New hope for weight loss after GLP-1 failure: Stomach-Sewing procedure tested
NCT ID NCT07190794
First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This study looked at whether a procedure called endoscopic sleeve gastroplasty (ESG) could help people with obesity who stopped taking GLP-1 weight loss drugs because of side effects or poor results. Researchers compared weight loss and safety in 18 adults who either had ESG plus lifestyle changes or just lifestyle changes alone. The goal was to see if ESG offers a good alternative for those who cannot use GLP-1 medications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Endoscopic sleeve gastroplasty (ESG) using the OverStitch or OverStitch NXT suturing system, plus lifestyle modification
What this could lead to
If successful, this could show that ESG is a safe and effective weight loss option for people who cannot tolerate or do not respond well to GLP-1 medications.
What could go wrong
This was a small, terminated study with only 18 participants, so results may not be reliable or apply to a broader population. ESG is a procedure with its own risks, such as infection or bleeding.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bariendo
Miami, Florida, 33179, United States