Teen weight loss mystery: hormones may be the culprit behind regain

NCT ID NCT05125822

Recruiting now Knowledge-focused Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the body's response to weight loss, not to test a new drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Meal replacement and lifestyle modification
What this could lead to: If successful, this could help explain why weight regain happens after dieting, pointing toward better long-term weight management strategies.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to a direct solution, and results may not apply to all teens with obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILDHOOD OBESITY

Contacts and locations

Locations

Ann & Robert H Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States

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