PREGNANCY

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study looks at whether structured nutrition counseling helps pregnant women with gestational diabetes improve their diet quality and reduce harmful substances called advanced glycation end products. About 48 first-time pregnant women aged 18-35 will be assigned to either cou…

This phase 3 trial tests whether giving daily progesterone injections for 6 weeks after a positive pregnancy test can improve live birth rates in women with low progesterone levels. The study includes 214 women aged 18-37 who became pregnant through IVF. Half will receive the ext…

This study will test an automated insulin delivery system (the Medtronic 780G pump with continuous glucose monitoring) in 20 pregnant women with type 2 diabetes. Participants join before 16 weeks of pregnancy and use the device until delivery. The main goal is to see how much tim…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This study looks at whether giving mothers high-flow oxygen during a C-section can help prevent oxygen shortage in the baby. Researchers will compare a special high-flow oxygen device (OptiFlow THRIVE) with standard low-flow oxygen. The trial involves 200 pregnant women scheduled…

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …

This study tests whether eating a balanced meal made from local foods once a day during pregnancy can help women in rural Pakistan handle heat stress better and have healthier babies. About 292 women will either eat this meal daily or continue their usual diet. Researchers will m…

This study tests whether portable AI-driven ultrasound devices can help frontline health workers in rural Ethiopia detect pregnancy complications early. About 1,059 pregnant women will be split into three groups: two using different AI ultrasound tools and one receiving standard …

This study tests an artificial intelligence (AI) tool that estimates a baby's weight from ultrasound videos. Researchers will compare the AI's estimates to standard measurements and the actual birth weight. The goal is to see if the AI tool is accurate enough to help doctors, esp…

This study will check if a simple finger stick blood sample gives the same pregnancy hormone (beta-hCG) levels as a standard blood draw from a vein. About 40 pregnant women will provide both types of blood samples. If the finger stick method is accurate, it could offer a less pai…

This study compares a new home pregnancy test, the Clara Multi-Level test, to a standard test. The new test aims to show different levels of the pregnancy hormone hCG, not just a yes/no result. About 180 women will use the test at a study center and answer questions about how eas…

This study looks at whether a noninvasive finger monitor can predict how pregnant women, including those with severe preeclampsia, respond to fluids. Researchers will compare the finger device to standard heart ultrasound in 88 women. The goal is to find a simpler way to guide fl…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study tests a counseling program called Healthy Families PrEP for HIV-negative women in rural Uganda who are planning pregnancy or recently gave birth. The program provides information and support to help women take daily PrEP pills to prevent HIV. Researchers will enroll 66…

This study will test whether giving women healthy lifestyle education before they get pregnant or in early pregnancy can improve their heart health and lower the chance of problems like gestational diabetes and preeclampsia. Two hundred women at risk for preeclampsia will be rand…

This study tests whether a single daily pill that combines HIV prevention (PrEP) and birth control is easier for women to take consistently than taking two separate pills. About 300 women without HIV will try both approaches in a crossover design, and researchers will measure adh…

This study tests an online program called STORK designed to help couples maintain their sexual well-being during the transition to parenthood. The program includes weekly modules during pregnancy and one after birth, covering common sexual changes and relationship skills. Researc…

This study tests a four-week mindfulness program for first-time pregnant women to see if it can reduce fear of childbirth and increase self-confidence and self-compassion. Participants attend eight face-to-face sessions that include breathing, body awareness, and emotional coping…

This study tests a specially designed exercise program for high-risk pregnant women who are hospitalized on bed rest. The exercises are done in bed and focus on strength and resistance. Researchers want to see if the program can help maintain muscle, reduce stress and anxiety, an…

This study tests a 4-week online mindfulness-based psychoeducation program for first-time pregnant women who have moderate to severe fear of childbirth. The program includes relaxation exercises, emotional awareness, and coping strategies. Researchers will measure changes in fear…

This study tests whether a four-session educational program during pregnancy can help first-time mothers breastfeed exclusively for three months after birth. The program focuses on building confidence and problem-solving skills. 160 pregnant women will either receive the program …

This study tests whether using a breast pump for nipple stimulation can safely start labor in pregnant women. The gentle suction may trigger the body's own oxytocin to encourage contractions. Researchers will measure total labor time and compare it to standard methods. The goal i…

This study tests a structured education program for first-time pregnant women to reduce fear of childbirth and stress, and to strengthen their belief in normal birth. About 72 women in their third trimester will either receive the program or standard prenatal care. The goal is to…

This study will test a 4-week mindfulness-based stress reduction program in 100 first-time pregnant women. The goal is to see if it lowers anxiety about the baby's health and improves overall psychological well-being. Participants will attend online sessions twice a week.

This study will compare two methods of closing the skin after a cesarean delivery: absorbable staples placed under the skin versus traditional hand-sewn stitches. About 237 women having a C-section will be randomly assigned to one method. The goal is to see which technique is fas…

This pilot study looks at whether it is safe and practical for pregnant women with type 1 or type 2 diabetes to continue using their insulin pump during labor, instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to keep using it whil…

This study tests whether eating 50 grams of milk chocolate during labor can shorten the second stage (pushing). Researchers will compare 180 healthy pregnant women who eat the chocolate to those who do not. The goal is to see if a simple energy boost can make labor faster and saf…

This study compares two ways to manage pain after a planned C-section: a small dose of morphine given with the spinal anesthesia, versus a nerve block (TAP block) using numbing medicine. One hundred women will be randomly assigned to one of the two groups. The goal is to see whic…

This study looks at whether using a weighted blanket can reduce nighttime leg cramps, improve sleep quality, and lower anxiety and stress in pregnant women. Fifty women in their third trimester will use the blanket for 14 days and compare results to a 14-day period without it. Th…

This study will test whether virtual doula services—accessed through a smartphone app—can improve birth outcomes and satisfaction for first-time mothers living in rural areas. 614 pregnant women in their second or early third trimester will be randomly assigned to receive either …

This study tests whether spraying 10% lidocaine on the skin before inserting an IV can reduce pain for women having a planned C-section. About 150 participants will receive either the lidocaine spray or a placebo (saline spray) before their IV is placed. They will then rate their…

This study tests whether a weekly exercise class, combined with pelvic floor therapy when needed, can reduce pelvic girdle pain in pregnant women. Forty women with pelvic pain will be randomly assigned to either the exercise program or standard prenatal care. Researchers will mea…

This study is testing a virtual reality (VR) platform designed to help first-time pregnant women prepare for childbirth and improve their mental wellbeing. The VR program includes education about childbirth and exercises to build coping skills and confidence. Researchers will com…

This study compares using an injection port versus standard needles for insulin delivery in pregnant women with diabetes. The port stays on the skin for three days, allowing insulin to be given without repeated needle sticks. Researchers want to see if this approach helps women s…

This study tests a simple tool—short information cards on a mobile phone—to help pregnant people feel more confident when deciding about prenatal genetic screening. About 1,400 participants will use the cards before their first doctor visit, or receive usual care. Researchers wil…

This study will test a new, high-speed ultrasound device on 10 healthy women pregnant with identical twins who share a placenta. The goal is to see if the device can take detailed pictures of the tiny blood vessels in the placenta. This information could help doctors better under…

This study will test whether regularly checking pregnant women for hidden genital infections can reduce problems like preterm birth and low birth weight. 250 pregnant women will be split into two groups: one gets the extra screening and treatment, the other gets standard care. Th…

This study will follow 120 women with twin pregnancies and their 240 children to see how environmental exposures, lifestyle, and diet affect health at birth and during the first year of life. Researchers will collect biological samples and use models to measure exposure to pollut…

This pilot study will test a smartphone app called Womb Watch that uses the phone's microphone to listen for fetal movements, like kicks, breathing, and hiccups. About 60 pregnant women between 28 and 40 weeks will record audio daily for 15 minutes. The goal is to see if the app …

This study follows 1,000 pregnant women and their partners from early pregnancy to about two months after birth. Participants fill out short questionnaires at key timepoints to track how their health information needs change. Some may also share data from their smartphones or wea…

This study looks at how body image dissatisfaction, eating behaviors, and daily stress relate to blood sugar levels in pregnant women. Researchers will monitor 50 women between 14 and 28 weeks of pregnancy using a continuous glucose monitor and daily surveys over 10 days. The goa…

This study looks at whether teaching first-time mothers how to do perineal massage during pregnancy can help them feel more in control, confident about a normal birth, and less afraid of childbirth. About 152 pregnant women in Turkey will either get this special education plus re…

This study tests whether a short video of Black women sharing their labor pain experiences can increase empathy in doctors and nurses. About 120 providers and their Black postpartum patients will take part. The goal is to see if this simple tool improves trust and understanding i…

This study will collect ultrasound images from 50 pregnant people between 18 and 28 weeks of pregnancy. The goal is to use these images to train artificial intelligence (AI) to automatically measure key parts of the baby, like head size and leg length. The results will help get t…

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This study looks at whether using a set method for cervical ripening (preparing the cervix for labor) leads to more vaginal deliveries. About 1,158 pregnant women will be randomly assigned to receive either a balloon catheter alone or a balloon catheter plus the medication misopr…

This pilot study looks at how sleep, physical activity, and meal timing in early pregnancy relate to blood sugar patterns and the risk of gestational diabetes. Researchers will track 140 pregnant women using wearable devices and an AI food-logging app. The goal is to see if real-…

This study will compare the quality of pre-anesthesia consultations done by video call versus in-person for pregnant women. 250 participants will be randomly assigned to one of the two methods. The main goal is to see if the video consultation misses any important safety informat…

This study works with patients and healthcare professionals to create educational resources about fertility and pregnancy for people with Primary Ciliary Dyskinesia (PCD). The goal is to develop a patient-friendly guide and a toolkit for doctors. The study will involve 30 partici…

This pilot study tests whether a single 60-minute group educational session on safe therapeutic exercise during pregnancy can improve pregnant women's knowledge, confidence, and physical activity levels. Thirty low-risk pregnant women will be randomly assigned to receive either s…

This study follows 376 pregnant women from late pregnancy to 12 weeks after birth. Researchers measure hip, pelvic, and abdominal muscle function to see if these factors are linked to how a baby is delivered (vaginal or cesarean) and whether women develop pelvic floor problems li…

This study will test whether a mobile app called MI MOM can improve pregnancy and postpartum health for 500 pregnant women on Medicaid. One group uses the app and gets text messages with health tips, videos, and optional support from a community health worker. The other group rec…

This study will test better ways to screen for tuberculosis (TB) in pregnant and postpartum women in Guinea-Bissau. Researchers will use a symptom checklist, stool tests, and AI-powered chest X-rays to find more TB cases. The goal is to improve health for mothers and babies and g…

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study looks at how doctors trust artificial intelligence (AI) when it estimates a baby's weight during pregnancy. Over 300 clinicians will review ultrasound cases and choose between AI-based or traditional weight estimates. Some doctors will also see how reliable the AI is. …

This study looks at how cystic fibrosis medications (CFTR modulators) change in the body during pregnancy and after childbirth in 30 women. Researchers will measure drug levels in blood, breast milk, and umbilical cord blood. The goal is to understand how these drugs work in preg…

This observational study follows 111 women with multiple sclerosis who received rituximab (or similar CD-20 antibodies) before or during pregnancy, and their infants. Researchers will measure the baby's B-cell levels, infection rates, and vaccine responses during the first year o…

This study tests a 30-minute online training for doctors and clinic staff called PROMOTE. The training teaches them about federal employment laws and how to counsel pregnant patients on workplace accommodations. Researchers will compare how often doctors document this counseling …

This study looks at how often pregnant women who have their water break early carry antibiotic-resistant bacteria. Researchers will collect samples from 250 women across French hospitals to track these bacteria and identify risk factors. The goal is to help doctors choose better …