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Lifestyle overhaul may rewrite Sperm's epigenetic code

NCT ID NCT04175678

Ongoing Knowledge-focused Sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how diet and exercise affect the epigenome—chemical marks on DNA—in sperm of overweight Hispanic men. Researchers will compare sperm from 20 healthy active men and 80 obese inactive men before and after a 12-week program of diet, exercise, or both. They will also check if changes last after stopping the interventions. The goal is to understand if a healthier lifestyle can reverse harmful epigenetic changes that might affect fertility and future children's health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
diet and exercise
What this could lead to
If successful, this could show that lifestyle changes can reverse unhealthy epigenetic marks in sperm, potentially improving fertility and reducing disease risk in children.
What could go wrong
This is an early-stage observational and interventional study with only 100 participants, all Hispanic men, so results may not apply to other groups. The long-term health impact on offspring is not directly tested.

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Conditions

The condition(s) this trial relates to.

Motor Activity multiple endocrine neoplasia multiple endocrine neoplasia type 1 Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY LIFESTYLE MEN OBESE

Contacts and locations

Locations

  • The Lundquist Institute

    Torrance, California, 90502, United States

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