New drug combo aims to shrink tough colorectal tumors before surgery
NCT ID NCT03926338
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether giving the immunotherapy drug toripalimab, with or without the anti-inflammatory drug celecoxib, before surgery can improve outcomes for people with a specific type of colorectal cancer (dMMR/MSI-H). About 270 participants will receive the drugs for 12 weeks, then undergo surgery. The main goals are to see how many patients have no cancer cells left at surgery and how long they stay cancer-free.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- toripalimab (an immunotherapy drug) and celecoxib (an anti-inflammatory drug)
- What this could lead to
- If successful, this could lead to a more effective pre-surgery treatment for a hard-to-treat form of colorectal cancer, potentially improving outcomes and reducing recurrence.
- What could go wrong
- This is an early-phase trial with a moderate number of participants. The combination may not work better than toripalimab alone, and side effects from immunotherapy or celecoxib are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, 510655, China
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