Can a brain ZAP boost thinking skills in severe mental illness?

NCT ID NCT06378463

Ongoing Symptom relief Sponsor: University of Groningen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining cognitive remediation training (a computer-based program to improve thinking skills) with mild brain stimulation (transcranial direct current stimulation) can help people with severe mental illness who live in supported housing. The goal is to improve daily functioning and personal recovery. 126 adults aged 18-65 are taking part, and the study compares the active treatment to a sham (fake) stimulation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial direct current stimulation (tDCS)
What this could lead to: If successful, this could point toward a way to improve thinking and daily living skills for people with severe mental illness who need supported housing.
What could go wrong: This is an early-stage study with only 126 participants, so results may not apply widely. The brain stimulation is mild, but individual responses can vary and benefits may be small.

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Conditions

The condition(s) this trial relates to.

psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE MENTAL ILLNESS

Contacts and locations

Locations

Cosis

Assen, Drenthe, 9400 AE, Netherlands
GGZ Friesland

Leeuwarden, Provincie Friesland, 8932 PA, Netherlands
Lentis

Zuidlaren, Drenthe, 9470 AC, Netherlands

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