Lifestyle overhaul may rewrite Sperm's epigenetic code
NCT ID NCT04175678
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how diet and exercise affect the epigenome—chemical marks on DNA—in sperm of overweight Hispanic men. Researchers will compare sperm from 20 healthy active men and 80 obese inactive men before and after a 12-week program of diet, exercise, or both. They will also check if changes last after stopping the interventions. The goal is to understand if a healthier lifestyle can reverse harmful epigenetic changes that might affect fertility and future children's health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
diet and exercise
What this could lead to
If successful, this could show that lifestyle changes can reverse unhealthy epigenetic marks in sperm, potentially improving fertility and reducing disease risk in children.
What could go wrong
This is an early-stage observational and interventional study with only 100 participants, all Hispanic men, so results may not apply to other groups. The long-term health impact on offspring is not directly tested.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Lundquist Institute
Torrance, California, 90502, United States