Tiny study probes why stomach balloons and stapling help people lose weight

NCT ID NCT04306445

Terminated Knowledge-focused Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at how gas-filled stomach balloons and a procedure called endoscopic sleeve gastroplasty affect stomach emptying, hunger hormones, and appetite in people with obesity. Researchers compared these treatments to a meal replacement program. The goal was to understand the mechanisms behind weight loss, not to test a new treatment. Only 3 people were enrolled before the study was stopped.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Obalon Balloon (gas-filled intragastric balloon) and endoscopic sleeve gastroplasty
What this could lead to: If successful, this could help doctors understand why these weight loss procedures work, potentially leading to better patient selection and longer-lasting results.
What could go wrong: This was a very small pilot study (only 3 participants) that was terminated early, so results are limited and may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

University of Colorado

Aurora, Colorado, 80045, United States

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