Could a common arthritis drug help prevent miscarriages?

NCT ID NCT06652113

Recruiting now Disease control Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether adding hydroxychloroquine (an anti-inflammatory drug) to levothyroxine (a thyroid hormone) can increase live birth rates in women with thyroid antibodies and unexplained recurrent pregnancy loss. About 800 women will take either the combination or levothyroxine alone, starting at least 8 weeks before pregnancy and continuing through pregnancy. The main goal is to see if more women in the combination group give birth after 28 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hydroxychloroquine and levothyroxine
What this could lead to: If successful, this could offer a new treatment option to help women with thyroid antibodies and unexplained recurrent pregnancy loss have a live birth.
What could go wrong: This is a mid-stage trial, so results are not guaranteed. The combination may not improve outcomes over levothyroxine alone, and hydroxychloroquine can have side effects like vision problems or heart issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pregnancy loss, recurrent, 4 pregnancy loss, recurrent, susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EUTHYROID WITH THYROID ANTIBODIES RECURRENT PREGNANCY LOSS

Contacts and locations

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Locations

Sun Yat-Sen Memorial Hospital
RECRUITING

Guangzhou, Guangdong, 510000, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510120, China

Contact Email: •••••@•••••

Contact Email: •••••@•••••

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