Infertility disorder

This study tests a new way to prepare sperm for in vitro fertilization (IVF) called HyperSperm. It compares the safety and effectiveness of this method to standard sperm preparation. The trial will involve 202 couples undergoing IVF and will measure how many embryos are healthy (…

This study tests whether a type of abdominal massage called visceral osteopathic manual therapy can improve sperm quality and blood flow in men with varicocele, a condition where veins in the scrotum become enlarged and can cause infertility. Thirty-two men aged 18-45 will either…

This study compares myo-inositol alone versus myo-inositol plus alpha-lactalbumin in 82 women with PCOS who want to conceive. Over 12 weeks, researchers will track pregnancy rates, menstrual regularity, and metabolic changes. The goal is to see if adding alpha-lactalbumin improve…

This phase 3 study tests a new weekly growth hormone injection (inpegsomatropin) against an existing one (givopegsomatropin) in 84 girls with Turner syndrome who have short stature. The goal is to see which works better for increasing growth over 52 weeks. Participants are prepub…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase pregnancy rates. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP-treated…

This study tests a new device that sorts sperm without spinning them, which may reduce DNA damage often seen in older men. It involves 378 couples where the male partner is 40 or older and the female partner has at least 5 mature eggs. The goal is to see if this device leads to m…

This study tests a more thorough varicocele surgery that strips away extra veins, compared to the standard method. About 160 infertile men with varicocele will be randomly assigned to one of the two procedures. The goal is to see if the extended stripping reduces the chance of va…

This study tests whether infusing a woman's own platelet-rich plasma (PRP) into the uterus can improve the uterine lining in women with a thin or unresponsive endometrium and a history of failed embryo transfers. About 80 women will receive either standard hormone therapy alone o…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either h…

This study compares giving three doses of a GnRH agonist (triptorelin) versus the usual single dose to trigger ovulation in women who produce many eggs during IVF. The goal is to see if multiple doses lead to more mature eggs and higher pregnancy rates. The trial plans to enroll …

This study tests whether a modified dual trigger (a mix of HCG and two doses of a GnRH agonist) works better than the standard HCG trigger for ovulation in women undergoing IVF. About 196 women with normal egg reserves will participate. The goal is to see if the new method improv…

This early study tests a drug called leflutrozole in 15 men who have no sperm in their semen due to a blockage-free cause. The drug is taken as a weekly capsule and aims to boost sperm production. Researchers will check if sperm appear in the semen after 12-20 weeks of treatment.

This study tests whether giving two medications (a GnRH agonist and HCG) instead of just HCG can help women with low ovarian response produce more mature eggs for IVF. About 164 women will be randomly assigned to receive either the double trigger or the standard HCG trigger. The …

This study tests whether giving men with low testosterone and no sperm in their ejaculate a combination of two hormones (hCG and FSH) can help them produce usable sperm for IVF. About 860 men will either receive the hormone therapy or standard care for 16 weeks. The goal is to se…

This study tests whether transplanting ovarian tissue from a sister can restore fertility and hormone production in women with premature ovarian failure (early menopause). Ten women will receive tissue from their non-identical sister, along with immunosuppressive drugs to prevent…

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compa…

This study tests whether a daily dietary supplement containing EGCG (from green tea), vitamin B12, hyaluronic acid, and folic acid can help men with HPV maintain genital health and possibly clear the virus. The trial will include 96 participants (48 couples) and compare those tak…

This study tests whether a lower daily dose (150 IU) of follicle-stimulating hormone (FSH) is as effective as a higher dose (225 IU) for women with normal ovarian reserve undergoing IVF. The main goal is to see if the lower dose leads to similar live birth rates while possibly re…

This study tests an AI-driven device called BAIBYS™ that automatically selects sperm based on movement, size, and shape for use in IVF. Half of the eggs from each couple will be fertilized using sperm chosen by the AI, and the other half using the standard manual method. The goal…

This clinical trial tests whether a traditional Chinese herbal formula, Bushen Tongzhi, can improve pregnancy rates in women with diminished ovarian reserve who are undergoing IVF. About 348 women aged 22-39 will take either the herbal granules or a placebo three times daily for …

This study tests whether taking royal jelly, a bee product, can improve sperm DNA quality and pregnancy rates in couples with unexplained infertility. Eighty men will take either royal jelly or a placebo daily for three months. Researchers will measure sperm damage, hormone level…

This pilot study tests whether a daily dietary supplement containing EGCG, folic acid, vitamin B12, and hyaluronic acid can help men clear an active HPV infection and improve sperm health. The study involves 34 couples trying to conceive, where the male partner has HPV and the fe…

This early-stage study tests a new drug called YB-1113 for women with premature ovarian insufficiency (early menopause). The goal is to see if it is safe and can help restart ovarian function, potentially allowing women under 40 to become pregnant. Only 6 participants will receiv…

This Phase 3 trial will test whether adding a traditional Chinese herbal formula to the standard fertility drug letrozole can improve natural pregnancy rates in women aged 22–39 with diminished ovarian reserve (low egg supply). The study plans to enroll 320 women who will receive…

This study compares two common fertility treatments—ICSI and IVF—to see which one helps couples with unexplained infertility have a baby. About 848 couples in China will be randomly assigned to one treatment. The main goal is to find out which method leads to more live births.…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase the chance of pregnancy. About 288 women with infertility will be randomly assigned to receive either PRP-treated sperm or standar…

This study will compare two advanced sperm selection techniques—PICSI and the ZyMot device—used during ICSI (a type of IVF). The goal is to see which method leads to more pregnancies. 300 couples will take part, with women aged 20-39. The results could help fertility clinics choo…

This study tests whether a woman's own immune cells, turned into decidual-like NK cells in a lab and then placed back into her uterus, can improve pregnancy chances. It includes 159 women with abnormal uterine NK cells and a history of reproductive failure. The main goal is to se…

This study tests whether two popular weight-loss drugs, semaglutide and tirzepatide, can improve sperm quality and help obese men have children naturally. About 180 men will receive either lifestyle advice, semaglutide, or tirzepatide for 32 weeks. Researchers will measure change…

This study aims to develop a non-invasive diagnostic test for endometriosis, a painful condition affecting 1 in 10 women. Researchers will combine AI-enhanced ultrasound with blood, saliva, and tissue markers to detect the disease without surgery. 365 women aged 18-45 with suspec…

This study aims to develop and validate an artificial intelligence tool that analyzes sperm quality using microfluidic technology. Researchers will test the tool on 200 men undergoing IVF or artificial insemination. The goal is to provide a more accurate, standardized diagnosis a…

This study tests an artificial intelligence algorithm called SiDTM v2.0 that helps embryologists choose the best sperm for a procedure called ICSI (a type of IVF). Currently, sperm selection is done by eye, which can vary between experts. The AI scores each sperm based on shape a…

This study tests whether a 12-week program of diet changes, supplements, exercise, and better sleep can improve fertility scores in women aged 20-40 who show early signs of fertility decline. Researchers will enroll 384 women across six medical centers in China, using the OvaRePr…

This study tests a web-based mind-body awareness program for women undergoing infertility treatment. The program includes education and relaxation practices over 3 sessions in 2 weeks. Researchers will measure if it improves fertility awareness and feelings of preparedness in 78 …

This study tests a 5-day online Theta Healing program—including meditation, visualization, and self-compassion exercises—in 142 women with PCOS. The goal is to see if it reduces fertility anxiety and improves body image compared to usual care alone. Results will be measured 6 wee…

This pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…

This study looks at a fertility drug called corifollitropin alfa in women aged 36 to 40 who are doing IVF. The goal is to see if the drug is safe and helps produce eggs. Researchers will track side effects and pregnancy rates over one year.

This study will test whether a 21-day spa program can improve hormone levels and well-being in 55 women aged 20-40 with infertility. Participants will receive comprehensive spa care including treatments and rehabilitation. The goal is to see if this approach can help reduce stres…

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) increases the chance of pregnancy in women who also took letrozole to stimulate their ovaries. About 690 women in Denmark will be randomly assigned to receive either progesterone vagina…

This study looks at whether using a laser to thin the outer shell of a frozen embryo (called laser-assisted hatching) can help women aged 35 and older have a baby. About 916 women will be randomly assigned to receive the laser treatment or standard care. The main goal is to see i…

This study looks at whether a gamified healthy lifestyle training program can help women going through fertility treatments (like IVF) adopt healthier habits and feel more in control. About 105 women will be split into three groups: one gets the game-like program plus a booklet, …

This study tests whether preparing the uterus for frozen embryo transfer with a completely natural cycle or a modified cycle (with ovulation-triggering medication) works better. It also looks at adding letrozole tablets early in the cycle. About 120 women undergoing IVF will be r…

This study tests whether intravenous lidocaine or magnesium sulfate can better stabilize blood pressure and heart rate as women wake up from general anesthesia during infertility-related laparoscopic surgery. Sixty-nine women will be randomly assigned to receive one of the two dr…

This study tests whether adding pure platelet-rich plasma (P-PRP) to sperm samples can improve sperm movement (motility) in a lab. Researchers will first standardize how to make P-PRP, then compare sperm quality after 24 hours with and without P-PRP. The trial involves 248 partic…

This study tests whether a 4-week Mindfulness-Based Stress Reduction (MBSR) program can lower stress, improve pregnancy adjustment, and reduce anxiety about the baby's health in women who became pregnant after infertility treatment. Forty-four pregnant women will be split into tw…

This study looks at whether the natural contractions of the uterus (called endometrial peristalsis) influence the chance of pregnancy in women undergoing frozen embryo transfer with hormone replacement therapy. Researchers will measure these contractions using ultrasound at three…

This study will look back at records from 92 IVF patients whose embryos came from abnormally fertilized eggs. Researchers want to see how often these embryos lead to pregnancy and live birth. The goal is to help fertility doctors make better decisions about whether to use such em…

This study looks at women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs, making IVF harder. Researchers are examining specific RNA molecules in the fluid around eggs to see how they relate to egg quality and embryo development. The goal is …

This study will check if menstrual blood can give the same health information as regular blood tests, uterine biopsies, and vaginal swabs. One hundred menstruating women aged 18 and over will provide samples during their period. The goal is to see if menstrual blood is a useful, …

This study will follow about 484 couples undergoing a type of IVF called ICSI to see if sperm DNA damage affects their chances of having a baby. Researchers will measure DNA breaks in sperm before and after a washing step, then track pregnancy and live birth rates. The goal is to…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

This study will survey about 950 men who stored sperm at a French fertility center before cancer treatment between 2010 and 2024. Researchers want to know how many later became fathers, whether naturally or with medical help, and if they used their frozen sperm. The goal is to be…

This study tests two different calcium treatments (ionophores) to help eggs fertilize during IVF when previous attempts failed. Researchers will compare which treatment works better and check embryo health. The study involves 20 couples with a history of low fertilization.

This study looks at whether one session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight. Sixty women will receive either real or fake stimulation while their heart activity…

This study will measure microplastics in semen, follicular fluid, and other samples from 1000 men and women seeking fertility treatment. Researchers will check if higher microplastic levels are linked to lower pregnancy rates and poorer egg or sperm quality. The goal is to better…

This study tests whether co-culturing immature human eggs with lab-grown ovarian support cells (made from stem cells) helps them mature in the lab. About 100 women undergoing IVF will donate leftover immature eggs, which will be split into two groups: one with standard lab matura…

This study will check the heart and blood vessel health of 120 women, some planning pregnancy naturally and some after IVF for infertility. Researchers want to see if infertility or IVF treatments are linked to higher heart disease risk. The goal is to learn how to run a larger s…

This study looks at whether transferring an embryo on day 2 or day 3 after fertilization leads to more live births in women aged 35 or older with low ovarian reserve. About 470 women will be randomly assigned to one of the two transfer times. The goal is to find out which timing …

This study will test an upgraded genetic test (PGT-A upgrade) on embryos from 1,700 IVF patients across multiple countries. The test looks for a wider range of chromosomal issues than standard tests. Researchers hope this will help select healthier embryos, reducing the chance of…

This study works with patients and healthcare professionals to create educational resources about fertility and pregnancy for people with Primary Ciliary Dyskinesia (PCD). The goal is to develop a patient-friendly guide and a toolkit for doctors. The study will involve 30 partici…

This study looks at 40 infertile men with varicoceles (enlarged veins in the scrotum) to see if blood flow measurements in the testicles can predict how well they will respond to surgery. Participants will have ultrasound and blood tests before and three months after a standard m…

This study looks at a hormone called relaxin in women who get pregnant through IVF. Researchers want to see if relaxin levels differ between fresh and frozen embryo transfers, and if low levels are linked to pregnancy complications. 60 first-time mothers will give an extra blood …

This study looks back at the egg donation process at Nancy University Hospital since France updated its bioethics laws in 2021. Researchers will review the records of about 60 women who started the donation process to see how many completed it and what helped or hindered them. Th…

This observational study looks at embryos from IVF that are not used for pregnancy to find molecular patterns related to embryo quality. Researchers hope to learn why some embryos are healthy and others are not, which could improve future fertility treatments. About 150 patients …

This study looks at a new program that helps children aged 6 to 18 with mild mental health issues get faster care by improving how doctors, nurses, and community providers work together. Researchers will interview healthcare professionals and families to find out what helps or hi…

This study looks at how the size and number of ovarian follicles (fluid-filled sacs containing eggs) on the day of the trigger shot affect how many eggs are retrieved during an IVF cycle. Researchers will measure follicles using ultrasound in 60 women aged 18-35 undergoing ICSI. …

This study looks at whether having a tattoo affects the chances of getting pregnant through IVF. Researchers will compare pregnancy rates in women with and without tattoos who are undergoing embryo transfer. The goal is to see if tattoo size, duration, or ink color play a role in…

This study will examine tissue samples from 30 women having surgery for bowel endometriosis to see if genetic changes in the affected bowel might increase the risk of colorectal cancer. The goal is to better understand any hidden connection and improve how doctors assess cancer r…

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…

This study will look at over 1,000 men visiting fertility clinics across India to understand how common male infertility is and what factors like smoking, obesity, and location might play a role. Researchers will use a new system called the Aphrodite Criteria to get a clearer pic…

This study tests whether rinsing (flushing) ovarian follicles during egg retrieval can increase the number of mature eggs collected for IVF. In 75 women undergoing IVF, one ovary will be flushed and the other will not, and the egg yields will be compared. The goal is to see if th…

This pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms …

This study looks at how different microbes (like bacteria and viruses) spread between couples who are having trouble getting pregnant. Researchers will collect samples from the mouth and genitals of 200 couples over two years. The goal is to understand infection risks and improve…

This study will survey 233 married women aged 18-45 who are seeking infertility treatment in Egypt to find out how common violence is against them. Researchers want to understand if infertility makes women more likely to experience abuse. The goal is to use this information to be…

This pilot study will test whether it is safe and effective to remove uterine fibroids and retrieve eggs in a single surgical step for infertile women aged 18–45. The researchers will track pregnancy, miscarriage, and live birth rates after frozen embryo transfer. Only 20 women w…

This study will look at 80 men with non-obstructive azoospermia (no sperm in semen due to poor sperm production) who are scheduled for bilateral microscopic testicular sperm extraction (micro-TESE). The goal is to see how often sperm can be successfully retrieved from a single te…

This study looks at fluid and tissue samples from the uterus and ovaries of women with moderate to severe endometriosis. Researchers want to find biological markers that explain why some women with endometriosis have trouble getting pregnant. The goal is to improve fertility trea…

This study will test a computer model that predicts infertility risk in women with uterine fibroids. Researchers will follow over 7,000 women aged 20-50 who want to conceive and have fibroids. The goal is to see if the model can accurately identify who might struggle to get pregn…

This study will analyze videos of developing embryos from 1,500 IVF cycles to see if a computer algorithm can predict which ones will successfully implant in the womb. Researchers will combine embryo growth patterns with patient health data to train the algorithm. The goal is to …