Could a seizure drug curb alcohol cravings? new trial investigates

NCT ID NCT05134857

Ongoing Disease control Sponsor: Washington State University Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether zonisamide, a drug currently used for seizures, can help adults with alcohol use disorder drink less. About 205 treatment-seeking participants will receive either zonisamide or a placebo, along with standard support. The study measures alcohol consumption through self-reports and breathalyzer tests over 14 weeks of treatment and follow-up.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zonisamide
What this could lead to: If successful, this could provide a new medication option to help people with alcohol use disorder drink less.
What could go wrong: This is a phase 2 trial, so it is still early. The drug may not work better than placebo, and side effects like dizziness or drowsiness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ALCOHOL USE DISORDER (AUD) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER (AUD)

Contacts and locations

Locations

Washington State University

Spokane, Washington, 99202, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.