New hope for teens with rare obesity: weekly shot shows promise
NCT ID NCT07302802
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a once-weekly injection of semaglutide (2.4 mg) can help teenagers with monogenic obesity lose weight and feel better. About 70 teens aged 12 to 20 will take the drug along with diet and exercise changes for 68 weeks. The main goal is to see if at least 10% of their body mass index (BMI) drops, and to track changes in hunger, body composition, mood, and quality of life.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Assistance Publique-Hôpitaux de Paris (AP-HP), Trousseau Hospital Paris, Pediatric Nutrition Department
NOT_YET_RECRUITINGParis, France
Contact Email: •••••@•••••
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Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid
NOT_YET_RECRUITINGMadrid, 28009, Spain
Contact Email: •••••@•••••
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Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, Ulm University Medical Centre
RECRUITINGUlm, 89075, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute for Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin
NOT_YET_RECRUITINGBerlin, 13353, Germany
Contact Email: •••••@•••••
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University Hospital for Children and Adolescents, Center for Pediatric Research, Medical Faculty, University of Leipzig
NOT_YET_RECRUITINGLeipzig, 04103, Germany
Contact Email: •••••@•••••
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University Medical Center Rotterdam, Erasmus MC-Sophia Children's Hospital
NOT_YET_RECRUITINGRotterdam, 3015 GD, Netherlands
Contact Email: •••••@•••••
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Wellcome-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre
NOT_YET_RECRUITINGCambridge, CB2 0QQ, United Kingdom
Contact Email: •••••@•••••
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