Psychiatric disorder

This phase 2 trial tests whether zonisamide, a drug currently used for seizures, can help adults with alcohol use disorder drink less. About 205 treatment-seeking participants will receive either zonisamide or a placebo, along with standard support. The study measures alcohol con…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This study tests whether combining home food delivery with video-based smoking cessation counseling helps rural smokers quit more than counseling or food delivery alone. Participants are adults aged 21-75 who smoke regularly and live in certain Arkansas counties. The goal is to s…

This study investigates whether combining the medication lovastatin with intensive reading tutoring can improve reading abilities in children and young adults (ages 8-20) with Neurofibromatosis Type 1 (NF1) who have reading disabilities. Participants first receive either lovastat…

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This study tests whether a rapid form of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can relieve depression in people with bipolar II disorder whose depression has not responded to other treatments. Participants receive either real or sham …

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study tests whether combining one-on-one financial coaching with access to safe, affordable banking services can improve both financial health and mental well-being for people recently released from jail or prison. Participants, who self-identify as having mental health or s…

This study tests a non-invasive brain stimulation technique called targeted temporal interference stimulation (tTIS) aimed at the caudate nucleus. The goal is to reduce drug cravings and improve decision-making in 60 adults with methamphetamine use disorder. Participants will rec…

This study compares a rapid weaning schedule to a slower one for newborns being treated with morphine or methadone for neonatal opioid withdrawal syndrome (NOWS). The goal is to see if a faster wean can reduce the number of days babies need opioid medication. The trial includes f…

This study will test whether using opioid-free anesthesia during knee replacement surgery can reduce the risk of long-term opioid use and chronic pain. About 700 adults scheduled for knee replacement will be randomly assigned to receive either standard opioid-based anesthesia or …

This phase 2 trial tests whether allopregnanolone, a natural hormone, can safely help repair the brain in people with early Alzheimer's disease. About 100 volunteers aged 55 to 80 will receive weekly infusions of the drug or a placebo for several months. Researchers will measure …

This Phase 2 study tests an experimental drug called BIIB080 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The drug is injected into the fluid around the spinal cord every 12 or 24 weeks. Researchers want to see if it can slow the worsening…

This study tests a telehealth program called the Ria Treatment Platform for people with alcohol use disorder. Participants receive medication, coaching, educational videos, and a Bluetooth breathalyzer through their phone. The goal is to see if this approach helps reduce heavy dr…

This study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effect…

This early-stage trial tests a single injection of ARO-ATXN2 in 36 adults with spinocerebellar ataxia type 2, a rare genetic disorder that affects movement and coordination. The main goal is to see if the drug is safe and how the body processes it. Participants are randomly assig…

This study tests whether personalized text messages can motivate people living with HIV in Vietnam to quit smoking. Participants receive motivational texts over six months and are encouraged to use a free government quitline that provides nicotine patches. The goal is to see if t…

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study tests a smoking cessation program called All Nations Breath of Life, designed specifically for American Indian communities. It involves 576 participants at four sites—two on reservations and two in urban areas. The program includes counseling and support, and success i…

This pilot study aimed to help people who had an opioid overdose by starting them on buprenorphine/naloxone in the emergency room and then connecting them to an addiction clinic. The goal was to reduce repeat overdoses and improve treatment engagement. However, the study was with…

This study is testing the long-term safety and effectiveness of a drug called TSND-201 for adults with PTSD. Participants who completed an earlier blinded trial of TSND-201 can receive up to three treatment courses over 48 weeks, each consisting of four weekly doses. The goal is …

This phase 2 trial tests whether mazdutide, a drug given as a shot, can help people with alcohol use disorder drink less. About 308 participants will receive either mazdutide or a placebo for up to 36 weeks. The study measures changes in drinking behaviors using a standard questi…

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This study tests a telephone-based version of the All Nations Breath of Life program, designed specifically for American Indians who smoke. Participants receive coaching calls over the phone and are compared to those in a general smoking cessation program. The main goal is to see…

This study aimed to see if asking people to put down a deposit (between $30 and $100) that they could earn back by meeting their drinking goals would help them drink less. Participants would wear a remote alcohol monitor to track their drinking. The study was withdrawn before any…

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This phase 3 trial tests whether the drug troriluzole can slow the progression of spinocerebellar ataxia, a rare genetic disorder that affects coordination and balance. About 300 adults with different types of SCA are randomly assigned to take either troriluzole or a placebo dail…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests whether a trauma-informed program called Strength at Home works better than the usual state-approved program for reducing intimate partner violence. About 800 men who are court-ordered to attend such programs, along with their partners, will take part. Researcher…

This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to ident…

This study tests different medication and counseling combinations to improve how long people stay in treatment for opioid use disorder and whether they can safely stop medication without relapsing. Over 1,500 participants choose either buprenorphine or naltrexone and are randomly…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study tests whether a personalized addiction monitoring program helps liver transplant patients avoid serious alcohol relapse one year after surgery. Researchers will follow 64 adults who are being evaluated for a liver transplant at a French hospital. The program includes m…

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This early-stage trial tests whether a single infusion of donated mesenchymal stem cells is safe for children with cerebral adrenoleukodystrophy (cALD), a rare and life-threatening brain disease. The stem cells are given as a temporary bridge to buy time before a more definitive …

This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…

This phase 2 trial tests a new drug called HB-1, which combines two blood pressure medicines (telmisartan and verapamil), to see if it can reduce unexpected panic attacks in people with panic disorder. The study plans to enroll 240 adults aged 18 to 65 and compare HB-1 against pl…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This study tests whether a virtual reality experience, where people see an avatar that looks like them in a park, can help those in early recovery from stimulant use reduce drug use and stay abstinent longer. Researchers will compare this VR experience to a plain VR park without …

This clinical trial is testing whether dimethyl fumarate, a drug already used for multiple sclerosis, can improve balance and walking in adults with adrenomyeloneuropathy (AMN), a rare nerve disease. Forty participants will take either the drug or a placebo daily for 36 months, w…

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

This study tests an experimental drug called RO7126209 (Trontinemab) in people with early to moderate Alzheimer's disease. The drug is given by IV infusion and aims to reduce amyloid plaques in the brain, a hallmark of Alzheimer's. About 241 participants will receive either the d…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This study tests a gene therapy called NGN-401 in 33 girls with Rett syndrome, a rare genetic disorder that affects development and movement. The therapy delivers a working copy of the MECP2 gene to try to improve skills and daily function. Researchers will measure success by whe…

This phase 2 trial tests whether lamivudine, an antiviral drug, can improve symptoms in people with Rett syndrome, a rare genetic disorder that affects movement, communication, and behavior. Ten participants will take the drug by mouth for a set period, and researchers will measu…

This study tests whether a mobile app can help parents of children aged 5-8 with disruptive behavior. 324 families will use either a standalone app, a coach-assisted app, or a control app. The goal is to see if digital tools can improve parenting skills and child behavior at a la…

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study tests whether citicoline, an over-the-counter supplement, can help young people ages 16 to 22 with alcohol use disorder. Over 4 weeks, participants receive either citicoline or a placebo. Researchers measure changes in immune markers, brain chemistry, and thinking skil…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study tests whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 participants will take rapamycin for 12 months while researchers monitor side effects and changes in memory and thinking. The goal i…

This study looks at whether the drug troriluzole can slow the progression of spinocerebellar ataxia (SCA), a rare genetic disease that affects movement and balance. Researchers will compare 909 patients who took troriluzole for up to three years with similar patients who did not …

This small pilot study tested whether propranolol, a beta blocker usually used for high blood pressure, can reduce alcohol drinking triggered by stress. Twenty adults with alcohol use disorder were randomly assigned to take propranolol or a placebo for about two weeks, then compl…

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

This study tests a trauma-informed program called TRUST for women leaving prison who have a history of substance use and violent victimization. The program includes individual and group sessions to build skills and support recovery. Researchers will measure changes in substance u…

This study planned to test the drug bumetanide in children aged 5 to 17 with autism of known cause. The goal was to see if it could improve autism symptoms. However, the trial was withdrawn before enrolling any participants, so no new information was gathered.

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study tests whether daily phone reminders can help people with schizophrenia or schizoaffective disorder remember to take their medication. 104 participants will receive repeated cues on their mobile phones for 30 days. The goal is to see if this improves medication adherenc…

This study tests whether using a dried blood spot test (a simple finger prick) can help people with hepatitis C start treatment faster than the usual method that requires a blood draw. The trial involves 141 participants who work with a peer support program and telemedicine. The …

This pilot study tests whether combining ketamine injections with talk therapy is a safe and acceptable way to treat moderate-to-severe methamphetamine use disorder in 17 publicly insured patients, some of whom have or are at risk for HIV. Participants receive three monitored ket…

This study tests an investigational drug called lecanemab in people aged 55-80 who have early signs of Alzheimer's-related brain changes but no memory problems yet. The goal is to see if the drug can slow cognitive decline and reduce amyloid buildup over about 4 years. Around 140…

This study tests whether benfotiamine, a form of vitamin B1, can safely slow memory and thinking decline in people with early Alzheimer's. About 406 adults aged 50-89 with mild symptoms will take the drug or a placebo for up to 72 weeks. Researchers will measure changes in cognit…

This study tests whether a personalized letter and proactive phone calls can help veterans with a newly diagnosed lung nodule quit smoking. The program uses the diagnosis as a 'teachable moment' to motivate quitting. Researchers will compare how many veterans use cessation servic…

This study tests whether a drug called Xiaflex (collagenase clostridium histolyticum) is safe and effective for men with Peyronie's disease who have already tried platelet-rich plasma (PRP) injections. Twelve men with stable penile curvature between 30 and 90 degrees will receive…

This study tests a personalized deep brain stimulation (DBS) approach for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten adults will first undergo brain mapping to find the best stimulation targets, then receive a DBS dev…

This phase 2 study tests a vaccine called JNJ-64042056 in 55 people with very early signs of Alzheimer's (no symptoms yet but tau buildup in the brain). The vaccine is designed to train the immune system to attack tau protein, which forms tangles in Alzheimer's. Participants rece…

This study tests a program called Just Care for Families, designed to help parents in rural Oregon who are involved with child welfare services and struggle with opioid or methamphetamine use. The program combines substance use treatment, mental health support, parenting training…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This study is testing the long-term safety of a daily pill called OLZ/SAM (olanzapine plus samidorphan) in 236 teenagers with schizophrenia or bipolar I disorder. Participants have already completed a previous study with the same drug. The goal is to see if the drug is safe and t…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and other brain functions in adults aged 65 to 80. It also checks for changes in blood pressure and overall life satisfaction. About 97 participants who are already in…

This study tests a program called REAL Fathers in Uganda, where respected community men mentor young fathers (ages 16-25) on positive parenting, conflict resolution, and family planning. Over 4,700 participants are involved. The goal is to see if this approach reduces intimate pa…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…

This study tests whether ibudilast, an anti-inflammatory drug used in Japan, can help people with alcohol use disorder drink less. Fifty adults will take either ibudilast or a placebo for 6 weeks, plus counseling. The main goal is to see if it reduces the number of heavy drinking…

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

This study tests whether adding peer recovery support—coaching from someone who has personally overcome opioid addiction—to standard medication treatment (buprenorphine) helps people stay in care longer. Fifteen adults with opioid use disorder will receive peer support for 180 da…

This early-stage study tests the safety of acamprosate, a drug used for alcohol dependence, in 30 adults with ALS who have a specific mutation in the C9orf72 gene. Participants take the pill three times daily for 24 weeks and undergo regular checkups, breathing tests, and spinal …

This study tests a drug called ACP-204 for treating psychosis (hallucinations or delusions) in people with Lewy body dementia. It is a 52-week open-label extension, meaning all 126 participants will receive the drug. The main goal is to check for side effects over the long term. …

This study tests a program called PICU Up! that helps critically ill children in the intensive care unit start moving earlier than usual. The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers will see if this approach r…

This study looks at whether adding topiramate (a seizure medication) to clozapine can help with weight loss and improve symptoms in people with treatment-resistant schizophrenia or schizoaffective disorder. About 50 overweight or obese adults aged 17-59 who are already on clozapi…

This expanded access program offers the experimental drug zervimesine (CT1812) to people aged 50 to 86 with mild-to-moderate dementia with Lewy bodies. Participants take one 100 mg pill daily for up to a year. The goal is to provide access to the drug and collect long-term safety…

This early-phase trial tests a single injection of AAV-MECP2 gene therapy into the spinal fluid of 8 girls aged 4-10 with Rett syndrome, a severe neurodevelopmental disorder. The goal is to see if the treatment is safe and can reduce disease severity. The study is not yet recruit…

This study compares a new blended therapy (online sessions plus in-person visits) to standard in-person therapy for teens with conduct disorder or antisocial behavior. Researchers want to see if the blended approach works just as well at reducing aggression, delinquency, and out-…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This early-stage study tests a gene therapy given through an IV for adults with cocaine use disorder who are in remission. The therapy helps the body produce an enzyme that breaks down cocaine quickly, reducing the drug's pleasurable effects. The main goal is to check safety, wit…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study tests whether starting alcohol use disorder treatment while still in the hospital helps people stay in treatment and drink less after they go home. 450 adults with moderate to severe alcohol problems will receive either a brief counseling session alone, or that session…

This Phase 1 study tests the safety of OLX-07010, a drug designed to stop tau proteins from clumping in the brain—a hallmark of Alzheimer's disease. Researchers will give single or multiple doses to 88 healthy adults and elderly volunteers to see how the body handles the drug and…

This study in India tests two common depression treatments—a talk therapy called the Healthy Activity Program and the antidepressant fluoxetine—in 1,500 adults with moderate to severe depression. The goal is to see which treatment works best for different people and to compare co…

This phase 2 trial tests whether a combination of intravenous immunoglobulin (IVIG) and rituximab can help people with psychosis caused by antibodies attacking the brain. 70 participants with acute psychosis and specific antibodies receive either the immunotherapy or a placebo. T…

This study is testing a specially adapted form of talk therapy for transgender and nonbinary people who have alcohol use disorder. The therapy, based on interpersonal psychotherapy, is designed to address unique life experiences that may affect drinking. The study will enroll 30 …

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This study tests if a mobile app called Stand Down, with or without extra support from a peer specialist over the phone, can help Veterans who drink heavily cut back. About 234 Veterans who screened positive for hazardous drinking and own a smartphone are taking part. The goal is…

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if it could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results ar…

This study tests an experimental daily pill (RO7269162) in 256 people who either have brain plaques but no symptoms, or have mild memory problems due to Alzheimer's. Participants take the pill or a placebo for about 1.5 years, with regular check-ups to monitor safety and brain ch…

This study tests whether a daily pill called buntanetap can help people with early Alzheimer's disease think more clearly and handle daily tasks better. About 760 adults aged 55-85 will take either the drug or a placebo for 18 months. Researchers will check memory, thinking, and …

This study tests whether a smartphone app can help people on medication for opioid use disorder stay drug-free. The app tracks location and sends alerts when users enter high-risk areas. Researchers will also use brain scans to understand why some people do better than others. Th…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This large study tests whether a simple iPad-based cognitive test, called MyCog, can help primary care doctors detect early dementia and cognitive impairment in underserved communities. Over 57,000 older adults from 24 clinics will take the test during routine visits. The goal is…

This study explores whether a taste test can serve as a diagnostic tool for depression. Participants with untreated major depressive disorder will take a taste test before and after starting an antidepressant prescribed by their doctor, and again six to eight weeks later. The goa…

This study tests whether a Turkish translation of the Four-Dimensional Symptom Questionnaire (4DSQ) helps Belgian general practitioners who don't speak Turkish better diagnose depression and anxiety in Turkish-speaking patients with language barriers. About 80 patients and their …

This study looks at whether measuring bladder wall thickness with an ultrasound can help predict treatment response in children aged 5-17 with lower urinary tract problems or bedwetting. Researchers will compare bladder wall measurements between the two groups and see if thicknes…

This study explores whether a self-administered digital test called eSAGE, combined with information from electronic health records and machine learning, can help detect early signs of cognitive impairment, including dementia and Alzheimer's disease. Researchers will analyze data…

This study tests a new radioactive tracer called Fluselenamyl for PET scans to detect beta-amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will check its safety and how well it works in 60 healthy volunteers and people with mild cognitive impairment o…

This study aimed to see if a special fMRI scan (fMRI-SAM) could help detect Alzheimer's disease early. Researchers planned to compare brain activity in 25 people with Alzheimer's, 25 with mild memory problems (MCI), and 60 healthy adults. The goal was to find differences that mig…

This study tests whether an AI system can help doctors identify patients with fatty liver disease who need specialist care. About 8,000 adults getting routine CT scans will have their images analyzed by AI to flag those at risk. The goal is to see if AI can improve detection and …

This early-phase study tests whether a single injection of pramlintide, a diabetes drug, can temporarily increase levels of Alzheimer's-related proteins in the blood, potentially revealing early signs of the disease. Researchers will measure changes in beta-amyloid and tau protei…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests two counseling programs to help women who use drugs in Tanzania start and stay on PrEP, an HIV prevention pill. 200 women will be randomly assigned to receive either brief motivational counseling, the same plus extra mental health support, or standard information…

This study tests a self-guided online program called CATCH-IT, designed to prevent depression in teenagers who are at risk. Researchers are working with 400 teens aged 13-18 across four health systems to find the best way to deliver this program in primary care. The goal is to se…

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current …

This study compares two ways to sedate ICU patients who need a breathing machine: inhaled sedation (using isoflurane gas) versus standard intravenous (IV) sedation. The goal is to see if the inhaled approach reduces the chance of delirium—a state of confusion that often occurs in…

This study tests whether providing HIV prevention (PrEP) and hepatitis C treatment together at one location works better than sending patients to separate clinics. About 446 people who inject drugs will be randomly assigned to either on-site integrated care or off-site referrals …

This study tests an 8-week group program called My Healthy Brain for adults aged 50 and older who have memory concerns but not dementia. The program teaches about lifestyle factors like exercise, sleep, and diet that may help prevent dementia. Researchers want to see if the progr…

This study tests whether a type of talk therapy called Interpersonal and Social Rhythm Therapy (IPSRT) can prevent bipolar disorder in teenagers (ages 12-18) who have a parent with bipolar disorder and are considered high-risk. Participants receive 8 sessions of IPSRT or a health…

This study tests a psychological empowerment program designed to prevent postpartum depression in pregnant women. 92 first-time mothers in Indonesia will take part in 5 group sessions over 3 weeks, focusing on control, confidence, and coping. Researchers will check if the program…

This study tests whether metformin, a drug used for diabetes, can prevent Alzheimer's dementia in people with mild cognitive impairment (MCI). Over 18 months, 326 overweight adults aged 55-90 with MCI will receive either metformin or a placebo. Researchers will track memory, brai…

This study tests whether sulforaphane, a compound found in broccoli, can prevent psychosis in 300 people at high risk. Participants take either sulforaphane or a placebo daily for a year, then are followed for another year. The main goal is to see if fewer people in the sulforaph…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests a non-invasive device that uses gentle electrical currents to stimulate the right amygdala, a brain area linked to emotion. Fifty adults with major depression will receive either real or sham stimulation for six weeks. Researchers will measure changes in mood, th…

This study tests whether listening to special audio fairy tales before sleep can improve speech, motor skills, and independence in a child with autism and central auditory processing disorder. The child stays at home with their mother, avoiding clinic stress. Early results from t…

This trial investigates whether combining two types of brain stimulation—intermittent theta burst stimulation (iTBS) and high-definition transcranial direct current stimulation (HD-tDCS)—can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal,…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study explores whether adding a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) to standard speech therapy can improve word-finding in people with aphasia after a stroke. The trial involves 50 adults who are at least six months …

This study investigates whether using a stress ball during port catheter needle changes can reduce pain, anxiety, and improve satisfaction in cancer patients. Fifty adult oncology patients will be randomly assigned to either use a stress ball or receive standard care. The goal is…

This study looks at whether pramipexole, a drug used for restless leg syndrome, can ease leg symptoms in women with X-linked adrenoleukodystrophy (ALD). About 24 women will take the drug or a placebo for two months. The goal is to see if it improves sleep, walking, and quality of…

This study tests whether smelling essential oils during skin surgery can reduce the unpleasant smell of burnt flesh from electrocautery and lower patient anxiety. About 111 adults having same-day skin procedures will be randomly assigned to receive either a real essential oil inh…

This study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…

This study tests whether a targeted nerve block (retrolaminar block) provides better pain relief after lumbar discectomy than the standard method of injecting pain medicine into the surgical wound. 130 adults having elective single-level herniated disc surgery will be randomly as…

This study tests a simple, drug-free approach to help people with moderate-to-severe dementia who struggle with eating. The experimental group receives a salivary gland massage combined with aromatherapy before meals for 20 days, while the control group gets a palm massage. Resea…

This study tests whether a smartphone app that delivers cognitive behavioral therapy (CBT) can help adults with social anxiety disorder. Participants use the app for 12 weeks, learning skills like cognitive restructuring and exposure exercises. The trial compares app users to a w…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 1…

This study tests whether a structured conversation between people with dementia or mild cognitive impairment and their care partners can reduce difficult symptoms like agitation and depression. The idea is that when care partners better understand the person's everyday preference…

This study tests whether DHA, a key omega-3 fatty acid found in fish oil, can improve symptoms of autism in children and adolescents aged 5 to 17. Participants receive either DHA or a placebo daily for 12 weeks. Researchers also look at genes and urine markers related to DHA to u…

This small study will test whether spending time with horses as part of therapy can help inpatients with emotionally unstable personality disorder (EUPD) manage their emotions and feel more connected to others. Six participants will take part in six sessions of equine-assisted ps…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This phase 2 study is testing whether fluoxetine, a widely used antidepressant, can reduce PTSD symptoms in 800 adults including active-duty service members, veterans, and civilians. Participants receive either fluoxetine or a placebo for 12 weeks, and researchers measure changes…

This study tests whether an 8-week internet-based mindfulness program (iMBSR) can improve brain health in adults aged 50 and older who have subjective cognitive decline, a potential early sign of Alzheimer's disease. Sixty participants will be randomly assigned to either the mind…

This study explores whether high-intensity interval training (HIIT) is a practical and acceptable treatment for adults with ADHD. Researchers will recruit 30 adults diagnosed with ADHD to participate in a 14-week exercise program combining strength and endurance training. The goa…

This pilot study explores whether combining a trauma-focused therapy called Deep Brain Reorienting (DBR) with a supportive group program is feasible and helpful for adults with complex dissociative disorders like Dissociative Identity Disorder. Ten participants will receive weekl…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study tests whether daridorexant, a drug used for insomnia, can reduce PTSD symptoms in 200 adults, including active-duty service members, veterans, and civilians. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in PTSD severity …

This study tests an 8-week online stress management program for health students in Sfax, Tunisia. The program combines cognitive-behavioral therapy and mindfulness meditation through videos, exercises, and motivational messages. Researchers will measure changes in stress, anxiety…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for obesity. The app uses strategies from cognitive-behavioral therapy to improve self-regulation and eating habits. Fifty teens will use the app for 16 week…

This study tests whether an accelerated form of transcranial magnetic stimulation (TMS) can safely and effectively reduce depression symptoms in people with major depressive disorder. About 50 participants aged 15 and older will receive the treatment in an open-label design. The …

This study tests whether a device that plays brief, soft sounds during deep sleep can enhance brain wave activity in people with mild cognitive impairment due to Alzheimer's disease. Participants use the device at home each night for three months, with an optional three-month ext…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This trial explores whether spending time on a farm with animals and nature can help socially withdrawn young adults (ages 18–30) with autism spectrum disorder. Participants take part in supervised group activities on a farm twice a week for 12 weeks. Researchers will interview p…

This study tests a web-based support program called Hospital GamePlan4Care for caregivers of veterans with dementia who are discharged from skilled nursing facilities to home. Fifty-five caregivers will receive either the program (website, emails, and phone coaching) or basic hea…

This study tests whether a special therapy using sights, sounds, touch, and other senses can help people with moderate Alzheimer's think clearer, feel calmer, and behave better. It also looks at whether this therapy reduces stress for their caregivers. Twenty-four people aged 65 …

This study tests whether a structured dance and movement program is practical and acceptable for people with functional neurological disorder (FND), a condition where the brain doesn't send proper signals to the body. Thirty adults with FND will be randomly assigned to either dan…

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study looks at whether Behavioral Activation (BA) therapy can change the habit of repetitive negative thinking (rumination) in people with major depression. Up to 120 adults will receive 12 sessions of BA over 11 weeks. Researchers will measure symptom changes and explore wh…

This pilot study tests a mobile app called Brain CareNotes designed to reduce the burden on unpaid caregivers of people with Alzheimer's or related dementias who live in rural areas. About 60 caregivers will use either the Brain CareNotes app or a basic education app for six mont…

This study tests whether a parent-led therapy called Pathways can improve social skills in 80 toddlers (16-30 months old) who show early signs of autism. One group of parents learns a technique to encourage mutual eye contact during play, while the other group uses the same thera…

This study tests whether combining cognitive remediation training (a computer-based program to improve thinking skills) with mild brain stimulation (transcranial direct current stimulation) can help people with severe mental illness who live in supported housing. The goal is to i…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…

This study tests a new virtual reality program designed to help adults with autism improve their social skills and daily functioning. 140 participants will either receive the VR training plus usual care, or usual care alone, for 3 months. Researchers will measure changes in socia…

This study tests whether giving first-time mothers online education about childbirth starting at 30 weeks of pregnancy can lower their risk of post-traumatic stress after delivery. Researchers will enroll 400 women and track their mental health through surveys at 6 weeks and 6 mo…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This study tests whether a pelvic floor massage technique (Thiele massage) can reduce pain during sex in women with chronic pelvic pain. It compares in-person treatment with guided self-massage at home via telehealth. The goal is to see if telehealth can be as effective as in-per…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help adults with long-term PTSD who are already taking antidepressants. Twenty participants will receive psilocybin, and some will also get trauma-focused talk therapy. The goal …

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This phase 3 study tests whether an oral medication called MM120 can reduce anxiety symptoms in adults with generalized anxiety disorder. About 214 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The…

This study tests whether a safe, painless brain stimulation technique called tDCS can improve verbal learning in people with Alzheimer's disease. Researchers will compare active stimulation to a sham (fake) version in 90 participants with typical or language-based Alzheimer's. Th…

This study tests whether injecting a dextrose (sugar water) solution around nerves in the neck can reduce PTSD symptoms like anxiety and brain fog. Twenty-four adults who have tried at least two medications and two non-drug treatments for PTSD will receive either the injection or…

This study tests a single cognitive behavioral therapy (CBT) program designed to help veterans who struggle with both anxiety (including PTSD) and hazardous drinking. The goal is to see if treating both issues together improves their daily functioning and reduces symptoms better …

This study tests whether a wearable light device can help improve sleep and daily rhythms in people with Alzheimer's who have sleep problems. Researchers will also use activity trackers and blood tests to better understand the disease. About 162 participants will try the light th…

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study tests whether a wearable headband that shines near-infrared light can improve depression and sleep in adults aged 60 and older with major depression. Participants will wear the device for up to 8 weeks, and researchers will track sleep, mood, and daily activity using a…

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study tests whether adding ketamine tablets to a new antidepressant can reduce depression symptoms faster in adults with major depression. Twelve participants will take four doses of ketamine over one week while starting a standard antidepressant. The goal is to see if sympt…

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study planned to test whether automated music therapy could help manage agitation and sleep problems in people with severe Alzheimer's living in nursing homes. An actigraph would detect sleep issues and trigger music sessions automatically. The trial was withdrawn before any…

This study tests a new program called BRIDGES, designed with teens, to help young people with depression become more active at their own pace. The goal is to see if increasing physical activity can reduce depressive symptoms. The study will involve 60 adolescents aged 12-19 who a…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in people with advanced cancer who are in palliative care. About 110 patients will be enrolled to compare different drug approaches. The goal is to improve com…

This study looks at whether special video games (serious games) that combine physical and mental exercises are a good value for managing Alzheimer's disease. About 136 people with mild to moderate Alzheimer's will either play these games with a therapist or receive usual care. Re…

This study aimed to see if a web-based self-help program called Deprexis could help orthopedic patients with major depressive disorder. The plan was to offer the 8-week online program to patients with depression and see if they would use it and if their mood and physical function…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests two 18-month talk therapy programs—Cognitive Enhancement Therapy and Enriched Supportive Therapy—for people with schizophrenia who have lasting negative symptoms like low motivation and social withdrawal. About 90 outpatients aged 18-60 will participate. The goal…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study tests whether a digital cognitive behavioral therapy program, supported by telephone coaching, can help reduce depression symptoms in pregnant women. About 634 mothers with mild to moderate depression were randomly assigned to either the guided digital program or stand…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep quality. The goal is to find simple, at-home way…

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study tests a new 20-session cognitive-behavioral therapy for adults aged 18 and older with anorexia nervosa. The goal is to help participants gain weight and reduce eating disorder thoughts and behaviors. Researchers will track changes in weight, anxiety, depression, and ea…

This study tests whether a type of counseling called behavioral activation therapy, combined with a nicotine patch, helps people quit smoking. It focuses on smokers who have low reward sensitivity, meaning they get less pleasure from rewards. About 85 participants will receive ei…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study tests whether a mobile app for PTSD, along with brief weekly support sessions, can help people who are already in treatment for alcohol problems. About 300 adults with both PTSD and alcohol use disorder will use the app or receive standard care. Researchers will track …

This study compares two treatments for body-focused repetitive behaviors like hair-pulling (trichotillomania) and skin-picking disorder. 26 adults will first take memantine (a drug) for 8 weeks, then receive 8 weeks of behavioral therapy. Researchers want to see which approach re…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who have lost weight and have little desire to eat. About 98 patients will receive either mirtazapine or a placebo for 29 days. Researchers will track ch…

This study planned to see if wearing light therapy glasses could help reduce depression and tiredness in children and teens who had a stem cell transplant. Participants would have used the glasses for about four weeks while their mood and sleep were tracked. However, the study wa…

This study tests whether a self-help handbook called the 5-Step Method can help family members cope with the stress of a relative's drug or alcohol misuse. 24 adults in the US will be split into two groups: one gets the handbook, the other does not. The goal is to see if the prog…

This study tests whether tolcapone, a drug used for Parkinson's disease, can reduce symptoms of obsessive-compulsive disorder (OCD) in adults. About 49 people with moderate to severe OCD will receive either tolcapone or a placebo. The main goal is to see if the drug safely lowers…

This study tests a structured 8-session group therapy called Integrated Grief Therapy (IGT) for adults who lost loved ones in the 2023 Türkiye earthquake. 190 survivors were randomly assigned to either the therapy or a waitlist. The goal is to see if the therapy boosts resilience…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This study tests whether a new type of group therapy, called Group Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. Sixty-four adults with mild to severe depression will either receive two full days of therapy or be placed on a waiting list. Res…

This study tests whether a new therapy called Emotional Resolution (EmRes) can help reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or a mindfulness-based gratitude exercise. The goal is to see if EmRes lead…

This Phase 2 trial tests a single intravenous dose of ketamine in 20 hospitalized teens and young adults with anorexia nervosa or atypical anorexia. Researchers want to see if ketamine helps the brain become more flexible, making it easier to learn new, positive associations with…

This study tests whether virtual reality (VR) brain exercises can help people with schizophrenia or bipolar disorder think more clearly and function better in daily life. 80 adults will either receive VR training twice a week for 12 weeks or continue their usual care. Researchers…

This study compares two parent training programs for 3-5 year olds with sleep problems and early signs of ADHD. One program focuses on behavior, the other adds sleep strategies. Researchers want to see if the sleep-focused approach is more helpful and practical for families in pe…

This study compares three proven PTSD treatments—talk therapy (prolonged exposure), antidepressant medication (paroxetine or venlafaxine), and their combination—in 304 veterans. Researchers aim to identify which treatment works best for whom, using personalized algorithms. Partic…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests whether combining music-based movement cues (patterned sensory enhancement) with mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disorder. Twenty participants will be split into two groups: one receiving…

This study tests whether personalized sequences of behavioral interventions can help minimally verbal preschoolers with autism improve their language skills. Researchers will compare two teaching approaches—JASPER (play-based) and DTT (structured)—to see which works best for each…

This study tests a speech therapy method called Rapid Syllable Transition (ReST) in children aged 5 to 8 with childhood apraxia of speech, a condition that makes it hard to say sounds correctly. The goal is to see if the therapy is practical and helps improve speech clarity and m…

This study looks at whether a mobile mindfulness app (Headspace) can help people being treated for opioid use disorder who also have a history of childhood trauma. Sixty participants will be asked to use the app daily for 30 days and visit the clinic four times to check stress le…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests whether a community-based music mindfulness program can reduce anxiety and depression in children aged 8-12 with ADHD or anxiety. Participants attend bi-weekly sessions for 8 weeks, wear fitness trackers, and complete surveys. The goal is to see if this approach …

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and a…

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This study tests a new program called PEAR that helps parents and teachers work together to manage ADHD and disruptive behavior in preschool children aged 2-5. The program adds extra support to a proven behavior tool called the Daily Report Card. Researchers want to see if PEAR i…

This study tests a single injection of F14, a long-acting form of the painkiller celecoxib, in 100 people undergoing total knee replacement. The goal is to see if it safely controls pain as part of a standard pain management plan. Participants receive the injection during surgery…

This study tests a program called I-CARE for teens aged 12-17 who are in a medical hospital waiting for mental health treatment after a suicide-related emergency. The program uses 7 short videos and workbook activities to help lower emotional distress and suicidal thoughts. Resea…

This pilot study tests a chatbot named SMILEY that teaches coping skills and safe social media practices to marginalized youth (ages 12-18) who experience depression and online victimization. Over 4 weeks, participants interact with the chatbot at their own pace to learn how to m…

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This early-stage study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). Twenty-eight adults with moderate-to-severe OCD who have not responded to standard treatments will receive…

This Mayo Clinic study is testing whether eating fermented foods like yogurt, kimchi, and sauerkraut can improve gut microbiome diversity in people with long COVID. Forty adults with long COVID symptoms will either add fermented foods to their diet or continue as usual. Researche…

This study tests a remote speech therapy program for 32 Korean-speaking people with Parkinson's disease and their families. The therapy includes 16 sessions over four weeks, plus daily home practice, to improve speech clarity. The goal is to see if this culturally adapted approac…

This study tests whether an autism-friendly mobile app can help children and teens (ages 8-17) with autism improve their toothbrushing skills and habits. Participants use either the special app or a basic control app for 3 months while researchers track brushing quality and habit…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study tests whether watching short video lessons instead of reading chapters can help adults with binge eating disorder stop binge eating. Eighty adults will either watch weekly videos or read text-based materials for 13 weeks, with brief online coaching sessions. The goal i…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests whether a probiotic supplement called Neuralli® MP can help adults aged 18 to 50 who have autistic traits. Participants take two capsules daily and set their own personal goals to track progress. The trial is small and open-label, meaning everyone knows they are …

This study tests a short, enhanced cognitive behavioral therapy (E-BCBT) for people hospitalized after a suicide crisis. 30 participants will either receive 5 therapy sessions during their stay or standard care. The goal is to see if this therapy reduces suicide attempts and suic…

This study tests whether a gentle nerve-stimulating earpiece can help newborns going through opioid withdrawal. The device is used up to four times a day for 20 days, just before each morphine dose. Researchers want to see if it reduces the number of days babies need morphine and…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study explores whether individualized transcranial magnetic stimulation (TMS) can improve symptoms in adults with irritable bowel syndrome (IBS). Participants receive 10 TMS sessions over two weeks, with brain scans and stool tests before and after to understand how the trea…

This Phase 3 study tests whether a single 25 mg dose of synthetic psilocybin can reduce depression symptoms in 238 adults with major depressive disorder. Participants receive either psilocybin or a placebo, and their depression severity is measured over 43 days. The trial also lo…

This study tests whether a device that sends mild electrical pulses to facial muscles can help treat major depression. Twenty adults with depression will use the device at home for 45 minutes daily over four weeks. The main goal is to see if the approach is feasible and safe, wit…

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This pilot study is testing whether giving people non-alcoholic beer or sparkling water can help them reduce their alcohol intake. 60 adults with alcohol use disorder who are already in treatment will receive one of the two drinks for 6 weeks. The main goal is to see if people fi…

This study compares how honey versus table sugar, each paired with almonds, affects blood sugar levels, hunger, and fullness in 58 healthy premenopausal women. Participants will eat snacks containing honey or sugar with or without almonds, and their glucose will be tracked with a…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests whether a smartphone app can help adults who are hospitalized for depression or suicidal thoughts. After leaving the hospital, participants use the app for 28 days to practice skills that encourage positive activities. The goal is to see if the app is easy to use…

This pilot study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve letter learning in 100 adolescents with dyslexia. Participants will learn new letter-sound relationships during six 30-minute sessions while receiving either ac…

This study tests a 12-session group program called Family Connections Transdiagnostic for relatives of people with emotional dysregulation disorders (like eating disorders or personality disorders). The program teaches skills in mindfulness, emotional regulation, and problem mana…

This study tests a new way to match dementia caregivers with each other for emotional support using a computer algorithm. Researchers want to see if matching based on personal preferences leads to better satisfaction and less stress than random matching. About 355 caregivers of p…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study tests a free app called LightBEAM that offers videos, forums, and exercises to help parents manage stress, anxiety, and depression. About 300 Canadian parents of children aged 18 months to 9 years will use the app for 12 weeks. The goal is to see if the app improves pa…

This study tests whether adding a new drug called ABX-002 to current treatments can improve depression symptoms in adults with bipolar disorder. About 30 people with bipolar depression will take the drug for 6 weeks, and some will have brain scans to see how it affects brain chem…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This study tests whether using a device that delivers light and sound stimulation for 60 minutes each day is safe and practical for people with mild Alzheimer's. Fifteen participants will use the device at home for 6 to 9 months. The main goals are to see if people can stick with…

This study tests whether a team of doctors, nurses, social workers, and community health workers providing palliative care at home can improve symptom control and reduce hospital visits for people with advanced dementia. About 153 patients and their family caregivers are taking p…

This early-stage trial tests whether a daily tablet called BI 1356225 can improve impulse control in people with opioid use disorder who are already taking buprenorphine. About 60 participants will be randomly assigned to receive either the study drug or a placebo for 8 days. Res…

This study aimed to see if a voice-changing device could make exposure therapy easier for people with PTSD. Patients would read their trauma story aloud while software altered their voice's emotional tone, hoping to reduce distress. The study was withdrawn before any participants…

This study tests an experimental nasal spray called fasedienol for quickly reducing anxiety during a public speaking challenge in adults with social anxiety disorder. About 238 participants will receive either the spray or a placebo and rate their distress levels. The goal is to …

This study tests whether an adapted version of Cognitive Processing Therapy (CPT), delivered via telehealth at syringe service programs, can reduce PTSD symptoms and help people stay on their opioid use disorder medication. Eleven adults who regularly use syringe services and are…

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This Phase 2 study is testing whether fluoxetine, a common antidepressant, can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either fluoxetine or a placebo for up to 12 weeks. The main goal is to see if PT…

This study tests an experimental drug called SLS-002 to see if it can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either the drug or a placebo twice a week for 8 weeks, then once a week for 4 more weeks.…

This study tests a digital cognitive behavioral therapy program (SilverCloud) for Spanish-speaking adults with depression or anxiety. 426 participants will either use the program on their own or get extra support from a peer coach via phone or messaging. The goal is to see if add…

This study tests whether a more targeted form of transcranial magnetic stimulation (TMS) can help people with schizophrenia whose symptoms don't improve with medication. The treatment uses each patient's own brain wave frequency (alpha rhythm) and MRI scans to precisely stimulate…

This pilot study tests a live music therapy program called AMUSED for older adults with severe dementia living in care facilities. Participants attend small group sessions twice a week for 12 weeks, either with music therapy or a reading activity. Researchers want to see if music…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This small early-phase study is testing whether psilocybin, the active ingredient in magic mushrooms, combined with supportive therapy can safely help people with obsessive-compulsive disorder (OCD) that hasn't responded to standard treatments. Ten adults with treatment-resistant…

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study tests whether combining transcranial magnetic stimulation (TMS) with virtual reality exercises and physical therapy can improve symptoms like balance, fatigue, and thinking in people with multiple sclerosis. Thirty participants will receive both real and sham TMS in a …

This study tests an experimental oral medication, ML-007C-MA, in 307 adults hospitalized with schizophrenia who are having a sudden worsening of psychosis. The goal is to see if the drug reduces symptoms like hallucinations and delusions better than a placebo. Participants take t…

This study looks at two medicines given before surgery to prevent delirium (confusion and agitation) in children aged 3 months to 9 years. One is a nose spray (dexmedetomidine), the other is a syrup (midazolam). The goal is to see which works better and is easier for kids to take…

This study looks at whether having therapy sessions in the morning or afternoon changes how well prolonged exposure therapy works for PTSD. About 52 adults with PTSD will receive 10 weekly therapy sessions via telehealth, either early in the day or late afternoon. Researchers wil…

This pilot study is testing a type of talk therapy called Metacognitive Interpersonal Therapy (MIT-ED) for adults with various eating disorders, including those who are underweight. The therapy aims to help people understand and manage the negative thoughts and feelings that driv…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a specially designed game while a therapist supervises them remotely via telemedicine. The goal is to see if this approach can improve balance and thinkin…

This study looks at whether an 8-week yoga program during pregnancy can lower the risk of postpartum depression and strengthen the bond between mother and baby. It involves 60 first-time mothers who are 26-28 weeks pregnant. Participants will either take yoga classes or receive s…

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This pilot study looks at whether a nasal spray of oxytocin, sometimes called the 'love hormone,' can improve trust and cooperation in people with borderline personality disorder (BPD). About 40 participants (some with BPD, some healthy) will play a trust game after receiving eit…

This study looks at whether a special recovery program can help older adults (65+) who experienced confusion (delirium) after emergency surgery. Participants will have virtual visits with a care coordinator and complete physical, cognitive, and psychological assessments over 18 m…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study follows adults who have knee replacement surgery using a fast-track recovery program called ERAS. Researchers want to know how many people still have pain three months later, how severe it is, and whether they still need strong painkillers. Participants answer simple q…

This study investigates cognitive problems in intensive care patients with acute respiratory distress syndrome (ARDS) who develop delirium (sudden confusion). Researchers use a non-invasive EEG cap and auditory tests to measure brain activity at the bedside. The goal is to identi…

This Phase 1 study aims to understand how the body processes ketamine after a cesarean delivery, and whether it can help with postpartum depression and pain. Fifty participants will receive a low-dose ketamine infusion, and researchers will measure drug levels and side effects. T…

This study investigates how the brain processes speech sounds to understand language. Researchers will record brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds while their…

This study aims to describe French gamblers who are at risk or have a pathological gambling problem. Researchers will collect information on their gambling history, personality, and other health issues. The goal is to compare this data with studies from other countries and to tes…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study aims to test a new assessment tool called the ANA, which uses surveys and computer tasks to measure three key brain functions related to addiction. Researchers will study 1,400 adults with alcohol use disorder to see how these brain functions relate to drinking behavio…

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study is creating a learning healthcare system for OnTrackNY, a program that helps young people (ages 16-30) who have recently experienced psychosis. Researchers will collect data and feedback from participants, families, and clinicians to continuously improve care. The goal…

This study looks at whether two blood markers, zonulin and LBP, can help detect liver damage in people with both ulcerative colitis (UC) and fatty liver disease. Researchers will measure these markers and use a special ultrasound to check liver stiffness in 100 adults with UC who…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study tracks 130 adults with PTSD from childhood trauma as they undergo Cognitive Processing Therapy. Researchers will measure brain activity, genetics, and behavior before and after treatment to understand how recovery happens. The goal is to uncover biological markers of P…

This study investigates factors that may influence cognitive skills—like memory, attention, and problem-solving—in women diagnosed with fibromyalgia. Researchers will assess thinking abilities using a detailed cognitive test and measure how fibromyalgia affects daily life. The go…

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study looks at how adults at risk for Alzheimer's disease react after learning their amyloid and tau biomarker test results. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the psychological and be…

This study looks at how childhood abuse and neglect change the brain in women with PTSD or dissociative identity disorder. Researchers will use MRI scans and cognitive tests to measure brain activity related to attention, emotions, and feelings of detachment. The goal is to bette…

This observational study surveys 150 adults with severe mental illness to learn how they use AI chatbots for mental health support. Participants answer a one-time anonymous online survey about their experiences, expectations, and concerns. The goal is to understand usage patterns…

This study tests whether an AI tool that uses electronic medical records can help predict and reduce delirium (sudden confusion) in older adults after major surgery. About 60 people aged 65 and older will take part. The goal is to see if giving doctors a delirium risk alert can l…

This study was designed to see if cognitive behavioral therapy for insomnia (CBT-I) could help teenagers with ADHD who also have trouble sleeping. It planned to enroll adolescents aged 11-18 with both ADHD and insomnia. However, the trial was withdrawn before any participants wer…

This study was designed to compare decision-making skills between bipolar patients who had attempted suicide and those who had not. Researchers planned to use computer tasks and questionnaires to measure thinking patterns. However, the study was withdrawn before enrolling any par…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study tracks a protein called neurofilament light chain in the blood of 342 people who carry genetic mutations linked to frontotemporal dementia (FTD). Participants provide blood samples every three months for three years, often from home. The goal is to see if this biomarke…

This study aims to uncover the genetic and environmental factors behind autism spectrum disorders (ASD), including autism, Asperger's syndrome, and PDD. Researchers will analyze gene expression in 240 participants aged 18 months and older who have an ASD diagnosis. The goal is to…

This study aims to validate two new tools that use artificial intelligence to predict a person's risk of developing opioid use disorder. One tool looks at genetic markers, and the other examines gut bacteria. Researchers will enroll 300 adults with or without opioid addiction to …

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study looks at how children with cancer and their parents handle the emotional challenges of the disease. Instead of focusing only on negative effects like posttraumatic stress, researchers also explore positive changes, such as personal growth. The study compares these fami…

This study looks at how proposed tobacco regulations might affect the buying and use habits of people in Appalachian Kentucky. About 473 adults who use tobacco daily will take online surveys and shop in a pretend online store where prices change. The goal is to see if rules like …

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study looks at how synthetic cooling additives (like WS-3 and WS-23) in e-cigarettes change how young adults perceive and use them. About 158 current e-cigarette users aged 21-29 will try different flavored e-liquids and report their satisfaction, sensory experiences, and pu…

This study looks at 300 patients with advanced liver scarring (cirrhosis) caused by hepatitis B or alcohol who have shown signs of getting better. Researchers want to understand what predicts this improvement and how long it lasts. The goal is to create clearer guidelines for whe…

This study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments …

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study enrolls people with ALS and related disorders, as well as healthy volunteers, to track biological markers (biomarkers) in urine, blood, and spinal fluid. The goal is to better understand how these markers change over time, which could help design more effective future …

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study tests a program that helps parents and teens work together to improve safe driving. It includes 588 teens aged 16-17 who have already received a traffic ticket. The program uses a smartphone app and in-car device to track risky driving and give feedback, aiming to redu…

This study uses a special PET scan to look at tau protein buildup in the brains of African Americans who are either cognitively normal or have dementia. Researchers hope to learn how these brain changes differ across racial groups. The study involves 240 participants and uses a t…

This study looks at whether adding aripiprazole to the antidepressant escitalopram can reduce pathological rumination—repetitive, intrusive negative thoughts—in people with major depressive disorder. 108 participants will receive either escitalopram alone or escitalopram plus ari…

This study tests whether doing clinical trial visits remotely (from home) works as well as coming into a clinic. About 200 adults will be randomly assigned to remote or in-person groups for intake and follow-up over 3 months. The goal is to see which method is better at keeping p…

This observational study follows 600 women who had an anal sphincter injury during childbirth in Finland between 2009 and 2021. Researchers want to understand how common long-term pelvic floor symptoms and sexual problems are after such injuries. Participants fill out questionnai…

This study looks at how to best help people with serious mental illness take part in a program that lowers heart disease risk. Researchers will test different support strategies at community mental health clinics in Michigan and Maryland. The goal is to find the most effective wa…

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This study uses brain scans and behavioral data from 267 adults (80 with autism, 79 with schizophrenia, and 108 healthy controls) to explore shared brain activity patterns related to social thinking. No new treatments are given; researchers analyze existing data to understand how…

This study looks at how fear of pain affects movement in 26 healthy adults. Researchers used verbal suggestions and inactive electrodes to create a sense of threat during walking and arm-pointing tasks. The goal is to understand how fear of movement changes walking speed, stride,…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…

This study uses a radioactive tracer called [18F]MK-6240 to take detailed pictures of tau protein clumps in the brain, a hallmark of Alzheimer's disease. Researchers will scan 200 people from families with a rare genetic form of Alzheimer's to see how tau buildup changes over tim…

This study looks at the best way to stop bladder control medication in children aged 5 to 14 who are currently dry. Some children will stop their medicine suddenly, while others will taper off gradually. The goal is to see which approach lowers the chance of wetting accidents ret…

This study looks at sleep patterns in 94 adults with major depressive disorder, comparing those with moderate-to-severe insomnia to those with mild or no insomnia. Participants wear a headband at home that records brain activity during sleep and also fill out sleep diaries and qu…

This study looks at how the severity of depression relates to erectile dysfunction and premature ejaculation in 100 married men aged 25–60 in the Sohag region of Egypt. Participants are clinically diagnosed with depression and sexually active. Researchers will use standard questi…

This study looks at how long-term exposure to secondhand tobacco smoke changes the lungs of never-smoking flight attendants who worked on planes before smoking was banned. Researchers want to see if a bronchodilator, a medicine that opens airways, can help with breathing problems…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study follows 600 mentally ill offenders in Italy and California over three years to compare two very different treatment systems. Italy uses community-based care, while California relies on long-term hospital stays. Researchers will track violence, recovery, and functioning…

This study follows 180 children with overweight or obesity to see how their thinking skills (like memory and self-control) relate to eating habits and weight changes over time. Researchers will use brain tasks and interviews to understand these links. The goal is to find better w…

This study is not a treatment trial. It aims to translate and test a new assessment tool (FARAS-IT) for adults with autism who are involved in the Italian criminal justice system. Researchers will enroll 100 adults with autism, including those in forensic psychiatric care, those …

This study follows 100 adults who drink alcohol at least weekly and have some interest in cutting back. Researchers want to see how alcohol use, suicidal thoughts, and decision-making are linked. Participants get access to a self-guided online cognitive behavioral therapy program…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study tracks 2,500 people with HIV in Brazil who are taking a common first-line treatment (tenofovir/lamivudine and dolutegravir) to see why some develop drug resistance. Researchers will test blood samples from those whose viral load remains detectable to look for resistanc…

This study looks at how different warning labels on cannabis edibles packaging change what people know, how safe they think the product is, and whether they want to try it. About 1,250 adults in the U.S. will view packages with different warnings and answer questions. The goal is…

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study looks at whether estrogen patches can improve mental flexibility and reward processing in young women (ages 14-35) with eating disorders linked to low estrogen. About 120 participants will receive either estrogen patches or placebo for 12 weeks. The goal is to understa…

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study follows 100 teens aged 13-18 who are already enrolled in a depression registry. For 30 days, they report their feelings and social media use twice daily via a phone app, then complete monthly surveys for 6 months. The goal is to understand how social media relates to d…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study follows 640 adults with normal cognition, mild cognitive impairment, or Alzheimer's disease to track brain changes over time. Researchers use advanced brain scans and genetic tests to understand how Alzheimer's develops. The goal is to find better ways to diagnose and …

This study looks at how gut bacteria change when young people (ages 12-35) with psychosis start taking antipsychotic medication. Researchers want to see if these changes are linked to weight gain and other metabolic problems. Participants provide stool and blood samples over 12 w…

This study aimed to see how well a blood test (phosphatidylethanol) detects heavy alcohol use. Researchers planned to compare test results in heavy drinkers and check how stable the samples are over time. However, the study was withdrawn before enrolling anyone, so no results are…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study uses special PET/CT scans to measure inflammation in the brains of people with Alzheimer's disease or Lewy body dementia. Researchers want to see if brain inflammation is linked to memory decline and other dementia symptoms. The study also tests a new radioactive trace…

This study aims to find which patients with treatment-resistant depression are most likely to get relief from a single low dose of IV ketamine. Researchers will use interviews, questionnaires, brain wave tests, and computer tasks to look for clues. The goal is to make this treatm…

This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…

This study looks at whether a single 2-hour group discussion for parents and caregivers can improve eating habits, mood, and parent-child relationships. About 112 Oregon parents of teens (ages 12-17) will either join the talk now or wait. Researchers will measure changes in both …

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study gives ketamine to 120 people with major depression and suicidal thoughts who are not on other psychiatric medications. Researchers use brain scans and a gentle nose swab to see how ketamine changes brain connections and neuron activity. The goal is to understand why ke…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study looks at whether training pediatricians to assess how mothers and babies interact can help identify early signs of child behavior issues or postpartum depression. Over 3,500 mother-child pairs are involved, with babies seen at their one-month checkup. The goal is to se…

This study explores how a specific brain area (the medial prefrontal cortex) influences the ability to savor positive experiences in people with depression. Researchers will use non-invasive brain stimulation (TMS) and brain scans (EEG and fMRI) to see if changing activity in thi…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT…

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study explores whether smartphone sensors can detect early changes in behavior that might signal cognitive decline. About 100 adults aged 65 and older living in assisted living facilities will have an app on their phones that tracks movement, typing patterns, and app usage f…

This study uses smartphone data to understand what triggers anxiety and alcohol use in each person, then tailors therapy to those specific triggers. 81 adults with anxiety and alcohol problems will receive 11 sessions of cognitive behavioral therapy (CBT) either personalized to t…

This study aimed to see if using real-time ultrasound during a thoracic epidural block makes the procedure more reliable. It was designed for adults with chest or abdominal pain or rib fractures. The study was withdrawn before enrolling any participants, so no results are availab…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This Stanford study is testing whether non-intrusive sensors placed in the home can automatically track neuropsychiatric symptoms like mood changes and agitation in older adults. Researchers will enroll 25 participants with or at risk of mild cognitive impairment or dementia, alo…

This study follows 1600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how peo…

This study aimed to see if measuring sertraline (Zoloft) levels in the blood and checking a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. The goal was to reduce side effects and improve treatment. However, the study was withdrawn …

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…