DEPRESSION

This study tests if a computer-delivered cognitive behavioral therapy can help people who have both an anxiety disorder and alcohol use disorder. The goal is to reduce heavy drinking and delay relapse. If effective, this program could be widely available at low cost. The study en…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in hot regions. About 3,200 people living in poor housing in Burkina Faso, Mexico, India, Niue, and Fiji will take part. Researchers will measure heart rate, blood sugar, mood, a…

This study tests whether a group therapy for PTSD, adapted for prisons, can help people reduce drug use, mental health issues, and crime after they leave prison. About 640 incarcerated adults across 10 US prisons will either receive the group therapy or a self-help workbook. Rese…

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin depression care and whether their mood and viral levels improve within a year. Ten clinics in Cape Town will be randomly …

This study tests a program to help low-income people with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, delivers them to the bedside and home, and offers support from pharmacy staff. Researchers wil…

This study looks at whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can help prevent depression from coming back. It involves 60 adults who already improved with iTBS. They will receive either standard weekly sessions or a sin…

This study tests a 9-week online program designed to help families of LGBTQ+ youth of color become more supportive and accepting. Researchers will measure changes in youth depression, anxiety, drug use, and other risks. The goal is to reduce health disparities caused by family re…

This study tests different methods to help adults with depression take their antidepressant medication regularly. Researchers will track medication use with electronic pill bottles and measure depression symptoms over 12 weeks. The goal is to find better ways to support medicatio…

This study tests a program called MILAP that brings together young married women, their husbands, and mothers-in-law to reduce depression and intimate partner violence. About 900 families in Nepal will take part. The program includes counseling and support to improve mental healt…

This study looks at whether combining guided exercise with cognitive behavioral therapy (CBT) can help Black men with type 2 diabetes and depressive symptoms improve their blood sugar control and quality of life. About 80 men will take part in a 7-month program that includes week…

This study tests a program called Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women with HIV and depression in Malawi. Researchers will enroll 400 women to see if the program reduces depression symptoms and helps them stay in H…

This study tests a combined therapy for mothers with PTSD who are at risk of child maltreatment. The treatment blends skills to manage emotions and improve parent-child interactions. Researchers will track changes in PTSD, depression, parenting behaviors, and reports of abuse or …

This study tests a parenting program designed to help Hispanic sexual minority youth (ages 13-19) and their families. The goal is to prevent or reduce drug use and depressive symptoms by improving parent support, acceptance, and family functioning. About 306 teens and their paren…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12–17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience to prevent substance abuse, intima…

This study tests a virtual reality game designed to help children aged 10 to 16 improve how they manage their emotions. The goal is to see if playing these VR games can reduce symptoms of anxiety and depression. About 160 kids will either play the emotion-training games or relax …

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study tests a therapy called Positive Affect Therapy (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more difficult childhood events (like abuse or neglect). The therapy focuses on increasing positive emotions and reward sensitiv…

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training includes online modules, live supervision, and a buddy system where new mentors learn from experienced ones. About 96 te…

This study tests a mindfulness-based sleep program for pregnant women with insomnia to see if it can prevent depression during and after pregnancy. 500 participants will be assigned to either the sleep program or standard care. The goal is to improve sleep and reduce the risk of …

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent future depression and anxiety. About 3,000 students in Swedish high schools will take part, and their results will be compared to stude…

This study tests a program called M-O-M-S to help pregnant women in areas hit by natural disasters feel less anxious and depressed. About 240 pregnant women will attend classes led by a mother-mentor to learn about emotional changes and prepare for labor. The goal is to see if th…

This study is testing whether a 4-month mindfulness program can help reduce sleep problems and depressive symptoms in healthcare workers (ages 20-65) and older adults (ages 55-90). Researchers will track changes in mood, sleep quality, and well-being using questionnaires and slee…

This study tests a coaching program for Black patients with long-term muscle or joint pain and depression. The program helps patients learn about and try non-drug pain treatments, like physical therapy or counseling. 304 participants will be randomly assigned to either the coachi…

This study looks at whether doing heated yoga or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression and track changes using a standard depression questionnaire. The goal is to see if either type of yoga offers meaningful…

This study tests whether a telemedicine-delivered cognitive behavioral program (RxWell) can help patients use fewer opioid painkillers after knee or hip replacement. About 150 adults with mild to moderate anxiety or depression symptoms will be enrolled. The program aims to improv…

This study tests a personalized, noninvasive brain stimulation treatment (TMS) for people aged 18-65 with persistent symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will receive either active or sham TMS over 10 s…

This study tests whether using a personalized brain scan to guide a non-invasive treatment called iTBS works better than the standard one-size-fits-all approach for people with major depression. 210 adults will receive 6 weeks of iTBS, with half getting the standard target and ha…

This study tests a 100% remote education program for 220 adults with moderate depression who recently started antidepressants. The program aims to help them stay on their medication and improve their symptoms. Participants will use an online platform from home, and researchers wi…

This study tests if an artificial intelligence (AI) avatar-led program can help employees with depression. About 50-80 UK adults will either use the AI program immediately or wait and use it later. Researchers will measure changes in mood, anxiety, and work performance to see if …

This study tests whether the JoyPop app can help 110 teens aged 12-17 in Canada better manage their emotions and reduce depression, anxiety, and stress while they wait for mental health services. Participants will either use the app or continue with usual care. The goal is to see…

This study looks at 680 low-income women in rural Bangladesh who have depression. It compares two approaches: depression treatment alone versus depression treatment plus help with poverty (like income support). The goal is to see if the combined approach leads to better mood, few…

This study compares two treatments for people who have both psoriasis and depression or anxiety. One group gets methotrexate alone, the other gets methotrexate plus an antidepressant (escitalopram). Over 6 months, researchers will measure changes in skin severity, quality of life…

This study is testing a mobile app called MAYA that offers cognitive behavioral therapy (CBT) to help with anxiety and depression in adults who have had a stroke. Researchers want to see if the app is easy to use and acceptable to stroke survivors. Ten participants aged 40-79 wil…

This study tests a 6-week group program called Emotion Focused Family Therapy (EFFT) that teaches parents advanced skills to help their child manage emotions and improve behavior. About 200 parents of children aged 7-15 with anxiety, depression, or behavior challenges will be ran…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in people with advanced cancer. About 188 participants will be randomly assigned to recei…

This study tests an online, self-guided therapy program for current or former public safety personnel (like police, firefighters, paramedics) who struggle with depression, anxiety, or PTSD. About 164 participants across Canada will try different versions of the program to see whi…

This study tests whether a free online program from the World Health Organization, called Doing What Matters in Times of Stress, can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with high stress levels will either ge…

This study is testing two self-guided online therapy courses for veterans who have depression or have had suicidal thoughts. About 472 veterans from several states will use one of the programs on their own computer or tablet. The goal is to see if these online tools are helpful a…

This study is testing whether a smartphone app can help doctors better understand and treat depression. Researchers will track daily symptoms, medication use, and treatment response in 200 adults with depression. The goal is to improve care by giving doctors real-time insights fr…

This study tests a new way to help teenagers in rural India with mental health issues like depression and anxiety. Instead of specialists, trained teachers will deliver the care. The goal is to see if this approach is practical and can improve teens' emotional well-being.

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep, anxiety, depression, or epilepsy. Researchers will track changes in symptoms and quality of life over 24 weeks using standard questionnaires. The goal is to understand how effect…

This study looks at how well common antidepressants work for teenagers aged 13 to 18 who have depression and didn't get better with their first medicine. Researchers will track changes in depression and anxiety scores over time. The goal is to find better treatment options for yo…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely reduce depression in people with cancer. About 86 adults with cancer-related depression will receive either electroacupuncture or a control treatment. The goal is to see if…

This study tests whether a daily probiotic can reduce depression symptoms in people with Parkinson's disease. 60 participants will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure mood changes using standard depression questionnaires. The g…

This study tests whether L-DOPA, a drug used for Parkinson's, can help people with depression who have high inflammation and lose interest in activities. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will track mood, motivation, and br…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD and depression after a sexual assault. About 45 adults in Ohio who experienced unwanted sexual contact will receive the therapy and be followed for one month. The goal is to see if this …

This study tests whether an experimental drug called TJ0113 can safely reduce depression symptoms. About 150 adults with moderate to severe depression will take either TJ0113 (at 200 mg or 400 mg) or a placebo daily for 8 weeks. Researchers will measure changes in depression scor…

This study tests whether daily, personalized music listening can help reduce anxiety and depression in people who recently had a stroke. 132 participants will either receive standard care plus 4 weeks of therapeutic music sessions, or standard care alone. The goal is to see if mu…

This study explores whether a keto-like supplement can change how the brain responds to positive and negative experiences in people with moderate to severe depression. 75 adults will take either the supplement or a placebo three times daily for 8 weeks, and undergo brain scans an…

This study tests whether a probiotic called Clostridium butyricum can improve anxiety and depression in people with functional dyspepsia, a common stomach disorder. About 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication.…

This study tests a specially adapted mindfulness program for older Black adults (age 50+) who have both chronic pain and mild to moderate depression. The goal is to see if this approach can improve quality of life and reduce how much pain interferes with daily activities, compare…

This study explores whether using a virtual reality headset to experience nature scenes can help reduce depression in people with progressive multiple sclerosis. Forty participants will use the Apple Vision Pro at home for short sessions over eight weeks. The goal is to see if th…

This study tests a new text-message program designed to help cancer survivors who feel depressed connect with mental health care. Researchers will enroll 60 cancer survivors who have signs of depression and own a cellphone. The program sends tailored texts and a referral link to …

This study looks at whether a type of therapy called cognitive analytic therapy guided self-help (CAT-GSH) works as well as the standard cognitive behavioural therapy guided self-help (CBT-GSH) for people with anxiety or depression who are coming back for more help. About 100 par…

This study explores whether music therapy can help children with depression. Twenty kids will attend 11 music therapy sessions, with some also going to recitals to discuss performance and creativity. Researchers will measure changes in resilience and depression symptoms to see if…

This study tests whether guanfacine, a medication currently used for blood pressure, can improve brain function and reduce depressive symptoms in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode. The g…

This study tests a short-term group therapy designed to help people with anxiety and depression. One hundred adults will be randomly assigned to receive either this new therapy or the usual group therapy. Researchers will measure changes in anxiety and depression symptoms after t…

This study tests whether adding a motivational lifestyle program to usual depression care helps people recover faster. 210 adults with depression will receive coaching on diet, exercise, and sleep. The goal is to improve mood, wellbeing, and quality of life.

This study tests a digital program designed to help immigrant women who have faced violence and struggle with PTSD or depression. The program provides tools to reduce stress, improve safety, and build self-care habits. Researchers will enroll 676 women to see if the app-based app…

This study is testing whether college students can be trained to deliver cognitive-behavioral therapy (CBT) to high school students in rural areas. The goal is to reduce symptoms of depression, anxiety, and stress in teens aged 13 to 18. The program aims to make mental health sup…

This study tests whether advancing sleep timing (going to bed and waking up earlier) can improve depression symptoms. 150 adults with moderate to severe depression, recently discharged from a psychiatric ward, will either receive usual care or a psychotherapeutic intervention foc…

This study looks at three ways to treat moderate depression in adults aged 18-65: usual care from a family doctor, therapy from a psychologist, or a structured step-by-step treatment plan from a doctor. The goal is to see which approach works best. About 171 people will take part…

This study tests whether a sleep-inducing drug called propofol, given with brief behavioral therapy, can improve deep sleep and reduce depression in adults aged 60 and older whose depression has not responded to standard treatments. Seventy participants will receive two propofol …

This study looks at whether taking high doses of vitamin B6 can change brain activity and reduce symptoms of anxiety and depression. Researchers will use EEG to measure brain waves and compare a vitamin B6 group to a placebo group. The study includes 44 adults aged 18 to 40 with …

This study tests a virtual program called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants work with a care coordinator online to create a personalized treatment plan, with support from their doctor and a psychiatrist if needed. The goal is…

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study tests if dance-movement therapy can reduce depression in teenagers. About 140 teens with moderate to severe depression will take part. They will be randomly assigned to either dance therapy or usual care, and their symptoms will be tracked using questionnaires and inte…

This study tests whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep quality, anxiety, depression, fatigue, and inflammation in 276 participants over 20 weeks. The goal is to see if a si…

This study tests whether adding social cognitive training—like learning to understand others' thoughts and feelings—makes standard talk therapy (CBT) more effective for depressed teenagers. About 82 teens aged 13-17 with depression will be randomly assigned to either enhanced CBT…

This study tests a short, guided self-help program called Self-Help Plus for university students who are behind on at least 3 exams and feeling significant distress. About 210 students will be randomly assigned to the program or usual support. The goal is to see if the program re…

This study tests a smartphone-based program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based activities. Researchers want to find out which parts of the program work be…

This study tests a behavioral health program called InSTILL for nursing home residents who feel depressed and their main support person. The program aims to help them cope with stress and build resilience. Researchers will compare the program to usual care and check if it is prac…

This study tests whether sexual counseling based on the extended PLISSIT model helps pregnant women improve sexual function, marital adjustment, sexual quality of life, and reduce depression, anxiety, and stress. About 70 pregnant women between 16-20 weeks will be randomly assign…

This study tests whether giving psilocybin (the active ingredient in magic mushrooms) followed by a type of brain stimulation called aiTBS is safe and can help people with depression that hasn't improved with other treatments. About 100 adults aged 22-65 with treatment-resistant …

This study tests if a special massage called Tui Jing therapy can help ease depression symptoms. Researchers will compare real therapy to a fake version in 64 adults with depression. They will measure mood, sleep, and brain activity to see if this gentle treatment works.

This study tests a sleep health program designed for U.S. Marines to see if improving sleep can also improve mental health and reduce suicidal thoughts. About 860 active-duty Marines will be randomly assigned to one of five groups that receive different combinations of sleep prog…

This pilot study tests whether ketamine infusions followed by a brief behavioral program can help veterans with chronic low back pain and depression. The goal is to see if the approach is safe, acceptable, and practical. About 44 veterans will take part.

This study tests whether mindfulness meditation or psychoeducation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to one of two groups. Researchers will compare changes in anxiety, depressi…

This study tests an internet-based sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers want to see if it works and if people find it helpful. About 56 adults from Saskatchewan will…

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. About 84 pairs will participate in a mind-body program designed to reduce anxiety, depression, and emotional distress. The goal is to see if the program is practical and helpful, …

This study is testing whether a single low dose of ketamine, given in the emergency department, can safely reduce suicidal thoughts. Researchers will enroll 50 adults who are having a mental health crisis and need hospital care. The goal is to see if this approach is safe and pra…

This study tests a personalized online program called MY-CHOICE for adults with heart disease who also have anxiety or depression. The program includes online lessons and optional video or phone calls with a therapist over 6-12 weeks. Researchers want to see if people find it hel…

This study looks at two common therapy techniques—changing unhelpful thoughts and practicing detached mindfulness—to see if using them together works better than using just one. Researchers will compare single, combined, and sequenced approaches in 93 adults with anxiety or depre…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain tumors will receive the therapy. The goal is t…

This study is for people with depression that hasn't improved with medication. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking. The goal is to see if this combination works better than brain stimulation alone…

This study looks at whether adding metformin, a common diabetes medication, to standard antidepressants can improve depression symptoms in obese individuals. Researchers will compare a group taking metformin with a group taking a placebo. The goal is to see if metformin helps red…

This study tests whether a smartphone app called Healthy Minds Program can reduce depression symptoms in teenagers. About 200 teens aged 14 to 19 with elevated depression will use the app for 20 weeks. Researchers will measure changes in depression and anxiety scores to see if th…

This study aims to improve depression care in Indian primary care settings. It will involve 1,500 adults with moderate to severe depression, who will receive either a type of talk therapy (Healthy Activity Program) or antidepressant medication (fluoxetine). The goal is to see if …

This study tests a new short-term therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety and/or depression. The therapy focuses on how young people see themselves and others, aiming to be more engaging and personalized than standard treatments.…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, and stressed. About 68 undergraduates in Taiwan will either use the app plus standard campus care, or just standard care. The app includes daily mood tracking, week…

This study tests whether a 12-session home-based talk therapy called Behavioral Activation can improve social functioning and mood in veterans recently hospitalized for heart disease. About 132 veterans will either receive this therapy or standard post-discharge care. Researchers…

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. About 120 adults with insomnia and depression will receive the sleep intervention and undergo brain scans to measure changes. The goal is to…

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests whether giving brain stimulation three times a day works better than once a day for teens with depression that hasn't improved with medication. Ten adolescents aged 16-19 will receive either accelerated or standard fMRI-guided theta burst stimulation. The goal is…

This study tests a smartphone app called Moodivate designed to help with depression in adults who have incurable cancer and feel down. About 279 participants will be randomly assigned to use the app or not for 12 weeks. Researchers will track changes in mood, anxiety, and quality…

This study tests two types of internet-based therapy for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose between a therapy focused on PTSD or one that covers all three conditio…

This study tests whether a smartphone app called JoyPop can help young adults (ages 18-25) better manage their emotions, anxiety, and depression while they wait for mental health services. About 110 participants from Northwestern Ontario will either use the app or continue with u…

This study is testing whether a single session of whole-body heating, with or without a cold water plunge, can reduce symptoms of depression. Researchers will recruit 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive e…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program is for adults on sick leave who are receiving mental health care. Participants will use an online tool that combines mental health support with work-focus…

This study tests a new method to dose repetitive transcranial magnetic stimulation (rTMS) for treating depression in people with spinal cord injury (SCI). Standard rTMS dosing relies on thumb movement, which many with SCI cannot do. The study will enroll 24 Veterans with SCI and …

This study is testing whether a self-guided online course that teaches dialectical behavior therapy (DBT) skills is practical and helpful for adults with mild-to-moderate depression and anxiety. About 40 participants will take the 8-week course and complete surveys to measure how…

This study tests a mobile program called WellPATH-PREVENT for adults aged 50 to 90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The goal is to see if the app helps them better manage their emotions and lowers their risk of future suicidal thoughts. P…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can better treat severe depression in teenagers aged 13 to 17. About 220 teens will be randomly assigned to receive either esketamine or a placebo durin…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study tests an internet-based therapy program called Empower@Home for older adults (50+) with walking difficulties who have mild or more depression symptoms. 64 participants will be randomly assigned to either the program or enhanced usual care. The goal is to see if the pro…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve cognitive problems and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's disease. Researchers will give TMS to the …

This study explores whether Parent-Child Interaction Therapy (PCIT) can help parents of children aged 2-7 with behavioral issues. Researchers will measure changes in stress, anxiety, depression, and oxytocin levels through surveys and saliva samples. The goal is to see if this th…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for college and university students with mild to moderate depression or anxiety. About 200 students in Saskatchewan can choose a 5-week, 8-week, or flexible course, all with optional therapis…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which one works better for autistic adults with depression or anxiety. About 300 participants from North Carolina and Virginia will receive therapy sessions …

This study looks at whether an online program called Mom-Net can help low-income mothers with depression. The program teaches coping skills through online lessons and live coaching. Researchers want to see if Head Start agencies can deliver this program effectively and if it redu…

This study tests if a guided app called SilverCloud, which teaches cognitive behavioral therapy skills, can help high school students with depression or anxiety. About 120 teens will either use the app or get usual school counseling. Researchers will measure changes in mood and w…

This study tests whether a new drug called CYB003 can safely reduce symptoms of major depression. About 330 adults with moderate to severe depression will receive either CYB003 or a placebo. The goal is to see if CYB003 improves mood and daily function better than a placebo.

This study tests a two-week smartphone program designed to help people who struggle to feel pleasure (anhedonia) and also experience depression, anxiety, or stress. Participants do three short daily exercises like savoring good moments or finding silver linings, delivered via aud…

This study tests whether a non-invasive brain stimulation technique called tDCS, guided by heart rate data, can help people with mild to moderate depression. One hundred adults will receive either real or sham tDCS at home for 10 days. The goal is to see if heart rate can predict…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests whether dapagliflozin, a medicine usually used for diabetes, can help reduce symptoms of major depression. About 60 adults with depression who have not improved enough with standard treatments will take the drug for a set period. The main goal is to see if their …

This study tests whether a single dose of ketamine given during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic trauma. About 90 participants will be randomly assigned to receive ketamine or standard …

This study tests two online mindfulness programs for younger breast cancer survivors (diagnosed at or before age 50) who have finished primary treatment and feel depressed. One program is a live class over Zoom, the other is a self-paced app. The goal is to see which approach bet…

This study tests a new program that combines counseling and faith to help African American adults with depression. About 50 people from 12 church groups in Wisconsin will take part. The goal is to see if this approach can reduce depression symptoms and improve well-being.

This study looks at two ways to decide the best treatment for anxiety and depression in 1,000 community college students. Participants will be placed into one of three care levels: self-guided online help, coach-guided online therapy, or care from a clinician. The goal is to see …

This study tests a new group program called BEAR for women who have experienced trauma and have current suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Researchers want to see if it's possible to run the pr…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors struggle with anxiety, depression, and PTSD, but few have access to mental health care. The app aims to help them manage these symptoms on…

This study tests a brain stimulation technique called rTMS to see if it can reduce knee arthritis pain and depression in older adults. Thirty volunteers aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS along with Tai Chi. The goal is to…

This study tests whether a special mushroom powder (Ganoderma lucidum spores) can reduce depression in women who have had thyroid cancer surgery. Three hundred female participants will take either the mushroom powder or a placebo for three months. The goal is to see if it improve…

This study tests whether cariprazine, a drug already approved for adults, can safely ease depressive episodes in children aged 10 to 17 with bipolar I disorder. About 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. …

This study tests a mobile app that uses cognitive behavioral therapy (CBT) to help treat depression. About 325 people aged 14 to 60 with depression or related mood disorders will use the app for 8 weeks, guided by AI. The goal is to see if the app reduces depression symptoms and …

This study tests an internet-based cognitive behavioral therapy (CBT) program called Good Days Ahead for older adults (50+) who have depression after an ICU stay. The goal is to see if treating depression can slow down memory and thinking problems. About 300 participants will be …

This study tests a therapy called PATH-Pain for 100 older adults with mild memory problems, chronic pain, and depression. The therapy helps people cope with pain and mood issues to improve thinking and daily function. Participants are compared to those receiving usual care.

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty participants with a life expectancy of 12 weeks to 2 years will receive either two doses of LSD or a very low dose as a placebo.…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again. It focuses on solving barriers like frailty, depression, or lack of support. The study includes 43 adults and will see if the program improves waitlist statu…

This study tests whether a painless, non-invasive brain stimulation technique called rTMS can help treat depression in adults with autism. Depression is very common in people with autism, but standard antidepressants often don't work well or cause side effects. The study will enr…

This study tests a new virtual reality training designed to help people with depression and low positive affect feel more joy and pleasure. 80 adults will be randomly assigned to either the VR reward training or a memory training control group for 7 weeks. The goal is to see if t…

This study tests a 7-session therapeutic song-writing program for young people aged 13 to 24 with mild to moderate depression. Participants will either join the program or be placed on a waitlist. Researchers will measure changes in depressive symptoms, self-stigma, self-esteem, …

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds a care manager to usual neurology visits to support emotional well-being. The goal is to see if this approach improves quality of life more than…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help adult children of genocide survivors who suffer from depression or anxiety. One hundred participants will receive the treatment in a controlled setting. The goal is to se…

This study tests a non-invasive brain stimulation method called rTMS to treat depression in people with spinal cord injury (SCI). Fourteen adults with SCI and major depression will receive rTMS daily for four weeks. The goal is to see if the treatment is safe and helps reduce dep…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study tests whether an app that uses brain scans (fMRI) to give feedback can help people with mild to moderate depression. About 240 adults aged 18-80 with depression will use the app to learn about positive emotions and brain chemicals. The goal is to see if this approach i…

This study tests a program called "Mindful Moms" to see if it can improve mood and health in pregnant women with depressive symptoms. About 200 pregnant women with mild to moderate depression will either take the mindfulness program or attend group education workshops. The goal i…

This study tests whether adding extra lessons on loneliness to an online therapy program (the Wellbeing Course) helps people with depression and anxiety feel better. About 494 adults from Saskatchewan who often feel lonely will take part. Over 8 weeks, they will complete online l…

This study tests different amounts of a safe, non-invasive brain stimulation called TMS in 60 older adults (ages 60-85) who have mild memory problems and depression. The goal is to find the best dose to improve both mood and thinking, which could help prevent dementia in the futu…

This study tests whether a nutritional drink called 'Think Tank' can help middle-aged women (40-60 years old) think more clearly after experiencing stress. Forty healthy women who drink caffeine daily will take either the drink or a placebo and then complete thinking and memory t…

This study is testing whether a treatment called TMS (transcranial magnetic stimulation) can reduce anxiety and depression in children and teens. About 120 young people aged 6 to 18 with a doctor's diagnosis will receive TMS, which uses magnetic pulses to stimulate the brain. The…

This study aims to find the best way to treat insomnia and depression together using digital behavioral programs. Researchers will compare different treatment sequences to see which order works best. The study involves 1,500 U.S. military veterans who have both conditions. The go…

This study tests whether a group therapy called narrative therapy can reduce depression in people aged 60 and older. Participants will attend eight sessions led by a trained counselor, where they share and reshape their life stories. The study includes 110 older adults with mild …

This study tests a 10-week online group program for adults with spina bifida to improve self-esteem, quality of life, and reduce anxiety and depression. Participants attend weekly 1.5-hour video sessions with 6-7 others, plus two follow-ups. The goal is to strengthen social skill…

This study tests whether heated yoga, sauna sessions, or a mindfulness app can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will be assigned to one of the three approaches and monitored for changes in…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study tests whether an 8-week mindfulness program, adapted for African American adults, can improve depressive symptoms and blood pressure control. About 60 participants from Chicago's South Side will learn stress management techniques like deep breathing and meditation. The…

This study tests a new 5-day accelerated version of TMS, a brain stimulation treatment already approved for depression and OCD. Researchers want to see if this faster approach can quickly improve symptoms and use brain scans to predict who benefits most. 500 adults with depressio…

This study tests whether a group therapy program led by trained non-specialists can reduce depressive symptoms in young adults aged 18-24 in Porto Alegre, Brazil. Fifty participants will be randomly assigned to either the therapy group or a waiting list. The therapy focuses on im…

This study tests whether a personalized, less time-consuming mobile cognitive behavioral therapy (CBT) program works as well as a standard one for easing anxiety and depression. About 100 young adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app …

This study tests whether a web-app based physical activity program can improve depressive symptoms in midlife Korean American women aged 40-60. Researchers will measure changes in depression, stress, and social support over time. The goal is to find a practical, accessible way to…

This study compares two attention-training programs (traditional vs. gamified) to a placebo version for adults with depression. About 600 participants will complete questionnaires, eye-tracking tasks, and clinical interviews. The goal is to see if the gamified version reduces dep…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will take a pharmaceutical-grade psilocybin pill and take part in guided discussions. The go…

This study tests whether a group-based therapy called Acceptance and Commitment Therapy (ACT) helps university students with anxiety and depression more than a general support group. About 48 students aged 18-28 with moderate symptoms will join. The goal is to see if ACT improves…

This study tests a program called ACT Together for parents of children with disabilities. It includes six online lessons and weekly phone coaching with an occupational therapist to help parents handle stress and difficult emotions. About 60 parents and therapists will take part t…

This study looks at whether the hormone estradiol can help perimenopausal women who started having depression, psychosis, or loss of interest in rewards during this life stage. About 100 women aged 44-55 will receive either estradiol or a placebo, and researchers will use brain s…

This study tests a way for orthopaedic surgeons to screen for depression in patients recovering from broken bones and offer medication treatment. About 100 adults who score at least mild depression after surgery can join. The goal is to see if antidepressant medication helps impr…

This study tests whether a short-term therapy for depression, called Enhanced IPT-B, can help Black mothers of children with asthma feel better and possibly improve their child's asthma. About 60 mothers will receive either the therapy or standard care plus extra support. The goa…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in adolescent refugees aged 14 to 18. About 80 participants will be randomly assigned to either the START NOW program or standard care. The goal is to see if t…

This study tests a 12-16 week online program called Parenting STAIR for military-connected mothers who have experienced trauma and have young children ages 2-10. The program helps moms manage strong feelings from past stress and improve their parenting. Researchers will compare i…

This study compares two forms of ketamine—IV ketamine (not FDA-approved for depression) and esketamine nasal spray (FDA-approved)—in 400 adults with treatment-resistant depression. The goal is to see which works better, is more acceptable, and has fewer side effects. Participants…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. About 40 adults will receive either psilocybin or a control drug, and researchers will track changes in mood, pa…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will measure changes in depression, anxiety, PTSD…

This study offers a free 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce symptoms of anxiety, depression, and stress while improving quality of life and healthy coping skills. Participants will complete surveys before and af…

This small pilot study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people who have mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The study will measure change…

This study tests an internet-delivered cognitive behavioral therapy course designed for new and expecting parents who struggle with anxiety or depression. Over 8 weeks, 60 participants will review online materials and complete questionnaires to track changes in symptoms. The goal…

This study tests whether customizing the electrical dose of ECT (electroconvulsive therapy) can better treat depression while protecting memory and thinking skills. About 50 older adults with depression will receive either a standard or personalized ECT amplitude. Researchers wil…

This study tests whether a mobile app called JoyPop can help Indigenous youth aged 18-25 in Northwestern Ontario manage their emotions and reduce stress while they wait for mental health services. Participants will either use the app or receive usual care. The goal is to see if t…

This study is for people who had a stroke at least 6 months ago and now have depression and trouble with focus or planning. Researchers want to see if using an iPad-based brain training program, along with learning new thinking strategies, can improve mood, memory, and daily life…

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause). The trial will include 180 adults aged 18-80 who have mild to moderate anx…

This study tests a single dose of an experimental drug called apimostinel, which may work quickly to improve depression symptoms with few side effects. Some participants will also do a computer-based cognitive training exercise to see if it helps the drug's effects last longer. T…

This early-phase study tests whether adding D-serine (an amino acid) to transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. About 60 adults with major depressive disorder will receive 30 treatment sessions. The goal is to see if the combin…

This study tests whether a computer-based cognitive training program can improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults aged 21-55 will be randomly assigned to either the active training or a sham version. The goal is to …

This study tests a culturally adapted cognitive behavioral therapy (CBT) for depression and anxiety in 50 adults living with HIV in Pakistan. Participants will either receive six therapy sessions from trained health workers or standard care. The goal is to see if this approach is…

This study tests a mindfulness program delivered through a smartphone app for young adults aged 18-24 who have experienced early life adversity. Participants will use the app, attend weekly Zoom group sessions, and wear a Fitbit to track sleep. The goal is to see if the program i…

This study is testing a 10-week online psychological treatment program for cancer survivors who are struggling with anxiety, depression, or fear of their cancer returning. It aims to find out which parts of the therapy are most helpful. The program involves 400 survivors in Swede…

This study tests whether an online therapy program called Empower@Home can help reduce depression symptoms in homebound older adults. The program delivers cognitive-behavioral therapy through a computer or tablet, with weekly support calls from trained coaches. Researchers will c…

This study aims to see if two simple programs can help reduce depression in elderly women in India. Over 5,000 women aged 55 and older will receive either one-on-one talk therapy (CBT), group social activities, both, or neither. The programs are run by trained local volunteers. R…

This observational study aims to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function to see how these factors relate. The…

This study looks at whether teaching mothers with depression to encourage positive emotions in their young children (ages 4-6) can increase the child's brain response to rewards. About 180 mother-child pairs will be randomly assigned to either a positive-affect coaching program o…

This online registry tracks pregnant women with migraines to see if a device that stimulates a nerve in the head is safe and helpful during and after pregnancy. About 550 women will fill out short surveys over 12 months, with no required changes to their current migraine treatmen…

This study talks to Latino teens with depression, their parents, and doctors to find out which support strategy—like peer groups, parent training, or care navigation—works best to help teens attend therapy. No new treatment is tested; the goal is to learn what people prefer and w…

This study tests a program called FOREST that teaches positive emotion skills to staff at a gun violence prevention agency. The goal is to reduce burnout, anxiety, and depression while improving well-being and job retention. About 100 workers will take part in the 9-month program…

This study is looking at whether brain scans can help predict how well people with depression, insomnia, or social anxiety will respond to internet-based cognitive behavioral therapy (iCBT). Researchers will measure brain activity patterns in 150 patients and 75 healthy volunteer…

This study looks at whether cognitive remediation—a type of brain training with coaching—can improve thinking skills, daily function, and behavior in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take …

This study looks at brain activity while people perform thinking tasks like memory and attention exercises. Researchers hope to learn how the brain works in conditions like dementia, ADD, and depression. About 30 adults with epilepsy who are already scheduled for brain monitoring…

This study tests whether a web-based app called PST-Aid helps therapists use problem-solving treatment more effectively for depression in community health centers. About 410 therapists and their patients will take part. The goal is to see if the app improves how well therapists a…

This study aims to learn more about what causes depression in teenagers and how the brain changes with it. Researchers will compare teens with depression to those without, using interviews, computer tasks, and brain scans. Participants may also receive free talk therapy or medica…

This study is testing a new program designed to support Lakota LGBTQ2S+ youth and their caregivers. The program includes 8 weekly group sessions to improve family relationships and reduce risks like depression, anxiety, and suicide. About 28 youth and their caregivers will take p…

This study follows 415 people with difficult-to-treat depression for 5 years after their original participation. Researchers will review medical records and genetic data to learn how symptoms, suicide risk, and treatment responses change over time. No new treatments are given; th…

This study looks at whether specially trained doulas can help pregnant people in rural Montana feel more confident and supported, and reduce symptoms of depression and anxiety after childbirth. About 75 participants will be split into three groups: one gets regular doula care, on…

This study uses smartphone apps and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to understand patterns in mood and thinking, not to test a treatment.

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological treatment at a health center, and another where they also receive community-based support. About 784 adults in …

This study looks at whether screening for social needs (like housing or food) with a focus on antiracism can help reduce chronic diseases such as high blood pressure, diabetes, and asthma. About 68,000 adults and children in primary care will take part. The goal is to see if this…

This study explores how brain stimulation affects decision-making in people with depression. Researchers will use techniques like TMS to temporarily alter brain activity while participants play game-like tasks. The goal is to understand which brain regions influence difficult cho…

This study looks at whether the quality and function of HDL (often called 'good' cholesterol) is different in people with depression compared to healthy individuals. Researchers will analyze blood samples from 90 adults to better understand why depression increases the risk of he…

This study looks at how often people develop depression and malnutrition after getting a surgical site infection following orthopedic surgery. Researchers will follow 300 adults for one year, checking their mental health and nutrition at regular visits. The goal is to better unde…

This early-stage study tests whether the experimental drug SP-624 can change brain activity patterns in healthy adults and those with major depression. Participants take the drug or a placebo daily for two weeks, and researchers use EEG brain scans and memory tests to look for ef…

This study looks at how a 9-week therapy called Engage & Connect changes brain activity related to social rewards in adults aged 50-80 who have depression and suicidal thoughts. Researchers will use brain scans to measure changes in areas linked to positive feelings. The goal is …

This study uses a special PET scan tracer to measure levels of an enzyme called PDE4B in the brain. Researchers want to see if people having a major depressive episode have lower PDE4B levels than healthy volunteers. Up to 108 adults aged 18-70 with depression or healthy will und…

This study uses brain scans to see how transcranial magnetic stimulation (TMS) affects the brain in healthy people and those with depression. About 97 adults aged 18-65 will have MRI scans while receiving single and repeated TMS pulses. The goal is to understand how TMS changes b…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people who recently had suicidal thoughts or attempts, those with past su…

This study is gathering information from 4,500 people who have had brain surgery for conditions like aneurysms, tumors, or epilepsy. The goal is to find out which factors help predict how well someone recovers. By collecting data on physical, thinking, and emotional health before…

This study looks at how severe childhood stress might change the brain and increase the risk of depression. Researchers will use brain scans to measure oxidative stress and brain activity in 160 women aged 20-32. The goal is to understand why some people stay resilient while othe…

This study tests an online parenting program for 500 Filipino families in California. Half of the parents will take the program, while the other half will receive standard handouts. Researchers will measure changes in parenting practices and children's depression and anxiety over…

This study is testing whether cameras, microphones, and wearable sensors can help doctors measure the severity of depression in hospitalized patients. Researchers will record interviews and track facial expressions, voice, movement, heart rate, and brain activity. The goal is to …

This study tests a program called FRAME that helps heart failure patients talk about mental health with their doctors and loved ones. About 7,300 adults with heart failure or at risk for it will take part. The goal is to see if the program works and can be used in regular heart c…

This study follows 540 adults with solid cancers to see how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to predict who might need extra support. No new treatment is given—the goal is to learn how to better help…

This study aims to create a new brain scan task that mimics social media to see how it affects teens with depression. About 60 teens aged 13-17 will have their brains scanned while using a custom social media app, then answer daily surveys for 16 days. Researchers will track brai…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these risks and improve quality of life. About 130 English-speaking adults with bipolar d…

This study looks at whether people with depression, with or without antidepressant treatment, have different skin blood flow and sweating responses to heat compared to healthy adults. Researchers will measure these responses during a 2-hour passive heating session. The goal is to…

This study looks at how a natural brain chemical called allopregnanolone affects depression in women going through menopause. Researchers will give a related substance (pregnenolone) to 80 healthy women aged 40-60 who have depressive symptoms. The goal is to understand the brain …

This study looks at how a gentle, non-invasive brain stimulation technique called temporal interference (TI) might improve social reward processing in people with depression. Researchers will use brain scans and thinking tasks to understand the brain circuits involved. The goal i…

This study looks at how chronic stress changes brain and immune function in people with HIV who use stimulants. Researchers will use brain scans and interviews to understand these changes, with the goal of finding better ways to treat depression and reduce stimulant use. The stud…

This study tests a 9-session group program for people with serious mental illness who have been in trouble with the law. The program aims to help them understand their mental health and reduce their chances of future legal problems. About 40 adults at Worcester Recovery Center an…

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have mild to severe depression. Using smartphone surveys several times a day, researchers will track how recent cannabis use and withdrawal affect mood, suicidal thoughts, and urges. The goal is to u…

This study is testing a smartphone app called TrueBlue that helps monitor symptoms of depression and anxiety. It is for adults who are at least 12 weeks pregnant or up to 12 weeks after giving birth. The goal is to see if the app is safe, easy to use, and works well for tracking …

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties to test if personalized training reduces daily negative emotions…

This study looks at how depression affects brain activity and how that changes with a treatment called transcranial magnetic stimulation (TMS). Twenty adults with major depression will get brain scans before and after 5 days of TMS. The goal is to see if a new imaging method can …

This study will analyze existing medical records from about 12,000 people treated for depression, OCD, or anxiety at Greenbrook clinics. Researchers want to compare how well two treatments—NeuroStar TMS and esketamine—reduce symptoms like low mood. No new treatments are given; th…

This study looks at whether the brain activity of a therapist and a client can become synchronized during a therapy session for mild to moderate depression. Researchers will measure brain waves using EEG while participants receive either behavioral activation therapy or psychoedu…

This study looks at whether thinking about death can increase feelings of depression and anxiety in healthy adults. Researchers will ask some participants to write about their own death and others to write about dental pain, then compare their emotional responses. The goal is to …

This study looks at whether a program called the Trauma Resilience and Recovery Program (TRRP) helps people who have been seriously injured get mental health support. About 350 English- or Spanish-speaking adults and teens admitted to a trauma center will take part. Researchers w…

This study aims to better understand how the brain controls mood by recording brain activity directly in people with depression or epilepsy. Researchers will use artificial intelligence to analyze these recordings and link them to mood changes. The goal is to improve treatments f…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded. No treatment …

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study looks at how stress and pain affect hormones and mood in 120 people with or without HIV, cannabis use disorder, and depression. Participants will do a pain stress task and give blood samples to measure stress chemicals. The goal is to understand these connections, not …

This study looks at how often sexual problems occur in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. About 140 women with relapsing-remitting MS will fill out questionnaires and take simple tests. T…

This study looks at how ketamine works in the brain to treat depression quickly. Researchers will use brain scans and other tests to understand why a single dose can lift mood within hours. About 150 adults with major depression and healthy volunteers will take part, receiving ke…

This study looks at how ketamine, a fast-acting antidepressant, works in the brain. Researchers want to see if blocking a specific receptor (AMPA) changes ketamine's effects. About 70 adults with treatment-resistant depression will stay at the clinic for 5 weeks, receive ketamine…

This study looks at why depression and heart disease often occur together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55 to see if changes in these pathways explain the link. The goal is to find new ways t…

This study compares two web-based apps to see which one better helps Latinas with anxiety or depression start mental health treatment. One app uses an interactive story with a character who gives treatment advice, while the other provides standard information and resources. The g…

This study looks at how sleep and light affect mood in women going through menopause. Researchers want to see if changing sleep timing for one night and using a light box for two weeks can help reset the body's internal clock and improve depression. Participants will provide urin…

This study aims to help families facing food insecurity and mothers with depression by providing resources like food, rent assistance, and mental health support. Researchers will enroll 2,000 caregivers of young children hospitalized at Texas Children's Hospital to see if these i…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) changes how the stomach works. Researchers will measure stomach emptying and capacity in 16 adults who already have the device. The goal is to understand the connection, not to test…

This study tests whether a new wearable device that uses ultrasound and light can safely and easily monitor blood flow in the brains of people who have had a stroke. Researchers will also include healthy older adults and people with dementia, depression, or delirium to compare re…

This study looks at whether mindfulness and meditation techniques can help mothers of premature babies in the NICU produce more breastmilk and feel less stressed. About 40 mothers will learn these techniques and researchers will measure changes in milk volume, stress hormones, an…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered online. It aims to help adults in New York State who struggle with worry, rumination, or self-criticism. The study will track changes in attention, emotional control, and mood over 6 th…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…

This study follows 5,000 children in a park-based afterschool program to see if it improves their physical fitness, weight, and mental health. Researchers will measure changes in body measurements, fitness tests, and questionnaires about anxiety and well-being. The goal is to und…

This study aims to see if community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to learn what works best to support mental…

This study looks at how cannabis use changes brain function in teenagers who also have depression. Researchers will track 280 teens over time, measuring their cannabis use, depression symptoms, and brain activity. The goal is to better understand the relationship between cannabis…

This study aims to understand why physical activity helps treat depression. Researchers will compare aerobic exercise to stretching in 250 adults with moderate depression. They will measure changes in mood, brain activity, and inflammation to find out how exercise works. The goal…

This study looks at how the antidepressant fluoxetine changes the way healthy young people (ages 18-24) process anger. Participants take either fluoxetine or a placebo daily for 7 days and complete tasks involving angry words, faces, and frustrating situations. Researchers measur…

This study will analyze data from up to 156,000 people who received NeuroStar TMS for depression, OCD, or anxiety. Researchers want to learn how patient age, symptoms, and treatment settings affect results. The goal is to improve real-world use of TMS, not to test a new treatment…

This study compares two programs—Mindfulness-Based Cognitive Therapy and a general wellness program—to see which one better helps people with mild depression control their emotions. About 76 adults with low-level depression symptoms will complete surveys, interviews, and computer…

This study follows up with 1,000 adults who previously took part in mood disorder research at the National Institute of Mental Health. Participants complete online surveys and optional phone interviews about their current symptoms, treatments, and well-being. The goal is to learn…

This study looks at how the brain handles threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences i…

This study uses special PET scans to see if inflammation in the brain is higher in people with major depressive disorder (MDD) during a depressive episode compared to healthy volunteers. Researchers will scan about 64 adults aged 18-70, including those with MDD and healthy contro…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study looks at how the brain, nervous system, and blood vessels work together in 80 adults having heart surgery. The goal is to better understand the link between heart disease and depression. Researchers will measure brain waves, heart rate control, and blood flow before an…