Obesity disorder

This study investigates how semaglutide (the drug in Ozempic and Wegovy) changes brain activity related to appetite and eating in people with obesity. Researchers will compare teenagers (ages 12–18) and adults (ages 30–45) using brain scans and meal tests to see if the drug affec…

This Phase 2 trial tests whether combining the supplement alpha-lipoic acid with the drug mirabegron can improve how the body processes sugar in people with obesity. Sixty adults aged 18 to 65 with a BMI between 30 and 45 will take the combination or a placebo for 4 weeks. The st…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar levels. Participants will play active video games at home, and researchers will track changes in weight a…

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This early-stage study tests a small implant placed under the skin that releases semaglutide (the drug in Wegovy) over 4 weeks. It involves 20 otherwise healthy overweight or obese adults. The goal is to see if the implant is safe and how it compares to weekly injections.

This pilot study tests a temporary, flexible tube called a duodenal-jejunal bypass sleeve. It is placed in the upper intestine using an endoscope and left for 3 months to help with weight loss and improve metabolic syndrome. The study involves 20 adults with obesity or excess wei…

This study tests a device called OverStitch NXT, which uses sutures to reduce stomach size through an endoscope (a tube down the throat), avoiding traditional surgery. It involves 136 obese Asian adults with a BMI of 27.5 or higher, some with diabetes or other obesity-related con…

This study tests whether a dietary supplement called MB-1 can help overweight and obese adults lose weight and improve metabolic health. One hundred participants will take either MB-1 or a placebo daily for 84 days. Researchers will measure changes in body weight, BMI, and other …

This Phase 2 trial tests whether adding LAE102 to the weight-loss drug tirzepatide can improve body composition in 60 adults with obesity. Participants receive weekly injections of either LAE102 plus tirzepatide or a placebo plus tirzepatide. The main goal is to see if the combin…

This phase 4 trial will study 240 adults aged 35-55 with class I/II obesity to see if weight loss from semaglutide (Ozempic/Wegovy) improves brain health. Participants will take the drug weekly for 80 weeks and undergo MRI scans, cognitive tests, and blood work. The study also in…

This pilot study tests whether a 10-week behavioral program can help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. The program includes medically tailored meals, a YMCA membership, and a meditation component. Researchers will follow 64 partic…

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This study tests an experimental drug called BI 3034701 to help people with obesity or overweight lose weight. About 300 adults aged 18-74 will receive either the drug or a placebo injection for 42 weeks, along with diet and exercise advice. Researchers will measure weight change…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This study looks at whether adding the Nutu digital health platform to a standard weight loss program helps people with obesity lose more weight and improve heart health. About 300 adults in the FLOW program will be offered Nutu, which includes AI coaching and tracking tools. The…

This Phase 3 study tests whether a weekly injection called zenagamtide helps Asian adults with overweight or obesity lose weight safely. About 400 participants will receive either the drug or a placebo for several weeks. The main goal is to see how much body weight changes, with …

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study will test whether replacing breakfast and a snack with a diabetes-specific nutritional drink (Glucerna) helps people with type 2 diabetes and obesity keep their blood sugar in a healthy range more often. About 198 adults will be randomly assigned to either the drink-ba…

This Phase 3 trial will test whether a new drug called zenagamtide helps people with obesity lose more weight than the current treatment semaglutide. About 650 adults will receive weekly injections of either zenagamtide, semaglutide, or a placebo. The main goal is to see how much…

This early-stage study tests whether a new drug, eloralintide, can improve how the body responds to insulin and manage weight in 115 adults with overweight or obesity. Participants will receive either the drug or a placebo injection and be monitored for about 35 weeks. The goal i…

This Phase 2 study will test whether a once-daily cannabis gummy can help people with obesity lose weight. Forty adults aged 18–65 with a BMI of 30 or higher will receive either the cannabis gummy or a placebo for a set period. The main goal is to measure changes in body weight.…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This Phase 2 trial tests whether BGM0504 tablets can help overweight or obese adults without diabetes lose weight. About 200 Chinese participants will take either the drug or a placebo daily for 20 weeks. Researchers will measure changes in body weight, waist size, and blood suga…

This study investigates whether a supervised, adapted physical activity program can improve how the body burns fat during walking in women with overweight or obesity, both with and without polycystic ovary syndrome (PCOS). Researchers will compare changes in fat oxidation and oth…

This pilot study will test whether supplements made from bilberries and olives can reduce inflammation and oxidative stress in people with prediabetes who are overweight. Researchers will collect blood, urine, and stool samples from 60 participants to measure changes in key healt…

This study investigates whether replacing some wheat flour with legume flours (chickpea, pea, or lentil) in Arabic bread can reduce blood sugar spikes after eating. Overweight or obese adults aged 18–65 will consume different breads and have their blood glucose and appetite measu…

This phase 3 trial tests a once-daily oral drug called aleniglipron for chronic weight management in 3600 adults with obesity or overweight who also have a weight-related health condition. Participants take the drug or a placebo for 76 weeks, along with diet and exercise changes.…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This trial tests whether a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can improve blood sugar control and reduce the need for insulin in adults with obesity and type 2 diabetes. Participants have poorly controlled diabetes despite taking standard medication…

This early-stage study tests an experimental drug called LY4174794 in 108 healthy volunteers who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to measure weight loss. Participants will receive either the drug or a p…

This study looks at whether adding lifestyle coaching to a new weight-loss medication (GLP-1) helps teens with obesity lose more weight and feel better. About 1,020 teens aged 12-17 will take the medication and be assigned to either intensive or basic lifestyle support. The goal …

This study looks at whether day hospitalization (going home at night) works as well as full-time hospital stays for teens aged 12-20 with severe obesity. About 126 participants will be followed to see how their weight changes six months after treatment ends. The goal is to find a…

This phase 3 study tests whether a weekly injection called UBT251 can help overweight or obese adults lose weight. Participants receive either the drug or a placebo for 52 weeks. The main goal is to measure the percentage change in body weight, with additional checks on waist siz…

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests a new medicine called NNC0662-0419 in 230 adults with obesity (BMI 30 or higher). Researchers want to see if different ways of increasing the dose over time can reduce stomach side effects while still helping people lose at least 25% of their body weight. The stu…

This study tests whether combining two experimental drugs, petrelintide and enicepatide, helps adults with obesity or overweight lose more weight than taking either drug alone or a placebo. About 486 participants will receive different doses or a placebo for several months. The g…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This study looks at whether adding professional dental cleaning to semaglutide treatment can improve both oral health and heart-related risks in children with severe obesity. About 50 kids will either get dental cleaning plus hygiene advice, or just hygiene advice. The goal is to…

This European trial tests a 24-week lifestyle program for 400 night-shift workers. The program, delivered via a mobile app and workshops, focuses on sleep, stress, diet, and exercise. The goal is to see if it helps workers sleep longer and improve their health.

This early-stage study tests whether a new oral drug, VRB-103, is safe and tolerable when taken alone or with another drug (ecnoglutide) in people with obesity or overweight. About 336 participants will receive either the drug or a placebo. The goal is to check for side effects, …

This study will test whether a 24-week home-based resistance exercise program, when added to the weight-loss drug tirzepatide, helps overweight and obese adults maintain muscle mass and strength. About 108 people starting tirzepatide will be randomly assigned to either exercise p…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This study tests a web-based program called Confident Moves designed to help adults with obesity increase their physical activity and improve overall health. About 348 adults aged 18-64 with a BMI of 25 or higher will be enrolled. Participants will use an online platform with sel…

This study tests a new tablet called DA-302168S to help people lose weight. It is for adults aged 18-75 who are overweight or obese. The study will compare the drug to a placebo to see if it is safe and effective. About 840 people will take part in China.

This study tests a new injectable drug called SRSD384 in 78 overweight or obese adults. In the first part, participants receive a single dose of SRSD384 alone. In the second part, they receive SRSD384 combined with another weight-loss drug, tirzepatide. The main goal is to check …

This study tests whether a probiotic called Akkermansia muciniphila (AKK PROBIO) can help obese children and adolescents aged 7 to 18 improve their weight and metabolism. Half of the 100 participants will take the probiotic capsules, and half will take a placebo. The goal is to s…

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight. Participants must have already been on weekly injections of semaglutide or tirzepatide for at least 6 months. The goal is to find …

This study tests a new drug called bofanglutide (GZR18) against the existing drug semaglutide for weight loss in 352 Latin American adults with overweight or obesity. Participants receive injections every two weeks (bofanglutide) or weekly (semaglutide) for 36 weeks, along with d…

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests whether taking inulin, a type of dietary fiber, can improve cholesterol and other heart-related risk factors in 600 overweight or obese adults who are already using GLP-1 medications (like semaglutide) for weight loss. Participants will take either 10 grams of in…

This study tests a telehealth program called Virtual Housecalls for teens aged 12-15 with class I obesity. The program provides 26 hours of lifestyle coaching via video calls. Researchers want to see if it helps teens maintain a healthier weight compared to standard care. The tri…

This Phase 2 trial tests a minimally invasive endoscopic procedure for weight loss in 10 adults with obesity (BMI 30-40, or 27-29.9 with related health issues). The procedure combines two techniques: one to reduce appetite by ablating part of the stomach lining, and another to sl…

This early-stage study will compare two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version for several weeks, and researchers will measure how the drug builds up in the body. The goal is to s…

This study looks at whether a 12-week structured diet and exercise plan can help adults aged 50 and older with obesity and insulin resistance lose fat and improve muscle function. Participants will receive all meals and exercise three times a week under supervision. The goal is t…

This study tests whether adding fecal microbiota transplantation (FMT) to a calorie-restricted diet and a diabetes drug (semaglutide) helps people with obesity and type 2 diabetes lose more weight and improve metabolism. Twenty adults aged 18-60 with a BMI of 30-40 and diabetes f…

This study tests whether patients can safely go home within 6 hours of bariatric surgery instead of staying overnight. 200 adults with obesity will be randomly assigned to same-day discharge or overnight stay. The main goal is to see how many need emergency care within a week.

This study reviews medical records of 500 adults with obesity or overweight who took a combination of sibutramine and topiramate for at least three months. The goal is to see how much weight they lost and if the treatment was safe and tolerable. This is a low-cost option that may…

This Phase 1 study tests a new drug called REGN20934 in 90 adults who are overweight or obese. The main goal is to check the drug's safety, side effects, and how the body processes it. Participants receive a single dose of either the drug or a placebo, and researchers monitor the…

This study compares two blood-thinning injections (tinzaparin and enoxaparin) to prevent dangerous blood clots after weight loss surgery. About 180 adults having laparoscopic sleeve gastrectomy or gastric bypass will be randomly assigned to one of the two drugs for 21 days after …

This study looks at whether combining GLP-1 medications (like semaglutide and tirzepatide) with Noom's app-based behavioral program helps people lose weight and improve heart health markers. Over 2,300 adults will be followed for 24 months, tracking weight, blood sugar, cholester…

This study will test whether adding whole-body electrical muscle stimulation (EMS) to a reduced-calorie diet helps people with obesity lose weight and improve metabolic health. Forty adults will be randomly assigned to either diet alone or diet plus EMS for 8 weeks. Researchers w…

This study tests four extra tools added to a 6-month mobile weight loss program for 580 adults with overweight or obesity. The tools include switching from detailed calorie counting to a simple traffic-light food system, a goal planning tool, extra personalized texts, and health …

This study looks at whether replacing sugary or refined-carb foods with one avocado each day can reduce inflammation and improve how the body handles insulin. It involves 38 overweight or obese adults with high inflammation markers. Participants will eat an avocado daily for four…

This study looks at whether adding exercise to the weight-loss medication tirzepatide helps people lose more weight and improve health markers like blood sugar and cholesterol. Researchers will enroll 24 adults aged 30–65 with overweight or obesity. Participants will take tirzepa…

This study will test whether tirzepatide (Mounjaro), a drug used for diabetes and weight loss, can help people with obesity-related heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in blood volume and body fat in 50 participants over 15 mon…

This early study tests whether adding an experimental drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo …

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study tests whether virtual classes about healthy eating and exercise can help Puerto Rican men lose weight. About 48 men will take part in online sessions for 4 months, with follow-up meetings. The goal is to see if the program is practical and leads to meaningful weight lo…

This early-stage trial tests the safety of an investigational injection called HRS9531 in 48 Chinese adolescents aged 12 to 17 who are obese. Participants receive either the drug or a placebo, and researchers monitor side effects, drug levels in the blood, and changes in weight a…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether a 12-week program of exercise and personalized diet counseling can help preserve muscle mass in obese adults taking GLP-1 medications like Wegovy. Twenty participants aged 40-55 will be followed to see if these lifestyle changes prevent the muscle loss of…

This study compares two weight management programs for children who have had acute lymphoblastic leukemia (ALL). About 80 children and their caregivers will be randomly assigned to either a basic educational program or a more intensive guided self-help program. The goal is to see…

This study looks at whether giving people feedback on their metabolic profile (blood test results) halfway through a 3-month low-starch, low-sugar diet helps them lose more weight. 300 overweight adults (BMI over 25) will follow the diet, and half will learn their metabolic impro…

This phase 2 trial tests whether quercetin, a dietary supplement found in many fruits and vegetables, can improve the function of tiny blood vessels in young adults with obesity. Forty participants will take either quercetin or a placebo daily for 30 days. Researchers will measur…

This phase 2 trial tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are overweight. Twenty adults with active arthritis despite standard treatment will take either disulfiram o…

This study tests different weight-loss strategies for adults aged 50 to 75 with obesity. Participants will follow either a high-protein or standard-protein diet for 16 weeks. Those who don't respond well may then receive extra protein supplements or resistance exercise training. …

This study looks at how exercise and eating more fruits and vegetables affect the heart and metabolic health of 120 teens aged 13–17 with obesity. Participants will be split into four groups: standard care, exercise only, diet only, or both exercise and diet. Over 12 weeks, resea…

This study will give 150 children and teens with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program helps improve their heart health over 6 to 12 months. Participants…

This early-stage trial tests a microneedle patch called DWRX5003 that delivers semaglutide, a drug used for obesity and type 2 diabetes. The study involves 72 healthy adults to check safety and how well the drug enters the body compared to standard injections. It is not yet testi…

This study tests a custom mouthpiece called Fuzzle that you wear during the day to help with weight loss. About 78 adults with obesity will use the device plus get diet advice, and their weight loss will be compared to those who only get advice. The goal is to see if the device h…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This study tests whether adding exercise-focused lifestyle coaching to a personalized diet plan improves health in 435 overweight or obese adults with metabolic syndrome. Participants will either follow a diet plan alone or a diet plan plus an intelligent lifestyle program that t…

This Phase 1 study tests a single dose of SYH2082 injection in 44 healthy adults who are overweight or have obesity. The main goal is to check safety and side effects, not weight loss. Participants will receive either the drug or a placebo, and researchers will monitor how the dr…

This study will test whether a low-calorie diet rich in medium-chain triglycerides (MCTs) from traditional Minangkabau foods can improve metabolic health in 40 obese adults. Participants will follow a diet based on coconut milk dishes for a period, and researchers will measure ch…

This early-stage study tests an experimental drug called CMS-D008 in 110 healthy and overweight or obese adults. The main goal is to check safety and how the body processes the drug, not weight loss. Participants will receive either the drug or a placebo as injections, and resear…

This study tests a 'Food as Medicine' program for 250 children aged 8-15 who are at risk for chronic diseases like obesity. Families get help from a community health worker who sets nutrition goals and connects them to healthy food resources. The goal is to see if this improves d…

This study tests a minimally invasive procedure called POSE2.0 for weight loss in 186 adults with obesity. The procedure uses stitches placed in the stomach without any incisions, combined with a diet and exercise program. Researchers will compare weight loss and safety between t…

This study tests whether taking a daily probiotic called Lactobacillus reuteri for one month can improve skin barrier damage in people with obesity. Researchers will measure water loss through the skin and check changes in gut and skin bacteria. The trial involves 140 adults aged…

This study tests whether a probiotic called Akkermansia muciniphila can help overweight and obese adults lose weight and improve their metabolism. Over 12 weeks, 76 participants will take either the probiotic or a placebo, while following a low-carb diet. Researchers will measure…

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This study tests an injection called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The goal is to see if the drug improves breathing during sleep and helps with weight loss over 52 weeks. Participants will rec…

This phase 2 study tests an experimental oral drug, NA-931, alone or with an approved injectable weight-loss medication (tirzepatide), in 224 overweight or obese adults aged 18-80. The main goal is to see how much weight participants lose over 48 weeks compared to placebo. The st…

This study tests whether adding metformin (a diabetes drug) to the standard psoriasis treatment secukinumab works better than secukinumab alone for overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. About 186 participants will be randomly assigned to r…

This study will test the safety and effectiveness of tirzepatide, a once-weekly injection, in 300 adults with obesity or overweight plus related health problems. Participants will receive increasing doses over 12 months while doctors track side effects, weight loss, and improveme…

This study will test whether taking liraglutide together with orlistat helps overweight or obese adults lose more weight than liraglutide alone. About 120 participants will be followed for 24 weeks. The goal is to see which approach works better in real-world conditions.

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study tests whether restarting semaglutide (Wegovy) just two weeks after sleeve gastrectomy helps teens with severe obesity lose more weight than surgery alone. About 150 teens aged 12–18 who were already on semaglutide before surgery will be randomly assigned to restart the…

This early-stage study tests a single dose of SA030 injection in 40 overweight or obese adults aged 18–55. The main goal is to check safety and how the body handles the drug. It is the first time SA030 is given to humans, so results will guide future research.

This study will test whether a natural fiber called oligofructose, found in foods like onions and bananas, can help improve blood sugar, cholesterol, and inflammation in Saudi adults with type 2 diabetes. A total of 100 people (50 with diabetes and 50 without) will take either th…

This study looks at whether using a mobile wellness app alone or with a wearable fitness tracker helps adults with overweight (BMI 25 or higher) manage their weight and get more active. About 300 people will be split into three groups: app plus tracker, app only, or standard heal…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study looks at whether a GLP-1 receptor agonist, a drug already used for diabetes and obesity, can improve fat buildup in the liver and blood in people with MASLD. Researchers will measure changes in fats, proteins, and genes in 30 participants who already take the drug. The…

This study tests whether a family-based weight management program can slow the start of puberty in girls aged 6.5 to 8 years who have overweight or obesity. Half of the 240 girls will join a 20-session program focused on healthy eating and activity, while the other half receive u…

This study tests a nutritional supplement called Redefine in 80 overweight adults who are already taking a weight-loss medication (semaglutide) and following a low-calorie diet. The goal is to see if Redefine is safe and helps preserve muscle mass while losing fat. Participants t…

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) for weight loss in 300 adults with obesity. ESG uses a special device to stitch the stomach smaller from the inside, without cutting or removing any tissue. The goal is to see if it helps people lose weight …

The Reset trial, led by Stanford University, aims to find the best combination of four dietary strategies for weight loss in a fully digital program. 208 adults with overweight or obesity will receive a 12-week remote intervention that includes daily self-weighing, weekly lessons…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This study tests a new medicine called CagriSema to help people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo for around one year. The main goal is to see how much weight they lose and check for any side effects.

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This study tests whether Vibegron, a drug already approved for overactive bladder, can improve metabolism, heart health, and physical and mental function in middle-aged and older adults with obesity. Forty participants will take the drug or a placebo for 12 weeks. The goal is to …

This pilot study tests whether giving people a choice between two weight management strategies—avoiding tempting foods or learning to resist them—helps them stick with the program better than being assigned a strategy. Sixty adults with overweight or obesity will either choose th…

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This study tests whether a specific ventilator mode called APRV can improve breathing and oxygen levels in very obese patients after elective heart surgery. 180 adults with a BMI of 40 or higher (or 35 with related health issues) will be randomly assigned to receive either APRV o…

This study looks at whether combining a structured exercise and nutrition program with weight-loss medication helps adults with obesity keep more muscle and stay physically strong, compared to taking the medication alone. About 120 adults aged 18-70 will take part over one year. …

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study tests whether vericiguat, a drug already used for heart failure, can improve how the body uses sugar and burns energy in Black adults with obesity and insulin resistance. Researchers will give 200 participants either vericiguat or a placebo daily for 12 weeks, measurin…

This study tests the drug tirzepatide (Munjaro) in 30 obese adults with congenital heart disease. Over 6 months, half get the drug and half get a placebo. Researchers will check if it improves exercise ability, heart function, and cholesterol. It is one of the first studies to lo…

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This early-stage trial will test two similar injectable drugs for obesity, called HUC2-676 and HUC2-676-R, in 40 healthy adults. Each person will receive a single dose of both drugs at different times to compare safety and how the body processes them. The study is not yet recruit…

This study tests whether a 12-week program of home-delivered DASH-diet groceries and cooking classes can help adults with high blood pressure and obesity lower their blood pressure and lose weight. 150 participants will be randomly assigned to either the food program or usual car…

This study tests whether adding the weight-loss drug orlistat to standard gout treatment helps obese patients lower uric acid levels and reduce gout attacks. 120 adults with gout and obesity will take either orlistat or a placebo for 24 weeks, along with diet and exercise advice.…

This early-stage study tests a single dose of an investigational drug called SGB-7342 in 45 adults who have obesity or are overweight. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves in the body and any weight changes.…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This study tests whether eating meals at times that match your body's internal clock can help people who have had weight-loss surgery keep the weight off and improve their health. About 246 adults who had sleeve gastrectomy at least six months ago will either follow standard diet…

This study compares two popular weight-loss drugs, semaglutide and tirzepatide, alone or combined with exercise, in 48 adults with obesity. The goal is to see which approach better reduces body fat while preserving muscle mass, and improves strength and metabolic health. Particip…

This study tests whether adding a weight-loss medication (a GLP-1 drug) to standard chemo-radiation before surgery helps rectal cancer patients with a high BMI. About 42 participants will either get the drug plus standard treatment or standard treatment alone. Researchers will me…

This Phase 3 trial tests whether zovaglutide, given as a shot every 4 weeks, helps people with overweight or obesity lose weight. About 744 adults will receive either the drug or a placebo for 52 weeks. The study measures how much weight they lose and how many achieve at least 5%…

This study tests an experimental oral drug called MDR-001 to help adults with overweight or obesity lose weight over 52 weeks. About 738 participants will receive either the drug or a placebo, along with lifestyle advice. The main goal is to see if the drug leads to meaningful we…

This study tests whether a weekly injection of tirzepatide (a diabetes drug) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or a placebo shot for 8 week…

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This study will test whether a 4-month Zumba program can improve heart health, hormone levels, and body composition in overweight and obese women, both before and after menopause. About 73 women will be randomly assigned to either Zumba classes or no exercise. Researchers will me…

This study tests two 2-month programs to help adults with overweight or obesity cut down on ultra-processed foods. One program uses standard diet tips like meal planning, while the other uses a 'dissonance' approach where participants take part in activism against the food indust…

This study tests a new injection called IN-B00009 to help adults with obesity or overweight lose weight. About 300 people will receive either the drug or a placebo for 40 weeks. The main goals are to see how much weight they lose and if the treatment is safe.

This study tests whether giving tranexamic acid (TXA) through a vein during weight-loss surgery can reduce blood loss in patients with a very high body mass index (BMI over 45). About 128 high-risk adults will receive TXA or a placebo to see if it lowers the need for blood transf…

This study tests a 20-week program combining a low-calorie diet with exercise in 70 people who have both obesity and COPD. The goal is to see if weight loss can improve how far they can walk in 6 minutes, as well as their lung function, symptoms, and inflammation. If it works, it…

This study will compare two types of minimally invasive gastric bypass surgery for people with severe obesity: one done with a robot (DaVinci) and the other done by hand (laparoscopy). Researchers want to see which approach leads to fewer complications and is more cost-effective.…

This study tests whether eating foods high in resistant starch (a type of fiber) can slow down memory and thinking problems in people who have a high genetic risk for cognitive decline. Seventy adults aged 40 and older with obesity or large waistlines will eat either high-resista…

This study is testing a new AI software called Soma that automatically measures muscle and fat from CT scans. Researchers will compare the software's measurements to those made by three expert radiologists using 200 CT scans from public databases. The goal is to see if the AI is …

This study tests whether the drug Qsymia, combined with lifestyle coaching, can prevent obesity in 140 adolescents and young adults (ages 18-25) who are overweight (BMI 25-30) and have a family history of obesity. Participants will receive either Qsymia or a placebo, plus coachin…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests a special silver-coated mesh placed during emergency abdominal surgery to see if it can prevent surgical site infections and incisional hernias. About 110 adults having urgent open abdominal surgery will take part. Researchers will track infection and hernia rate…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This study tests whether an AI-informed peer-mentoring program can help healthy 12- to 25-year-olds eat better and move more to prevent obesity. Participants will be split into three groups: AI-assisted peer mentoring, traditional peer mentoring, or standard health education. Res…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This study looks at whether using secure digital systems to share information between pediatricians and WIC nutritionists can help mothers get consistent advice on responsive parenting—like how to respond to a baby's needs for healthy eating, sleep, and activity. About 380 pregna…

This study tests if digital videos and tips can help prevent obesity in babies during their first year. About 50 mothers in a home visiting program will watch short modules on feeding, sleep, and activity. Researchers will check the babies' weight and ask mothers about their habi…

This trial tests whether a nutrition program designed with input from students, parents, teachers, and cafeteria staff can improve the weight and eating habits of adolescents. About 2,600 teens in grades 7-9 across 52 schools in India and Nepal will take part. Researchers will me…

This study tests a 24-week school program to prevent myopia, obesity, and mental health problems in children aged 8-11. The program includes animated videos, family activities, and health lessons. Researchers will compare these kids to those receiving standard health education, t…

This study tests whether replacing some regular gym classes with specialized physical education courses can prevent common health issues like nearsightedness, overweight, anxiety, and depression in junior high students. Two hundred students will be randomly assigned to either the…

This study will test a family support model that combines two existing programs: a universal school-based program for all first graders and a targeted program for parents of children with overweight or obesity. Researchers will enroll 126 parents of children aged 6-12 in Sweden t…

This study tests a mobile app called FLAGs that gives parents personalized advice on feeding and lifestyle for their infants. Researchers will enroll 440 mothers with higher risk of childhood obesity. Half will use the app, half will get standard care. The goal is to see if the a…

This study tests whether adding 3D reconstruction and virtual reality to standard body image counselling helps patients feel better about their body after weight-loss surgery. 80 adults on the waiting list for bariatric surgery will be split into two groups: one gets traditional …

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study tests whether a temporary catheter placed during laparoscopic sleeve gastrectomy can be used to re-dose nerve-blocking medicine (bupivacaine and dexamethasone) if severe pain or nausea break through after surgery. It includes 30 high-risk patients, such as young women …

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study tests a smartphone app that combines acceptance and commitment therapy, a pedometer, and health education to help overweight or obese adults reduce weight-related shame and lose weight. Sixty participants will be randomly assigned to use the app or receive standard hea…

This study looks at whether giving a low dose of the hormone HCG can improve the chance of having a baby for overweight women who use frozen embryos in a natural cycle. About 750 women will take part. The goal is to see if this extra hormone support helps more women give birth.

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This study tests whether a flexible, symptom-guided dosing plan for tirzepatide can reduce nausea and vomiting compared to the standard dosing plan in adults with obesity who do not have diabetes. Participants will be randomly assigned to one of two dosing strategies and followed…

This study tests whether tracking only high-calorie, low-nutrition foods (Red Zone Foods) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if a simpler approa…

This study looks at whether whole body vibration can improve muscle function, physical fitness, and breathing in people who have had bariatric surgery. Sixty adults who had surgery at least 6 weeks ago will be split into three groups: one does vibration exercises, one does resist…

This study tests whether a daily lutein supplement made from microalgae can slow cognitive decline in postmenopausal women with obesity. 300 women aged 48-60 will take either 6 mg, 14 mg, or a placebo for 180 days. Researchers will measure changes in memory, attention, and inflam…

This study will test two different nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will receive either an intertransverse process block or an external oblique intercostal plane block. Researche…

This study tests two different nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will receive either an intertransverse process block or a subcostal transversus abdominis plane block. The goal is…

This study looks at whether brief, intense stair-climbing sessions (called 'exercise snacks') can improve blood vessel function and body composition in overweight adults aged 18-35. Sixty participants will be split into four groups, including a no-exercise control group, for 6-8 …

This study tests a new approach called 'snack exercise' for adults aged 65 and older who are overweight. Instead of one long workout, participants do several short bursts of activity throughout the day. The goal is to see if this easier routine helps improve health, fitness, and …

This study will compare two ultrasound-guided nerve blocks—the external oblique intercostal plane block and the subcostal transversus abdominis plane block—for controlling pain after laparoscopic sleeve gastrectomy. Ninety adults aged 18–65 will receive one of the blocks plus sta…

This study tests whether a 10-week camp program can help children and teens (ages 7-14) reduce binge eating. Some parents will also receive special training to see if it adds extra benefit. Researchers will follow participants for up to 5 years to track lasting effects.

This study tests two different drugs—dexmedetomidine and low-dose ketamine—given during weight-loss surgery to see which one reduces pain and the need for morphine afterward. Ninety adults having bariatric surgery will be randomly assigned to one of the two drugs or a placebo. Th…

This study tests whether 12 weeks of daily breathing exercises using a special device can reduce sleep apnea severity and improve sleep quality in 10 adults with severe obesity (BMI over 40) and obstructive sleep apnea. Participants will do progressively harder breathing workouts…

This study tests an internet-based self-help program designed to reduce psychological distress in adults with obesity (BMI 30 or higher). 224 participants will be randomly assigned to one of two therapy-based online programs or a waitlist. The program lasts 6 weeks and includes f…

This study tests a mobile app designed for obese children aged 8-10 to improve their eating attitudes, awareness, and confidence in making healthy food choices. The app works on smartphones and offline, and includes input from nurses and software experts. Researchers will measure…

This study tests a non-invasive device that stimulates the vagus nerve through the ear in 60 men aged 25-35 with central obesity (waist >94 cm, BMI ≥30). The goal is to see if it lowers inflammation (IL-6 levels) and reduces waist size. Participants must be otherwise healthy, non…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study tests if giving the asthma drug salbutamol during weight-loss surgery can improve breathing in obese patients. Researchers will measure lung function during surgery and check for breathing problems afterward. The goal is to see if this simple addition can reduce compli…

This study tests whether an extra nerve block given during weight-loss surgery can lower pain, nausea, and the need for painkillers in the first three days after surgery. About 200 adults having gastric bypass or sleeve gastrectomy will be randomly assigned to get either standard…

This study tests a 6-session group therapy based on polyvagal theory, designed to help people with obesity become more aware of body signals and better manage emotions. Ten participants from an NHS weight management service will be randomly assigned to start the therapy after 14 …

This study will test whether adding a breathing muscle trainer to aerobic exercise helps adults with obesity and chronic low back pain. Forty-eight participants will be split into two groups: one using the trainer at a low resistance and one at a higher resistance. Researchers wi…

This study will compare two devices that blow gas into the belly during laparoscopic sleeve gastrectomy (a weight-loss surgery). The goal is to see if one device causes less pain after surgery than the other. About 74 adults aged 22 to 65 having planned sleeve gastrectomy will be…

This study compares two devices used during robotic gastric sleeve surgery to see which causes less shoulder, neck, and chest pain afterward. About 74 adults having non-emergency sleeve gastrectomy will be randomly assigned to receive either the AirSeal or DV5 insufflation system…

This study tests if placing stitches only in the lower part of the stomach works as well as placing stitches in both the lower and upper parts for weight loss. Ten adults with obesity will get one of the two stitch patterns using a device called Endomina. Researchers will track h…

This study tests whether taking probiotics can reduce digestive side effects like nausea and diarrhea in people starting weight-loss drugs such as semaglutide or tirzepatide. Fifty adults with obesity will take either a probiotic capsule or a placebo daily for 26 weeks. The goal …

This study tests whether a single dose of gabapentin, given before weight-loss surgery, can reduce pain and the need for other painkillers in the first 24 hours after the operation. About 102 people having bariatric surgery will receive either gabapentin or a placebo. The goal is…

This study looks at whether a nerve block (TAP block) given after laparoscopic gastric sleeve surgery can help the gut work normally again sooner. Sixty adults having weight-loss surgery will either get the block or standard pain care. Researchers will track gut symptoms using pa…

This study tests whether listening to a guided imagery recording can reduce pain, anxiety, fear, and stress, and improve sleep quality in people recovering from bariatric surgery. Seventy adults will be randomly assigned to either listen to the recording or receive standard care.…

This study tests whether watching a 20-minute virtual reality video of a calming forest can reduce pain, anxiety, fear, and stress, and improve sleep in people having bariatric surgery. Seventy patients will be randomly assigned to either the VR experience or standard care. Resea…

This study follows 400 children aged 5 to 7 with obesity or normal weight until age 12. Researchers will track puberty signs, hormones, genes, diet, and chemical exposures to see what predicts early puberty. No treatments are given; the goal is to gather information.

This natural history study looks at how life events during childhood might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60, measuring food intake, physical activity, blood sugar, and body fat. Participants will also…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This phase 1 trial tests a new investigational drug, SCB0020160, for the first time in humans. Healthy adult men aged 18 to 65 receive either the drug or a placebo to evaluate safety, tolerability, and how the drug moves through the body. The study also looks at whether food affe…

This study will follow 440 adults aged 40-89 who are starting a weight management program that includes drugs like semaglutide or tirzepatide along with lifestyle coaching. Researchers will measure changes in biological age using a blood-based aging clock over 6 months. The goal …

This observational study looks at how being overweight or obese, and changes in lifestyle, impact work performance, quality of life, and well-being in medical residents. Researchers will track 600 participants for 12 months, measuring body weight, lifestyle habits, and using ques…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study compares two types of food labels to see which one better helps Indonesian adults spot unhealthy products. Researchers will show 1,000 participants either a nutrient warning label or the Nutri-Level label and test their ability to identify foods high in sugar, salt, or…

This study looks at how incretin-based therapies (like GLP-1 drugs used for weight loss) affect breathing in people with obesity. Researchers will analyze data from 48 adults aged 25-60 with a BMI of 30 or higher. They will use machine learning to find patterns that predict impro…

This study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…

This study looks at how packaging with warning labels and cartoon characters influences what Colombian teens aged 12 to 17 think about buying and eating ultraprocessed foods. About 1,960 teens will view different product images online and answer questions about how likely they ar…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This early-phase study will test how insulin given as a nasal spray affects nerve activity and blood flow in the brain and legs. Researchers will compare 64 adults with obesity and insulin resistance to healthy-weight individuals. The goal is to understand how obesity changes the…

This study looks at whether using ultrasound to measure neck tissue thickness can better predict difficult airway in obese patients undergoing surgery. Researchers will compare ultrasound measurements with standard tests in 52 adults. The goal is to improve safety during anesthes…

This study looks at how a 12-week aerobic exercise program affects brain activity and stress hormones in veterans with overweight or obesity. Researchers will use brain scans and stress tests to see if exercise changes how participants react to pictures of high-calorie foods and …

This study will test whether smelling a pleasant food odor (madeleine scent) before drinking a sugary solution changes how the body handles blood sugar. Twenty adults, some with obesity and mild insulin resistance and some without, will each undergo two sessions: one with the sce…

This study looks at how having extra body fat and being resistant to insulin can change the way your brain learns to like or want certain foods. Researchers will give 50 adults flavored drinks with sweetener, sometimes with extra calories, to see how their preferences shift. The …

This study follows 40 adults who recently had laparoscopic sleeve gastrectomy for obesity. Over 6 months, researchers will measure changes in blood sugar, cholesterol, gut barrier markers, and digestive symptoms. The goal is to understand how the surgery affects gut health and me…

This study looks at whether a measurement called Body Roundness Index (BRI), which uses waist size and height, can predict death in adult intensive care unit (ICU) patients. Researchers will measure BRI in 550 adults when they enter the ICU and track their outcomes, including dea…

This study follows 40 people who recently had laparoscopic sleeve gastrectomy to see how their eating behavior, nutrition, and appetite-regulating hormones change over 6 months. Researchers will measure hormones like ghrelin, GLP-1, and PYY, along with dietary intake and eating a…

This study tests whether showing health warnings, tasty-sounding labels, or both can encourage 1,000 Chinese college students to pick sugar-free drinks over sugary ones. Participants will make drink choices on a platform, and researchers will track which options they select. The …

This study looks at how losing fat versus muscle during a low-calorie diet changes your resting metabolic rate. About 150 adults with overweight or obesity will follow a structured diet, and researchers will measure body composition and metabolism before and after. The goal is to…

This study looks at whether brown adipose tissue (brown fat), which burns energy as heat, can predict how well people with obesity respond to the weight loss drug semaglutide (Wegovy). Eighty adults starting semaglutide will have PET/CT scans before and after 24 weeks of treatmen…

This study will use a painless ultrasound to examine tongue stiffness, thickness, and other features in 80 adolescents aged 12-18 with obesity and sleep-disordered breathing. Participants are already enrolled in a weight-loss program. The goal is to better understand how the tong…

This study will measure how the body uses energy and burns fat in 10 people with extreme obesity (BMI of 60 or higher). Participants will spend 23 hours in a special metabolic chamber and drink a labeled water to track energy use over a week. The goal is to better understand meta…

This study looks at how obesity changes the way genes work in people with gum disease. Researchers will compare obese and non-obese adults before and after a deep cleaning treatment. They aim to understand why obese individuals may have worse gum inflammation and how it might be …

This study looks at whether simple physical tests like stair climbing, walking, and standing up from a chair are reliable and accurate for people with obesity. Researchers will test 55 adults with a BMI of 30 or higher, repeating the tests a week apart to check consistency. The g…

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This observational study will look at how body composition (fat and muscle) relates to breathing endurance and exercise capacity in 100 adults with obesity and a restrictive breathing pattern. Participants will undergo tests like spirometry, body fat measurement, and a six-minute…

This study will measure how body roundness index (BRI) relates to breathing and exercise ability in 120 adults with obesity. Participants will have lung function tests, breathing muscle strength tests, and a six-minute walk test. The goal is to see if BRI can help identify people…

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

This study looks at how people with severe obesity perceive internal body signals (like hunger and fullness) before and after bariatric surgery. Researchers will follow 300 adults for two years to see if changes in body awareness and views on illness affect eating behaviors after…

This early-stage study is testing a new medicine for overweight and obesity. The main goal is to see how the drug behaves in people with different levels of liver function, from normal to severely reduced. About 35 adults aged 18-80 will take a single dose, and researchers will m…

This study looks at whether taking a calcium butyrate supplement for 4 weeks can improve how immune cells (monocytes) work and change gut bacteria in adults with obesity. Butyrate is a natural substance made by gut bacteria that helps reduce inflammation. The study will compare t…

This study tests a smartphone app called NutriTrack that uses artificial intelligence to help people with obesity or overweight track what they eat and how they feel. About 50 adults will use the app for 4 weeks. The main goal is to see if the app is easy to use and helpful for b…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This study looks at whether eating chia seeds while breastfeeding can change the makeup of breast milk and reduce inflammation in mothers who are overweight. About 80 mothers will take chia seeds for 6 weeks, and researchers will measure nutrients and health markers in their milk…

This large study tests whether using electronic health records and text messages can help more adults with obesity enroll in proven weight-loss programs. Over 5,000 patients from community health centers will be invited to join. The goal is to see if simple clinic prompts and fol…

This study looks at whether rotating the head 45 degrees to the left improves the view of the vocal cords during video laryngoscopy in obese adults. Fifty patients with a BMI of 30 or higher will be observed. If the maneuver works, it could offer a simple way to reduce airway com…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This online study with 2,800 Hong Kong adults tests whether front-of-package warning labels about added sugar reduce people's intention to buy sugary drinks. Participants will choose a beverage in a simulated shopping task. The goal is to see if simple labels can guide healthier …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at how certain natural chemicals (endocannabinoids) influence the development of fat cells from stem cells found in belly fat. Researchers will take small fat samples from 30 people undergoing abdominal surgery, including healthy controls, people with obesity, an…

This study aims to understand how a less invasive stomach procedure called endoscopic sleeve gastroplasty changes digestion, hormones, and gut bacteria compared to traditional weight-loss surgery. Researchers will follow 40 adults with obesity to measure stomach emptying and othe…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study will compare weight-loss plans made by ChatGPT with those made by a human dietitian. 21 adults with obesity will be split into three groups: one gets AI-only advice, one gets a dietitian's plan, and one gets a combination of both. The goal is to see which approach lead…

This observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The…

This study is testing a new physical activity support program called Movámonos for Spanish-speaking adults who are overweight or obese and not very active. The goal is to see if the program is something people like and can stick with. About 20 people will take part to help resear…

This study looks at whether one session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight. Sixty women will receive either real or fake stimulation while their heart activity…

This study looks at how fat tissue in the upper body reacts after a meal, comparing people with obesity to those at a healthy weight. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue work…

This study looks at whether certain autoantibodies (proteins that mistakenly attack the body) are more common in people with obesity and if they are linked to related health problems like type 2 diabetes. Researchers will study 160 adults with a BMI over 30. The goal is to better…

This pilot study tests whether patients having laparoscopic gastric bypass can safely go home the same day if they use a remote monitoring device. Forty adults will be randomly assigned to either same-day discharge with remote monitoring or an overnight hospital stay. The study w…

This study looks at whether showing people personalized 3D body avatars of their potential weight loss changes how satisfied and committed they feel compared to just seeing numbers on a scale. About 250 adults who want to lose weight will take a one-time online survey. Researcher…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides personalized advice on side effects and dose adjustments. The study is in its early stages, with only 16 participants, and is…

This study looks at whether common environmental chemicals like PFAS, bisphenol A, and pesticides are linked to childhood obesity. Researchers will measure levels of these chemicals in blood, urine, and hair samples from 80 children aged 6 to 15—half with obesity and half without…

This study looks at whether a bedside lung ultrasound can help doctors see how well the lungs of obese patients are opening during a breathing machine procedure. The goal is to find the best air pressure to keep lungs open and improve oxygen levels. About 45 adults with a BMI of …

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study compares how two weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect acid reflux in 128 obese patients. Participants will be randomly assigned to one surgery, and their reflux will be measured before and after using a 24-hour pH test. The goal is to see …

This study will look back at medical records of critically ill trauma patients with severe obesity who needed a breathing tube in the ICU. It aims to compare how often dangerous airway events happen in patients with morbid obesity versus super obesity, and whether higher BMI make…

This study looks at whether using ultrasound can better predict if placing a breathing tube will be difficult in obese patients (BMI over 35). Researchers will compare ultrasound measurements of the neck with standard tests like the Mallampati score. 70 adults having planned surg…

This study watches how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and drug levels in 2,100 adults during surgery. The goal is to understand why heavier patients may have more complications, …

This registry study will follow 10,000 Chinese adults with obesity or overweight across 50 hospitals. Researchers will collect data on weight, lab tests, and liver health over 6 and 12 months. The goal is to understand current treatment patterns and outcomes in real-world clinica…

This observational study will examine how posture habits and body awareness relate to physical function in 80 women aged 18-65 across different BMI categories (normal weight to obesity). Participants will fill out questionnaires and perform simple movement tests. The goal is to u…

This study works with 35 primary care clinics to help them screen patients for physical inactivity and refer them to community-based exercise programs. The goal is to see if this approach can be smoothly integrated into routine care and whether it leads to better health outcomes …

This study will look at medical records of 1700 adults with obesity who took tirzepatide along with lifestyle coaching at several Dutch clinics. Researchers want to see how much weight people actually lose after six months and how doctors prescribe the medication in daily practic…

This early-stage study will test an experimental drug called HDM1005 in 42 overweight or obese adults. Researchers want to see how HDM1005 affects stomach emptying and whether it changes how the body processes common medications like metformin, atorvastatin, warfarin, and digoxin…

This study tests whether adjusting ventilator pressure during laparoscopic sleeve gastrectomy can improve lung function and reduce breathing complications. Forty-six obese patients will receive either individualized pressure settings or a fixed setting. The goal is to see if the …

This study will review medical records of 500-800 children aged 2-18 who attended NHS weight management clinics and had genetic tests for obesity. The goal is to see how often these tests find a genetic cause and whether certain traits, like developmental delays or eating behavio…

This pilot study looks at how the diabetes and weight-loss drugs semaglutide and tirzepatide directly affect blood vessels and heart function, beyond their known effects on weight. Researchers will infuse the drugs into the arm or bloodstream of 112 volunteers with different body…

This study will gather medical data and blood samples from up to 25,000 adults with obesity who visit a special clinic. Researchers hope to learn more about why obesity happens, what treatments work best, and how to improve patients' health. No new treatments are being tested; in…

This study will follow 150 mothers and their babies for 6 months to see how a mother's weight and diet affect her breastmilk and her baby's growth. Researchers will measure mom's body fat, diet, and health markers, and analyze breastmilk for nutrients and immune factors. The goal…

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study looks at whether a special digital follow-up system plus nurse-led education can help people feel better and stay active after weight-loss surgery. About 52 adults who have had bariatric surgery will take part. Half will get the extra digital support and exercise progr…

This study watches how carbon dioxide gas, used to inflate the belly during laparoscopic weight-loss surgery, changes blood bicarbonate levels. Researchers will track 85 adults having sleeve gastrectomy or gastric bypass to see if these changes relate to how long the gas is used …

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easi…

This study follows 52 adults who are about to stop taking injectable weight loss drugs due to insurance changes. Researchers will measure a brain protein called Agouti-related peptide (AgRP) and track weight changes over 3 months. The goal is to see if this protein can predict wh…

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study will give 10 overweight men a daily pill called ATR-258 for 8 weeks to see how it changes signaling pathways in their muscles. Researchers will take small muscle samples and measure blood sugar control and body composition. The goal is to understand the biology, not to…

This study looks at how weight loss affects the energy the body uses to digest food (called dietary thermogenesis) in teens with obesity. Researchers will compare 30 obese adolescents before and after weight loss with normal-weight teens. The goal is to understand if losing weigh…

This study looks at how lowering insulin levels changes the way the liver makes sugar and fat. Researchers will give 36 overweight or obese adults with insulin resistance and fatty liver disease two different insulin infusions—one that keeps insulin high and one that lowers it by…

This study looks at whether exercising in the morning or evening helps the body handle sugar better in people with prediabetes who have an extreme natural body clock. Twenty-eight adults with prediabetes and overweight will do a single cycling session at 9 AM, 5 PM, or no exercis…

This study tests whether a special breathing exercise, called intermittent inspiratory muscle training, can have an immediate effect on blood sugar, heart rate, and blood vessel stiffness. Researchers will compare this breathing workout to normal breathing in 48 healthy, obese, a…

This observational study tracks 100 adults to see how Roux-en-Y gastric bypass surgery changes gut bacteria and related metabolic products over 12 months. Participants include people having surgery, those with obesity on diet alone, and healthy normal-weight individuals. Research…

This study will follow 800 pregnant women to see if weight stigma and discrimination contribute to complications like gestational diabetes. Researchers will also examine psychological factors such as trauma and eating disorders. The goal is to better understand the link between b…

This study looks at how two different exercise programs affect a protein called Sestrin-2, which is linked to inflammation and metabolism, in women with obesity and high blood pressure. About 42 women aged 30-65 will do either moderate steady exercise or brisk interval exercise f…

This study looks at whether eating 4-5 servings of dairy foods daily (like milk, cheese, and yogurt) can improve brain function and thinking skills in overweight adults aged 40-75. Participants will be randomly assigned to a high-dairy or low-dairy diet for several weeks. Researc…

This study looks at why metabolism often slows down when people with obesity lose weight through diet and exercise. Ten participants will follow an 8-week lifestyle program while researchers measure changes in body composition, core temperature, and energy use. The goal is to und…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study explores whether smartphone addiction is connected to obesity and reduced physical fitness in young adults. Researchers will observe 212 people aged 18-25 who use their phones over 5 hours daily and have a sedentary lifestyle. The goal is to understand these relationsh…

This study will give 40 obese adults semaglutide for 12 weeks to see how it changes their gut bacteria. Researchers will use stool samples and lab tests to understand the effects. The goal is to learn how semaglutide works on gut flora, not to test weight loss directly.

This small study will test whether a stomach ultrasound can work in people who have already had bariatric surgery. Ten adults scheduled for another surgery will have their stomachs scanned before and after the procedure. The goal is to see if ultrasound can measure stomach size a…

This study will check if a simple breathing measurement called the ROX index, taken before bariatric surgery, can predict which patients will have low oxygen levels in the first 12 hours after surgery. Researchers will measure the ROX index along with other risk scores in 80 adul…

This study will compare two devices that measure muscle relaxation during anesthesia in 30 obese patients having weight-loss surgery. One device tracks thumb movement (AMG), the other measures muscle electrical signals (EMG). The goal is to see which is more accurate for guiding …

This study looks at how children's eating behaviors, like eating quickly or eating large portions, are linked to brain activity and body fat. Researchers will follow 420 children aged 7 to 9 for one year, using brain scans and meal observations. The goal is to understand why some…

This study investigates how two molecules—glycerol from fat and lactate from the blood—are converted into glucose by the liver, especially in people with type 2 diabetes. Researchers will compare these processes in 48 adults with and without diabetes or obesity. Participants rece…

This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lun…

This study looks at whether injecting the blood thinner enoxaparin into the arm or the abdomen works better for preventing blood clots in people with severe obesity (BMI over 40). Researchers will measure drug levels in the blood to see which injection site gives the right amount…

This study tests an online platform called Precare that provides educational content and appointment management for people waiting for bariatric surgery. Researchers want to see if it is easy to use, acceptable to patients, and helps them feel more ready for surgery. About 1,050 …

This study looks at how obesity and gastroesophageal reflux disease (GERD) are connected. Researchers will measure how common obesity is among 200 adults with GERD. The goal is to better understand the link between these two conditions.

This study will test how accurate 10 different heart rate monitors are in 52 overweight young adults, both at rest and during exercise. The goal is to find the best way to measure heart rate at the point where the body burns the most fat. This is an observational study to gather …

This study looks at how the body's energy use changes when overweight or obese adolescents walk with simulated weight loss. Researchers will use a special treadmill that reduces the effect of gravity to mimic being at a normal or overweight weight. By measuring energy burned and …

This study will check for stress, anxiety, depression, sleep problems, and bad breath in 110 adults with obesity who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a portable breath tester. The goal is to learn more about these issues…

This study looks at hormone changes in 67 children aged 5 to 18 with simple obesity (BMI at or above the 95th percentile). Researchers will measure hormones like insulin, leptin, and cortisol to see how excess weight affects growth and metabolism. The goal is to better understand…

This study will examine the connection between high uric acid levels (hyperuricemia) and non-alcoholic fatty liver disease (NAFLD) in 111 obese adults. Researchers will use blood tests, ultrasound, and FibroScan to measure uric acid, liver fat, and liver scarring. The goal is to …

This study will give 28 women with obesity either a calorie-restricted DASH diet or a standard American diet for 4 weeks. Researchers will track weight changes and analyze stool samples to see how diet affects gut bacteria and related health markers. The goal is to understand how…

This study looks at how obesity and low iron levels affect iron buildup in the liver and heart, and how weight-loss surgery might help. Researchers will compare people with and without iron deficiency before and after bariatric surgery. The goal is to better understand these conn…

This study will check how common it is for obese people with sleep apnea to still have low breathing at night even when using a CPAP machine. About 139 adults will wear a special skin sensor that measures oxygen and carbon dioxide levels overnight. The goal is to find out how man…