Smarter radiation aims to cut side effects in prostate cancer relapse
NCT ID NCT07515651
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a personalized radiation approach for men whose prostate cancer has returned after surgery. Using PSMA PET scans, doctors will give higher radiation doses to active cancer spots and lower doses to healthy areas, all in just 5 treatments over two weeks. The goal is to reduce side effects while keeping the cancer under control. Fifty participants will be followed for five years to track side effects and cancer recurrence.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Image-guided radiotherapy (SBRT) with PSMA PET-based dose adjustment
- What this could lead to
- If successful, this approach could reduce treatment side effects while maintaining high cure rates for prostate cancer that has returned after surgery.
- What could go wrong
- This is a small, early-phase trial (50 participants) without a comparison group, so results may not apply broadly. There is also a risk that lowering radiation to some areas might allow cancer to return.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Health Network - Princess Margaret Cancer Center
Toronto, Ontario, M5G 2M9, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can surgery boost control of spread prostate cancer?
- Can a better scan sharpen radiation for prostate cancer?
- A sharper eye on prostate cancer: could new imaging spare healthy tissue?
- Can a new drug combo tame resistant prostate cancer?
- Hormone therapy showdown: can an oral pill beat the shot for prostate cancer patients?
- Can tracking tumor movement during radiation make treatment more precise?