Three-Day fast reshapes fat cells and boosts fat burning, study hints
NCT ID NCT07692646
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This study investigates what happens inside the body after an 84-hour fast. Researchers will measure peak fat oxidation (how well the body burns fat during exercise), mitochondrial coupling (energy efficiency in cells), and changes in the extracellular matrix (the scaffold around fat cells). The trial includes 40 healthy adults—half with normal weight and half with obesity—to see if fasting affects these processes differently depending on body weight and sex.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 84-hour fasting
- What this could lead to
- If successful, this could reveal how fasting changes the body's ability to burn fat and remodel tissue, pointing toward new approaches for weight management.
- What could go wrong
- This is a small, early-stage study with only 40 participants. Results may not apply to older adults or people with medical conditions. Fasting for 84 hours can be difficult and may cause side effects like dizziness or fatigue.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2033
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy normal weight men aged \[18,40\] and BMI \[18,25\] * Healthy normal weight women \[18,40\] and BMI \[18,25\] * Healthy obese men \[18,40\] and BMI \[30,40\] * Healthy obese women \[18,40\] and BMI \[30,40\] Exclusion Criteria: * Present or former cardiovascular disease and chronical inflammatory disease * Consumption of medications and supplements that influence substrate use at rest and/or during exercise * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Biomedical Sciences
RECRUITINGCopenhagen, 2200, Denmark
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