New study aims to unlock Radiation's hidden effects on head and neck cancer

NCT ID NCT06487403

Recruiting now Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people newly diagnosed with head and neck squamous cell carcinoma who are scheduled for curative surgery or radiation therapy. Researchers want to see how radiation changes MRI scans and immune-related markers in tumors. About 40 participants will be randomly assigned to one of two standard radiation schedules, and some will also take pimonidazole tablets to help measure oxygen levels in tumors. The goal is to gather information that could improve future treatment planning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (external beam radiotherapy) and pimonidazole tablets
What this could lead to: If successful, this could help doctors better understand how radiation affects tumors and immune responses, potentially leading to more personalized radiotherapy schedules.
What could go wrong: This is a small, early-stage exploratory study with only 40 participants, so results may not apply broadly. It focuses on measuring biomarkers, not on proving a new treatment works.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

Contacts and locations

Locations

Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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