PROSTATE CANCER (DIAGNOSIS)

This study tests whether early referral to a cardio-oncology specialist can lower heart risks in prostate cancer patients receiving long-term hormone therapy (ARPI). About 80 men with high-risk or advanced prostate cancer and additional heart risk factors will be assigned to eith…

This study tests two types of targeted radiation therapy (177Lu-PSMA-617 and 225Ac-PSMA-617) in 45 men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see which therapy delivers more radiation to the tumor and how it affects the immun…

This phase 2 trial tests whether taking abiraterone 250 mg with food and prednisone can lower testosterone to castration levels in prostate cancer patients, without using standard hormone-blocking injections or surgery. The study enrolls 60 men with prostate cancer who need hormo…

This study is testing whether an artificial intelligence (AI) model can accurately predict which prostate cancers are aggressive and need treatment. Researchers will combine MRI and ultrasound images with tissue samples from 3,000 men. The goal is to reduce unnecessary biopsies a…

This study is testing a new type of PET/CT scan that targets a protein called ACP3 to find prostate cancer tumors. Researchers will compare it to standard PSMA/FDG scans in 100 adults with newly diagnosed or recurrent prostate cancer. The goal is to see if the ACP3 scan is more a…

This study is testing new types of MRI scans to see if they can more accurately find and grade prostate cancer without using contrast dye. Researchers will compare these new scans with standard MRI results and tissue samples from surgery or biopsy. About 300 people with suspected…

This study aims to develop a blood test that detects RNA from tiny particles (exosomes) to predict if prostate cancer has spread to the bones. Researchers will analyze blood samples from 1,000 men with newly diagnosed prostate cancer and compare results with PSMA PET scans. The g…

This study tests a new way to decide who needs a prostate biopsy. Instead of relying only on MRI, it adds a blood test called Prostate Health Index (PHI) to better tell which men have dangerous prostate cancer. The goal is to safely skip biopsies in men with low-risk findings, re…

This study is testing a new blood test called HeLP™ that looks at proteins in platelets to diagnose prostate cancer. Researchers want to see if it can be a safe and accurate alternative to current tests like PSA, MRI, and biopsy. The study will enroll 300 men suspected of having …

This study compares two prostate biopsy techniques to see which one better detects clinically significant prostate cancer. About 592 men with a suspicious MRI lesion will be randomly assigned to receive either targeted plus perilesional biopsy or targeted plus systematic biopsy. …

This study follows 100 men who have suspicious spots on prostate MRI but no significant cancer on their first biopsy. Over one year, they will have repeat MRI scans and biopsies to see if changes in those spots predict the development of clinically significant prostate cancer. Th…

This study is testing whether adding a PSMA PET scan to the usual MRI can better detect prostate cancer that has come back after focal therapy. Focal therapy treats only the cancerous part of the prostate, but cancer can sometimes return. The PSMA PET scan uses a radioactive dye …

This early-stage trial tests a new robot and ultrasound probe, called ProBot, designed to make prostate biopsies more precise and comfortable. The study will enroll 60 men with suspected prostate cancer to see if the device is safe and works as intended. If successful, it could l…

This study tests whether combining PSMA PET scans with machine learning can accurately grade prostate cancer without invasive biopsies. Researchers will enroll 220 men with suspected or confirmed prostate cancer. If successful, this approach could reduce unnecessary biopsies and …

This study tests whether a digital exercise program with online group sessions can help prostate cancer patients on hormone therapy exercise more regularly. 160 participants will either get standard care or standard care plus the digital program. Adherence is tracked with a weara…

This study tests a 12-week prehabilitation program for 20 prostate cancer patients about to start hormone and radiation therapy. The program includes physical exercise and a 4-day residential session with education and activities. Researchers want to see if patients and their fam…

This study looks at how well a telehealth program called National TeleOncology works for veterans newly diagnosed with lung, colorectal, prostate, or breast cancer. Researchers will track how many veterans use telehealth visits and whether the program affects the quality of care …

This study aims to describe the characteristics of prostate cancer in Algeria, including patient demographics, symptoms, diagnosis methods, and treatments. Researchers will collect data from 2,000 men aged 19 and older with confirmed prostate cancer. The goal is to better underst…

This study follows 500 men who had their prostate removed for cancer. Researchers check PSA levels soon after surgery to see if they can predict if the cancer will come back or spread. No new treatments are given—just standard care and observation.

This study looks at how the immune system changes in men with prostate cancer who receive brachytherapy (internal radiation). Researchers will collect blood and tissue samples before, during, and after treatment to track immune cells and DNA. The goal is to better understand the …