Could a popular Weight-Loss drug help people with rare genetic obesity?
NCT ID NCT06380426
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 175 adolescents and adults with monogenic obesity—a rare form caused by specific gene changes—who are taking semaglutide (Ozempic/Wegovy). Researchers will track weight and BMI changes over 4 years to see if the drug helps control weight in this group. The goal is to provide real-world evidence for using semaglutide in people who often don't respond well to diet, exercise, or surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
semaglutide (Ozempic/Wegovy)
What this could lead to
If successful, this could show that semaglutide is an effective treatment for managing weight in people with rare genetic obesity.
What could go wrong
This is an observational study, not a controlled trial, so results may be less reliable. It is also small (175 people) and focused on a rare condition, so findings may not apply broadly.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU Pitié Salpêtrière - APHP
RECRUITINGParis, 75013, France
Contact Phone: •••-•••-••••
Contact
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Centre de référence Syndrome de Prader-Willi et autres obésités avec troubles du comportement alimentaire (PRADORT). Service de Nutrition, GH Pitié-Salpêtrière, APHP
NOT_YET_RECRUITINGParis, 75013, France
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••