New drug combo aims to tame rare inflammatory disease
NCT ID NCT07068165
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding lenalidomide to standard steroid treatment can better control active IgG4-related disease (IgG4-RD), a rare condition that causes swelling and damage in organs. About 198 adults will receive either lenalidomide plus prednisone or prednisone alone for up to 52 weeks. The main goal is to see if the combination lowers the chance of the disease flaring up again.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lenalidomide (a drug that modifies the immune system) combined with prednisone (a steroid)
- What this could lead to
- If successful, this could offer a new treatment option for people with active IgG4-related disease, potentially reducing relapses and allowing lower steroid doses.
- What could go wrong
- This is a mid-stage trial with only 198 participants, so results may not apply to everyone. Lenalidomide has known side effects like low blood counts and increased infection risk.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peking Union Medical College Hospital, Beijing, Beijing 100050
RECRUITINGBeijing, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New drug aims to stop IgG4 disease relapses without Long-Term steroids
- Experimental CAR-T injection aims to tame autoimmune diseases
- Scientists investigate immune cell role in rare IgG4 disease
- Old drug, new hope: could filgotinib tame rare immune diseases?
- New scan could shine a light on hidden inflammation
- New drug shows promise for rare inflammatory disease