New embryo test could boost IVF success without poking the embryo

NCT ID NCT04000152

Terminated Diagnosis Sponsor: Igenomix Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new, non-invasive way to check embryos for chromosome problems before IVF. Instead of taking a cell from the embryo, doctors analyzed the fluid the embryo grew in. The goal was to see if this method could help choose the embryo most likely to lead to a healthy pregnancy. The trial involved 296 patients but was stopped early, so we don't have final answers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) via spent blastocyst media analysis
What this could lead to: If successful, this could offer a cheaper, safer way to choose the healthiest embryo for IVF without harming it.
What could go wrong: The trial was terminated early, so results are limited. The test may not be accurate enough to replace current methods, and its benefit on pregnancy rates is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abortion, Spontaneous aneuploidy chromosomal disorder Chromosome Aberrations infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEUPLOIDY CHROMOSOME ABNORMALITY INFERTILITY

Contacts and locations

Locations

Centro Procreazione Assistita DEMETRA

Florence, Firenze, 50141, Italy
Crecer: Centro de Reproducción y Genética Humana

Mar del Plata, Buenos Aires, Argentina
Hospital Ruber Internacional

Madrid, Madrid, 28035, Spain
Hôpital Foch

Suresnes, Suresnes, 92150, France
Nilo Frantz - Centro de Reprodução Humana

Boa Vista, Porto Alegre, 91330-002, Brazil
Saresa - Reproducción Humana Asistida

Salta, Salta Province, 4400, Argentina
Società Italiana Studi di Medicina della Riproduzione (S.I.S.M.e.R.)

Bologna, Bologna, 40138, Italy
Vida - Centro de Fertilidade

Rio de Janeiro, Rio de Janeiro, 22793-080, Brazil

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