One pill to prevent HIV and pregnancy? new study tests simpler option for women

NCT ID NCT07288190

Not yet recruiting Prevention Sponsor: HIV Prevention Trials Network Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a single daily pill that combines HIV prevention (PrEP) and birth control is easier for women to take consistently than taking two separate pills. About 300 women without HIV will try both approaches in a crossover design, and researchers will measure adherence through blood tests. The goal is to see if a simpler regimen improves daily use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DPP (single pill combining FTC/TDF and ethinyl estradiol/levonorgestrel)
What this could lead to: If it works, this could make it simpler for women to prevent both HIV and pregnancy with just one daily pill.
What could go wrong: This is a small, early-phase study (Phase 2) with only 300 participants, so results may not apply to everyone. It focuses on adherence, not on actual HIV or pregnancy prevention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS PREGNANCY

Contacts and locations

Locations

Eswatini Prevention Center CRS

Mbabane, Eswatini
MU-JHU Research Collaboration (MUJHU CARE LTD) CRS

Kampala, Uganda
Spilhaus CRS

Harare, Zimbabwe

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