Womb transplants could let infertile women give birth
NCT ID NCT02656550
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This study is testing whether a uterus transplant from a living or deceased donor can help women who were born without a uterus or had it removed to have a baby. Up to 38 women with working ovaries will receive a transplant and then try to get pregnant through IVF. The main goal is a successful live birth, but women will need to take anti-rejection drugs for life, so this is a disease-control approach, not a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
38 people
The number who actually took part.
- Started
-
Nov 2015
- Expected to finish
-
Nov 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
20 to 35 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Women diagnosed with Absolute Uterine Infertility (AUI) and intact native ovaries. 2. Women of childbearing age 20-35. 3. Human papillomarvius negative or received vaccination for human papillomarvius virus (HPV). Subjects with a history of HPV in the past must show a negative history since and test negative at screening. 4. A subject who is negative for Gonorrhea, Chlamydia and Syphilis. 5. A subject with the history of Herpes (HSV-2) with no current symptoms. Subject may require preventative maintenance per study doctor discretion. 6. Subjects have received counseling regarding infertility alternatives to uterine transplant such as adoption or surrogate pregnancy. 7. Willing to undergo in-vitro fertilization and medically cleared for in-vitro fertilization. 8. Evaluated by a fertility specialist and determined to have good ovarian reproductive potential and ability to carry fetus to term. 9. Must have the ability to fund, either through third party coverage or through other their own personal financing, any expenses associated with assisted reproduction services provided to them. 10. Meets physiological recipient criteria Exclusion Criteria: 1. Subject with Diabetes Mellitus Type I and II by medical history or elevated hemoglobin A1c blood test. 2. Subject has known hypersensitivity to Tacrolimus, Thymoglobulin or CellCept. 3. Subject with existing hypertension, per investigator's discretion. 4. Subject who has a history of solid organ or bone marrow transplant. 5. Subject who has history of cancer in last five years. 6. Subject with a body mass index \>30. 7. Subject with an active infection. 8. Subject who is seropositive for HIV, HBV, HCV 9. Subject with technical obstacles as per anatomical malformations, which pose a high surgical risk in the judgment of the investigator. 10. Subject unwilling or unable to comply with study requirements. 11. Subject unable to undergo in-vitro fertilization or not cleared for transplant. 12. Subject who has smoked within the last 12 months. 13. Subject who has alcohol or drug abuse within 12 months of screening. 14. Subject with any pre-existing clinical or medical conditions that would pose the subject at an increased risk, as per the investigator's discretion.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Absolute uterine infertility are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Baylor University Medical Center
Dallas, Texas, 75246, United States