Obesity disorder

This study tests whether a wearable bioimpedance wristband (like a fitness tracker) helps people with severe obesity and knee osteoarthritis improve their body composition—gaining muscle and losing fat—before joint replacement surgery. All participants receive coaching on body co…

This study looked at whether a procedure called endoscopic sleeve gastroplasty (ESG) could help people with obesity who stopped taking GLP-1 weight loss drugs because of side effects or poor results. Researchers compared weight loss and safety in 18 adults who either had ESG plus…

This trial investigates whether a remote digital support program, including a connected pedometer and online coaching, can help people aged 30–50 who are scheduled for bariatric surgery become more physically active in the months before their operation. Participants use a digital…

This study tested whether combining weight management (diet and exercise guidance) with a daily hormone pill (megestrol acetate) could help obese patients with early-stage endometrial cancer who want to preserve their fertility. The goal was to see if the cancer would completely …

This study tested whether adding cognitive remediation therapy and emotional skills training to standard obesity treatment could reduce food cravings and improve weight management. It involved 144 obese adults who reported food cravings. The program included weekly group sessions…

This study aimed to see how well semaglutide works for weight loss in everyday medical practice, outside of a strict research setting. It involved 100 adults with obesity who were already planning to take the drug. The study was stopped early, so results are limited, but it may s…

This small pilot study tested whether a low-carb diet (50-100 grams of carbs per day) combined with the diabetes drug dapagliflozin could improve blood sugar control in people with chronic kidney disease and prediabetes or type 2 diabetes. Four participants were split into two gr…

This small pilot study tested whether nabilone, a synthetic drug similar to cannabis, could help obese adults lose weight. The trial aimed to check safety and feasibility, but it was terminated early, so we don't have clear results. Only 18 people were enrolled, making it too sma…

This study tested an online program that combined exercise guided by the FITT-VP principle with dietary advice for children and adolescents with obesity. The program included small group exercise sessions three times a week for 16 weeks, plus dietary guidance. Researchers compare…

This study looked at whether a plant-based diet and lifestyle changes could help people with type 2 diabetes, prediabetes, or obesity improve their health. Researchers aimed for diabetes remission (normal blood sugar without medication for at least 3 months) or significant weight…

This study looked at whether using a combination of weight-loss medications could help people with obesity lose weight and improve the health of their blood vessels. It involved 128 adults aged 40-75 who were obese and had at least one heart risk factor. The study was stopped ear…

This study tested a new drug called CK-0045 in 90 adults with type 2 diabetes and overweight or obesity. Participants received weekly injections of CK-0045 or a placebo for 16 weeks to see if it improved blood sugar after meals and reduced body weight. The trial was terminated ea…

This study tested whether a special chewing gum with fiber could help obese children lose weight and improve their metabolism. About 93 children were to take part, but the study was stopped early. The gum aimed to change gut and mouth bacteria to support weight control.

This study aimed to see if a phone-delivered program could help Latino children in rural Nebraska manage their weight. About 76 parent-child pairs were to be assigned to either the program or a waitlist. The study was terminated early, so results are limited.

This early-stage study tested an experimental drug called FT-4101 in 14 overweight or obese adults with NASH, a serious fatty liver disease. The main goals were to check safety and see if the drug could reduce liver fat. The study was stopped early, so results are limited.

This study looked at whether medically tailored meals and a behavioral app (Noom) could help people maintain weight loss after stopping GLP-1 medications like Wegovy. It enrolled 39 adults who had lost at least 10% of their body weight on GLP-1s and had stopped the drug within th…

This study aimed to see if bariatric surgery or medical weight loss (diet and exercise) helps severely obese patients lose enough weight to safely undergo hip or knee replacement. Only 3 people took part before the study was stopped early. The goal was to get patients to a BMI of…

This study aimed to compare a standard sleeve gastrectomy (removing part of the stomach) with a modified version called N-Sleeve, which adds a wrap around the top of the stomach to prevent acid reflux. The trial was designed for people with severe obesity and GERD, but only 2 pat…

This study tested a mobile telerehabilitation program called Telemouv in 50 adults with obesity (BMI over 30). Participants used the app for three months to encourage healthy behavior changes and fat loss. The trial was terminated early, so we don't have final results on whether …

This study looked at whether a specific type of exercise, combining aerobic and resistance training in short bursts, could improve metabolic health in overweight or obese breast and prostate cancer survivors who had finished treatment. The goal was to reduce insulin resistance an…

This study tested a program called Communities for Healthy Living (CHL) that helps families with young children (ages 3 to 5) eat better and be more active. The goal was to prevent childhood obesity by empowering parents and kids in Head Start programs. The study was ended early,…

This study tested a special device called the Traxi panniculus retractor, which holds excess belly tissue out of the way during cesarean deliveries. The goal was to see if it could shorten surgery time, improve breathing, and increase satisfaction for both patients and doctors. T…

This study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clear…

This study tested whether a 3D ultrasound device (Accuro) helps anesthesiologists place epidural needles for pain relief during labor in women with a BMI of 40 or higher. The device was compared to the standard blind approach using touch. The trial was terminated early, so result…

This study looked at how being obese as a teenager might affect emotional memory and the connections between two key brain areas: the amygdala and hippocampus. Researchers compared obese and normal-weight adolescents aged 12-17 using MRI scans while they performed memory tasks. T…

This study looked at whether using ultrasound to guide central venous catheter placement reduces complications in obese intensive care unit patients. Researchers planned to include 450 patients, but the study was terminated early. The goal was to compare complication rates betwee…

This pilot study tested whether remote check-ups (using a chatbot questionnaire and video calls) could work as well as in-person visits for people who had weight-loss surgery. Only 7 adults living far from the hospital took part. The goal was to see if this approach could improve…

This study looked at how gas-filled stomach balloons and a procedure called endoscopic sleeve gastroplasty affect stomach emptying, hunger hormones, and appetite in people with obesity. Researchers compared these treatments to a meal replacement program. The goal was to understan…

This study tested if a special measurement called transpulmonary pressure could help obese patients with breathing failure get off ventilators sooner. Only 4 people took part before the study was stopped early. The goal was to reduce time on the ventilator and lower risks like in…

This study aimed to find blood and tissue markers that could predict whether obese patients with type 2 diabetes would go into remission after bariatric surgery. Researchers planned to measure 9 specific molecules in blood samples and also collect fat and muscle tissue during sur…

This study looked at how insulin works in the skin of people with plaque psoriasis who are also overweight or have prediabetes. Researchers took small skin samples from both psoriasis patches and healthy skin to measure insulin activity. The goal was to understand if insulin acts…

This study looked at whether measuring resting metabolic rate (how many calories your body burns at rest) before bariatric surgery can help predict weight loss after the procedure. Researchers planned to enroll 84 adults scheduled for primary bariatric surgery and use a device ca…

This study compared two brands of surgical staplers (Covidien and Ethicon) used in sleeve gastrectomy for people with severe obesity. Researchers wanted to see if one device caused fewer complications like bleeding or leaks. The trial was terminated early and enrolled 62 adults, …

This early study tested whether a special MRI technique using inhaled xenon gas can detect brown adipose tissue (BAT) in healthy adults. Brown fat burns calories to generate heat, and researchers wanted to see if this imaging method could measure its activity. The study involved …

This study looked at whether weight-loss surgery can lengthen telomeres, which are caps on our DNA that shorten as we age. Researchers compared telomere length in people with severe obesity who had surgery versus those who did not. The goal was to see if rapid weight loss might r…

This study looked at whether blocking certain nerve signals can improve how the body uses insulin and reduce inflammation in people with obesity and high blood pressure. Ten participants took two drugs—moxonidine and amlodipine—to lower nerve activity. The goal was to see if this…