Massive trial aims to find better ways to treat severe lung failure
NCT ID NCT05440851
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 23 times
Summary
This large study is testing multiple new treatments for people with severe breathing failure who need oxygen or a ventilator. It will include up to 6,250 participants and use a flexible design to quickly identify which treatments work best. The goal is to improve survival and reduce long-term health problems in these very ill patients.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ASST Grande Ospedale Metropolitano Niguarda
RECRUITINGMilan, MI, 20162, Italy
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Auckland City Hospital
RECRUITINGGrafton, Auckland, 1023, New Zealand
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Azienda Socio-Sanitaria Territoriale Ovest Milanese
RECRUITINGLegnano, MI, 20025, Italy
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Bendigo Health Victoria
RECRUITINGBendigo, Victoria, 3550, Australia
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Brantford General Hospital
RECRUITINGBrantford, Ontario, N3R 1G9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Universite de Sherbrooke
RECRUITINGSherbrooke, Quebec, J1J 3H5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre hospitalier de l'Université de Montréal (CHUM)
RECRUITINGMontreal, Quebec, H2X 0C1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cité de la Santé Hospital
NOT_YET_RECRUITINGLaval, Quebec, H7M 3L9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Clínica Universidad de La Sabana
RECRUITINGChía, Cundinamarca, Colombia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cortellucci Vaughan Hospital
RECRUITINGVaughan, Ontario, L6A 4Z3, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Flinders Medical Centre
RECRUITINGBedford Park, Southern Adelaide, 5042, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Grace Hospital
RECRUITINGWinnipeg, Manitoba, R3J 3M7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Halton Healthcare
RECRUITINGOakville, Ontario, L6M 0L8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hamilton Health Sciences Centre - General
RECRUITINGHamilton, Ontario, L8L 2X2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hamilton Health Sciences Centre - Juravinski
RECRUITINGHamilton, Ontario, L8V 1C3, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Health Sciences Centre - Winnipeg
RECRUITINGWinnipeg, Manitoba, R3A 1R9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hospital Josep Trueta (Girona)
RECRUITINGGirona, 17007, Spain
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Hospital Universitario de Getafe
NOT_YET_RECRUITINGGetafe, Madrid, 28905, Spain
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King Abdulaziz Medical City- Riyadh
RECRUITINGRiyadh, 11426, Saudi Arabia
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Kingston Health Sciences Centre
RECRUITINGKingston, Ontario, K7L 2V7, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lakeridge Hospital
RECRUITINGOshawa, Ontario, L1G 8A2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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London Health Sciences Centre - University Hospital
NOT_YET_RECRUITINGLondon, Ontario, N6A 5W9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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London Health Sciences Centre - Victoria Hospital
NOT_YET_RECRUITINGLondon, Ontario, N6A 5W9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MUHC - McGill University Health Centre (Glen Site)
RECRUITINGMontreal, Quebec, H4A 0B1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mackenzie Health
RECRUITINGRichmond Hill, Ontario, L4C 4Z3, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medical University of South Carolina (MUSC)
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Middlemore Hospital
RECRUITINGAuckland, 2025, New Zealand
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Mount Sinai New York City
RECRUITINGNew York, New York, 10029, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nanaimo Regional General Hospital
RECRUITINGNanaimo, British Columbia, V9S 2B7, Canada
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National University of Singapore
RECRUITINGSingapore, 119077, Singapore
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Nepean Hospital
RECRUITINGKingswood, New South Wales, 2747, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Niagara Health Systems
RECRUITINGSaint Catherines, Ontario, L2S 0A9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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North York General Hospital
RECRUITINGNorth York, Ontario, M2K 1E1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nova Scotia Health Authority
RECRUITINGHalifax, Nova Scotia, B3S 0H6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oak Valley Health
RECRUITINGMarkham, Ontario, L3P 7P3, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oregon Health & Science University (OHSU)
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ospedale Maggiore, Fondazione IRCCS Ca Granda, Milano
RECRUITINGMilan, MI, 20122, Italy
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Ottawa Heart Research Institute
NOT_YET_RECRUITINGOttawa, Ontario, K1Y 4W7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Parc Taulí University Hospital
ACTIVE_NOT_RECRUITINGSabadell, Barcelona, 08208, Spain
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rotorua Hospital
RECRUITINGRotorua, 3010, New Zealand
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Royal Jubilee Hospital
RECRUITINGVictoria, British Columbia, V8R 1J8, Canada
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2050, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sacre Coeur du Montreal
RECRUITINGMontreal, Quebec, H4J 1C5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Scarborough Health Network
RECRUITINGToronto, Ontario, M1P 2V5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sentara Health
RECRUITINGNorfolk, Virginia, 23507, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sinai Health, Mount Sinai Hospital
RECRUITINGToronto, Ontario, M5G 1X5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St Vincents Sydney
RECRUITINGDarlinghurst, Sydney, 2010, Australia
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St. Boniface Hospital
RECRUITINGWinnipeg, Manitoba, R2H 2A6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Joseph's Hamilton
RECRUITINGHamilton, Ontario, L8N 4A6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Paul's Hospital
RECRUITINGVancouver, British Columbia, V6Z 1Y6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Surrey Memorial Hospital
RECRUITINGSurrey, British Columbia, V3V 1Z2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taranaki Base Hospital
RECRUITINGNew Plymouth, 4310, New Zealand
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The Austin Hospital
RECRUITINGHeidelberg, Victoria, 3084, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Johns Hopkins Medicine
RECRUITINGBaltimore, Maryland, 21224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Ottawa Hospital
RECRUITINGOttawa, Ontario, K1H 8L6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Trois Riviere (CHAUR)
RECRUITINGTrois-Rivières, Quebec, G8Z 3R9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Unity Health Toronto
RECRUITINGToronto, Ontario, M5C 2T2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Universidad de La Sabana
RECRUITINGChía, Cundinamarca, Colombia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Health Network
RECRUITINGToronto, Ontario, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact
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University Hospital Geelong
RECRUITINGGeelong, Victoria, 3220, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alberta/Edmonton University Hospital
RECRUITINGEdmonton, Alberta, T6G 2X8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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University of Arizona
RECRUITINGTucson, Arizona, 85724, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Calgary
RECRUITINGCalgary, Alberta, T2N 1N4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Los Angeles (UCLA)
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Cincinnati College of Medicine
RECRUITINGCincinnati, Ohio, 45267, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Colorado Hospital
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky
RECRUITINGLexington, Kentucky, 40506, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland Medical System
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan Health
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh Medical Center (UPMC)
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of San Diego (UCSD)
RECRUITINGSan Diego, California, 92121, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Saskatchewan
RECRUITINGSaskatoon, Saskatchewan, S7N 0W8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Utah Health
RECRUITINGFarmington, Utah, 84025, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Ann Arbor Healthcare System
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vancouver Island Health - Royal Jubilee Hospital & Nanaimo Hospital
RECRUITINGVictoria, British Columbia, V8R 1J8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt university medical center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wake Forest University School of Medicine
RECRUITINGWinston-Salem, North Carolina, 27101, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University
RECRUITINGSt Louis, Missouri, 63130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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William Osler Health System
RECRUITINGBrampton, Ontario, L6R 3J7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Windsor Regional Health
RECRUITINGWindsor, Ontario, N8W 1L9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wollongong Hospital
RECRUITINGWollongong, New South Wales, 2500, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.