Psychiatric disorder

This trial tests whether online group dialectical behavioral therapy (DBT) is as effective as traditional face-to-face group DBT for women with bulimia nervosa. Participants will be randomly assigned to either 12 weeks of online or in-person group therapy, and researchers will co…

This study tests whether the nicotine concentration in vape pods affects how well smokers can quit. 312 adult smokers who want to quit will use either low or high nicotine salt e-liquids for three months, plus receive counseling. The goal is to see if higher nicotine levels lead …

This study tested a new way to stimulate the brain in people addicted to amphetamines. Nine adults received closed-loop transcranial alternating current stimulation (tACS), which adjusts the stimulation based on their real-time brain activity. The goal was to improve executive co…

This trial tests whether Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy can improve fine motor skills in children aged 2-6 with developmental delays. Participants receive either MNRI sessions or standard care for four weeks. The study measures changes in hand funct…

This trial tests whether letting smokers adjust their own nicotine patch dose—based on their smoking history and withdrawal symptoms—helps them stay smoke-free longer than the standard fixed-dose patch. Adult smokers who smoke at least 10 cigarettes a day and are motivated to qui…

This trial tests an experimental medicine called BI 1569912 in adults aged 18 to 65 with major depressive disorder whose current antidepressants aren't working well enough. Participants take a single dose of the drug or a placebo, in addition to their usual antidepressant, and ar…

This study tests whether adding DIR/Floortime—a child-led, relationship-based therapy—to standard care helps children aged 4-12 with mild-to-moderate autism improve emotional, social, communication, and daily living skills. Half the children receive the 10-week Floortime program …

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This study tests an updated version of the BRITE app, called ViraBrite, which sends suicide safety planning materials and coping skills to teens when they are feeling high emotional distress. Twenty teens who have recently attempted suicide or had suicidal thoughts with a plan wi…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This pilot study tests whether combining ketamine injections with talk therapy is a safe and acceptable way to treat moderate-to-severe methamphetamine use disorder in 17 publicly insured patients, some of whom have or are at risk for HIV. Participants receive three monitored ket…

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This trial tests whether different intensities of breathing exercises (inspiratory muscle training) can improve diaphragm function, thinking, sleep, and mood in young adults aged 18-25 who have low muscle mass. Participants will be randomly assigned to high-intensity, moderate-in…

This trial tests an 8-week online coaching program that teaches parents of preschool autistic children how to use everyday interactions to boost their child's social communication. Families are randomly assigned to either the coaching program or a waitlist, and the study measures…

This trial tests a Family Mental Health Navigator (FMHN) program for publicly insured youth aged 6-17 who are already receiving services at a San Francisco hospital. The program pairs families with a navigator who uses mobile health tools to help them get referrals and start trea…

This trial tests whether levetiracetam, a drug used for seizures, can reduce overactivity in the hippocampus—a brain area linked to memory—and improve cognitive function in people with schizophrenia or schizoaffective disorder. Participants receive either levetiracetam or a place…

This completed study tested Igalmi, a fast-dissolving film placed under the tongue, for managing frequent agitation in people with schizophrenia or bipolar disorder. 29 adults received the drug as needed for 7 days in a clinic. Researchers looked for signs that the drug might sto…

This trial compares two psychological treatments for obsessive-compulsive disorder (OCD): metacognitive therapy, which focuses on changing unhelpful thinking patterns, and exposure and response prevention, the current standard behavioral therapy. The study aims to see if metacogn…

This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help adults with alcohol use disorder when added to their usual treatment. Nine adults will receive 10 sessions of stimulation over the right frontal brai…

This study tests whether adding the sleep medication suvorexant to standard buprenorphine treatment can improve sleep and medication adherence in people with opioid use disorder who have recently used fentanyl. Participants first stay in a residential setting for five days to sta…

This first-in-human study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The drug is an antibody that targets PD-L1, a protein involved in immune regulation. The main goal was to check safety and how the drug moves through the body, not yet to pro…

This study tested whether giving caregivers prize draws for attending court hearings, treatment sessions, and probation meetings could reduce substance use and delinquency in teens already in juvenile drug court. Fifty-three teens aged 13-17 and their caregivers took part. The go…

This trial tests whether a digital clinic, delivered through a smartphone app, can improve health outcomes for people with alcohol-associated liver disease (ALD) and alcohol use disorder (AUD). Participants' doctors are randomly assigned to refer them to this digital platform in …

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests whether adding Gottman couple therapy to usual depression treatment helps women with major depressive disorder who are in distressed relationships. The therapy focuses on improving communication and emotional connection between partners. Researchers will compare …

This study tests whether an AI-based decision support tool can help therapists deliver internet-based cognitive behavioural therapy (iCBT) for depression, panic disorder, and social anxiety. About 400 adults with these conditions will receive 12 weeks of iCBT, with therapists usi…

This study tested a program that combines community-based fetal ultrasound with care navigation to help pregnant women with substance use disorder engage in prenatal care and substance use treatment. The program used motivational interviewing and strength-based education to suppo…

This trial tests whether a non-invasive technique called transcranial electrical stimulation (tES) can help reduce ADHD symptoms and improve thinking skills in children and teenagers aged 7 to 18. The approach uses low-intensity electrical currents applied to the scalp to gently …

This pilot study tests whether a coordinated care program can help people with alcohol-related liver disease access addiction and mental health services more easily. The program brings together liver specialists, addiction medicine, and psychiatry to streamline referrals and care…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests whether aripiprazole, a medication already used for behavioral symptoms, remains safe and tolerable for children and adolescents with autistic disorder when taken daily for up to a year. Most participants will have already completed a short-term trial of the drug…

This study tests a refined computer alert that prompts emergency room doctors to order a consultation with an addiction counselor for patients with opioid use disorder. Researchers will enroll 300 adults with moderate to severe opioid use disorder who visit the ER. The goal is to…

This trial tests four family-oriented counseling programs designed to support children and adolescents (ages 3-18) who have a parent with a mental illness or addiction. The programs range from brief therapy for children showing signs of distress to preventive sessions for those w…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…

The BEAT-AD study is testing whether a low-carb, high-fat ketogenic diet can improve thinking and memory in 120 adults with mild cognitive impairment, a precursor to Alzheimer's. Participants are randomly assigned to either a ketogenic diet or a low-fat diet for 16 weeks, with fo…

This trial tests whether a daily supplement called WeNatal For Him can improve markers of male fertility, including sperm quality, testosterone levels, energy, and libido. Forty men aged 30 and older who report low energy and low libido will take three capsules each morning for t…

This trial tests whether a probiotic called Weizmannia coagulans BC99 can improve liver function in people who have been heavy drinkers for at least a year. Participants take either the probiotic or a placebo daily for 60 days. Researchers measure changes in liver enzymes and gut…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial tests whether video-based teleconsultation counseling can help people stop smoking as effectively as traditional face-to-face clinic visits. About 68 adults who smoke will receive either teleconsultation or in-person counseling, with researchers tracking quit rates, cr…

This trial tests whether a structured psychoeducation program based on the solution-focused approach can improve self-efficacy, psychological well-being, and addiction outcomes in adults with substance use disorder. Participants who have completed detoxification are randomly assi…

This trial tests whether an experimental drug called KH607 can reduce symptoms of postpartum depression in adult women. Participants take the drug or a placebo once daily for two weeks. The study measures changes in depression scores to see if KH607 offers a safe and effective sh…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This phase 2 trial is testing whether an experimental antibody called bepranemab can slow the progression of Alzheimer's disease in people with early-stage symptoms. Participants receive either bepranemab or a placebo by intravenous infusion over 80 weeks. The study measures chan…

This phase 3 trial is testing whether the experimental drug lumateperone can safely reduce manic symptoms in adults hospitalized with bipolar I disorder who are currently experiencing a manic or mixed episode. Participants will receive either lumateperone or a placebo daily for s…

This trial uses brain scans to see whether 8 weeks of mindfulness-based group therapy changes how the brain processes reward, craving, and self-control in people with heroin addiction. About 157 adults on medication for opioid use disorder will be randomly assigned to mindfulness…

This study tests a program called Compassionate Mind Training for Teachers (CMT-T) to see if it can reduce depression, anxiety, and self-criticism in elementary school teachers. Forty teachers from public schools in Aracaju, Brazil, will take part in group sessions that include m…

This study looks at whether taking two approved medicines together—escitalopram for depression and atorvastatin for high cholesterol—can improve both mood and blood fat levels in adults. Participants are adults diagnosed with both a depressive episode and mild-to-moderate dyslipi…

This study tests whether a type of talk therapy called cognitive behavioral therapy (CBT) can help teenagers with panic disorder. The therapy includes 11 weekly sessions designed to change how teens think about and react to panic symptoms. Participants track their anxiety daily. …

This study tests whether an intensive, 8-day form of cognitive behavioral therapy (CBT) can help adolescents with panic disorder and agoraphobia. The therapy includes 15-20 hours of one-on-one sessions focused on changing anxious thoughts and gradually facing feared situations. S…

This study tests whether personalized motivational text messages can help adults with anorexia nervosa increase their motivation to change and their calorie intake. Participants receive these texts alongside cognitive behavioral therapy (CBT), which is provided at no cost. The st…

This study tests whether a virtual reality program, based on the transtheoretical model of behavior change, can help university students quit smoking. Participants will use VR goggles to practice coping skills in realistic scenarios. The goal is to see if this training boosts the…

This study explores whether eating fewer ultra-processed foods (like packaged snacks and fast food) can help lift mood in people with moderate-to-severe depression. Participants either receive meal kits with minimally processed foods or get nutritional guidance only. The study al…

This study tests whether a smartphone app called Brain Safe can help older adults reduce their use of strong anticholinergic medications, which are linked to a higher risk of Alzheimer's disease. The trial enrolls 700 adults aged 60 and older who currently take such medications. …

This study tests a home-based parenting program called BRIGHT for pregnant women receiving treatment for opioid use disorder. The program starts in the third trimester and continues for six months after birth, focusing on the parent-child relationship, mental health, and infant d…

This study tests two versions of cognitive behavioral therapy (CBT) for adult women with a specific form of bulimia nervosa that also involves borderline personality traits. One therapy focuses only on eating disorder symptoms, while the other also addresses mood and relationship…

This study compares two treatments for depression in children aged 7 to 13: a family-focused therapy that works with both the child and parents, versus individual therapy for the child alone. The family approach aims to improve parent-child interactions, communication, and coping…

This study tests a personalized cognitive remediation program for people with schizophrenia or schizoaffective disorder. Participants work on computer-based cognitive exercises and take part in group discussions to improve thinking skills like memory and attention. The goal is to…

This trial tests whether a 12-week exercise program can improve motor skills, aerobic capacity, and quality of life in children aged 5–13 with autism spectrum disorder. Participants do activities like walking, balancing, and ball games. Researchers compare them to a non-exercisin…

This study tests a smoking cessation program designed for adults with serious mental illness. Participants receive a combination of videogame-based physical activity, smoking cessation counseling, and the medication bupropion. The goal is to see if this approach is feasible and a…

This study tests two approaches to help people recently involved with the justice system start HIV prevention or treatment and substance use care. One group gets standard patient navigation; the other can choose from a menu of services including in-person clinics, a mobile health…

This study tests whether adding the drug Mexidol to standard care can improve thinking and memory in adults aged 75 and older who have mild cognitive issues due to poor blood flow in the brain, but not dementia. Participants receive Mexidol first as an IV infusion for 5 days, the…

This study tests a new virtual reality (VR) software that delivers behavioral activation therapy for people with depression. Behavioral activation helps people re-engage in positive activities to improve mood. Participants use hand-tracking to interact with the VR environment, co…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study tests whether a noninvasive brain stimulation technique called iTBS-TMS can reduce suicide risk in adults with major depression or borderline personality disorder who are experiencing suicidal thoughts. Participants receive either real or sham (placebo) stimulation to …

This study tests whether a new drug called AVP-786 can help people with major depressive disorder who have not gotten enough relief from standard antidepressants. Participants take AVP-786 or a placebo alongside their current antidepressant for 10 weeks. The main goal is to see i…

This study looks at switching from risperidone to aripiprazole (Abilify) in people with schizophrenia who are not getting enough symptom relief or are having side effects from risperidone. Participants are randomly assigned to one of two ways to switch medications over 12 weeks. …

Autistic children drown at 160 times the rate of their peers, yet standard swim lessons often fail them. This study tests a new approach that adapts instruction based on a child's sensory profile—whether they seek, avoid, or have mixed reactions to sensory input. Researchers will…

This phase 3 trial investigates whether adding aripiprazole (Abilify) to an antidepressant improves symptoms in adults with major depressive disorder who have not responded adequately to antidepressants alone. Participants take either aripiprazole or a placebo alongside their usu…

This study tests whether bosutinib, a drug currently used for leukemia, can safely treat dementia with Lewy bodies (DLB). The trial involves 30 adults aged 25–90 with DLB, who will take either bosutinib or a placebo daily for three months. Researchers will monitor side effects an…

This study tests whether a group-based behavioral program, where caregivers are actively involved, can help autistic preschoolers improve social communication, play skills, and daily adaptation. The program is compared to one-on-one therapy. Researchers will measure changes in au…

This trial tests a decision-making tool designed to help ICU staff decide when to use physical restraints. The tool uses objective measures of a patient's mental state and equipment needs, along with family involvement. The goal is to reduce the use of restraints and related inci…

This study tests whether a behavior therapy program called Partnering to Achieve School Success (PASS) can improve outcomes for children aged 5-11 with ADHD from low-income families. Children are randomly assigned to receive PASS integrated into their primary care visits or to re…

This trial studies three approaches for adults with major depression that hasn't responded to standard antidepressants. Participants either add aripiprazole (Abilify) to their current medication, add repetitive transcranial magnetic stimulation (rTMS), or switch to venlafaxine XR…

This trial compares a generic form of cariprazine (a drug used for schizophrenia) to the brand-name version Reagila®. Healthy adults aged 18 to 55 receive a single dose of either the generic or brand drug under fasting conditions. The main goal is to see if the generic version is…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression. Adults aged 22 and older will record their voice, and the device's assessment will be compared to a standard clinical interview. The goal is to see if the device can acc…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression in adults. About 1,600 English-speaking adults aged 22 and older will record their voices, and the device's screening results will be compared with a standard clinical in…

This study tests a telemedicine tool called the TAP, designed to assess autism symptoms in toddlers aged 18-42 months. Researchers will compare diagnoses made via video call with traditional in-person evaluations to see how accurate the tool is. The goal is to make autism diagnos…

This study tested whether a portable eye-tracking device can help diagnose autism in young children in Kenya. 27 children aged 14-72 months watched pictures and videos while the device measured their eye movements. The goal was to see if these eye-tracking patterns match a clinic…

This study tests whether simple digital questionnaires can help primary care doctors identify new cases of Alzheimer's and related dementias during annual checkups. About 3,150 adults aged 65 and older without prior memory loss diagnosis will participate. The goal is to see if th…

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

This trial tests whether a one-day online workshop based on cognitive behavioural therapy (CBT) can reduce the risk of postpartum depression and anxiety. Pregnant women in their third trimester who have a history of depression but are not currently depressed will be randomly assi…

This study tested whether a lifestyle physical activity program, using a Fitbit tracker and coaching calls, could help pregnant women at risk for cannabis use reduce their use. Sixteen women who used cannabis at least weekly before pregnancy and had mild depression or anxiety too…

This trial tests whether short, equipment-free exercise sessions in the classroom can ease anxiety, depression, and stress while boosting physical activity in medical students. Around 105 students will be split into groups receiving either two, one, or no exercise sessions per we…

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training pr…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tests whether a parenting program can help expectant couples learn to co-parent as a team and reduce heavy drinking in fathers. 368 couples are enrolled during pregnancy and followed for a year after birth. The program includes group classes and individual sessions foc…

This study tests whether a nurse-led program combining lifestyle education and cognitive play-based training can reduce dementia risk among older adults living in residential care. About 134 residents from seven care homes in Cairo, Egypt, will receive either the intervention or …

This trial tests whether a comprehensive, community-wide strategy can reduce opioid overdose deaths by 40% in 67 communities hardest hit by the crisis. The approach, called Communities That HEAL, brings together local leaders, healthcare, justice, and community groups to implemen…

This study looked at how common mild cognitive impairment is among adults aged 50-65 in Kerala, India, and tested a one-month program combining nutrition advice, exercise, brain games, social support, and heart health management. The goal was to see if this approach is practical …

This trial tests whether solanezumab, an antibody that targets amyloid plaques in the brain, can slow the progression of memory problems in people who have no symptoms but show early signs of Alzheimer's-related brain changes. Participants are older adults with normal thinking an…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This study tested a program where trained peer navigators (women with similar experiences) helped women in the criminal justice system access HIV prevention services like PrEP. The goal was to reduce stigma and improve linkage to care. Thirty women participated, and the study mea…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This pilot study tests whether giving insulin as a nasal spray can prevent delirium (sudden confusion) in adults aged 65 and older after complex heart surgery. About 30 participants will receive either the insulin spray or a placebo before and after surgery. The goal is to see if…

This study tested new ways to prevent opioid misuse and addiction in teens and young adults (ages 16-30) who visited the emergency department. Participants received support starting in the ER and continuing through telehealth after they went home. The goal was to find the most ef…

This study tests whether virtual prenatal yoga classes can prevent postpartum depression in pregnant women who have a history of depression. About 62 women will be randomly assigned to either take yoga classes or receive standard care. Researchers will track depression symptoms a…

This trial tests a school-based curriculum called Smart Talk, designed to reduce cannabis use and intentions among middle and high school students. Over five lessons, the program targets misperceptions, refusal skills, stress, and coping. Researchers will measure whether students…

This trial tests a 12-week group program designed to help adults aged 65 and older address modifiable risk factors for dementia, such as high blood pressure and cognitive decline. Participants meet weekly for an hour to learn about brain health and practice evidence-based lifesty…

This study tests whether low-cost virtual reality (VR) tools, like 360° video and a new VR Photoscan process, can help people with post-traumatic stress disorder (PTSD) engage more easily with trauma-focused therapy. Participants will receive standard therapy (TF-CBT) either alon…

This trial tests whether an online psychiatric nursing program based on the Tidal Model can improve psychological resilience and self-compassion in adults diagnosed with anxiety disorder. Participants are randomly assigned to either receive eight one-on-one online nursing session…

This trial tests three different approaches to help people with bipolar disorder become more physically active. Participants are randomly assigned to receive brief advice alone, or brief advice plus supervised and home-based exercise with either health education or cognitive-beha…

This pilot study tests a mobile app called Brain CareNotes designed to reduce the burden on unpaid caregivers of people with Alzheimer's or related dementias who live in rural areas. About 60 caregivers will use either the Brain CareNotes app or a basic education app for six mont…

This trial tests whether listening to personalized music during cataract surgery can reduce anxiety and pain. About 100 patients having surgery under local anesthesia will either receive standard care or also listen to their preferred instrumental music (60-100 beats per minute) …

This study tests an online Emergency Preparedness Toolkit for caregivers of people with dementia. The toolkit helps caregivers find a backup caregiver so they can focus on their own health needs during an emergency. About 68 caregivers aged 55 and older who live with their partne…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested a daily dietary supplement (DITTO Cycle Supplement) in 40 women aged 18-45 who regularly experience period symptoms like cramps, bloating, fatigue, and mood swings. Over three menstrual cycles, researchers tracked changes in symptom severity and quality of life …

This study tested whether a structured education session led by a nurse could lower anxiety and improve quality of life in 188 adults having their first shock wave lithotripsy for kidney stones. The education covered what to expect during the procedure, pain management, and recov…

This study tests whether a virtual reality (VR) mindfulness app can reduce anxiety before surgery and acute pain after surgery. Adults scheduled for surgery will use the VR headset for up to 25 minutes, and researchers will measure changes in anxiety and pain scores, as well as u…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study looks at whether adding sensory and cognitive activities—like listening to music, gentle touch, or brain exercises—to standard ICU care can help adults recover faster after heart surgery. About 125 patients will be randomly assigned to one of four groups to see which a…

This study tests whether a 15mg dose of the painkiller ketorolac works as well as a 30mg dose for relieving kidney stone pain in the emergency department. About 86 adults with severe pain will receive one of the two doses, and their pain levels will be tracked over several hours.…

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This study explores whether sleep problems in children with ADHD are linked to being overly sensitive to everyday sensations, like touch or sound. It tests a bedtime routine called 'Power Down' that uses gentle massage and calming cues to help children relax before sleep. The stu…

This study tests an 8-week hybrid physiotherapy program for adults aged 45-75 who live with both chronic pain and depression. The program combines weekly face-to-face sessions on pain science with guided exercises and online videos. Researchers will measure changes in pain intens…

This six-week study tests whether two liquid supplements, BrainJuice Peach Mango and BrainJuice ACTIVE Pomegranate Acai, can improve cognitive function, performance, and mood in healthy adults aged 18-57 who have concerns in these areas. Participants drink one supplement daily fo…

This study tests a program called I2-ART, where trained family navigators support caregivers of minority children with ADHD. The goal is to help families follow through with recommended treatments like medication or behavior therapy. The study involves about 108 participants and …

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study tests a 12-week supervised exercise program for adults with severe mental illness, such as schizophrenia, bipolar disorder, or major depression. The program combines cycling, strength training, and breathing exercises in twice-weekly sessions. Researchers will measure …

This study tests whether adding a sensor-based exergame to regular table tennis practice can help adolescent boys with mild autism react faster and move more quickly during play. Half of the 24 participants will do 20 minutes of light-based reaction training twice a week for 8 we…

This study tests an online program called SAGE LEAF that teaches positive emotion skills to family caregivers of people with dementia. Over 6 weeks, participants learn techniques like gratitude and mindfulness through short lessons and daily practice. The goal is to see if the pr…

This study tested whether a natural compound called palmitoylethanolamide (PEA) can help reduce depression in people with bipolar disorder. 34 adults who were already taking a mood stabilizer took PEA or a placebo. Researchers measured changes in depression scores and looked at h…

This study tests an 8-week online group program that teaches parents of young autistic children (ages 2-6) strategies to support their child's social communication and development. Parents attend weekly sessions and practice techniques at home. Researchers will measure changes in…

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This phase 2a trial tests CYB004, a synthetic version of the psychedelic DMT, combined with talk therapy in 36 adults with moderate-to-severe generalized anxiety disorder. The study aims to see if the drug is safe, tolerable, and can reduce anxiety symptoms compared to an active …

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This trial tests a new psychoeducation program that teaches military veterans with PTSD how sensory processing affects their stress, emotions, and daily life. Participants learn strategies to better regulate overwhelming situations, improve sleep, and engage socially. The study a…

This study tests whether a medically supervised 12-week ketogenic diet is practical for 6 adults with PTSD in Germany. The main goal is to see if people can stick to the diet and complete the study. It is not designed to measure how well the diet works for PTSD symptoms, but it m…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This trial is testing a program called TEAMSS, designed to help fifth graders with elevated anxiety transition more smoothly to middle school. The program includes reading materials, a school tour, group sessions, parent meetings, and teacher consultations. The goal is to see if …

This trial tests whether watching a 30-40 minute augmented-reality animation that shows a child's journey through surgery can reduce anxiety in children aged 3-12 before adenotonsillectomy. Half the children will watch the animation before surgery, while the other half receives s…

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This study tested whether adding a long-acting stimulant (methylphenidate) to regular antipsychotic medication can improve thinking and daily function in people with schizophrenia or schizoaffective disorder. Thirty-five adults who were stable on their current treatment took the …

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This trial tests whether a daily synbiotic supplement, combining probiotics and a prebiotic fiber, can ease common perimenopause and menopause symptoms like poor sleep, anxiety, and brain fog. Women aged 44–55 experiencing these symptoms will take either the active supplement or …

This study tested whether a specialized swim program (Sensory Enhanced Aquatics) helps autistic children aged 5-9 learn swimming and water safety better than standard lessons. Fifty-one children participated in 16 half-hour lessons. Researchers measured swimming skills before and…

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This study tested whether online occupational therapy-based parent coaching could improve feeding problems in children aged 3-6 who were born prematurely. 39 mothers participated, with some receiving coaching and others not. The coaching aimed to teach mothers better feeding stra…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This trial tests whether playing with a rainbow parachute can improve upper arm strength and social-emotional skills in children aged 5 to 8 with developmental delays. Half the children will do parachute games for 8 weeks, while the other half does rhyming activities. Researchers…

This study tested a brain stimulation technique called closed-loop tACS in 21 people with methamphetamine addiction. The device uses brain wave patterns to deliver targeted electrical stimulation aimed at reducing cravings. Researchers measured craving levels and impulse control …

This study tested whether repeated doses of ketamine, an FDA-approved anesthetic, could speed up the effects of talk therapy (Prolonged Exposure) for PTSD in 75 veterans. Participants received either ketamine or a placebo alongside therapy. The goal was to see if ketamine could r…

This trial tests whether a structured, nurse-led empowerment program can boost mothers' knowledge and caregiving practices for children with nocturnal enuresis (bedwetting). Around 200 mothers of children aged 6-12 will either receive the program in small group sessions or contin…

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This study tests an online psychological support program based on Acceptance and Commitment Therapy (ACT) for mothers of children with autism. The program aims to reduce parenting stress and improve mothers' mental health, which may also benefit their children's behavior. Mothers…

This trial tests a 12-week guided self-help program for parents of young children (ages 2-6) with neurodevelopmental disorders like autism or ADHD. The program combines a workbook, online modules, and group sessions to teach acceptance and mindfulness skills. The goal is to see i…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This trial tests whether a dissolvable film placed under the tongue, containing the drug dexmedetomidine (BXCL501), can reduce agitation in people with schizophrenia. Participants are adults aged 18 to 65 who are clinically agitated. The study compares different doses of the film…

This trial tests whether low-frequency whole body vibration—standing on a gently vibrating platform—can improve motor skills and sensory integration in children aged 5 to 9 with mild to moderate autism. Participants receive vibration sessions alongside routine physical therapy, a…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tested a sublingual film containing dexmedetomidine (BXCL501) to quickly calm agitation in 100 older adults with dementia. Participants received either the drug or a placebo, and researchers measured changes in agitation scores and side effects. The goal was to find a …

This study tested a medicine called BXCL501 for calming sudden episodes of agitation in people with dementia. It involved 151 participants who took the medicine only when needed over 12 weeks. The goal was to see if it safely reduces severe restlessness, tension, or aggression.

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tests a new online program called Tiny Heroes, designed to help parents of anxious children aged 3 to 6. The program teaches parents cognitive behavioral therapy techniques through four online modules. Researchers want to see if it is practical and effective in reducin…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study tests whether haptotherapy, a gentle touch-based therapy, can reduce anxiety and improve bonding in pregnant women who have had a previous abortion. Eighty women between 28 and 32 weeks of pregnancy will receive five 45-minute group sessions. Researchers will measure a…

This trial tests whether an 8-week mindfulness-based stress reduction program can help first-time pregnant women feel less depressed, improve their psychological well-being, and strengthen their attachment to their unborn baby. About 108 women in their first pregnancy, between 13…

This study tests whether an 8-week mindful self-compassion program can reduce self-harm, improve emotional control, and boost quality of life in 60 adults with borderline personality disorder. Participants learn mindfulness and self-kindness techniques. The goal is to see if this…

This study explores whether listening to music after a cesarean section can help first-time mothers feel less pain and anxiety, and improve their breastfeeding success. Participants will be divided into groups, with one group listening to music and the other receiving standard ca…

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linke…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This study tests whether a precise type of radiation, called stereotactic radiotherapy, can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18 to 50 who have not improved after at least two antidepressant trials will receive the treatment. R…

This trial asks whether wearing a virtual reality (VR) headset before and during short hand surgeries can help reduce pain and anxiety. Adults undergoing elective hand surgery with local anesthesia and sedation will use the VR headset as a distraction. Researchers will measure se…

This study tests whether a special therapy using sights, sounds, touch, and other senses can help people with moderate Alzheimer's think clearer, feel calmer, and behave better. It also looks at whether this therapy reduces stress for their caregivers. Twenty-four people aged 65 …

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This study tested a program that combines mindfulness training, music listening, and video counseling to help new mothers manage depression and persistent pain after childbirth. The program was designed for use in outpatient care and includes digital tools. 1,720 healthy women wh…

This study tested an investigational medication called BXCL501 (dexmedetomidine) given as a film under the tongue for episodes of agitation in people with schizophrenia, schizoaffective disorder, or bipolar disorder. The trial included 452 adults aged 18-75 and compared the drug …

This study explores whether a single-session sleep training program can improve sleep and reduce symptoms of borderline personality disorder (BPD) in teenagers. Teens aged 13-18 with BPD symptoms will receive a brief intervention based on the TSC-Youth protocol, which teaches hea…

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study tests whether weekly live harp music sessions can reduce behavioral symptoms like agitation and anxiety in nursing home residents with moderate-to-severe dementia. Participants in memory care units will listen to a harp therapist play during the late afternoon, a time …

This trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood shortly after a single dose. Around 53 generally healthy adults will take either one of the supplements or a placebo, then complete a series of computer and paper…

This study tests a smartphone app called Orbi, which uses cognitive behavioural therapy (CBT) to help people with long-term physical conditions cope with depression and anxiety. 60 participants will either use the app plus usual charity support, or charity support alone, then swi…

This study tested a short, skills-based anxiety treatment for veterans in primary care. 177 veterans with anxiety symptoms were randomly assigned to either the new treatment or usual care. The goal was to see if the brief therapy reduces anxiety and improves daily functioning bet…

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

This study tests a mobile app-based training designed to help people with social anxiety disorder interpret ambiguous social situations in a more positive, less threatening way. Adults aged 18-60 with moderate to severe social anxiety will use the app over several sessions, and r…

This study tests whether giving family caregivers of people with Alzheimer's or related dementias a tailored list of local resources – addressing needs like food, housing, and support services – can boost their confidence in caregiving. About 360 caregivers in specific Chicago zi…

This study looks at whether coloring mandalas can lower stress, anxiety, and pain in women who have a missed abortion (a pregnancy loss before 10 weeks). About 126 women will be randomly assigned to either color mandalas or receive standard care. Researchers will measure changes …

This pilot study tested whether a gentle brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment. Participants received either real or sham stimulation over 10 sessions across two weeks. The goal was to see…

This study looked at whether a web-based program called webSTAIR, which teaches skills to manage emotions and relationships, is feasible and helpful for people with PTSD who are on a waitlist for behavioral health treatment. Seventy adults from a hospital clinic in Boston took pa…

This study compares online parent coaching to in-person coaching for improving social communication in toddlers with autism or social communication delays. About 188 children aged 18-33 months will take part. Parents learn techniques to engage their child during play, aiming to i…

This study tests whether using virtual reality glasses or doing breathing exercises during chemotherapy can help reduce anxiety in breast cancer patients. Participants will be divided into three groups: one using VR glasses, one doing guided breathing exercises, and one receiving…

This study tests a type of brain stimulation called accelerated theta burst stimulation (a form of TMS) to see if it can lower cravings for methamphetamine in people living with HIV. Thirty adults aged 18-65 with HIV and a history of meth use will receive the treatment. The goal …

This study tests whether the medication lisdexamfetamine (Vyvanse) can help people who experience loss-of-control eating after bariatric surgery and didn't improve with earlier treatments. About 60 adults who had gastric bypass or sleeve gastrectomy will receive either the drug o…

This study looks at whether adding active video game training to standard occupational therapy can improve how children with developmental coordination disorder (DCD) see and plan movements. About 70 children aged 5 to 8 will be split into two groups: one gets video games plus th…

This trial tests whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can reduce auditory hallucinations in people with schizophrenia who haven't found relief from antipsychotic medications. Participants receive either real tDCS or a…

This study tests whether combining two types of exercises—sensory motor training and special stretches—can reduce toe walking and improve foot posture in children with mild autism. Researchers will measure changes in foot position and sensory responses in 36 children. The goal is…

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This trial is testing a web-based app called Active Ease, designed to help people with severe mental illness living in residential care become more physically active. The app includes educational content and guided exercise demonstrations. Researchers will compare two residential…

This trial tests whether a structured CBT-based program can strengthen psychological resilience and improve quality of life in adults with bipolar disorder who are in remission. Participants will attend sessions focused on psychoeducation, self-management, and coping strategies. …

This study tested whether listening to nada yoga music or squeezing a stress ball can lower anxiety and pain during a Pap smear. 128 women aged 30-56 took part. Researchers measured their anxiety and pain levels before, during, and after the test. The goal was to find simple, dru…

This trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This trial tests whether a smartphone app called MindBoba, which uses problem-solving therapy techniques, can help Chinese Americans reduce stress and anxiety. Participants will be randomly assigned to use MindBoba, a standard cognitive-behavioral therapy app, or receive no app. …

This trial tests whether daily omega-3 fish oil supplements can improve sleep, mood, and behavior in children who have sleep problems and symptoms of ADHD, autism, or both. The study takes a symptom-focused approach, aiming to identify which specific difficulties—like emotional u…

This study tests whether a short, personalized music listening session with a therapist can lower anxiety, stress, and pain in cancer patients starting radiation therapy. 72 adults will be randomly assigned to receive music therapy during their first radiation session or standard…

This study tested whether wearing virtual reality goggles showing relaxing nature scenes with music could help patients feel less anxious and more comfortable during a prostate biopsy. Seventy adults undergoing the procedure were randomly assigned to either wear the goggles or re…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This trial aims to find the optimal dose of bupivacaine, a local anesthetic, for starting epidural pain relief during labor. It will enroll 100 healthy women with a single, full-term pregnancy who request an epidural for pain. The goal is to determine the dose that provides effec…

This study follows 140 people with obstructive defecation syndrome (ODS) — a condition that causes straining and difficulty passing stool — who are scheduled for surgery. Researchers will measure depression and anxiety using standard questionnaires before and after the procedure,…

This trial compares two types of nerve blocks for pain relief after open gastric cancer surgery. The blocks are injected near the abdominal wall to numb the area, potentially reducing the need for opioid painkillers, which can cause side effects like drowsiness and constipation. …

This trial tests whether a mindfulness-based neurofeedback program can help racial and ethnic minority college students reduce performance anxiety and improve academic performance. Participants practice mindfulness meditation while a device monitors their brain activity and provi…

This study compares a new external catheter (PureWick) to a standard one for men who leak urine at night. About 100 adult men who currently use diapers or pads will test each device at home overnight. The goal is to see which device captures more urine, causes fewer skin problems…

This study tested whether acupressure—a technique using gentle pressure on specific points on the body—can reduce anxiety, embarrassment, and fear in people undergoing a bladder function test called urodynamics. Sixty-eight adults were randomly assigned to receive either acupress…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study tests whether wearing virtual reality glasses during a cystoscopy—a procedure to look inside the bladder—can reduce pain and anxiety. Half of the participants will use VR while the other half receives standard care. The trial aims to see if VR can make the experience m…

This study tests whether wearing virtual reality goggles that show calming nature scenes with music can reduce pain, anxiety, and changes in heart rate and blood pressure during urodynamics, a procedure that checks how well the bladder works. Half of the participants will wear th…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This trial tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce psychological and existential distress in people with advanced, terminal illness. Participants receive rTMS sessions while on a palliative care unit, and researchers measure changes in depress…

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This trial tests whether adding a ChatGPT-powered educational tool to standard instructions helps first-time colonoscopy patients achieve better bowel cleansing and feel less anxious before the procedure. Adults undergoing their first colonoscopy are randomly assigned to receive …

This study tests whether a four-week mindfulness program can reduce symptoms of depression, anxiety, and stress in college students in Guangzhou, China. Participants are randomly assigned to either the mindfulness training or a health education control group. The study also looks…

This pilot study tests whether a ketone drink can help people with anorexia or bulimia by reducing the drive to binge or restrict food. Forty participants will take the drink twice daily for two weeks, and researchers will measure changes in eating behaviors, mood, and brain acti…

This 12-week trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood in healthy adults. Participants take one of the supplements or a placebo daily and complete four one-hour sessions of cognitive and mood tests. The goal i…

This trial tests whether Acceptance and Commitment Therapy (ACT), a type of talking therapy that focuses on psychological flexibility, can reduce depressive symptoms in people with bipolar disorder. Participants will attend 12 weekly group sessions of ACT alongside their usual me…

This trial tests whether watching an entertaining video through virtual reality glasses or on a tablet can reduce pain, anxiety, and fear in children aged 7 to 12 during intravenous (IV) cannulation in an emergency department. Children are randomly assigned to one of three groups…

This trial tests whether an internet-based self-help program called Couple HOPES can reduce PTSD symptoms and improve relationship satisfaction in couples where one partner is a military member, veteran, first responder, or healthcare worker with COVID-19-related PTSD. Participan…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

This trial tests whether an intensive version of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), delivered during a hospital stay, helps children and teens aged 11–17 with PTSD after sexual abuse. Researchers compare the inpatient program to standard outpatient therapy to s…

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This pilot trial tests whether adding microcurrent neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard care alone. MCN uses scalp sensors to deliver barely perceptible electrical pulses tailored to each person's brain …

This trial tests whether a pectoral nerve block using the anesthetic bupivacaine can reduce pain and opioid use in adults receiving a cardiac implantable electronic device (CIED). Participants are randomly assigned to receive either the nerve block or a placebo injection. The stu…

This trial tests whether a tailored lighting intervention, controlled by a wireless device, can improve sleep and mood in people with Alzheimer's disease. Participants receive either active lighting designed to affect the body's internal clock or a control lighting with no intend…

This trial tests whether an eight-session cognitive-behavioral psychoeducation program can reduce internalized stigma in adults with bipolar disorder who are in remission. Participants are randomly assigned to the program or usual care, and their stigma levels are measured before…

This trial tests whether shared virtual reality (VR) experiences can improve quality of life, mood, and family closeness for older adults with mild cognitive impairment or dementia who live in senior communities, and for their adult children who live far away. Participants will t…

This trial tests a new couple-based therapy called Sage for people with borderline personality disorder who struggle with self-injury or suicidal thoughts. The therapy, delivered remotely over 12 sessions, aims to reduce these behaviors by addressing both emotional distress and r…

This phase 2 trial is evaluating whether an experimental drug called KH607 can safely reduce symptoms of depression in adults with moderate or severe major depressive disorder. The study has two parts: first, all participants receive KH607 openly to check safety and how the drug …

This trial tests whether distraction techniques—like drawing, reading a story, watching a cartoon, or using a toy nebulizer and mask—can lower fear and anxiety in children aged 3 to 6 during inhalation therapy for respiratory infections. Children are randomly assigned to one of t…

This pilot trial tests whether a brief group therapy called EMDR-IGTP-OTS can reduce posttraumatic stress symptoms in migrants attending an adult education center in Italy. Participants receive four structured group sessions on consecutive days and are compared with a control gro…

This trial tests whether a structured, therapist-led dance program can improve cognitive-motor skills, balance, self-esteem, and sensory processing in children aged 6 to 12 with ADHD. Over five weeks, participants attend ten dance sessions designed to combine rhythm and movement …

This trial tests whether a 4-week progressive muscle relaxation (PMR) program can reduce psychological stress and improve bowling speed and accuracy in male cricket medium-fast bowlers aged 18-25. Participants are assigned to either PMR sessions before warm-ups or standard traini…

This trial compares two versions of an internet-based emotional awareness and expression therapy (I-EAET) for people with functional somatic disorder—a condition where physical symptoms like chronic pain or fatigue have no clear medical cause. One group gets weekly written feedba…

This trial compares two types of first interviews for people with functional somatic disorders — conditions like irritable bowel syndrome or fibromyalgia where physical symptoms have no clear medical cause. One interview focuses on life stress and emotional factors, while the oth…

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The…

This trial tests whether a short-term, intensive talk therapy called ISTDP can help people whose physical symptoms—like chronic pain, fatigue, or stomach issues—have not improved with other treatments. The therapy focuses on uncovering and processing unconscious emotions that may…

This trial tests whether using an immersive virtual reality headset during the first postoperative orthopedic dressing change can reduce anxiety and pain in children and adolescents aged 6 to 18. Participants are randomly assigned to either wear the VR headset during the procedur…

This trial investigates whether a 20-minute virtual reality nature scene or the Benson Relaxation Technique can lower anxiety and increase happiness in adults who have recently had bariatric surgery. Participants are randomly assigned to one of two groups or a control group, and …

This trial investigates whether daily exposure to a bluish-white light (at least 300-500 lux for two hours) can improve sleep efficiency, reduce depression, and calm agitation in people with mild to moderate Alzheimer's or related dementias. Participants are assigned to one of th…

This study is testing a prescription digital therapeutic app, OTX-601, designed to deliver evidence-based PTSD treatment through a smartphone. Researchers are comparing two versions of the app—one with a higher 'dose'—against standard care (therapy and/or medication) in 40 adults…

This phase 3 trial is testing whether the experimental drug lumateperone can safely reduce manic symptoms in people hospitalized with bipolar I disorder. Participants will receive either lumateperone or a placebo daily for several weeks, and researchers will measure changes in ma…

This study tests whether a six-session video-based cognitive behavioural family intervention is practical and helpful for people with schizophrenia and their family caregivers. The program aims to reduce expressed emotion (critical or hostile communication) and improve symptoms a…

This early-stage trial is testing an experimental drug called lumateperone in children aged 5 to 12 who have autism spectrum disorder and symptoms of irritability. The study aims to see how the body processes the drug and whether it is safe and tolerable at different doses. It is…

This trial tests whether a simple breathing exercise routine can help people recovering from general surgery feel less pain, anxiety, and nausea. About 149 adults who had laparoscopic gallbladder or hernia repair will either receive standard care or practice deep breathing exerci…

This study tests two online programs for people with mild to moderate anxiety or depression who are not already in therapy. One program focuses on five daily behaviors linked to better mood, while the other uses a forgiveness process to address relationship issues. Participants c…

This trial compares two diets—low-FODMAP and lactose- and gluten-free—in adults with irritable bowel syndrome (IBS). Each participant tries both diets for four weeks, with a one-week break in between, to see which one better reduces gut symptoms and improves mental health. The go…

This trial tests a 9-session mindfulness and compassion program, called Cuida2, in 5th and 6th graders. Students are randomly assigned to either the program or a relaxation-based control group. Researchers measure changes in emotional and behavioral problems, academic performance…

This trial tests whether coloring pre-drawn mandala patterns for at least 30 minutes each day can lower anxiety and depression in adults awaiting open-heart surgery. About 69 first-time heart surgery patients will be randomly assigned to either the coloring activity or usual care…

This pilot trial explores whether Nintendo Switch exergaming—active video games like RingFit Adventure and Switch Sports—can improve motor skills in autistic youth aged 5 to 30. Participants are randomly assigned to an exergaming group or a no-intervention control group. The stud…

This trial tests whether an ultrasound-guided nerve block called the mid-transverse process to pleura (MTP) block can improve pain control in children aged 5 to 15 undergoing open chest surgery. Half of the 50 participants will receive the block with bupivacaine before the incisi…

This trial tests whether mental strategy training can reduce overactivity in the hippocampus — a brain region that often becomes hyperactive in early Alzheimer's — and improve memory in people with mild cognitive impairment (MCI). Participants aged 60–80 with MCI will practice fo…

This study tests whether two dietary supplements—eicosapentaenoic acid (EPA), an omega-3 fatty acid, and specialized pro-resolving lipid mediators (SPMs)—can reduce depressive symptoms in adults with long COVID. Participants take either EPA, SPMs, or a placebo daily for 12 weeks.…

This trial tests a school-based counselling program called Knowledge Insight Tools (KIT), which is based on cognitive behavioural therapy (CBT). It is designed for secondary school students aged 11-18 who are struggling with anxiety and low mood. Participants first go through a w…

This study tests PAfitME™, a telehealth program that uses personalized motion exergames to help young adult cancer survivors (ages 18–39) improve their physical function. The program is tailored to each person's fitness level, fatigue, and pain. Researchers will see if it is feas…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This trial tests three methods to prepare children aged 6–12 for a pulmonary function test (spirometry): routine verbal instruction, verbal instruction with a live demonstration, or watching an animation. The goal is to see which approach helps children perform the breathing mane…

This study tests a mobile app designed to help people with social anxiety shift their attention away from threatening faces and toward neutral ones. Adults aged 18-60 with social anxiety disorder will use the app for three weeks. Researchers will measure changes in anxiety sympto…

This study tests whether playing a recording of a mother's heartbeat, breathing, and chest vibrations to her newborn during phototherapy for jaundice can reduce maternal anxiety and stress. Forty mothers and their full-term newborns will take part, with half receiving the heartbe…

This trial tests whether a gentle electrical stimulation of the vagus nerve through the ear (tVNS) can help athletes recover more quickly after intense training. About 121 professional athletes in sports like swimming, athletics, and gymnastics will use the device daily for 60 mi…

This trial compares a new painkiller called oliceridine to the standard drug sufentanil for women undergoing hysteroscopy, a procedure to look inside the uterus. The goal is to see if oliceridine provides effective pain control with fewer side effects like nausea or breathing pro…

This study tests whether a computer-based program called cognitive control training (CCT) can help people with depression feel less negative mood and rumination. Participants with high depression scores complete three sessions of CCT or a comparison task over two weeks. The goal …

This study investigates how avoidance behaviors contribute to depression and anxiety in teenagers, and tests a group therapy called Group Behavioral Activation Therapy (GBAT). The therapy involves 15 weekly sessions teaching skills to understand and change avoidance patterns. Res…

This study tests whether combining a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with a type of talk therapy called acceptance and commitment therapy (ACT) can help veterans who have both chronic pain and depression. The goa…

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The…

This study tests whether watching an animated educational video before laparoscopic tubal ligation reduces anxiety and pain more than standard verbal counseling. Eighty women are split into two groups: one receives routine verbal information, the other watches a video. Researcher…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This trial compares two ways to manage pain during hip replacement surgery: an ultrasound-guided nerve block (PENG block) versus injecting anesthetic directly into the joint. The study includes 60 adults scheduled for anterior hip replacement under general anesthesia. The main go…

This trial tests whether a newer nerve block called PENG block provides better pain relief than the standard intra-articular injection for people undergoing hip replacement surgery. Both methods use the anesthetic lidocaine. The study will measure how much morphine patients need …

This study tests a personalized cognitive training program called CBM-TAF for adults with obsessive-compulsive (OC) symptoms. The program targets a specific thinking pattern known as thought-action fusion (TAF), where people believe having an unwanted thought is as bad as acting …

This trial investigates whether a drug called remimazolam can prevent emergence delirium—a state of confusion and agitation—in children aged 3 to 12 after tonsillectomy or similar procedures. Children are randomly assigned to receive either remimazolam or a placebo (salt water) b…

This study investigates whether listening to music before, during, and after intrauterine device (IUD) insertion can lower pain and anxiety while improving satisfaction. Researchers will compare women who receive music therapy to those who do not, measuring anxiety levels with a …

This trial investigates whether a supplement made from Nepalese pepper (Zanthoxylum armatum) can improve cognitive abilities like attention, memory, and decision-making in young competitive gamers aged 16 to 34. Participants take either a low or high dose of the extract, caffeine…

This study investigates whether taking lion's mane mushroom or a blend of lion's mane and reishi mushroom for 28 days can improve wellbeing in women aged 18-26 who feel stressed or anxious. Participants are randomly assigned to receive one of the mushroom supplements or a placebo…

This study tests whether wearing virtual reality glasses and watching a calming nature video during hemodialysis can help lower anxiety and keep vital signs stable. Researchers are enrolling 56 adults who are receiving dialysis for the first time. Half will watch a 4K nature vide…

This study tests whether using a stress ball or watching a short aquarium video with music can reduce fear, anxiety, and pain in children aged 6 to 12 who need an enema for constipation or bloating in the emergency department. Children are randomly assigned to one of the two dist…

This study tests whether adding game-like features to a 12-week mindfulness program can help first-year nursing students reduce burnout, stress, and anxiety. Participants are randomly assigned to a gamified mindfulness group, a standard mindfulness group, or a minimal-treatment c…

This study tests whether giving people with dementia a lifelike doll to care for can reduce their need for medications like antipsychotics and improve their mood and behavior. The trial involves 142 residents aged 65 and older across six nursing homes in China, comparing those wh…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests a specially adapted form of cognitive behavioral therapy for insomnia (CBT-i) in people with bipolar disorder who have sleep problems. The therapy includes sleep scheduling, light exposure, and relaxation techniques. Researchers want to see if it improves sleep q…

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this ap…

This study tests two digital sleep interventions designed to help teenagers aged 12-14 improve their sleep regularity and mental health. Participants wear a Garmin device and use a smartphone app that provides personalized feedback on their sleep patterns. The goal is to see if t…

This study tests a structured nursing program called 'Conectando Corazones' (Connecting Hearts) designed to help family caregivers of older adults with dementia. The program includes six sessions over 12 hours, combining in-person meetings with independent work, to improve how ca…

This study investigates whether the Benson Relaxation Technique, a simple mind-body practice, can lower fear of childbirth, anxiety, and stress in pregnant women. About 60 women in their third trimester (weeks 28–38) will either practice the technique or receive routine care. Res…

This pilot study tests whether a single session of repetitive transcranial magnetic stimulation (rTMS) can improve the brain activity behind working memory — the ability to hold information in mind. The trial includes teenagers with ADHD and working memory deficits, as well as he…

This study tests whether a short session of age-appropriate play and a structured briefing for parents can lower anxiety in children aged 2 to 11 who are about to have an MRI under sedation. Half of the children receive this psychological preparation before the scan, while the ot…

This trial investigates whether listening to classical music, with or without binaural beats, can lower anxiety and pain in men undergoing a prostate biopsy. Participants are randomly assigned to hear Samuel Barber's Adagio for Strings, the same piece embedded with a 6-Hz binaura…

This study investigates whether performing progressive muscle relaxation exercises before an endometrial biopsy can help reduce pain, lower anxiety, and improve comfort in premenopausal women. Participants will be women aged 40 or older with irregular cycles who need this biopsy.…

This study tests whether a new medication, toludesvenlafaxine, can safely reduce anxiety symptoms in adults with generalized anxiety disorder. Participants receive either a low dose, a high dose, or a placebo pill daily for 8 weeks. The main goal is to see if the drug lowers anxi…

This pilot study tests whether a brief psychological program called Problem Management Plus (PM+) can help reduce anxiety and depression symptoms in people held in Dutch remand prisons. The program, developed by the World Health Organization, teaches problem-solving, stress manag…

This pilot study tests a 10-session group program called AgingUP, designed for adults aged 50 and older living with severe mental illness. The program uses cognitive-behavioral and self-compassion techniques to help participants challenge negative beliefs about aging and mental i…

This study looks at whether ethnic minority adolescents who have experienced racial discrimination show stronger biological stress responses when faced with subtle racism. Researchers will measure blood pressure, stress hormones, and other markers while teens take part in a simul…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This completed study from the National Institute of Mental Health looked at over 1,500 women to better understand the symptoms of premenstrual syndrome (PMS) and a severe form called PMDD. Researchers used interviews, rating scales, and hormone tests to track mood and behavior ch…

This study follows 1600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how peo…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study explores whether a wrist-worn sensor can identify early signs of delirium in hospitalized adults aged 65 and older. Delirium is a common and serious complication of hospitalization, and early detection is key. Participants wear a consumer-grade sensor on their wrist to…

This study looks at whether children born with heart defects who need surgery might also have delays in speech and thinking. Researchers will check the children's cognitive and language skills before their operation and again one and two years after. The goal is to see if speech …

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning about their Alzheimer's-related brain scan results. It includes 100 Black and White adults with amnestic mild cognitive impairment. The…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This pilot trial is testing whether a program called CRUSH, designed to teach sexual health and relationship skills, is practical and well-received by autistic adults aged 18 to 30. Participants will attend 15-20 group sessions with one-on-one coaching and complete assessments be…

This study looks at whether antimuscarinic drugs used for overactive bladder (OAB) affect how long ejaculation lasts and the time before a man can ejaculate again. Researchers will follow men aged 20 to 50 who are prescribed tolterodine or propiverine for OAB. Participants fill o…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women…

This study uses brain scans to compare how a single dose of two ADHD medications—guanfacine (a non-stimulant) and lisdexamfetamine (a stimulant)—affect brain function in children and teens with ADHD, relative to a placebo. Participants perform tasks of attention, working memory, …

This trial tests whether a gamified app-based training program can improve intensive care unit (ICU) nurses' understanding of delirium, their confidence in learning about it, and their clinical reasoning skills. Around 100 registered nurses working in adult ICUs will use the app,…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

This study explores the link between gut bacteria and alcohol use disorder (AUD). Researchers compared gut microbiota in three groups: current heavy drinkers with AUD, people with AUD who have been abstinent for at least 4 weeks, and healthy moderate drinkers. Participants provid…

This study tests whether a mild electrical brain stimulation technique called transcranial direct current stimulation (tDCS) can alter brain activity in adults with major depression. Using MRI to guide the stimulation, researchers will measure changes in brain connectivity and al…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study looks at whether spending 2 to 3.5 weeks at a device-free summer camp in Maine can improve mental health and brain activity in teens aged 12 to 17. Researchers will measure changes in mental health scores and brain waves (EEG) from the start to the end of camp. The goa…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study asks whether a scenario-based simulation, where nursing students interact with an actor portraying a person with schizophrenia, can boost their knowledge, empathy, and caregiving skills. Around 105 students will complete questionnaires before and after the simulation, …

This observational study tests a mobile app that uses a dynamic difficulty adjustment system to personalize cognitive activities for people with mild cognitive impairment or mild Alzheimer's disease, as well as healthy older adults. The goal is to see if the app can reach a stabl…

This study tests whether a fast form of brain stimulation (accelerated iTBS) can improve thinking and memory in 30 adults with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. Participants will receive both real stimulation and a sham (fa…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This study looked at whether flavor chemicals in e-cigarettes can make them more addictive by changing brain function. 36 regular tobacco users (ages 21-60) had their brain activity measured while vaping, and their puffing behavior was tracked over 10 days. The goal was to unders…

This study tested whether a pharmacist-led program could help older adults with dementia and their caregivers reduce unnecessary medications. The program included an educational brochure, a telehealth visit with a pharmacist, and tailored recommendations for the patient's doctor.…

This study looked at how well patients, their family members, and doctors agree when rating agitation episodes in people with bipolar disorder or schizophrenia. Thirty-three adults received a treatment called BXCL501, and researchers compared different questionnaires to see which…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This study investigates how three weeks of cannabis abstinence influences brain responses to threat, reward, and cannabis cues in women with cannabis use disorder. Participants are randomly assigned to either continue using cannabis as usual or abstain for three weeks, with lab v…

This study tests whether breathing exercises and aerobic exercise can change levels of certain brain and inflammation markers in people with major depression. Forty adults diagnosed with depression will do daily breathing and aerobic exercises for three weeks. Researchers will me…

This study looks at whether post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists is linked to higher rates of complications in the patients they operate on. Researchers will screen surgical staff for PTSD using questionnaires and then track the recovery of thei…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This study looks at how often people who visit a community psychiatrist have had suicidal thoughts in the two weeks before their appointment. Researchers will ask about 262 adults to fill out questionnaires measuring suicidal risk, psychological pain, and self-esteem. The goal is…

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study looks at whether a person's natural sleep preference—being a morning person, night owl, or in between—is linked to the risk of waking up confused after surgery. Researchers will review records from 235 older adults (65+) who had non-cardiac surgery under general anesth…

This study looks at pain, sleep quality, eating habits, and physical activity in 50 adults with bipolar disorder who are currently stable (euthymic). Researchers will use questionnaires to measure these factors and better understand how they affect quality of life. The goal is to…

This study looks at how the gut microbiome and its chemical byproducts relate to gastrointestinal and behavioral symptoms in children with autism. By tracking 23 participants over time, researchers hope to identify biological markers that could one day help manage these symptoms.…

This study looks at how the brain changes during a depression treatment called repetitive transcranial magnetic stimulation (rTMS). People receiving rTMS will have MRI brain scans before, during, and after their six-week treatment course. The scans will help researchers see wheth…

This study investigates how aging and schizophrenia influence metamemory—the ability to judge one's own memory accuracy. Researchers will compare four groups: younger and older adults with schizophrenia, and younger and older healthy controls. Participants will rate their confide…

This study asks whether a routine blood test measure called the neutrophil-lymphocyte ratio (NLR) can help predict delirium—a state of sudden confusion—in older adults after hip fracture surgery. Delirium is a common and serious complication in elderly patients, and inflammation …

This study looks at what makes some women naturally lean without dieting or eating disorders. Researchers will compare eating habits, physical activity, body composition, and appetite responses in three groups: constitutionally lean women, normal-weight women, and women with anor…

This observational study will look at 138 adults with hemophilia and joint damage to understand how central pain mechanisms and psychological factors like anxiety affect pain interference in daily activities. Researchers will measure pain intensity, sleep quality, and pain self-e…

This study followed survivors of the 2015 Paris terrorist attacks for up to 6 years, using brain scans to see how trauma affects the brain's ability to control unwanted memories. Researchers compared 216 survivors with people who were not exposed to the attacks. The goal was to u…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study tests a new mobile app that uses an avatar guide to help young adults (ages 18-29) who struggle with binge drinking and suicidal thoughts. The goal is to see if the app is easy to use and if people will stick with it. Ten participants from the emergency department will…

This study looks at whether trained community health workers can help Korean American elders with dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program improves access to medical services …

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors…

This study followed nearly 5,000 U.S. teenagers from 10th grade into their early twenties to track how their health behaviors—like diet, exercise, substance use, and driving—changed over time. Researchers collected surveys, genetic samples, and neighborhood data to understand wha…

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This study investigates whether sleep duration and timing influence nicotine dependence, cravings, and withdrawal differently in Black and white smokers. Researchers will compare daily smokers and non-smokers, monitoring sleep with an Actiwatch and having participants undergo a s…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This study uses brain scans to explore how sleep and mood are connected in people with major depression compared to healthy volunteers. Participants undergo overnight sleep deprivation while researchers measure changes in brain activity, fluid flow, and mood. The goal is to uncov…

This trial tests whether a communication training program for primary care doctors can improve how they discuss pain with patients and manage opioid prescriptions. Doctors are randomly assigned to receive the training or standard guidelines. Researchers then record patient visits…

This study tracks thousands of heart-surgery patients to identify factors that may increase the risk of postoperative delirium — a state of sudden confusion. Researchers are examining whether medications like statins and beta blockers, the use of a heart-lung machine, or the leng…

This study explores whether a radio drama can shift negative attitudes toward mental illness in rural Uganda. Researchers will measure stigma levels among community members, traditional healers, religious leaders, and families of those with mental illness. The drama is adapted fr…

This study explores the experiences of people diagnosed with a psychiatric disorder who have used psychedelic substances on their own to relieve symptoms. Researchers will conduct in-depth interviews with 20 participants to understand their motivations, methods, and perceived eff…

This trial tests whether adding role-play video demonstrations to an online course helps fifth-year medical students at Ain Shams University learn doctor-team communication skills. One group receives the standard online course, while the other also watches recorded videos showing…

This study investigates whether the hormone estradiol influences PTSD symptoms and brain activity related to fear and stress in women. Researchers will give some participants an estradiol patch and others a placebo before MRI scans that measure brain responses to threatening cues…

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This trial investigates whether smoking or vaping cannabis increases the frequency of premature atrial and ventricular contractions — early or extra heartbeats that can feel like skipped beats. Over 14 days, regular cannabis users will be randomly assigned to consume or avoid can…

This study looks at whether falls and mobility problems can signal very early, preclinical Alzheimer's disease in older adults who are still cognitively normal. Researchers will follow 355 volunteers aged 65 and older, some with and some without biological signs of Alzheimer's, t…

This observational study looks at whether the types of bacteria living in the gut, along with diet and lifestyle, are linked to a person's risk of catching SARS-CoV-2. It follows over 900 children, their family members, and teachers in Spain for 17 months. Researchers collect sto…

This study tests a CE-marked mobile app that scans a person's eyes to detect whether they have used certain drugs. Healthy volunteers will take a common medicine that mimics the effects of cannabis or amphetamines, then use the app to see if the eye measurements change. The goal …

This study investigates what makes cognitive-behavioral therapy effective for children and teens aged 7 to 16 with anxiety or depression. Researchers will analyze therapy sessions and outcomes to identify which techniques and processes lead to improvement. The goal is to understa…

This study tests very low, single doses of psilocybin—the active compound in magic mushrooms—in healthy adults to find a dose that is safe and does not cause psychedelic effects like hallucinations or altered consciousness. Participants receive either a low dose of psilocybin (ra…

This study looks at how common dissociative tendencies are in adults with obesity who are seeking medical or surgical help for the first time. Participants fill out questionnaires that measure dissociation, eating behaviors, and other related factors. The goal is to better unders…

This study investigates whether the defibrillation threshold testing (DFT) procedure, which checks that an implantable cardioverter-defibrillator (ICD) can deliver a strong enough shock to restore normal heart rhythm, causes any injury to the heart muscle. Researchers measure lev…

This study explores how adults who stutter process and produce speech compared to those who do not. Participants complete computer-based listening and speaking tasks over one or two visits. The goal is to better understand the underlying differences in speech processing that may …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This observational study compares functional movement, dynamic balance, and lower body strength between 144 professional and amateur male soccer players. Participants undergo standardized tests like the Functional Movement Screen, Y-Balance Test, and jump and strength assessments…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study tests whether a smartphone app can help doctors and patients make better medication choices for first-episode psychosis. Participants use the app to report symptoms and functioning in real time, giving clinicians up-to-date information to guide shared decisions. The go…

This study looks at how well university athletes sense their own body signals (like heartbeat or tension), their stress levels, anxiety, and sleep quality, and how these relate to physical tests like grip strength, jump height, flexibility, and balance. Researchers also check if …

This study explores whether a dye called indocyanine green (ICG) can be used to track immune cells in the brain of people with Alzheimer's. Participants receive an ICG infusion, and a special light device measures the dye in the brain after 48 hours. The goal is to develop a non-…

This study investigates whether levels of the hormone ghrelin in the blood differ between people with various types of dementia, including Alzheimer's disease and dementia with Lewy bodies. Researchers will collect blood samples from 85 participants over age 60, both fasting and …