PREGNANCY

This Phase 3 trial is testing the safety and immune response of the MVA-BN mpox vaccine in 359 pregnant and postpartum women in the Democratic Republic of the Congo. Some women receive the vaccine during pregnancy, others right after giving birth, and a small group gets it as an …

This study tests whether combining text message support for pregnant women who smoke with special training for their doctors can help them quit. About 840 women at Duke and Pitt will receive smoking cessation texts throughout pregnancy. Some doctors will also get extra training o…

This study looks at whether taking omega-3 fatty acid supplements can help lower very high triglyceride levels in pregnant women. High triglycerides during pregnancy can increase the chance of having a large baby. The study involves 40 pregnant women with elevated triglycerides a…

This study tests whether having more frequent checkups with an obstetric provider or a study nurse during the first year after childbirth can help women with high blood pressure or diabetes manage their health better. One hundred women with Medicaid insurance who had these condit…

This study tests whether group prenatal care, where women with diabetes meet together with a healthcare provider, works better than standard one-on-one visits. Researchers will track blood sugar levels and weight after delivery in 117 pregnant women with type 2 or gestational dia…

This study tests whether providing 10 home-delivered meals per week, plus brief weekly support, can improve diet quality and promote healthy weight gain in low-income Black pregnant women with overweight or obesity. Seventeen women from Alabama are taking part. Researchers are ch…

This study tests a mobile health program called i-PregMom, which includes a smartphone app and digital food diary, to help pregnant women manage their blood sugar and weight gain. Researchers will enroll 160 first-time mothers and track their progress from early pregnancy (10-14 …

This study is testing two tuberculosis (TB) prevention treatments in pregnant women who also have HIV. The goal is to see if these treatments are safe and how they interact with the HIV medication dolutegravir. About 252 pregnant women will take either a daily TB drug for one mon…

This study tests a team-based care model for pregnant and postpartum women with opioid use disorder in low-resource clinics. About 1,350 participants will receive coordinated support to start and stay on medication, reduce overdose risk, and improve well-child visits. The goal is…

This pilot study is testing a lifestyle physical activity program to help pregnant women cut down on cannabis use. The study includes 50 pregnant women aged 18 and older who used cannabis at least once a week before pregnancy and want to stop. Participants will be guided to incre…

This study tests whether screening pregnant women for malaria with a highly sensitive rapid test during the first trimester, followed by treatment if positive, can improve newborn health. Over 2,000 women in malaria-prone areas will be compared to those receiving usual care. The …

This study tests whether taking riboflavin (vitamin B2) and a form of folate can prevent high blood pressure in pregnant women who have a specific gene variant (MTHFR TT). About 2250 women in their first trimester are being recruited. Those with the gene variant will receive the …

This study tests a remote program called StEP:Prenatal that uses a mobile app to coach pregnant women on healthy eating, physical activity, and stress reduction. About 276 pregnant women in their first trimester will either receive the program or standard care. The goal is to see…

This study compares two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. Both drugs are given along with a balloon catheter. The goal is to see which drug leads to a faster delivery and whether it increases the chance of a v…

This study looks at whether progressive muscle relaxation and finger grip exercises can lower stress, anxiety, and fatigue while improving sleep in pregnant women with preeclampsia. About 90 women will be split into three groups: one doing relaxation exercises, one doing finger g…

This pilot study tests a 10-week mindful eating self-help program for pregnant women who binge eat. Participants use a book and a smartphone app to learn mindful eating skills. The study aims to see if the program is feasible, acceptable, and helpful for reducing binge eating and…

This study tests a device called Emagina that uses a small balloon to train the pelvic floor muscles during pregnancy. The goal is to see if it makes the perineum more flexible and reduces tears or the need for stitches during childbirth. About 88 first-time mothers will either u…

This study tests whether listening to educational podcasts can reduce intense fear of childbirth in couples. About 50 pregnant women and their partners will be randomly assigned to receive podcast training or standard care. The goal is to lower anxiety, improve emotional well-bei…

This study tests whether using a virtual reality (VR) relaxation program can reduce nausea and vomiting, improve sleep quality, and increase comfort in pregnant women. About 90 women in early pregnancy (6-14 weeks) will either use VR relaxation or receive standard care. The goal …

This study tests whether a mindfulness-based childbirth and parenting class can lower anxiety in pregnant women. Sixty women with elevated worry will be randomly assigned to either the mindfulness class or a standard childbirth education class. Researchers will track changes in a…

This study looks at whether eating three dates each morning can help reduce vomiting and improve hemoglobin levels in pregnant women experiencing morning sickness. Forty pregnant women will be randomly assigned to eat dates, take standard anti-nausea medication, or follow dietary…

This study looks at whether teaching ThetaHealing meditation to first-time pregnant women can help reduce their pain and fear during labor. Forty healthy women in their first pregnancy will learn the meditation method before birth and use it during labor. Researchers will also us…

This study tests whether a structured exercise program during the second and third trimesters of pregnancy can improve the mother's fitness, blood vessel health, and weight gain, as well as the baby's health at birth. Sixty-four first-time pregnant women will participate. The goa…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This pilot study tests whether giving calcium carbonate to pregnant women during labor induction can shorten the time needed and reduce the need for C-sections. Researchers will compare 250 women who receive calcium with a historical control group. The goal is to see if this simp…

This study tests a special education program for first-time mothers that combines hypnosis techniques with breastfeeding information. The goal is to see if it helps mothers feel more confident and motivated to breastfeed. About 80 healthy pregnant women will take part, and resear…

This study looks at health records of about 1,100 women who took Wegovy during pregnancy and compares them to those who did not. The goal is to see if the drug increases risks for birth defects or other problems in babies. Researchers will use insurance claims data to track outco…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study is exploring what happens when women have better financial access to birth control. Researchers are tracking about 5,000 women in Michigan to see how it affects their use of contraception, pregnancy rates, education, jobs, finances, and overall well-being. The goal is …

This study looks at whether taking DHA (an omega-3 fatty acid) supplements during pregnancy can improve maternal health, reduce stress, and lead to better birth and brain development outcomes for babies. Researchers are giving 168 low-income African American women either DHA or a…

This study looks at whether showing a short video to pregnant women at least 24 hours before a planned C-section helps them better understand the risks and benefits of anesthesia. Researchers will compare how well these women make informed decisions about their care versus those …

This study looks at whether a simple urine pregnancy test taken 2 weeks after a medication abortion can reliably show the abortion is complete, instead of waiting the usual 4 weeks. About 400 people with very early pregnancies (up to 42 days) will take weekly tests and answer sym…

This study looks at sleep health in 50 low-income pregnant women. Researchers will use a home sleep test and a wrist activity monitor to measure sleep. They want to see how sleep relates to heart health and social factors. The goal is to create better sleep screening and treatmen…

This study tests whether a structured group nutrition program helps pregnant women gain weight within recommended ranges. 216 women with uncomplicated pregnancies will either attend three group classes plus a cooking session, or receive standard care with a brochure. Researchers …

This study tests a brief home visitation program for pregnant and postpartum women. Half of the 450 participants will receive at least two free home visits from a community health worker, who will provide resources and tools to prepare for the baby. The other half will receive st…

This study looks at how mental health and stress impact blood sugar levels in pregnant women, and how this might contribute to gestational diabetes. Researchers will follow 150 women with healthy single-baby pregnancies to understand these connections. The goal is to better ident…

This study aims to understand how the body's response to insulin changes during pregnancy in people with type 1 diabetes. Researchers will analyze data from continuous glucose monitors and insulin pumps used by 100 participants from before pregnancy to six months after birth. The…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study follows 9,000 pregnant women in Zambia from early pregnancy through one year after birth. Researchers collect medical details and biological samples to learn why preterm births happen, with the goal of finding new ways to prevent them. No treatment is given—this is an …

This study aims to understand how drugs like cocaine, alcohol, marijuana, and cigarettes taken during pregnancy affect the way mothers and babies bond. Researchers will look at the baby's brain and behavior shortly after birth. The study involves 150 mothers and their newborns.

This study was designed to see if a device called ClearSight™, which measures blood flow non-invasively, works as well as an ultrasound in pregnant women at term. The goal was to help doctors give the right amount of fluids during labor, avoiding both too little and too much. How…

This study follows pregnant women who took Wegovy for obesity or overweight to see if it affects the baby's health. Researchers compare these women to similar pregnant women who did not take Wegovy. The goal is to check for birth defects and other health issues in infants during …

This study uses donated placentas from healthy pregnancies to measure how much sugammadex, a drug used to reverse anesthesia, passes from mother to baby. Researchers will test drug levels in both the maternal and fetal sides of the placenta in a lab model. The goal is to provide …

This study aims to create clear, expert-backed recommendations for using vitamins, minerals, and other supplements during pregnancy. Currently, there is a lot of variation in how doctors prescribe these products. The study will involve 15 specialists who will answer questions in …

This study tests whether using virtual reality (VR) during a C-section can lower the chances of postpartum depression and anxiety. Researchers will compare 98 pregnant women who use VR during surgery to those who don't, measuring mood and brain chemicals linked to depression. The…

This study brings together 15 skin experts to create clear guidelines on safe skin care during pregnancy. The goal is to recommend ingredients like vitamin C and hyaluronic acid while advising against retinoids and high-dose salicylic acid. The results will help doctors guide pre…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …

This study uses insurance claims data to see if taking the constipation drug prucalopride during pregnancy is linked to birth defects or other problems for mothers and babies. Researchers will compare pregnant women who took prucalopride, those who took other constipation medicin…

This study was designed to see if a special MRI technique could measure blood flow in the placenta during pregnancy. The goal was to compare placentas in pregnancies where the baby is growing poorly (IUGR) with healthy pregnancies. However, the study was withdrawn before any part…

This study tested a 30-minute online training for doctors and nurses to help them counsel pregnant patients about workplace rights and accommodations. The trial was withdrawn before enrolling any participants, so no results are available. The goal was to see if the training could…