Infertility disorder

This study tests a device that uses heat to ablate (destroy) a small part of the ovary in women with polycystic ovary syndrome (PCOS) who have trouble getting pregnant. The goal is to restore ovulation without needing daily medication. About 195 women will be randomly assigned to…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…

This study aimed to see if the drug clomiphene citrate could help men with a condition called non-obstructive azoospermia, where the body produces little to no sperm. The plan was to give the drug or a placebo for nine months, then check if sperm could be found in the semen or th…

This study tests if a new growth hormone medicine (somapacitan) given once a week works as well as the standard daily growth hormone (Norditropin) for children who are very short due to being born small, or having Turner syndrome, Noonan syndrome, or unknown causes. About 412 chi…

This Phase 3 trial tests whether taking Elagolix, a hormone-blocking drug, before IVF can increase live birth rates in women with endometriosis. About 97 women will receive either Elagolix or a placebo before their IVF cycle. The goal is to see if this pre-treatment improves the …

This study tests whether a progesterone shot under the skin works as well as a vaginal gel for supporting early pregnancy after a frozen embryo transfer. About 688 women aged 35 to 42 with infertility will take part. The goal is to see which method leads to more successful pregna…

This study compares two common fertility treatments—letrozole alone versus clomiphene citrate plus tamoxifen—in 240 women with infertility due to ovulation problems. The goal is to see which approach leads to more ovulations and pregnancies. Participants will be monitored with ul…

This study offers girls and young teens facing strong cancer treatments the chance to freeze a piece of their ovary before therapy begins. The goal is to help preserve their ability to have biological children later in life. Around 100 participants will undergo a safe procedure t…

This study tests a new long-acting growth hormone (lonapegsomatropin) given once a week, compared to the standard daily growth hormone shot, in 48 prepubertal children with Turner syndrome who have not had growth hormone before. The goal is to see if the weekly shot is safe and h…

This early-stage study tests whether stem cells from umbilical cords can help women with a thin uterine lining become pregnant. The treatment aims to thicken the lining and reduce scarring, potentially improving pregnancy and live birth rates. The study involves 24 women aged 20-…

This study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone)—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one of the drugs for three months. The goal is to find new options for male inf…

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments that could harm their fertility, such as chemotherapy or radiation. The tissue is removed surgically and stored. Later, if they want to have children, the tissue can b…

This early study tests whether two drugs—denosumab and letrozole—can help men with a specific type of infertility (non-obstructive azoospermia) start producing sperm. Sixteen men will take the drugs for about three months, and researchers will check for sperm in their semen or te…

This study compares two medications—gonadotropin and clomiphene citrate—to see which better improves sperm health in men with fertility problems. About 500 men with abnormal sperm analysis will be randomly assigned to one of the drugs. The goal is to measure changes in sperm coun…

This study tests whether shining a special red light on embryos during IVF can help them grow better. As women age, the energy centers in their cells (mitochondria) weaken, making it harder for embryos to develop. The light therapy aims to boost that energy. Researchers will comp…

This study is testing whether a uterus transplant from a living or deceased donor can help women who were born without a uterus or had it removed to have a baby. Up to 38 women with working ovaries will receive a transplant and then try to get pregnant through IVF. The main goal …

This study tests whether a low-caffeine green tea extract (EGCG) can shrink uterine fibroids and improve pregnancy and live birth rates in women aged 18-40 who have been trying to conceive for at least six months. Participants take the extract and are monitored for changes in fib…

This study tests whether platelet-rich plasma (PRP), made from a woman's own blood, can improve pregnancy rates in those who have had multiple failed embryo transfers. 180 women will receive PRP either as an injection into the uterus lining or as a simple infusion, and their outc…

This study looks at whether men with a specific gene mutation (TDRD9) get more benefit from L-carnitine, a common supplement, to improve sperm count and movement. About 50 men with low sperm count and motility will take L-carnitine for 3 months. Researchers will compare changes i…

This study tests whether text messages and counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,310 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This study compares a new microfluidic device, SwimCount Harvester, to standard sperm preparation methods in couples undergoing IVF with genetic testing (PGT-A). About 1,600 couples will be randomly assigned to one of the two methods. The goal is to see if the device leads to mor…

This study explores transplanting a uterus into women who cannot get pregnant because they were born without a womb or had it removed. Ten women under 40 with a healthy donor will receive the transplant. The goal is to see if the procedure is feasible and can restore fertility, t…

This experimental study tests whether frozen-thawed testis tissue, when grafted under the skin, can produce sperm in men with infertility. Five men will receive their own stored tissue. The goal is to see if viable sperm can be retrieved, potentially offering a future fertility o…

This study tests a new coating on a hip replacement implant that may help prevent infections and help the implant bond better with the bone. About 340 adults needing a hip replacement will receive either the coated or standard implant. The goal is to see if the coated implant wor…

This study tests a non-surgical method to collect sperm from men with a condition called azoospermia, where no sperm is found in the semen. Using ultrasound guidance, doctors flush and suction fluid from a part of the testicle to retrieve sperm. If successful, this could help inf…

This study looks at whether giving a higher dose of the progesterone supplement Endometrin to women with low blood levels on the day of embryo transfer can improve pregnancy rates and lower miscarriage risk. About 150 women aged 18-42 undergoing frozen embryo transfer will be spl…

This study tests whether a uterus transplant from a deceased donor can help 10 women with uterine factor infertility (missing or damaged uterus) give birth. Participants first create embryos through IVF, then receive the transplant, and later attempt pregnancy. The main goal is t…

This study looks at whether flushing the fallopian tubes with an oil-based dye after a standard foam test can improve the chance of having a baby. About 736 infertile women aged 18-40 with at least one open tube will be randomly assigned to get the extra flush or not. The main go…

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study is testing a new sperm quality test called SpermQT. It aims to see if the test can predict how likely a couple is to get pregnant with treatments like IUI or IVF. About 1,000 couples will take part, and researchers will track pregnancy outcomes based on the test result…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This pilot study tests whether an online stress management program called Stress Free Now can lower stress and possibly increase pregnancy rates in women aged 18-34 who have been trying to conceive for 6-12 months. Forty women will be randomly assigned to either the program or a …

This study tests whether music therapy can reduce anxiety and improve pregnancy rates in women receiving artificial insemination. Researchers will compare pregnancy outcomes in 254 women who receive standard care plus music therapy versus standard care alone. The goal is to see i…

This study tests a new device called the Catheter Caps Case (C3) for dialysis patients. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adults with a dialysis catheter will try the device for 15 minutes, and researchers will measu…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study looks at whether a low-fat diet can increase reproductive hormones in women with obesity. Thirty women with regular cycles and no other hormone issues will follow a carefully controlled diet. The goal is to see if diet alone can improve hormone levels linked to fertili…

This study tests a new device called CorVision, a tiny lens made from collagen that is placed inside the cornea to improve near vision in people with presbyopia (age-related difficulty seeing up close). 110 adults aged 40-65 will receive the implant in one eye through a minimally…

This study planned to check whether vitamin D levels affect pregnancy rates in women undergoing IVF. It was withdrawn before enrolling any participants, so no data or conclusions are available. The idea was to measure vitamin D in blood samples and compare it to IVF outcomes like…

This study looks at whether transferring a frozen embryo on day 6 or day 7 of progesterone treatment leads to more live births. It includes 316 women aged 18-43 who have at least one high-quality, genetically normal embryo. Researchers will track pregnancy and miscarriage rates t…

This study looks at two methods for choosing which embryo to transfer during IVF: the standard way (looking at shape) and a newer way that also tracks how fast the embryo grows. The goal is to see which method leads to more live births. About 520 couples having their first or sec…

This study tests a patient navigator program for 28 underserved people struggling with infertility. The navigator helps with insurance, appointments, and tests to speed up care. Researchers compare their progress to similar patients from the year before. The goal is to see if thi…

This study tests whether a benchtop incubator helps more embryos reach the blastocyst stage compared to a standard box incubator in people undergoing IVF. 252 participants will have their eggs split and placed in both incubators. The goal is to see which device supports better em…

This study records 30-second videos of embryos from 1,000 IVF patients and uses artificial intelligence to analyze their movement patterns. The goal is to see if these patterns can predict whether an embryo will lead to a successful pregnancy. Participants receive standard care a…

This study compares a new at-home vaginal device (Kegg) that measures electrical changes in cervical mucus to standard methods like urine hormone strips and mucus checks. About 500 women aged 18-40 will use the device for three menstrual cycles. The goal is to see if the device c…

This study reviews medical records from about 400 couples where the male partner has a condition called non-obstructive azoospermia (NOA), meaning no sperm is found in the semen. All couples used IVF with a special sperm injection technique. The goal is to see if testing embryos …

This study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers collect health data, biospecimens, and environmental information to understand how parents' exposures affect pregnancy outcomes and child development. The goal is to f…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

This study looks at freezing ovarian tissue in girls with Turner syndrome, a condition that often causes early ovary failure and infertility. Researchers want to find out which patients are most likely to have healthy eggs in their tissue by checking their genes, hormones, and me…

This study checks whether tiny plastic particles, called microplastics, can be found in the cells and fluid around eggs in women undergoing fertility treatment (ICSI). Researchers will collect samples from 100 women to see if microplastics are present. The goal is simply to find …

This study investigates how obesity-related factors like high insulin and fat levels may disrupt fertility in women. Researchers will measure hormone changes and metabolic responses in 84 women. The goal is to understand the underlying causes and inform future treatments to impro…

This study follows 1,500 Asian women using REKOVELLE for the first time during IVF to see how well it works in everyday medical practice. Researchers will track live birth rates and how the drug is used. The goal is to understand its real-world effectiveness and safety for this s…

This study tests a new injectable fertility drug (QL1012D) against an approved one (Gonal-F®) in 48 healthy women aged 18-45. The goal is to see if the new drug works the same way in the body and is just as safe. Participants receive both drugs at different times to compare them …

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This observational study follows 2000 women aged 40 or younger with breast cancer to see how having a baby after diagnosis affects their survival and disease return. It also checks the growth and health of their children. The goal is to gather information, not to test a new treat…

This study looks at how breast cancer itself may affect a woman's ability to have children later. Researchers are comparing egg quality and hormone responses in 100 women with breast cancer versus healthy egg donors. The goal is to understand why cancer can reduce the number and …

This study watches embryos grow using time-lapse cameras and compares their development to genetic test results. Researchers hope to find visual clues that indicate a healthy embryo. 2000 IVF patients are taking part. If a link is found, it could lead to a less invasive way to ch…

This study tests a text-messaging program that sends reminders and educational videos to people starting fertility testing. The goal is to see if it helps them complete all the required tests faster. About 160 new female patients at Penn Fertility Care will take part, and half wi…

This study follows 300 fetuses and children with sex chromosome disorders to track their growth, organ development, and overall health. Researchers will also look at genetic and gut microbiome factors. The goal is to better understand how these conditions affect children over tim…

This study looks at fetuses with sex chromosome disorders (like extra or missing X or Y chromosomes) that were either miscarried or electively aborted. Researchers will analyze the placenta and fetal tissues to see how the chromosome changes affect gene activity and development. …

This study looks at whether using sperm from a second ejaculate (collected 1-2 hours after the first) can improve fertilization and embryo quality in ICSI, a type of IVF. Researchers will compare sperm quality and pregnancy outcomes between first and second ejaculates in 108 coup…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …

This study explores whether a woman's pain threshold, measured before the procedure, can predict how much anesthesia she will need during egg retrieval for IVF. Researchers will measure pain thresholds in 30 women and track the amount of sedatives they use. The goal is to persona…

This study looks at how the process of diagnosing infertility affects the sexuality of couples. Researchers will survey 80 heterosexual couples to see if the diagnosis and testing cause sexual problems. The goal is to better understand the link between infertility and sexual heal…

This study was designed to see how a hormone called GnRH is processed by the body when given through a small pump (OmniPod) instead of a needle. It was meant for healthy women aged 18 to 40 with regular periods. However, the trial was withdrawn before any participants were enroll…

This study uses machine learning to analyze data from 5,000 IVF patients to identify patterns that predict successful pregnancy. Researchers hope to create a tool that helps doctors personalize treatments, improving success rates and reducing the emotional and financial burden on…

This study was designed to see if a new monitoring algorithm could detect early signs of ovarian damage in women and girls who had cancer treatment. Researchers planned to compare a group using the new algorithm with a group that received standard care. However, the study was wit…

This study tests whether group virtual preconception care can improve pregnancy and health outcomes for people with infertility. About 140 patients from Penn Fertility Care will either join biweekly group sessions or receive usual care. Researchers will track blood pressure, weig…