Infertility disorder

This study tested whether combining weight management (diet and exercise guidance) with a daily hormone pill (megestrol acetate) could help obese patients with early-stage endometrial cancer who want to preserve their fertility. The goal was to see if the cancer would completely …

This study offered continued treatment with EryDex to 101 people with ataxia telangiectasia (A-T) who had finished a previous trial. The main goal was to monitor safety, including side effects and serious events. The study was terminated early, and it did not aim to cure the dise…

This early-stage trial tested whether adding the drug FE999302 to standard IVF hormones could increase the number of high-quality embryos in women undergoing fertility treatment. The study enrolled 310 women aged 18–40 with specific hormone levels. The trial was terminated early,…

This early-phase study looked at whether giving an extra fertility drug (FE 999302) at different times during ovarian stimulation could improve the number of good-quality embryos in women undergoing IVF. The trial included 106 women with high ovarian reserve and was stopped early…

This Phase II trial tested a drug called N-Acetyl-L-Leucine (IB1001) in 17 people with Ataxia-Telangiectasia, a rare genetic disease that affects movement and immunity. The study aimed to see if the drug could improve symptoms and slow the disease over time. The trial was termina…

This study compared two approaches for women with deep endometriosis who want to get pregnant: surgery to remove endometriosis or fertility treatment (IVF). Researchers planned to track pregnancy and live birth rates. The trial was stopped early after enrolling 38 women, so the r…

This study tested a new, non-invasive way to check embryos for chromosome problems before IVF. Instead of taking a cell from the embryo, doctors analyzed the fluid the embryo grew in. The goal was to see if this method could help choose the embryo most likely to lead to a healthy…

This study looked at how a man's smoking habits might affect a couple's ability to have a baby. Researchers compared fertile and infertile couples, measuring smoking markers like carbon monoxide and cotinine in blood, semen, and hair. The goal was to understand if smoking damages…

This study aimed to understand how chemotherapy impacts the ability to have children in young women (ages 18-37) with breast cancer. Researchers measured ovarian reserve (egg supply) using hormone levels and follicle counts before, during, and up to 24 months after treatment. The…

This study looked at how the body responds to certain hormones (kisspeptin and GnRH) in people who carry gene variants linked to infertility. Researchers measured natural hormone patterns and responses to stimulation in 16 participants. The goal was to better understand reproduct…

This study aimed to create a library of biological samples and clinical data from 250 women with unexplained infertility or low ovarian reserve. Researchers collected blood, DNA, vaginal swabs, and fluid from egg retrieval to help future studies find markers that predict pregnanc…

This study looked at whether high levels of male hormones (hyperandrogenism) lower the chance of IVF success in women with PCOS. Researchers planned to track 32 women aged 18–39, but the study was terminated early. The goal was to see if these hormones affect pregnancy rates afte…