthy eating and physical activity for their school-aged children. About 743 children from 4 primary schools in Mexico City will take part, with some schools …

This study looks at how genetics, eating habits, and lifestyle affect obesity risk in adults aged 18 to 70 in Georgia. One hundred participants will be split into two groups: one follows a reduced-portion diet and exercise plan for 8 weeks, while the other serves as a control. Re…

This study looks at whether a community-based program focused on healthy eating and exercise during and after pregnancy can lower the chances of obesity and type 2 diabetes in mothers and their children. About 1,000 pregnant women in urban areas will take part. The goal is to see…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests a personalized coaching program for low-income Hispanic families with young children (ages 4-6) to prevent obesity. The program helps families overcome daily barriers to healthy eating and physical activity. 301 parent-child pairs will be followed for several yea…

This study tests a program to help new bus operators avoid gaining weight and succeed at work. About 284 new hires from several transit agencies will take part. Some will get the special program, while others follow usual routines. The goal is to see if the program helps them sta…

This early-stage study tests a new medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body processes it. About 63 participants will receive either the study drug or a placebo as an injection under the skin. The me…

This study tested a 24-week weight loss program delivered via video calls for 22 breast cancer survivors who were overweight or obese. The goal was to see if the program was practical and well-liked, and whether it improved quality of life, physical activity, and mood. Participan…

This study looks at two ways to manage pain during weight-loss surgery (sleeve gastrectomy) in 70 adults. One group gets standard opioid painkillers, the other gets a mix of non-opioid drugs. The goal is to see if the opioid-free approach can reduce opioid use and still control p…

This pilot study tests a new group program called Move Healthier, designed to help people with overweight or obesity increase their exercise using cognitive and behavioral skills. The goal is to see if it boosts physical activity without raising the risk of disordered eating. Onl…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for obesity. The app uses strategies from cognitive-behavioral therapy to improve self-regulation and eating habits. Fifty teens will use the app for 16 week…

This pilot study is testing whether a mulberry leaf extract supplement (Reducose) can help control blood sugar spikes after meals in obese children and adolescents. Eighty participants will take either the supplement or a placebo twice daily for 12 weeks. Researchers will measure…

This study compares the effects of soy soft pretzels and wheat pretzels on inflammation in 30 men with obesity. Researchers want to see if the natural chemicals in soy can reduce chronic inflammation, which is linked to health problems like cancer. Participants will eat either so…

This study tests whether a 16-week mindfulness-based nutrition group program is feasible and acceptable for adults with obesity who are already taking GLP-1 medications. Forty participants will either join the group program plus usual care or receive usual care alone. The program…

This study tests an 8-week mindfulness program (MB-EAT) for people who had bariatric surgery at least six months ago and struggle with eating guidelines. About 85 participants will be split into two groups: one gets the mindfulness training, the other does not. Researchers will t…

This study tests a remote program called ReConnect for people who had bariatric surgery about 2 years ago and their romantic partners. The program uses weekly handouts and videos with positive psychology activities to improve mood, resilience, and relationship satisfaction. 82 co…

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether drinking hydrogen-rich water can make a 4-week weight loss retreat more effective for overweight and obese teens. Sixty adolescents will be randomly assigned to get either hydrogen water or plain water, while all follow the same retreat program. Researche…

This early-stage study tests a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it over about 8 weeks. Participants receive multiple doses of the drug, and researchers monito…

This study tests a smartphone app that monitors when you might be about to break your diet and sends helpful alerts or tips. About 200 adults with obesity and heart risk factors will use the app alongside a standard online weight loss program. The goal is to see which types of al…

This study looks at how losing weight affects sexual function and sperm quality in men with severe obesity. About 59 men will either have weight-loss surgery or follow a standard diet plan. Researchers will measure changes in sexual health, hormone levels, and sperm quality to se…

This study looks at whether adding online yoga classes to an internet-based weight loss program can help people lose more weight and keep it off. About 210 adults with obesity will take part. Everyone gets a 12-month online weight loss program, and after 3 months, some also get y…

This study looks at whether exercising once a week or three times a week is better at reducing liver fat in adults who are centrally obese and have non-alcoholic fatty liver disease (NAFLD). Three hundred Chinese adults aged 18-69 will be assigned to either a once-weekly or thric…

This study looks at whether two types of exercise training can improve body composition, heart and lung function, and quality of life in people who have had bariatric surgery. Researchers will compare high-intensity interval training (HIIT) and moderate-intensity continuous train…

This study tests whether adding virtual reality (VR) training to standard balance exercises can improve balance, stability, mobility, and quality of life in people with obesity. Sixty participants aged 20-40 with a BMI between 30 and 40 will be randomly assigned to either balance…

This study tests whether an 8-week nutrition education program focused on fiber-rich foods (like fruits, vegetables, and whole grains) is acceptable and helpful for people with diabetes, prediabetes, or obesity. Researchers will track participants' weight and dietary changes over…

This study tests whether a mix of ketamine and dexmedetomidine (ketodex) can reduce the need for strong painkillers after laparoscopic sleeve gastrectomy in obese patients. Eight adults with a BMI over 35 are randomly assigned to receive either ketodex or standard opioid-based an…

This study tests whether adding group weight-loss classes to standard cardiac rehabilitation helps people with atrial fibrillation and obesity lose at least 10% of their body weight. About 120 adults will take part, with half getting the extra classes. The goal is to see if this …

This study looks at whether a weight loss program designed for adults who have had a knee replacement can help them lose weight, be more active, and have less pain and better function. About 182 overweight or obese adults who had knee replacement within the last 6 months will tak…

This pilot study aimed to test a parent-only training program for children aged 8-12 with both ADHD and overweight or obesity. Parents would learn weight management skills and strategies to help their child's focus and planning. However, the study was withdrawn before any partici…

This study looks at whether 8 weeks of resistance training with blood flow restriction can improve muscle strength, body measurements, and health markers in adults with obesity. Thirty participants aged 18 to 40 with a BMI between 30 and 40 will do leg and arm exercises using lig…

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This study tests a smartphone app called eTRIP, which uses artificial intelligence to help people with overweight or obesity make healthier food choices and stick to their weight loss goals. Some participants also wear a continuous glucose monitor for 10 days to see how their blo…

This study tests whether a program combining motivational interviewing and mindfulness can help people who regain weight after bariatric surgery. About 52 adults who have regained at least 5% of their lowest weight after surgery will take part. The goal is to see if this approach…

This study tests whether virtual reality sessions with a psychologist can improve body image dissatisfaction in people who had bariatric surgery 18 to 30 months ago. Eleven participants will either receive 10 weekly VR sessions or standard follow-up care. The main goal is to see …

This study looks at whether a dietary supplement called Pivit can help overweight adults lose weight and manage their appetite. All 125 participants will take Pivit for three months and track their weight at home using a personal scale. The study is observational, meaning there i…

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…

This study looks at whether taking probiotics after sleeve gastrectomy (a type of weight-loss surgery) can reduce constipation and other stomach issues. About 200 adults with severe obesity will take either a probiotic blend or a placebo for three months after surgery. Researcher…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study looks at whether a low-fat diet can increase reproductive hormones in women with obesity. Thirty women with regular cycles and no other hormone issues will follow a carefully controlled diet. The goal is to see if diet alone can improve hormone levels linked to fertili…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study follows 50 adults in a community weight loss program to see how daily stress levels relate to weight loss, physical activity, and sleep. Participants will answer quick surveys on their phones and wear a wrist device to track activity and sleep. The goal is to understan…

This study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…

This study follows mother-infant pairs from birth to 24 months to see how early nutrition, environmental exposures, and family factors relate to growth, development, and allergies in preterm and term infants. Researchers will use questionnaires and biological samples to examine h…

This study looks at how estrogen levels influence body composition and muscle function in midlife women (ages 35-60) who are starting a GLP-1RA medication for weight loss. Researchers will measure changes in weight, muscle mass, bone density, and strength over time. The goal is t…

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference…

This study looks at whether routine blood tests taken before weight-loss (bariatric) surgery can help predict who might face complications within 30 days after the operation. Researchers will review medical records of 600 adults who had bariatric surgery, checking levels of certa…

This early-stage study looks at how the experimental drug BI 456906 attaches to receptors in the liver and pancreas that control appetite and weight. About 30 adults with obesity will receive either BI 456906 or the approved weight-loss drug semaglutide for 17 weeks. Researchers …

This study uses brain scans to see how negative feelings change food choices and reward processing in people with binge eating disorders. Researchers will compare healthy individuals, those with obesity, and people with binge eating disorder or bulimia. The goal is to understand …

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. Researchers will track weight, body fat, sleep, and eating habits in 128 adults over 13 months. The goal is to find out if timing your workouts can he…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This study follows 50 adults who are about to start GLP-1 therapy for obesity or type 2 diabetes. Researchers will track how their eating habits change over 12 weeks using diet quality scores and body weight. The goal is to understand what dietary support people need while on the…

This study aims to measure heart and metabolic risk markers—such as insulin resistance and fat distribution—in young adults aged 18 to 30 with type 1 diabetes and a body mass index under 25. Researchers will track changes over one year using glucose clamps and meal tests. The goa…

This study looks at health records of about 1,100 women who took Wegovy during pregnancy and compares them to those who did not. The goal is to see if the drug increases risks for birth defects or other problems in babies. Researchers will use insurance claims data to track outco…

This early-stage study looks at how a new weight-loss drug, maridebart cafraglutide, changes the way the body processes oral contraceptives. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth control hormone…

This observational study uses magnetic resonance imaging (MRI) to track how fat and muscle distribution changes in adults with obesity who undergo bariatric surgery. Participants receive MRI scans before surgery and at 1, 6, and 12 months after to measure visceral fat, subcutaneo…

This study tests whether a biomarker found in saliva can predict how much weight people with obesity will lose when taking semaglutide. Researchers will compare weight changes in biomarker-positive and biomarker-negative participants over 24 weeks. The goal is to personalize obes…

This study investigates how severe calorie restriction—achieved through weight-loss surgery—changes the types of fat stored in muscle and how muscles respond to insulin. Researchers will compare normal-weight participants with those who are obese and scheduled for gastric bypass.…

This early-stage study tests an experimental drug called PF-08653944 in 20 overweight or obese adults. Researchers want to see how it affects the speed at which the stomach empties food, using a common painkiller as a marker. The main goals are to understand the drug's effects an…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

This study investigates why some people with obesity develop heart and metabolic problems while others do not, and which diet—Mediterranean, low-carb, or low-fat—best supports metabolic health. Researchers will follow 300 participants, including lean and obese individuals, over s…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This pilot study will compare two diets—one high in ultra-processed foods and one typical American diet—in 6 adults with overweight or obesity. Participants will try each diet for two weeks in random order. The goal is not to prove which diet is better, but to see if a larger stu…

This study tests if a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer common illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengthe…

This study was designed to look at how tiny energy-producing parts of cells (mitochondria) in the liver might be linked to fatty liver disease in people with obesity who were scheduled for weight-loss surgery. Researchers planned to take small liver samples during surgery to stud…

This study follows 250 obese adults who are having a weight-loss procedure—either surgery or an endoscopic stomach reduction. The goal is to see how often acid reflux (GERD) develops afterward, including silent reflux with no symptoms. By tracking symptoms and using tests, resear…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This pilot study looks at whether regularly measuring body fat in very preterm infants (born at 28-32 weeks) can help reduce excess fat gain by 3 months of age. Researchers will use a special machine to measure body composition shortly after birth, at 32 weeks, and again at 36 we…

This study was designed to create a registry of medical information from children aged 1 to 18 with obesity. The goal was to collect historical and clinical data from medical charts to help researchers better understand pediatric obesity. However, the study was withdrawn before e…

This observational study will follow 125,000 adults with employer-based insurance to see how GLP-1 and GLP-1/GIP obesity medications (like Wegovy and Zepbound) affect weight, healthcare use, and medical costs. Researchers will compare people who take these drugs to those who don'…

This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…

This study looks at how head and neck position (sniffing vs. ramped) and the type of blade used on a video laryngoscope affect how quickly a breathing tube can be placed in 140 severely obese patients (BMI 40 or higher) undergoing elective surgery. The goal is to find the best co…

This study follows 300 families with children aged 2 to 6 years over three years to understand how ongoing stress might lead to weight gain. Researchers will measure stress hormones and behaviors to see what role they play. The goal is to learn, not to test a treatment, so no new…

This observational study looks at whether a computer program can analyze voice recordings to predict weight loss success in Latino adults with obesity. Researchers will record participants answering one question about their weight loss journey and use AI to guess their personalit…

This study examines whether low-calorie (low energy density) and high-calorie (high energy density) foods act as substitutes in a meal. Researchers will serve 62 healthy-weight adults different combinations of foods across four sessions and measure how much they eat. The goal is …

This study was designed to see how well the stomach-acid drug dexlansoprazole is absorbed before and after gastric bypass surgery, and how often ulcers occur afterward. It planned to enroll smokers with obesity who were scheduled for surgery. However, the study was withdrawn befo…

This study tests whether Eatable Alphabet cards—a fun, child-friendly nutrition tool—can help kids ages 2 to 10 with overweight or obesity eat more fruits and vegetables. About 160 children in a weight management program will use the cards, and parents will report changes in thei…

This study looks at how compounds from mango (gallotannins) and a probiotic called Lactiplantibacillus pentosus affect gut bacteria and inflammation in people with obesity. Researchers will analyze stool samples from 20 participants (lean and obese) after giving them mango juice,…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study follows 180 children with overweight or obesity to see how their thinking skills (like memory and self-control) relate to eating habits and weight changes over time. Researchers will use brain tasks and interviews to understand these links. The goal is to find better w…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at 54 obese women getting knee replacements to see if a stemmed or non-stemmed tibial implant works better. The goal is to find out which type reduces the risk of the implant collapsing or loosening over time. Researchers will track these outcomes to guide future…

This study looks at whether digital health tools like text messages, videos, or AI conversations can improve the physical and mental health of middle school students. About 800 students aged 11 to 13, with normal weight, overweight, or obesity, will be split into four groups to c…

This study explores whether genetic differences explain why some people benefit more from chili pepper compounds (capsaicinoids) for weight control. Researchers will give supplements to 100 adults with overweight or obesity and measure changes in body fat, appetite, and metabolis…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study looks at whether reducing exposure to everyday chemicals called endocrine disruptors (found in plastics, cosmetics, and food) can help people with overweight or obesity lose weight. About 226 participants will either follow a program to lower chemical exposure or use a…

This study looks at how long you need to fast and how stopping the diabetes/weight-loss drug tirzepatide changes the amount of food left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 people with type 2 diabetes or obesity. The goal …

This registry will follow 10,000 people with obesity who are taking or starting standard weight-loss medications. Researchers will collect data on how well the drugs work and any side effects over time. The goal is to understand the real-world benefits and risks of these treatmen…

This study looks at how the body's internal clock (circadian rhythm) affects heart disease risk, especially in people with obesity. Researchers measured blood pressure and other heart markers in 17 lean and overweight adults over 5 days. The goal is to understand if obesity creat…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance, a condition where the body doesn't use insulin well. Researchers will analyze fat samples from 50 people having weight-loss surgery to see if c…

This study directly measures how GLP-1 medications (like Ozempic) change the way people eat. Researchers use a special device to track every sip of sugary and fatty drinks in 140 adults with obesity. The goal is to understand exactly how these drugs reduce calorie intake, not jus…

This study looks at whether taking weekly cold water baths (18°C) for at least 12 weeks can boost brown fat activity in people with obesity. Brown fat is a type of body fat that burns energy to generate heat. Researchers will use special scans to measure blood flow and fuel use i…

This study follows 225 pregnant women—some who had gastric bypass or sleeve gastrectomy, and some without surgery—to see how blood sugar changes affect fetal growth. Participants wear a continuous glucose monitor and activity tracker for 10 days each trimester. The goal is to lea…

This study was designed to test whether a fasting-mimicking diet (FMD) can activate beige/brown adipose tissue—a type of fat that burns calories—in people with overweight. Researchers planned to measure changes using PET scans, thermal imaging, and blood tests. However, the study…

This study looks at how brown adipose tissue (brown fat) changes when young adults with obesity follow a calorie-restricted diet to lose 8-10% of their body weight. Researchers will use PET-CT scans and molecular tests to measure brown fat activity and compare it to a group maint…

This study was designed to see if a new type of airway device can prevent dangerous drops in oxygen levels during anesthesia in patients who are at high risk, such as those with obesity or sleep apnea. Researchers planned to compare the new device with standard ones in adults und…

This study aims to collect information from weight management clinics across the UK to understand who uses these services, what treatments they receive, and how well they do. Researchers will enroll up to 41,000 people who are already attending these clinics. The goal is to impro…

This study looks at how amino acids trigger the liver to release hormones in healthy people and those with non-alcoholic fatty liver disease. Researchers will give amino acid infusions with or without a drug that blocks natural hormone production. By comparing the results, they h…

This study looks at how fat tissue takes up sugar in people with obesity, comparing those with normal blood sugar to those with insulin resistance. Researchers will use labeled sugar infusions and PET scans to measure sugar uptake in fat and muscle. The goal is to understand why …

This study tests whether infusing a natural hormone called LEAP2 can reduce how the brain reacts to pictures of food in people with obesity. Twenty-eight men with a BMI between 30 and 50 will receive either LEAP2 or a placebo on two separate days and undergo brain scans. The goal…

This study looks at how changing the length of the small intestine re-routed during gastric bypass surgery affects metabolism and inflammation. Researchers will compare two surgical techniques in 50 people with severe obesity and also include 15 healthy lean individuals as a comp…

This study uses PET scans to look at the brain's reward system in 30 people who had bariatric surgery 2-3 years ago. Researchers want to see if differences in dopamine receptors explain why some patients lose more weight than others. Participants will have brain scans before and …

This study reviews medical records of 300 adults with overweight or obesity who took weight management medications. Researchers want to see how much weight patients lost after 12 months and whether blood sugar and cholesterol improved. No new treatments or visits are required—onl…

This small pilot study looks at how eating foods made with soybean oil or palm oil every day for four weeks changes blood fatty acids and body weight in overweight adults. Sixteen participants will try both oils in a crossover design. The goal is to see if people can stick with t…

This study looks at ways to help adults in rural Pennsylvania become more physically active. It includes 880 people who are overweight, have type 2 diabetes, or are not very active. Researchers will track activity levels using questionnaires and wearable devices to see what works…

This study aimed to see if adding pramlintide to semaglutide (Wegovy) could change appetite and eating habits in obese people with prediabetes. It also tried to find ways to predict who would respond best to obesity medication. The trial was withdrawn before any participants were…

This study was designed to see if adding the amino acid isoleucine to a healthy, low-isoleucine diet would change how the body responds to insulin in people with obesity and prediabetes. It planned to enroll adults with a BMI of 30 or higher who also had metabolic syndrome. The s…

This study looks at how eating meals with high or low 'reward value' (like tasty vs. bland food) affects brown fat activity and gut-brain signals. Researchers will scan 30 lean and overweight adults to measure changes in brown fat, gut hormones, and brain receptors after each mea…

This study looks at how popular weight-loss drugs like semaglutide and tirzepatide affect food cravings and diet quality in people with obesity. Over 24 weeks, participants fill out surveys and food diaries to track changes. The goal is to understand whether these medications imp…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

This study tests a new classroom setup where traditional desks are replaced with standing desks, fitballs, and wall boards to get kids moving more. Researchers will track 500 students in Spain to see if this reduces sitting time and improves thinking, fitness, and well-being. The…

This study looks at whether measuring body water with a harmless device can help detect obstructive sleep apnea (OSA) in pregnant women with severe obesity. OSA is common but often missed in this group, and can be dangerous for both mother and baby. Researchers will enroll 52 wom…

This study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers collect health data, biospecimens, and environmental information to understand how parents' exposures affect pregnancy outcomes and child development. The goal is to f…

This 12-month study looks at how a lifestyle program—including group sessions and support from a nurse, dietitian, and kinesiologist—may help women aged 35-75 with obesity improve their weight, heart health, and body image. Some participants may also use GLP-1 weight-loss medicat…

This study looks at how iron levels in the brain, gut bacteria, and blood sugar are connected to thinking and memory in people with obesity. Researchers will track 138 adults aged 30-65 using brain scans, glucose monitors, sleep trackers, and cognitive tests. The goal is to under…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

This study looks at how a continuous 72-hour dose of glucagon (a hormone) affects energy expenditure in healthy, non-diabetic obese adults. About 30 participants will receive either glucagon or a placebo through an IV. The goal is to understand the body's energy use, not to treat…

This early-phase study tests how well 20 healthy obese adults tolerate increasing doses of glucagon, a hormone that raises blood sugar. Researchers measure nausea levels to find the highest dose people can handle before feeling sick. The goal is simply to understand tolerability,…

This study looks at how exercise changes the signals muscles send to the rest of the body, especially those that help burn fat. Researchers will compare obese, lean, and athletic participants to find proteins or genetic codes released from muscle during exercise. The goal is to b…

This study aims to understand why people on a weight loss program sometimes break their diet rules (called 'lapses'). Researchers will use smartphone surveys and wrist sensors to track behaviors, feelings, and surroundings in 150 adults with obesity. The goal is to identify patte…

This study looks at how genes and fat cells differ in people with apple-shaped (belly fat) versus pear-shaped (hip and thigh fat) bodies. Researchers will use body scans and fat biopsies from 27 healthy adults to compare fat tissue at the molecular level. The goal is to better un…

This study looks at how natural compounds in strawberries and raspberries (polyphenols) affect inflammation and gut bacteria in overweight adults with mild inflammation. About 105 participants will eat berry products or a control diet for 4 weeks. Researchers will measure blood a…

This study looks at why children and teens choose to be physically active. Researchers measured fitness, motor skills, thinking abilities, and motivation in 325 third-graders. The goal is to learn how to encourage kids to stay active for better long-term health.

This study looks at how nutritional counseling and exercise affect telomeres—the protective caps on our chromosomes that shorten as we age—in elderly women. Researchers will compare women with and without obesity, measuring changes in telomere length and other aging markers after…

This study looks at how the body handles different types of meals after losing about 16-18% of body weight through either a low-calorie diet or gastric bypass surgery. Researchers will measure insulin, blood sugar, fats, and other markers in 30 adults with obesity but without dia…

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight.…

This study follows 50 obese patients who are having weight-loss surgery (laparoscopic sleeve gastrectomy). Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure changes in pancreatic fat and insulin function. The goal is to see if los…

This study looks at how diet and exercise affect the epigenome—chemical marks on DNA—in sperm of overweight Hispanic men. Researchers will compare sperm from 20 healthy active men and 80 obese inactive men before and after a 12-week program of diet, exercise, or both. They will a…

This study investigates how obesity-related factors like high insulin and fat levels may disrupt fertility in women. Researchers will measure hormone changes and metabolic responses in 84 women. The goal is to understand the underlying causes and inform future treatments to impro…

This study compares an 8-week virtual group program called the Healthy YOU Program to standard weekly email tips for overweight adults. Researchers want to see if the program helps people eat better, move more, and keep those changes for at least 3 months. They will also look at …

This early-phase study at Vanderbilt University Medical Center is looking at how certain nerve signals (called sympathetic vasoconstriction) might interfere with insulin's ability to widen blood vessels and take up sugar. The researchers will give a drug called phentolamine into …

This study looks at 49 adults who had bariatric surgery at least 5 years ago and later regained weight or didn't lose enough. Researchers want to understand how disordered eating, emotional eating, and nutrition affect weight regain. The goal is to help create better follow-up ca…

This study aimed to find the best level of breathing support (PEEP) for severely obese patients on ventilators. Researchers planned to compare two PEEP levels during breathing tests to see which helped patients breathe easier and come off the ventilator sooner. However, the study…

This study planned to analyze data from a large U.S. health survey to see if eating a diet rich in antioxidants is linked to better metabolic health in overweight or obese adults. Researchers would have looked at body mass index and markers like blood sugar and cholesterol. Howev…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study looks at why people who lose weight often experience a greater-than-expected slowdown in metabolism, making it harder to keep weight off. Researchers will compare three lifestyle approaches—resistance training, calorie restriction, and time-restricted eating—in 75 over…

This study looks at how amino acids (building blocks of protein) affect the release of glucagon and insulin compared to sugar alone. Researchers will test 30 adults who are healthy, have type 2 diabetes, or are obese. The goal is to better understand these hormone responses, not …

This study aims to find biomarkers that identify people at risk of a disproportionate drop in resting metabolic rate during and after weight loss. Sixty participants with obesity will follow a 6-month meal replacement program with lifestyle advice. Their resting metabolic rate an…

This study looks at whether losing weight through gastric bypass surgery changes bile acids differently than losing weight through a strict low-calorie diet. Researchers will measure bile acid levels in stool samples from 21 people with obesity. The goal is to understand if the s…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study looks at whether an 8-week program of eccentric (lengthening) resistance training can improve muscle strength, nerve function, and health markers like blood sugar and cholesterol in obese, inactive women. 24 women aged 25-45 with a BMI over 23 will be assigned to eithe…

This study looks at how a personalized, calorie-restricted diet affects metabolism in overweight or obese Chinese adults. Researchers will measure how the body uses energy before and after a 12-week diet plan. The goal is to understand why people respond differently to the same d…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study follows 20 people who had sleeve gastrectomy about 8 years ago to see how their weight, body measurements, and health markers have changed. Researchers compare current data with measurements taken before surgery and 6 months after. The goal is to understand long-term w…

This study follows 14 adults who had a second weight-loss surgery (conversion bariatric surgery) because they didn't lose enough weight or regained weight after their first surgery. Researchers will measure changes in weight, body fat, muscle, and blood tests over one year. The g…

This study looks at why some people with obesity develop conditions like type 2 diabetes while others don't. Researchers are comparing three popular diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants to see how they affect insulin sensitivity and over…

This study looks at whether the natural compounds in olive oil, called polyphenols, can improve heart health markers like cholesterol, inflammation, and gene activity. Researchers will give two types of olive oil to healthy, overweight, and obese adults aged 20-45. The goal is to…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…

This study creates a registry of 240 patients hospitalized with decompensated heart failure with preserved ejection fraction. Researchers will track medical history, body composition, imaging, and blood markers to see how these factors relate to short- and long-term outcomes. The…

This early-stage study checks if a new obesity drug, RAY1225, changes how the body processes common medicines like warfarin, atorvastatin, metformin, and digoxin. About 32 healthy adults will take RAY1225 along with these drugs to measure blood levels and watch for side effects. …

This study compares two ways of reconnecting the intestine during a type of weight-loss surgery called SADI-S. About 82 adults aged 18-70 having this surgery will be randomly assigned to either a hand-sewn or stapled connection. The goal is to see which method leads to fewer earl…

This observational study at the University of Maryland will follow 40 pregnant women to see how their physical activity levels influence the development and function of the placenta. Participants will provide biological samples and health information during pregnancy and at deliv…

This study looks back at 199 adults in Sweden who had their Roux-en-Y gastric bypass reversed between 2007 and 2023. Researchers want to understand why the reversal was needed, whether symptoms got better, and how weight changed. The goal is to gather information to help doctors …

This study tests whether adjusting the breathing machine's pressure to each patient during laparoscopic bariatric surgery can prevent lung collapse and improve oxygen levels. Forty adults with obesity will be randomly assigned to either a fixed pressure or a pressure tailored to …

This study looks at how not having reliable access to enough food might make it harder to lose weight. Researchers are giving 12 women who face food insecurity and have obesity and prediabetes a steady supply of healthy, low-calorie meals for a period. They will measure changes i…

This study follows pregnant women who took Wegovy for obesity or overweight to see if it affects the baby's health. Researchers compare these women to similar pregnant women who did not take Wegovy. The goal is to check for birth defects and other health issues in infants during …

This study aimed to understand how the timing of meals changes daily patterns of natural chemicals in the body that influence eating for pleasure and energy use. It planned to enroll healthy adults without sleep or metabolic disorders. However, the study was withdrawn before any …

This study looks at how exercise training changes the way muscles process fat and sugar, which is linked to insulin resistance and type 2 diabetes. Researchers will study healthy, lean, and overweight participants before and after a 16-week running or yoga program. The goal is to…

This study tests whether a Family Navigator—a trained helper who connects families to resources like parking passes and text reminders—can reduce dropout from pediatric obesity programs. About 108 children aged 6–17 and their caregivers will either get usual care alone or usual c…

This study follows 70 healthy infants from rural Pakistan over their first two years of life. Researchers will regularly test the babies' gut bacteria to see how it changes and whether it relates to their growth and nutrition. The goal is to understand why some children become ma…

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study aims to understand how bariatric surgery affects the body's tissues, like fat, muscle, and liver, and how it improves insulin sensitivity. Researchers will collect tissue and blood samples from 500 adults undergoing surgery or other procedures. The goal is to learn the…

This study follows 60 adults who completed a weight loss program 3 years ago. Researchers will measure their weight, body fat, physical activity, sleep, and eating patterns to see how these habits relate to keeping weight off. Participants wear activity trackers and use a phone a…

This study looks at how insulin in the brain changes blood flow and nerve signals in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, as well as nerve activity. The goal is to understand basic body functions, not to treat any disease.

This study looks at how exercising in the morning versus the evening, and on an empty versus full stomach, changes the way your body burns energy and fat. Researchers will measure these effects in 20 adults with overweight or obesity who are already active. The goal is to better …

This study looks at how dairy fat, especially a component called milk fat globule membrane, affects inflammation after a high-fat meal. Thirty-eight adults with metabolic syndrome or obesity will consume shakes with different fats, and researchers will measure inflammatory marker…

This study looks at how eating cheese, compared to a non-dairy cheese substitute, changes inflammation levels in the body over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand the shor…

This study looks at whether changing what you eat can help people lose more weight after bariatric surgery. Researchers will track hunger, calorie intake, and energy use in 44 patients who had sleeve gastrectomy. The goal is to find better ways to support long-term weight loss af…

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study aimed to measure pressure inside the chest (pleural pressure) in people with morbid obesity using a low-dose CT scan and a thin balloon placed in the esophagus. Researchers planned to compare 6 people with a BMI over 40 to 6 people with a BMI under 30. The study was wi…

This study compares the eating habits of 44 people who had sleeve gastrectomy surgery for obesity. Researchers want to understand why some patients lose more weight than others by looking at hunger, appetite, and related hormones. The goal is to find dietary patterns that lead to…

This study looks at whether the standard doses of the antibiotic cefazolin given before bariatric surgery are high enough for obese patients. Researchers will measure drug levels in the blood and tissues of 70 patients to see if they reach the needed concentration to prevent infe…

Researchers are analyzing data from 8,000 patients who had bariatric surgery for severe obesity. The goal is to learn which procedures lead to the best weight loss and health improvements, while also tracking risks like complications and death. This study does not test a new trea…

This study follows 113 people scheduled for either gastric bypass or sleeve gastrectomy to see how the surgery affects their social experiences and well-being. Participants will fill out daily diaries about their social interactions and mood at 6 weeks and 1 year after surgery. T…