New study reveals hidden blood flow dynamics when reducing shock medications

NCT ID NCT07653659

Recruiting now Knowledge-focused Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study observes 30 adults with distributive shock who are on a ventilator and receiving norepinephrine to maintain blood pressure. Researchers measure critical closing pressure—the pressure at which small blood vessels collapse—before and 30 minutes after doctors reduce the norepinephrine dose. The goal is to understand how these changes affect tissue perfusion and guide safer medication management in intensive care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors better understand how to safely reduce blood pressure medications in shock patients, potentially improving recovery.
What could go wrong: This is a small observational study with only 30 participants, so results may not apply to all patients. It does not test a new treatment, only measures existing care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS DISTRIBUTIVE SHOCK HEMODYNAMIC ASSESSMENT

Contacts and locations

Locations

Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China

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