Psychiatric disorder

This study investigates whether a daily probiotic supplement containing Lactobacillus bacteria can help reduce alcohol cravings, withdrawal symptoms, and the severity of alcohol use disorder in adult men. Participants take either the probiotic or a placebo for 12 weeks, and resea…

This study tests whether adding a smartphone-based incentive program to standard counseling helps veterans with alcohol use disorder reduce heavy drinking. Participants use a mobile app to submit breath alcohol readings and earn rewards for abstinence. The trial compares this com…

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This phase 3 trial tests whether a new formulation of dexmethylphenidate (CTx-1301) can improve attention and reduce ADHD symptoms in adults for up to 16 hours. Participants take an optimized dose (25, 37.5, or 50 mg) and complete math tests in a simulated classroom. The study co…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This phase 3 trial tested whether giving preterm babies a drug called darbepoetin weekly could improve their brain development and reduce the need for blood transfusions. 650 infants born between 23 and 28 weeks of pregnancy were treated until they reached 35 weeks or went home. …

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This study tests whether a 12-week occupational therapy program based on the Model of Human Occupation (MOHO) can improve life skills and quality of life in mentally ill offenders. Twelve male offenders from a prison in Chennai, India, will attend 24 structured therapy sessions o…

This study tests whether a wide-spectrum nutritional supplement can improve mitochondrial function in children with autism spectrum disorder (ASD). Mitochondria are the energy factories in cells, and some children with ASD have abnormal mitochondrial activity. The trial enrolls c…

This study tests a program called Project YES+ for youth aged 15-21 living with HIV in Zambia. The program combines peer mentoring with mental health support to reduce stigma, violence, and depression. Researchers will enroll 400 participants to see if the program is feasible and…

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This study tests whether newborns with neonatal abstinence syndrome (NAS) who receive a high-calorie formula for two weeks gain weight better than those on standard formula. The babies are managed using the Eat, Sleep, Console approach. The main goal is to see how much weight the…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This phase 1 trial tests a single injection of TV-44749, an extended-release form of olanzapine, in Chinese adults with stable schizophrenia. The study aims to check safety, tolerability, and how the drug moves through the body. Participants receive one of three doses of the inje…

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study compares a fully automated digital screening and brief intervention (e-SBI) to the traditional in-person approach for reducing harmful alcohol consumption. Researchers will enroll over 500 adults from Brazilian public health clinics to see which method works better at …

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This study tested a long-acting injectable (LAI) form of the drug lumateperone in 52 adults with stable schizophrenia or schizoaffective disorder. Participants received a single injection of one of several LAI formulations, along with oral capsules, to see how the drug behaves in…

This study tested whether offering smokers more frequent and personalized outreach, plus more treatment choices like nicotine patches and text support, helps more people quit compared to standard care. Over 12,000 adult smokers from 10 primary care clinics took part. The goal was…

This large Phase 3 trial tested whether the diabetes drug semaglutide, taken as a daily pill, can slow cognitive decline in people with early Alzheimer's disease. About 1,840 participants received either semaglutide or a placebo for up to 3 years and 4 months. The study measured …

This study tested a behavioral program called CAE-AYA to help teens and young adults with bipolar disorder take their medication more consistently. The program included up to five in-person sessions and a follow-up phone call over eight weeks. Researchers measured adherence using…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tested the safety and tolerability of aripiprazole (Abilify) in 21 children and adolescents aged 10 to 17 with schizophrenia or mania. Participants took daily doses of 2 to 30 mg for 14 days. The main goals were to see how many could tolerate the highest dose without s…

This trial investigates whether replacing red or processed meat with pulses (like beans, lentils, and chickpeas) can improve markers of heart health and change the gut microbiome. Participants are adults aged 18-65 with unhealthy, sedentary lifestyles who eat at least three servi…

This study tested whether giving buprenorphine treatment in group medical visits (instead of one-on-one) helps people with opioid use disorder stay abstinent and remain in treatment. Eighteen adults already on buprenorphine but still using opioids took part in weekly 90-minute gr…

This completed trial tested a new approach for opioid use disorder: shining a specific type of near-infrared light on the scalp for just 4 minutes. The idea is to stimulate a healthier side of the brain to reduce addiction. Researchers compared the active light treatment to a sha…

This study tests an oral capsule called AK0901 (AZSTARYS) in children aged 6 to 12 with attention deficit hyperactivity disorder (ADHD). The trial compares the drug against a placebo to see if it reduces ADHD symptoms like inattention and hyperactivity. Researchers measure sympto…

This study tested the safety of a new drug called KarXT in 173 adults with schizophrenia. Researchers slowly increased the dose to see how well participants tolerated it and whether food affected the drug. The main goal was to track side effects, with secondary measures looking a…

This study tested whether text message reminders and rewards could help people who smoke to stick with their quitline counseling and take their medication. Twenty adults who smoked daily took part. They received a prescription for a stop-smoking drug and were referred to a quitli…

This Phase 3 trial tested an investigational drug called SEP-363856 in 464 people with schizophrenia who were experiencing acute psychosis. Participants received either the drug or a placebo daily for up to 9 weeks. The study measured changes in symptoms like hallucinations and d…

This study tested whether offering small gift cards for quitting smoking helps low-income smokers stay smoke-free. 320 uninsured or Medicaid patients received either standard care (counseling and medication) or standard care plus financial rewards for verified abstinence. The mai…

This study tested different ways to help daily smokers quit by comparing two medications (varenicline and nicotine patches/lozenges), how long to take them before quitting, how long to continue after quitting, and the level of counseling. Over 500 smokers from primary care partic…

This study tests whether virtual reality exposure therapy (VRET) can help men with alcohol use disorder reduce their psychological dependence on alcohol and prevent relapse. Eighty men who have completed detox will be randomly assigned to either VRET or standard treatment. VRET u…

This phase 2 trial tested whether cannabidiol (CBD) can reduce craving and anxiety in 76 adults with opioid use disorder who were already on opioid agonist therapy (like methadone). Participants took CBD or a placebo twice daily for 4 weeks, then all took a higher dose of CBD for…

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This study tested whether a paced breathing app could help women with substance use disorder resist triggers in real time. 77 women used the app whenever they felt a craving or faced a trigger. Researchers tracked substance use and feedback to see if the app helped reduce drinkin…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This study tests whether measuring tobacco smoke exposure in children, using a simple blood test, can help parents quit smoking. About 865 parents of young children (12 or younger) who smoke will be enrolled. The goal is to see if this approach, combined with support, leads to mo…

This study tests whether a 15-week aerobic exercise program at the YMCA can help smokers who are highly sensitive to stress quit smoking. Participants work with a personal trainer three times a week and also receive support from a national quitline. The goal is to see if exercise…

This trial investigates whether a single 4 mg dose of the steroid dexamethasone, given intravenously before hip fracture surgery, can lower the risk and severity of postoperative delirium in adults aged 60 and older. Delirium is a sudden state of confusion that often occurs after…

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants…

This study tested the safety and effects of nilotinib, a cancer drug, in 43 people with Dementia with Lewy Bodies (DLB). DLB is a common type of dementia that shares features with Parkinson's and Alzheimer's. The goal was to see if nilotinib is safe and changes brain biomarkers, …

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This small study tested whether transcranial magnetic stimulation (TMS) can lower blood pressure and ease PTSD symptoms in women aged 18-44 who have both conditions. Four participants received 30 TMS sessions over 6 weeks. Researchers measured changes in 24-hour blood pressure an…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This trial tests whether a team-based approach, including a dedicated nurse care manager, can help primary care clinics provide medication treatment for opioid use disorder. The study involves 12 clinics across five U.S. states, with half using the new approach and half continuin…

This Phase 3 study tested whether ecopipam can safely maintain tic control in 216 people with Tourette's disorder, ages 6 and up. Participants first received open-label ecopipam, then those who responded were randomly switched to placebo or continued ecopipam to see if benefits l…

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

This study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…

This study tested whether a once-monthly injection of aripiprazole can help people with schizophrenia avoid a relapse of symptoms. Over 900 adults took part, first switching to oral aripiprazole, then receiving either the long-acting shot or another treatment for up to 38 weeks. …

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study compares a smartphone app (iPhone Level) to a specialized device (BROM) for measuring how much the lower back can bend forward, backward, and sideways. Researchers will enroll 120 healthy male university students aged 18–25 with normal body weight. If the app works wel…

This study tested a tablet-based platform called Tenèpsia® for remote cognitive assessments in 250 healthy adults and people with cognitive impairment. The goal was to collect normal test scores and validate the digital tool for diagnosing neurocognitive disorders. If proven reli…

This study looked at whether a special brain scan called 18F-FDG PET can help doctors tell the difference between cognitive problems caused by psychiatric conditions versus neurodegenerative diseases like Alzheimer's. Researchers studied 20 adults with cognitive impairment who ha…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested a digital program designed to prevent teens from starting to misuse opioids. About 533 high school students who had never misused opioids but were at higher risk took part. The program aimed to increase their understanding of the serious risks of misusing prescr…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tests whether an 8-week program combining gentle yoga and tai chi with acceptance-based techniques can lower the risk of developing anorexia nervosa in female college students who already have elevated body shape concerns. Participants are randomly assigned to the mind…

This study tested whether giving mannitol, a substance that reduces brain swelling, could prevent delirium in older adults hospitalized for a heart attack. Fifty patients aged 65 and older with high inflammation levels were included. The goal was to see if mannitol could lower th…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while researche…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tests whether shining a specific type of near-infrared light on the front of the brain can safely help people with major depressive disorder. The light is thought to boost energy production in brain cells, which may improve mood. Researchers will measure changes in dep…

This study tests whether a non-invasive brain stimulation device, used at home, can safely and effectively ease symptoms of major depression in people who have not improved with medication. Participants use the device for 30 minutes a day, five days a week, for four weeks. The tr…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

This trial explores whether a group-based psychomotor therapy—using breathing, relaxation, and body awareness exercises—can be a practical and acceptable way to help young adults (ages 18-35) with anxiety. The study focuses on whether people will join and stick with the program, …

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This study tests whether a 6-week mindfulness program (MBSR) can reduce PTSD symptoms and improve quality of life in people who have been in a road traffic accident. About 110 adults aged 18-60 with PTSD will be randomly assigned to either MBSR or standard care. Researchers will …

This study tests whether a specific type of talk therapy called cognitive behavioral therapy (CBT) can help people with body dysmorphic disorder (BDD). Participants receive 22 weekly one-on-one CBT sessions that teach them to challenge negative thoughts and behaviors about their …

This study tested whether giving teens with ADHD and their parents a question list or a short video before a doctor visit helps them talk more openly and get better care. About 126 English-speaking teens aged 11-17 with ADHD took part. The goal was to see if these tools improve s…

This study tests whether writing about imagined future scenarios (worst-case, best-case, or neutral) can reduce social anxiety symptoms. 270 adults with elevated social anxiety will complete three online writing sessions over three weeks. Researchers will measure changes in anxie…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This pilot study in Pakistan tests a culturally adapted psychological therapy (Y-CMAP) for autistic young people aged 14-24 who have a history of self-harm. The therapy is based on cognitive behavioral therapy and includes 8-10 sessions over three months. The study will check if …

This trial tests whether a program called MyRAKAN Autism, which combines video modeling with virtual reality, can help autistic young adults improve their social communication skills. Participants attend eight sessions over five weeks, practicing skills like eye contact, conversa…

This study tested whether using a stress ball during a routine fetal checkup (non-stress test) helps pregnant women feel less anxious and more comfortable. 70 pregnant women participated. The goal was to see if this simple, drug-free tool can improve the testing experience for mo…

This study tests whether a headset that delivers tiny electrical pulses to nerves behind the ear can reduce anxiety in teens aged 12-17 with Generalized Anxiety Disorder. Sixty participants will use either the active device or a sham (fake) device for 30 minutes a day, 5 days a w…

This study tests a non-invasive brain stimulation technique called tACS in 50 children and teens aged 6-18 with ADHD. The goal is to see if a mild electrical current applied to the scalp can improve attention and executive function. Participants will receive both real and sham st…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study tests whether combining two sedatives, dexmedetomidine and esketamine, can lower the chance of delirium (sudden confusion) in older patients (60+) after surgery in the ICU. Delirium is common and can lead to worse outcomes. The trial will involve 100 participants and t…

This study tests an oral drug called SDX (serdexmethylphenidate) to see if it safely reduces excessive daytime sleepiness in adults with idiopathic hypersomnia, a condition where people feel extremely sleepy during the day despite getting enough sleep at night. Participants will …

This study tests whether watching short telenovela-style videos can reduce anxiety and boost confidence in African-American and Hispanic family caregivers of hospice patients. 62 caregivers will either watch the videos during telehealth visits or receive usual hospice care. The g…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This trial tests whether a type of talking therapy called CBT-AR can help young people aged 12 to 25 with avoidant/restrictive food intake disorder (ARFID). ARFID is an eating disorder where people avoid certain foods or eat very little, not because of body image concerns but due…

This study tests whether a mindfulness app called Headspace can help low-income parents reduce stress, anxiety, and depression. Participants use the app on their own schedule for guided meditations. Researchers measure changes in stress and mood over time to see if the app provid…

This study looks at whether berberine, a natural compound, can improve cognitive problems like memory and attention in people with schizophrenia. One hundred adults aged 18-60 will take either berberine or a placebo pill for 12 weeks, in addition to their regular antipsychotic me…

This study tested whether using a virtual reality headset showing calming scenery for 20-30 minutes could lower anxiety in parents whose children were in the hospital. 485 parents participated, and their anxiety levels were measured and compared to standard care without any tech-…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tests a group program that combines mindfulness and art therapy for adolescents with a history of abuse. The program aims to improve how teens see their bodies and reduce feelings of shame. Participants attend sessions that include meditation, creative art activities, …

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild memory or thinking problems more than exercise alone. Thirty-four participants will be followed for six months to measure changes in activity level, thinking skills…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study is testing a mobile app that gives weekly suggestions to help people with binge eating and obesity. The goal is to see which suggestions work best and in what order. About 300 adults who binge eat regularly and have a BMI of 30 or higher are taking part. The app tracks…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested whether older adults with mild cognitive impairment or early Alzheimer's can use a tablet-based brain-training app at home. 52 participants played 12 different games for 8 minutes each, daily for two weeks. The goal was to see if the app was easy to use and acce…

This study tested a new capsule called MI078 in 72 women with postpartum depression. The women took the drug or a placebo for 3 days. Researchers measured depression scores to see if the drug helps symptoms and to find the best dose. The trial is complete, and results will show i…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This study tested whether a single infusion of stem cells from donated umbilical cord tissue could improve social communication in children with autism. 137 children aged 4 to 12 took part. The main goal was to see if their socialization and communication scores improved after si…

This study tested whether an internet-based exposure therapy program can reduce distress related to physical symptoms better than standard education about healthy lifestyle habits. 161 adults in Stockholm with significant distress from somatic symptoms participated. The treatment…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This completed study tested whether taking a daily whey protein drink rich in phospholipids for 6 to 12 weeks could improve memory, mood, and overall wellbeing in healthy adults aged 25 to 49. 119 participants were randomly assigned to receive either the active supplement or a pl…

This study tested an experimental drug called CLE-100 (oral esketamine) in 99 adults with major depression that didn't get better after trying at least two standard antidepressants. Participants took CLE-100 or a placebo pill alongside their usual antidepressant for several weeks…

This study tested whether adding group music therapy to standard speech therapy helps autistic children aged 3-5 improve their language and social skills. Forty children were split into two groups: one got music therapy plus usual speech therapy, the other only speech therapy. Af…

This study tested whether special light glasses could improve sleep, concentration, and mood in university students. 39 students with sleep problems wore the glasses for three weeks. The goal was to see if different light intensities made a difference. If successful, light therap…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether watching calming nature videos through virtual reality glasses or doing progressive muscle relaxation exercises could reduce anxiety in high-risk pregnant women during a non-stress test (NST). 126 women were randomly assigned to one of three groups: VR, …

This study tested whether squeezing a stress ball or listening to music during coronary angiography (a heart imaging procedure) can lower pain and anxiety. 180 patients were randomly assigned to use a stress ball, listen to music, or receive standard care. Researchers measured an…

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This study tested whether a guided, telehealth-based aerobic walking program could improve thinking, mood, and quality of life in people who had a traumatic brain injury (TBI). Researchers enrolled 112 participants and measured changes in brain blood flow, walking ability, and me…

This study tests whether a mobile app providing education based on the Life Model can help reduce anxiety and improve daily living activities in people who have had their thyroid gland removed for benign disease. About 68 participants will either receive standard discharge instru…

This study tested whether giving electroacupuncture 30 minutes before major surgery could lower the chance of postoperative delirium (sudden confusion) in patients aged 65 to 90. Over 1,100 participants were randomly assigned to receive real or sham acupuncture. The goal was to s…

This study tested whether watching an animated educational video before a nail biopsy could reduce anxiety, improve understanding, and boost satisfaction. Thirty adults scheduled for a nail biopsy were shown the video. Researchers measured their anxiety, health literacy, and sati…

This pilot study tested a new type of brain stimulation, called accelerated intermittent theta burst stimulation (aiTBS), for people with anxiety disorders or PTSD. Fifteen participants received the non-invasive treatment targeting a novel brain area. The study measured changes i…

This study tested whether an intensive, center-based version of Pivotal Response Treatment (PRT) can improve social communication in preschoolers with autism. 75 children aged 2 to 4 years participated. The therapy combined weekly parent training with center-based sessions for a …

This study tested whether online counseling from a nurse, starting 24 hours before a colonoscopy, could help patients feel less pain and anxiety and be more comfortable. Sixty adults were split into two groups: one got standard care, the other got extra nurse support via face-to-…

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This study tested two treatments for avoidant/restrictive food intake disorder (ARFID) in 53 children and teens aged 10-18. One group received cognitive-behavioral therapy (CBT-AR) and the other received nutrition counseling. The goal was to see which approach better reduces fear…

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested an online version of Parent-Child Interaction Therapy for parents of children aged 2-7 with disruptive behaviors. Twenty-one parents received a 10-week online program with video coaching sessions. The goal was to see if this approach is feasible and acceptable, …

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This completed trial tested whether virtual reality therapy can help people with anorexia or bulimia. 96 participants either received virtual reality sessions plus usual care, or usual care alone. In the VR sessions, they created an avatar representing their 'eating disorder voic…

This completed study tested two psychological techniques—imagery rescripting and imaginal exposure—in 6 adults with obsessive-compulsive disorder (OCD) who experience distressing future-oriented images. Participants completed daily and periodic questionnaires to track symptoms. T…

This small, completed study tested whether a gentle brain stimulation technique called tDCS, combined with computer-based cognitive training, is safe and tolerable for adults with anorexia or atypical anorexia. One participant received either real or fake stimulation over 10 sess…

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tests whether watching virtual reality videos of mountains, beaches, and waterfalls before coronary angiography can lower anxiety, boost comfort, and improve patient satisfaction. Researchers will compare first-time angiography patients who use VR goggles to those who …

This pilot study tested a digital mental health program called TEPS for teens aged 12-18 with anxiety. Sixty-six participants were recruited from public libraries and randomly assigned to the digital program or usual library services. The study measured how acceptable, usable, an…

This study tested whether metformin, a drug used for diabetes, can improve cognitive problems in people with schizophrenia. 120 participants took either metformin or a placebo for 24 weeks. Researchers measured changes in thinking skills and brain scans to see if metformin helps.

This study looked at whether virtual reality exposure therapy can reduce anxiety in people with a fear of flying. 84 participants who were diagnosed with flight phobia and had a smartphone took part. The researchers measured changes in flight-related anxiety using questionnaires …

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study compared two psychological treatments—cognitive behavioral therapy (CBT) and Ericksonian hypnosis—for reducing symptoms of depression and anxiety. 45 adults with symptoms but no formal diagnosis were randomly assigned to CBT, hypnosis, or a no-treatment control group. …

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tests whether cognitive behavioural therapy for insomnia (CBT-I) can improve sleep and ADHD symptoms in adolescents aged 12 to 18 who have both ADHD and insomnia. Participants receive either CBT-I plus usual care or usual care alone. The goal is to see if addressing in…

This study tested a swimming and water safety program designed for children with autism spectrum disorder. The program uses individualized teaching methods and sensory modifications to help kids learn to swim and stay safe around water. Over 350 children with autism took part, an…

This study tested a virtual reality program called Impact VR to help youth aged 10-17 with conduct disorder learn to recognize and regulate emotions. The program involved four weekly sessions in a private setting. Researchers measured changes in callous-unemotional traits, conduc…

This study tests whether the drug mevidalen can safely improve thinking, memory, and daily function in people with mild-to-moderate Alzheimer's disease. About 300 participants will receive either mevidalen or a placebo for 26 weeks. The main goal is to see if the drug eases sympt…

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study tested a 22-minute online training program for parents of children aged 5-12 with long-term health conditions. The training taught simple skills based on Acceptance and Commitment Therapy (ACT) to help parents support their child's anxiety. Only 17 parents took part, a…

This study tests whether a new dental anesthesia pen causes less pain and anxiety than a traditional syringe in children aged 6 to 12 who need a filling. Each child will try both methods (with a two-week break in between) so they can compare the experience directly. The goal is t…

This study tested whether transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic fields to stimulate specific brain areas — can improve daily functioning in veterans with PTSD. Researchers compared real TMS to a sham (fake) treatment in 59 veterans.…

This small study tested whether a type of brain stimulation called iTBS could help people who have both hoarding disorder and depression. Fourteen adults received 20 sessions over 4 weeks. Researchers measured changes in hoarding and depression symptoms, as well as brain connecti…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tests whether Snoezelen multisensory therapy — a calming, personalized experience using lights, sounds, textures, and scents — can reduce agitation, depression, and anxiety in older adults with dementia. Sixty participants with mild to moderate dementia will receive ei…

This study compared an online yoga program with an online behavioral therapy for adults with depression. Over 500 participants were randomly assigned to either yoga or therapy for 12 weeks. Researchers measured depression symptoms and well-being at several points to see which app…

This study tests whether immersive virtual reality (VR) can safely help people with schizophrenia improve their thinking skills, reduce symptoms, and function better in daily life. Forty adults with schizophrenia or schizoaffective disorder will either receive VR-based cognitive …

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This study tests whether an 8-week choral singing program can improve the well-being of nursing home residents with dementia. Participants attend one 75-minute group singing session each week, plus a dress rehearsal and final concert. Researchers measure changes in stress hormone…

This study tested whether a 7-minute paced breathing exercise (6 breaths per minute) could reduce anxiety and stress in 30 adults before outpatient GI procedures like colonoscopy. Participants used a noninvasive vibratory device in the waiting room. Researchers measured changes i…

This study looked at whether holding powerful poses before exposure therapy can increase testosterone levels and make treatment for social anxiety more effective. 73 adults with social anxiety disorder participated. The goal was to see if this simple change could help people feel…

This study tested whether a simple computer task, called the Approach Avoidance Task (AAT), could help smokers quit. The task aims to change automatic, unconscious thoughts that make people want to smoke. 52 daily smokers who wanted to quit took part. Researchers measured changes…

This study tested whether D-cycloserine, an antibiotic that helps the brain unlearn fear, can improve cognitive-behavioral therapy (CBT) for social anxiety. 152 adults with social anxiety took either D-cycloserine or a placebo before or after their therapy sessions. Researchers w…

This study tested whether Collaborative Problem Solving (CPS), a behavioral approach that teaches caregivers to address children's underlying thinking skill deficits, can improve executive function and reduce behavioral symptoms in 54 youth receiving home-based mental health care…

This study tested whether combining a gentle brain stimulation technique called tDCS with memory and thinking exercises could help people with early Alzheimer's. Twenty-two participants received either real or fake stimulation during 10 sessions of cognitive training. Researchers…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This study tested whether a 10-session Dialectical Behavior Therapy (DBT) skills program could reduce rumination (repetitive negative thinking) and cognitive avoidance (avoiding difficult thoughts) in middle-school teachers. Thirty-four female teachers in Iran took part, with hal…

This study tested whether a computer joystick task that trains people to avoid smoking-related images can help them quit smoking when added to standard care. 96 daily smokers who wanted to quit participated. The training aimed to change automatic, unconscious tendencies to approa…

This study investigates whether an 8-week yoga program can help female smokers manage stress and nicotine withdrawal when trying to quit. Participants attend two 60-minute yoga sessions per week and provide hair and saliva samples to measure stress hormones. The goal is to see if…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This study tested whether a drug called isradipine, combined with virtual reality scenes of smoking, could lower cigarette cravings. 78 daily smokers took part. The goal was to see if this approach could help people quit smoking by reducing their urge to smoke when faced with tri…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study tested whether osteopathic manual therapy (a hands-on treatment) could reduce symptoms of alcohol withdrawal in hospitalized adults. 26 patients were enrolled and their withdrawal symptoms were measured using standard questionnaires. The goal was to see if adding osteo…

This study tested two ways to improve dental care for children with autism. One group received a dental toolkit with tips and resources. The other group got the toolkit plus special parent training to help with brushing and dentist visits. The goal was to see if the extra trainin…

This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, alon…

This study looked at whether a recreational ballet program called Ballet for all Kids can help children with autism spectrum disorder (ASD) improve their motor skills. 32 children aged 6-12 with ASD participated in the program for 12 weeks. Researchers measured changes in coordin…

This study tested if a social robot could help children aged 4-12 with chronic diseases feel less fear and pain during a blood draw. 90 children were split into three groups: one that played with a robot, one that played a digital game, and one that received standard care. The go…

This study tested whether watching telenovela-style educational videos can help family caregivers of hospice patients feel more confident and less anxious. 59 caregivers participated over 8 weeks. The approach used weekly video lessons during regular hospice visits.

This study tested a 12-week music therapy program for 76 care home residents with dementia or cognitive impairment. Residents received individual music therapy sessions, and staff were trained to use music techniques. The goal was to see if music therapy could reduce unmet care n…

This study tests whether adding a caregiver training program to a visual mapping assistive technology (MapHabit) improves daily life for people with Alzheimer's or dementia and reduces stress for their caregivers. Fifty patient-caregiver pairs will use either the technology alone…

This study tested whether giving oral probiotics to adolescents before non-cardiac, non-digestive surgeries could reduce anxiety and depression afterward. 150 teens aged 12-17 were randomly assigned to receive either probiotics or a placebo. Researchers measured anxiety and depre…

This study looked at whether art therapy can reduce anxiety and improve mental strength in people with chronic kidney disease who are on hemodialysis. Eighty adults who had been on dialysis for at least six months took part. The results measured changes in anxiety and psychologic…

This study tested a virtual reality (VR) program designed to stimulate thinking skills in 45 people with mild cognitive impairment. Participants used VR headsets to do tasks like virtual shopping and recipe sequencing over 8 sessions. The goal was to see if the VR program was eas…

This study tested whether low-intensity ultrasound waves aimed at a specific brain area could help reduce negative symptoms of schizophrenia, such as lack of motivation and social withdrawal. 78 adults with stable schizophrenia received either real or fake ultrasound over 20 days…

This study tested a mobile app called EASE to help people manage anxiety and depression during the COVID-19 pandemic. It included 822 adults who identified as Black, Hispanic, or American Indian and had significant anxiety or depression symptoms. The app provided symptom tracking…

This completed study tested a combination of music therapy, health education, and physical exercise in 20 older adults (over 60) living in Valencia who felt unwanted loneliness. The goal was to see if these group activities could reduce loneliness and improve mental health. Becau…

This study tested if immersive virtual reality (VR) can improve memory and thinking in people with Alzheimer's disease. 33 participants wore VR headsets to explore scenes from 1960s Burgos, Spain, designed to trigger personal memories. Researchers measured changes in cognitive te…

This study looked at whether a web-based program called webSTAIR, which teaches skills to manage emotions and relationships, is feasible and helpful for people with PTSD who are on a waitlist for behavioral health treatment. Seventy adults from a hospital clinic in Boston took pa…

This completed trial tested whether a 4-week mindfulness program delivered via smartphone app could reduce anxiety and stress in college students. 289 students participated, practicing daily mindfulness exercises. The study measured changes in anxiety levels and perceived stress …

This study tested a structured online program for parents of children with autism or ADHD. 90 families took part to see if the program could lower parental stress, improve coping skills, and boost social support. Researchers compared parents who received the program to those who …

This study looked at whether giving a special therapy called EMDR to people in the emergency room right after a traumatic event could help prevent post-traumatic stress disorder (PTSD). About 110 adults who were at high risk for PTSD took part. The therapy uses eye movements to h…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested a non-invasive brain stimulation technique called rTMS, guided by each person's unique brain activity map, to see if it could improve thinking and memory in 46 people with mild Alzheimer's disease. Participants received either real or fake (placebo) stimulation …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study tested whether a gentle ear stimulation technique could reduce stress and anxiety in healthcare workers during the COVID-19 pandemic. 62 workers were randomly assigned to receive the stimulation or be placed on a waiting list. The goal was to see if this simple, non-dr…

This study tested a virtual reality app called StoryTelling Medicine (STM) to see if it could reduce anxiety in children aged 8–13 before elective surgery. The app guides kids through hospital settings in a fun, interactive way. Researchers measured anxiety, heart rate, and stres…

This pilot study tested whether a gentle brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment. Participants received either real or sham stimulation over 10 sessions across two weeks. The goal was to see…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested whether wearing virtual reality glasses during a common kidney stone treatment (ESWL) can lower patients' pain, anxiety, and improve comfort. Seventy adults undergoing the procedure for the first time took part. Researchers measured pain, anxiety, and comfort le…

This study tested whether acupressure—a technique using gentle pressure on specific points on the body—can reduce anxiety, embarrassment, and fear in people undergoing a bladder function test called urodynamics. Sixty-eight adults were randomly assigned to receive either acupress…

This study tested a gentle brain stimulation technique (HD-tDCS) combined with computer-based memory exercises in 60 people with early Alzheimer's. The goal was to see if this combination could improve thinking and memory more than either treatment alone. Researchers also used br…

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested whether personalized magnetic brain stimulation (TMS) is safe and helpful for people with early Alzheimer's disease. Forty participants received either real or fake TMS to see if it could improve memory and thinking. The goal was to find a non-drug way to ease s…

This study tested a shorter version of Cognitive Processing Therapy (CPT) for Veterans with PTSD. Many Veterans drop out of the standard 12-session therapy, missing the most helpful parts. The goal was to find which therapy components work best and deliver them in fewer sessions …

This study tested whether listening to Baroque music for 30 minutes could reduce anxiety in 18 adults with major depressive disorder. Participants listened to a specially chosen set of Baroque pieces, and their anxiety levels were measured before and after. The idea is that the m…

This study tested two smartphone-based digital treatments alongside standard medication for people with schizophrenia who struggle with low motivation and lack of pleasure. Over 460 adults and teens took part for 16 weeks. The goal was to see if these apps could ease these tough …

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This study tested whether a chatbot providing instant messaging support via WhatsApp could help adult smokers in Hong Kong quit. Over 1,000 participants received either brief advice plus chatbot support or brief advice alone. The goal was to see if the chatbot led to higher quit …

This pilot study tested whether a mindfulness program could help veterans with chronic pain and thoughts of suicide. 76 veterans took part to see if the program was acceptable and could reduce pain, depression, and suicide risk. The goal was to improve quality of life and daily f…

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This study tested a program based on Acceptance and Commitment Therapy (ACT) for 64 caregivers of people with mental disorders. The program aimed to help caregivers build psychological resilience, manage stress better, and feel less burdened. Results showed that those who took pa…

This small pilot study tested whether a daily probiotic (Lactobacillus rhamnosus) could reduce abdominal pain and anxiety in children aged 9 to 13. Nine children who had both anxiety and stomach pain took the probiotic for 30 days. Researchers measured changes in pain and anxiety…

This study tested a short therapy called Painhunting for adults in Kazakhstan who felt depressed after a stressful life event, like losing a loved one. 84 people were randomly assigned to get the therapy right away or join a waitlist. The therapy involves up to six one-on-one ses…

This study tested whether using magnetic pulses (rTMS) on the brain while people recall their traumatic memories can reduce PTSD symptoms. 39 adults with PTSD for at least 3 months received either 10Hz or 1Hz rTMS over 2 weeks. Researchers measured changes in PTSD severity using …

This study tested a prescription smartphone app called RiSolve for women with overactive bladder (OAB). The app provides an 8-week program of bladder training, pelvic floor exercises, and digital cognitive behavioral therapy. Researchers enrolled 46 women in Ireland to see if the…

This study tested whether a herbal supplement called Redormin 500 (made from valerian and hop extracts) can help people with occasional sleep problems think more clearly during the day and feel better overall. Forty healthy adults with mild sleep issues took either the supplement…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This study looked at whether motivational interviewing, a type of counseling that boosts inner motivation, can help nursing students feel less anxious and more confident about their clinical practice. 66 first-year nursing students took part in a randomized trial. The goal was to…

This study tested whether a treatment called radiofrequency, combined with a special massage, can reduce pain during sex that starts after having a baby. 80 women who had pain 4 to 12 months after giving birth took part. The goal was to see if this approach could lower pain and i…

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study tested a program called ASPEN, which coaches parents of young children with autism in low-resource communities. The program includes 12 sessions teaching parents strategies to improve their child's social communication and play skills, while also reducing parenting str…

This study tested whether task-specific electrical stimulation can improve upper limb motor skills in 30 children aged 4 to 7 with spastic quadriplegia cerebral palsy. The therapy uses mild electrical pulses to activate muscles during functional tasks. The goal was to see if this…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study tested whether Caplyta (lumateperone), a drug already used for other mental health conditions, can reduce symptoms of borderline personality disorder (BPD). Sixty adults with BPD received either Caplyta or a placebo pill for 8 weeks. Researchers measured changes in BPD…

This study tested whether a natural supplement called ultramicronized palmitoylethanolamide (umPEA) can improve smell, taste, and other sensory issues in children with autism. Eighty children took either umPEA or a standard treatment (probiotics plus omega-3) for six months. Rese…

This study tested a type of talk therapy called Behavioral Activation (BA) in 10 U.S. veterans who have both alcohol use disorder and PTSD. BA helps people change their daily activities and thinking to reduce drinking and PTSD symptoms. The study compared BA to another therapy ca…

This study tested a device called Reacor that uses biofeedback to teach mindfulness by showing your heart rate and brain waves in real time. 188 adults with anxiety disorders were split into three groups: biofeedback alone, the medication escitalopram alone, or both together. The…

This completed Phase 2 trial tested whether a drug called sunobinop can reduce alcohol cravings in people with moderate to severe alcohol use disorder who want treatment. Forty participants took either sunobinop or a placebo pill daily. Researchers measured cravings using questio…

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took …

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study looked at whether adding game elements to tai chi can improve thinking skills and reduce challenging behaviors in children with autism. About 100 children aged 9 to 12 took part. They were split into three groups: one did gamified tai chi, one did regular tai chi, and …

This study tests whether a smartphone app can help reduce negative symptoms of schizophrenia, such as lack of motivation and pleasure. It includes 73 adults and older teens who already completed a previous trial with the same app. Participants use the app for 16 weeks alongside t…

This early-phase study tested whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could reduce withdrawal symptoms in 25 adults with opioid use disorder who were gradually reducing their methadone dose. Participants received either real HBOT at two …

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study tested how different warning labels (pictorial vs. text-only) and flavor descriptors (sweet vs. none) on little cigar and cigarillo packages affect people's attention and emotional reactions. Researchers used eye tracking and skin sensors on 90 adult tobacco users. The…

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This completed early-phase study looked at how opioid use disorder changes the way people make decisions. Twelve adults with moderate to severe opioid use disorder completed gambling tasks and had brain scans while receiving oxycodone, placebo, or remifentanil. The goal was to un…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological therapy at a health center, and another where they also receive community support to encourage them to seek and…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This study looks at whether a smartphone-based program can help veterans with depression begin and continue mental health treatment. Researchers will analyze medical records to find out who struggles to engage in care, then test an eHealth tool that lets veterans track their mood…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study tests whether an 8-hour digital learning program using virtual reality (VR) and augmented reality (AR) can improve dementia care knowledge, attitudes, and teamwork among long-term care professionals. About 150 staff from 12 care institutions in Taiwan take part, with s…

This study looked at how schizophrenia affects physical activity, balance, muscle strength, and thinking skills. Researchers measured these abilities in 35 adults diagnosed with schizophrenia. The goal was to better understand the challenges patients face, which could help improv…

This study adapts an existing advocacy program, called ASSIST, for Latinx families of autistic youth aged 12 and older. The program teaches parents how to advocate for adult disability services, aiming to improve access to care. Researchers will test the adapted program with 48 S…

This study tests whether suvorexant (Belsomra), a sleep medication, can lower brain activity linked to cannabis cravings. Twenty adults who use cannabis daily will take the drug for 14 days and undergo brain scans before and after. The goal is to see if the medication reduces the…

This study looks at whether people with dyssynergic defecation—a condition where the pelvic muscles don't relax properly during bowel movements—are more likely to have psychiatric disorders like anxiety or depression. Researchers will compare 148 patients to healthy volunteers us…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This trial compares two high-intensity training programs—CrossFit and running-based HIIT—in elite male distance runners who live and train at moderate altitude. Over six weeks, participants train five days per week and undergo tests for aerobic fitness, strength, and blood marker…

This study tested a harm reduction program designed specifically for Black adults who misuse opioids or stimulants. 63 participants completed surveys before and after the program to see if their knowledge, confidence, and willingness to use overdose prevention techniques improved…

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study looked at two specific proteins in the blood of people with bipolar disorder during a manic episode and compared them to healthy volunteers. The goal was to see if these proteins, which are linked to inflammation and brain cell communication, could help explain the con…

This study looks at whether certain antibiotics given before surgery are linked to postoperative delirium in adults over 65 having elective non-cardiac surgery. Researchers will track antibiotic use and check for delirium twice daily. The goal is to provide safety evidence to gui…

This study looked at levels of a specific enzyme, α-N-acetylgalactosaminidase, in the blood of people with panic disorder who had never taken medication. Researchers compared these levels to healthy individuals and checked for connections with symptom severity and inflammation. T…

This study examines whether levels of a blood enzyme called α-N-acetylgalactosaminidase differ between people with schizoaffective disorder during acute episodes and those in remission, compared to healthy individuals. The goal is to better understand the biological processes beh…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This completed Phase 2 study tested whether a special PET scan using a tracer called UCB-J can measure synaptic density—the connections between brain cells—in people with Alzheimer's disease. Researchers scanned 100 participants across different stages, from healthy to dementia, …

This study used brain scans to see if heavy drinking causes inflammation in the brain and how that affects memory and thinking. 74 adults aged 30-75, including heavy drinkers and healthy volunteers, had PET and MRI scans along with thinking tests. The goal was to measure brain in…

This completed study looked at how the brain processes reward signals to improve mood in people with depression. Researchers used brain scans, a mild magnetic stimulation technique (TMS), and a single injection of buprenorphine (a painkiller) to see how these affect brain activit…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This study looked at whether doing short, frequent exercise sessions (called 'exercise snacks') is better for your mental health than doing longer, less frequent workouts. 180 healthy young adults were split into two groups: one did six 15-minute cycling sessions per week, the ot…

This study looked at whether a 12-hour online training course in psychological first aid (based on the RAPID model) could improve people's communication and listening skills. Ten participants completed the training and were tested before and after. The goal was to see if such tra…

This study looks at whether children with ADHD are more likely to have very flexible joints (benign joint hypermobility) and if a certain blood marker differs. Researchers will compare 171 children aged 6 to 12—some with ADHD and some without—using physical exams and blood tests.…

This study tested whether three weekly sessions of basic disaster awareness education could improve disaster literacy and reduce earthquake anxiety in adolescents aged 10-14. A total of 128 students from two middle schools in Erzincan took part, with half receiving the education …

This completed study looked for genetic changes linked to autism spectrum disorder in over 1,600 participants. Researchers focused on genes involved in brain cell communication, hoping to understand which biological pathways are involved. The goal was to gather knowledge that cou…

This study tested a two-day training program designed to help newly graduated nurses speak up about patient safety concerns. 76 nurses from a hospital in Ankara, Turkey, were split into two groups: one received the training, the other did not. Researchers measured changes in comm…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study from Nantes University Hospital looked at 144 people to see if there is a link between materialism (how much someone values money and possessions) and problem gambling. Researchers compared a group of problem gamblers with a group of non-problem gamblers usin…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study developed and tested a new questionnaire called the Excessive Emotional Behaviors Scale (EEBS) for Chinese adults experiencing anxiety or depression. Researchers interviewed 18 people and surveyed 637 participants to refine the scale, which measures behaviors like avoi…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This completed study looked at the experiences of 275 extended family members (like grandchildren, siblings, and nieces/nephews) who care for a person with dementia. Researchers interviewed caregivers about their daily tasks, stress, and use of support services. The goal is to us…

This study looked at whether brain activity patterns can predict how well people with major depression or social anxiety respond to cognitive behavioral therapy (CBT). Over 200 participants were randomly assigned to 12 weeks of CBT or supportive therapy. Researchers measured brai…

This study tested a 10-week emotional intelligence program for first-year college students aged 18-25. The program aimed to improve how students identify, understand, use, and manage emotions. Researchers measured changes in emotional attention, clarity, and regulation, as well a…

This study explored whether experiencing subtle racial slights (microaggressions) makes Latinx smokers want to smoke more or makes it harder to quit. Thirty daily smokers who identified as Hispanic or Latino took part. Researchers measured their smoking behavior, withdrawal sympt…

This study tests a tool called the Cultural Formulation Interview-Engagement Aid (CFI-EA), designed to help clinicians and patients from different cultural backgrounds communicate better. The goal is to see if using this tool improves patient satisfaction and keeps people in trea…

This study measured the activity of an enzyme called glucocerebrosidase in 236 people with and without Lewy body dementia. The goal was to see if lower enzyme activity could help identify patients who might benefit from treatments already used for Gaucher disease. The study did n…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study tested a culturally tailored mental health training called First Face for Mental Health in seven Tribal nations. Over 550 participants completed surveys before and after training to see if it increased knowledge, confidence, and ability to help during a mental health c…

This study tested whether a role model-based ethics course could reduce moral injury and stress in 101 second-year medical students in Taiwan. Students chose between a standard version with stories and handouts, or an enhanced version with extra writing and guest speakers. Resear…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at 6 children with past PTSD to see if changes in attention and memory could predict a relapse. Researchers used computer tasks and standard tests to measure brain function. The goal is to find early warning signs so families can get help sooner.

This study looks at 65 veterans with PTSD who use cannabis frequently. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—participants simply report their cannabis use and well-being…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a ne…

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This study compared two types of orthodontic appliances—removable braces and clear aligners—in 24 children aged 6 to 12 with crossbite. Researchers measured changes in speech, oral hygiene, pain, anxiety, and quality of life over two weeks. The goal was to understand how each app…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study surveys anesthesiologists to explore whether feelings of being a fraud (impostor phenomenon) are linked to everyday memory and attention lapses. Participants complete online questionnaires about impostor feelings, cognitive failures, anxiety, depression, sleep quality,…

This study tested a digital app called CICADAS, designed to improve thinking skills in teenagers with autism. Sixty-eight teens aged 11-18 used the app for up to 40 hours, doing exercises that adapt to their ability. The goal was to see if the app is acceptable and easy to use, n…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This study tested a 6-week museum-based programme called 'Refresh and Reconnect!' for older adults with mild cognitive impairment or mild dementia. Participants took guided tours and joined artist-led activities like dance, art, or drama. Researchers measured changes in quality o…

This completed study in Norway looked at how opioids like morphine, oxycodone, and fentanyl affect patients' mood and pain right before surgery. Over 1,000 healthy adults scheduled for day surgery answered questions about anxiety, relaxation, and pain after receiving a small dose…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. R…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study tested whether using augmented reality (AR) or a 3D hip model helps first-year nursing students learn how to give intramuscular injections better than traditional methods. 146 students were randomly assigned to practice with AR, a 3D model, or a standard model. Researc…

This study tests whether recalling a positive memory can improve mood and decision-making in 80 adults recovering from methamphetamine use disorder. Participants will do computer tasks and brain scans before and after remembering a happy event or a neutral memory. The goal is to …

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked at 15 people with depression who experienced temporary dissociative states (feeling disconnected from reality) while taking Esketamine. Researchers used interviews to understand these experiences better. The goal is to learn more about this side effect to improv…

This study looked at how much intravenous (IV) medication is wasted in intensive care units (ICUs) across France. Researchers measured the amount of prepared but unused drugs thrown away, which can harm the environment. Over 1,000 patients took part, and the goal was to find ways…

This study watched 60 adults getting electroconvulsive therapy (ECT) for severe depression to see if their need for anesthesia changed over multiple sessions. Researchers measured the dose of anesthetic used each time and how it related to seizure quality and recovery. No new tre…

This study looked at what makes it hard for new moms with postpartum depression to get mental health care, especially online. Researchers interviewed 10 women and then tested a virtual patient navigation program with 26 moms over 2 months. The goal was to see if the program was e…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This study tested whether a computer program could predict which older patients (over 75) would have unnecessary days in the hospital. Researchers analyzed electronic health records from 102 patients in an acute geriatric unit. The goal was to create an algorithm that flags when …

This completed study looked at how adults with autism spectrum disorder (ASD) process emotions in moral situations, compared to people without autism. Researchers used stories about harm and accidents, then asked participants to quickly identify faces or judge if facial expressio…

This study tested a program designed to make medication for opioid use disorder more culturally appropriate for American Indian and Alaska Native communities. Researchers worked with four healthcare sites to help them better support patients starting and staying on these medicati…

This study looked for hidden genetic changes in 10 children with developmental delays who had a balanced chromosomal translocation (a rearrangement of DNA that appears normal under a microscope). Researchers used high-resolution DNA microarrays to check for tiny missing or extra …

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study looked at how much injectable drug is prepared but not used in operating rooms across France. Over 3,700 patients were included. The goal was to measure waste and find ways to reduce it, helping the environment and improving healthcare practices.

This study tested a brief digital alcohol intervention for smokers who drink heavily. Participants enrolling in a smoking cessation program through an online portal were offered the intervention if they scored high on a drinking questionnaire. The main goal was to see how many pe…

This study looked at how people with schizophrenia process sounds and remember where information comes from. Researchers tested 50 participants (patients and healthy controls) using computer tasks. The goal was to understand if trouble telling sounds apart relates to difficulty d…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study tested whether oxytocin nasal spray helps people with social anxiety disorder learn safety from watching others. About 120 adults received either oxytocin or a placebo and underwent brain scans. The goal was to see if oxytocin improves the brain's ability to tell threa…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This study surveyed 186 adults with sickle cell disease in the U.S. to learn how the COVID-19 pandemic impacted their stress, anxiety, pain, and healthcare use. Participants completed online questionnaires about their medical history, mental health, and experiences during the pan…

This completed study looked at 1,740 newly married couples to see if the bacteria in their mouth, eyes, and gut are linked to sleep problems, vision issues, and mood. Participants provided samples and completed surveys about sleep, anxiety, depression, and dry eye symptoms. The g…

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether listening to upbeat music can change how people with depression perceive emotions in faces and voices. Researchers compared the effects of positive and neutral music in 39 adults with and without depression. The goal was to see if positive music could…

This study looks at why young women with anorexia nervosa lose bone density. Researchers will compare 160 patients with 160 healthy women to measure bone mass and check hormones and other markers. The goal is to find the key factors behind bone loss, which could lead to better tr…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study compared two types of radiation for people with 11 to 20 brain tumors that spread from other cancers. One group got Gamma Knife radiosurgery, which targets each tumor precisely. The other got whole brain radiation, which treats the entire brain. The goal was to see whi…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This study looked at 128 physiotherapy students to see if taking an academic literacy class helped with their reading, writing, and thinking skills. Researchers compared students who took the class to those who did not using surveys. The goal was to understand if such education b…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at two ways to assess ADHD in children aged 8-17: a brief protocol (medical history, interview, rating scales) and a comprehensive one that also includes neuropsychological testing. Researchers wanted to see if the shorter method is as reliable, valid, and cost-…

This study investigates whether chronic cannabis use impairs contrast sensitivity — the ability to see objects clearly against their background, especially when they are moving. Researchers will compare three groups: cannabis addicts, tobacco-only smokers, and non-smokers. Partic…

This pilot study tested a community-based intervention for people with psychosis in Malawi, Nigeria, Sierra Leone, and Zimbabwe. The program includes peer support from someone who has experienced psychosis, case management, and help with daily activities like finding work or soci…

This study looked at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers collected samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotiona…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This completed early-phase study at Yale University tested how different doses and delivery rates of IV nicotine affect its abuse potential and its ability to reduce smoking urges. Twenty daily smokers received low and high doses of nicotine at various speeds. The goal was to bet…

This study tested whether a 6-session online class called HEARTS helps autistic adults feel more satisfied with their friendships and dating relationships, compared to a 6-week online discussion group. Ninety-two autistic adults took part over three months, completing surveys abo…

This study tested a family navigator program and a smartphone app to help low-resourced families of young children (ages 3-5) with autism find and access services. 52 families took part. The program aimed to improve parents' knowledge, skills, and confidence in getting support fo…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This study looked at whether chewing gum before eating ice cream affects how much people eat. Twenty normal-weight adults who liked mint chocolate chip ice cream took part. They either chewed mint, cinnamon, or no gum before a computer task where they earned ice cream. The main g…

This study looked at whether combining two existing drugs—duloxetine (an antidepressant) and methylphenidate (an ADHD medication)—could reduce the desire to drink alcohol in people with alcohol use disorder. Nineteen adults who were not seeking treatment participated in a lab set…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at how stress and negative emotions influence decision-making and eating behavior in women with binge-eating disorder. Researchers used brain scans to understand activity in reward and self-control areas during everyday choices. The goal was to learn more about …

This study looked at whether an adaptive e-learning course on urgent medical conditions could reduce anxiety and improve skills in junior doctors starting work in emergency departments. 233 new doctors were randomly assigned to either take the course in their first six weeks or r…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This study tested a training program for prenatal healthcare providers to help them use medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers looked at data from over 1,000 patients to see if the program increased use of MAT and improved health…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…