Weekly shot may replace daily growth hormone for turner syndrome kids

NCT ID NCT05690386

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests a new long-acting growth hormone (lonapegsomatropin) given once a week, compared to the standard daily growth hormone shot, in 48 prepubertal children with Turner syndrome who have not had growth hormone before. The goal is to see if the weekly shot is safe and helps children grow as well as the daily shot. Participants will be randomly assigned to one of three doses of the weekly drug or the daily drug, and their growth will be tracked for up to 2 years, with an optional extension.

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Conditions

The condition(s) this trial relates to.

Turner syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ascendis Pharma Investigational Site

    Palo Alto, California, 94304, United States

  • Ascendis Pharma Investigational Site

    San Diego, California, 92123, United States

  • Ascendis Pharma Investigational Site

    Aurora, Colorado, 80045, United States

  • Ascendis Pharma Investigational Site

    Orlando, Florida, 32827, United States

  • Ascendis Pharma Investigational Site

    St. Petersburg, Florida, 33701-4804, United States

  • Ascendis Pharma Investigational Site

    Atlanta, Georgia, 30322, United States

  • Ascendis Pharma Investigational Site

    Idaho Falls, Idaho, 83404, United States

  • Ascendis Pharma Investigational Site

    Chicago, Illinois, 60611, United States

  • Ascendis Pharma Investigational Site

    Boston, Massachusetts, 02114, United States

  • Ascendis Pharma Investigational Site

    Saint Paul, Minnesota, 55102, United States

  • Ascendis Pharma Investigational Site

    Las Vegas, Nevada, 89113, United States

  • Ascendis Pharma Investigational Site

    Lake Success, New York, 11042, United States

  • Ascendis Pharma Investigational Site

    Chapel Hill, North Carolina, 27599, United States

  • Ascendis Pharma Investigational Site

    Cincinnati, Ohio, 45229, United States

  • Ascendis Pharma Investigational Site

    Oklahoma City, Oklahoma, 73104, United States

  • Ascendis Pharma Investigational Site

    Portland, Oregon, 97239, United States

  • Ascendis Pharma Investigational Site

    El Paso, Texas, 79902, United States

  • Ascendis Pharma Investigational Site

    Fort Worth, Texas, 76104, United States

  • Ascendis Pharma Investigational Site

    Seattle, Washington, 98105, United States