DEPRESSION

This study tested a new program in HIV clinics to better identify and treat substance use, depression, and anxiety. Over 10,000 HIV-positive adults used tablets to screen for these issues during routine visits. Those who screened positive could then receive counseling from a beha…

This study tested a non-invasive brain training method called neurofeedback for adolescents who have had suicidal thoughts or a recent suicide attempt. Participants aged 11-18 learned to control their own brain activity in real-time while inside an MRI scanner. The goal was to se…

This Stanford University study aimed to understand which brain circuits are involved in anxiety and depression. Researchers enrolled 167 adults experiencing symptoms and offered them an 8-week treatment course of either medication (Pramipexole) or magnetic brain stimulation (rTMS…

This study tested whether a structured team-based care model works better than usual treatment for adults with depression in Denmark. 325 patients worked with their regular doctor plus mental health professionals in a coordinated plan. Researchers measured whether this collaborat…

This study tested whether a non-invasive light therapy, delivered through a headset to the forehead, could help reduce symptoms of major depression. Fifty adults with depression were randomly assigned to receive either real light treatment at different settings or a fake (sham) t…

This study compared two common talk therapies—Cognitive Behavioral Therapy (CBT) and Emotion-Focused Therapy (EFT)—to see which is more effective for people with depression. Researchers followed 112 adults with moderate to major depression, measuring their symptoms and experience…

This study tested whether combining mental health therapy with job coaching helps people on sick leave due to anxiety or depression return to work faster. Over 600 participants in Denmark were randomly assigned to receive either standard stepped mental health care or this care in…

This study explored whether adding whole-body heat therapy (like a medical sauna) to standard cognitive behavioral therapy (CBT) could help people with major depression. Thirty adults with depression received eight weeks of CBT and were randomly assigned to also get either real o…

This study tested whether adding pizotifen to the antidepressant escitalopram works better for depression than escitalopram alone. Researchers followed 88 people with depression, measuring their symptoms using a standard questionnaire. The goal was to see if the combination treat…

This study tested a special therapy program designed to help people living with HIV quit smoking. The program focused on reducing anxiety and depression, which are common challenges that make quitting harder. Researchers compared this 9-session therapy to standard quit-smoking ad…

This study tested a short program called the Making Connections Intervention (MCI) designed to help Black teenagers with depression feel more comfortable starting and sticking with treatment. The program, delivered in schools, used digital tools and personal sessions to make ther…

This study tested a personalized brain-training therapy for people with major depression who struggle to feel pleasure. 19 participants were randomly assigned to receive either the real therapy or a sham version to compare safety and effectiveness. The goal was to see if this the…

This study tested whether adding a non-drug treatment to standard care could better help pregnant women and new mothers with depression. The treatment involved using a bright light box each morning and following a personalized sleep schedule. Researchers compared this combined ap…

This study tested whether a new program that combines mental health treatment with job coaching helps people return to work faster. It involved 900 people in Denmark who were on sick leave due to conditions like anxiety, depression, or stress. Researchers compared this integrated…

This study tested whether a counseling program delivered by text and video calls could help young adults (ages 18-29) living with HIV stay engaged in their medical care. The 8-month program aimed to address common challenges like depression and substance use that can interfere wi…

This study looked at whether GLP-1 medicines like semaglutide and tirzepatide, used for weight loss, also improve mental health and quality of life. It followed 90 veterans with obesity for six months while they received this treatment. The key finding was that participants repor…

This study tested whether a special three-week program could improve thinking skills. Participants, including healthy adults and people with stable depression or bipolar disorder, spent time in a room with low oxygen levels (like being at high altitude) while doing brain-training…

This study tested whether a new medicine, JS1-1-01, is effective and safe for treating moderate to severe depression. It involved 267 adults who were randomly assigned to receive either the drug or a placebo (a dummy pill) for comparison. The main goal was to see if the drug redu…

This study tested whether a special support program was helpful and practical for mothers who recently had a preterm baby. The program provided care coordination and motivational coaching to help with stress, depression, follow-up doctor visits, and healthy habits. Researchers en…

This study tested whether adding a smartphone app to standard talk therapy helps veterans with depression recover faster. Researchers compared veterans using the app alongside therapy to those using therapy alone. The goal was to see if the app made it easier for veterans to lear…

This study tested a new way to find and treat depression in teenagers at local health clinics in Mozambique. Researchers compared a special group talk therapy program to the usual care that was already available. The goal was to see if this new approach could work well in areas w…

This study tested whether timing magnetic brain stimulation (TMS) to match a person's natural brain rhythms works better for depression than standard TMS. Researchers compared two groups: one received TMS timed to their brain's alpha wave rhythm, while the other received standard…

This study tested if a special coaching program focused on sleep and daily routines could help people recently discharged from the hospital for depression. Participants used a phone app to track their mood and sleep. One group also received weekly phone coaching to help stabilize…

This study tested whether a smartphone app could help people with mild-to-moderate depression. 315 adults used the app, which provided short daily therapy sessions, for 8 weeks. Researchers compared the app to a placebo version to see if it safely reduced depression symptoms and …

This study tested a new counseling program called THRIVE for people with HIV who were hospitalized and had not been regularly seeing their HIV doctor. The program aimed to help 75 participants overcome feelings of avoidance and stigma so they would continue their outpatient HIV c…

This study tested whether sending trained community health workers to visit pregnant women at home could improve health for both mothers and their babies. It followed nearly 1,500 women in rural South Africa for a year after giving birth. The program aimed to help with challenges…

This study tested a new parenting program designed specifically for parents who are depressed and have children with emotional or behavioral problems. The goal was to see if the program was practical to run and acceptable to parents, and if they would stick with it. Researchers w…

This study tested whether adding an antidepressant to standard psoriasis medication works better than the psoriasis medication alone for people who have both psoriasis and depression or anxiety. Forty adults with moderate-to-severe psoriasis and significant depression/anxiety wer…

This study tested a new team-based care model for treating depression in Danish general practice clinics. Researchers compared this collaborative approach, which combined therapy, education, and medication management, against standard consultation methods. The goal was to see if …

This study tested whether a 6-week mindfulness training program could help overweight teenagers who are at risk for developing type 2 diabetes. Researchers compared mindfulness training against two other approaches—cognitive behavioral therapy and health education—to see which wa…

This study tested a new support program for clinics to improve care for adults with multiple long-term conditions like HIV, diabetes, and high blood pressure. Over 1,800 participants in South Africa either received standard care or the new ENHANCE program, which included special …

This study tested a new way to help refugees suffering from PTSD and depression by combining standard mental health therapy with direct help for real-world problems like unemployment and language barriers. It involved 196 unemployed refugees in Denmark. Researchers compared the u…

This study tested three different support models to help community health workers in Vietnam provide better depression care. It involved 1,382 participants and compared basic training to more intensive support like ongoing supervision and group learning. The goal was to find the …

This study tested a French version of a questionnaire called HSCL-25 to see if it helps general practitioners diagnose depression more accurately. Over 1,100 adult patients visiting their primary care doctor participated. Researchers compared the results of this new questionnaire…

This study tested whether a digital screening system called 'eScreening' works better than standard paper methods in VA clinics. The goal was to see if using iPads helps identify mental health issues like PTSD, depression, and suicide risk more quickly and reliably in post-9/11 V…

This study tested whether painting roofs with a special reflective coating could help keep homes cooler in Niue, a Pacific island nation facing record heat. Researchers compared health and home environment data from 288 adults living in houses with either the new cool roof coatin…

This study tested a family program designed to prevent mental illness in teenage girls who were recently forced to flee Venezuela for Colombia. The program involved the girls' entire family, including male siblings and caregivers, to create a more supportive home environment. Res…

This study tested a family-focused program designed to prevent depression in children whose mothers have a history of depression. It involved 73 children aged 8-12 and their mothers, who participated in 8 online sessions. The main goal was to see if the program could improve how …

This study tested whether a 12-week program could prevent major depression in older adults grieving the loss of a spouse. 151 participants at risk for depression tracked their sleep, meals, and activity using digital tools and received health coaching. Researchers compared this g…

This study tested two new types of brief online messages designed to encourage COVID-19 vaccination, specifically for adults with anxiety or depression who are less likely to get the shot. Researchers compared these new approaches—one using storytelling to counter misinformation …

This study tested an online parenting program for rural parents who misuse opioids or other substances. It aimed to improve parenting skills, reduce stress, and help prevent future substance use problems in both parents and their young children. Researchers compared the online pr…

This study tested a 10-week family program designed to prevent emotional problems in children whose parents have depression. It compared a full family program (with parent training, child therapy, and shared meals) against parent training alone. The research focused on low-income…

This study tested a program in pediatric clinics to help low-income parents support their child's early development and school readiness. Researchers combined two approaches: video coaching during doctor visits and optional home visits for families needing extra support. They fol…

This study tested whether a 6-week group therapy program for depression could improve the body's response to insulin and help prevent type 2 diabetes in at-risk teenage girls. Researchers compared the therapy group to a health education group and followed 147 participants for one…

This large study investigated whether taking daily vitamin D or fish oil supplements could prevent depression in older adults who were not currently depressed. Over 18,000 participants were randomly assigned to take either the real supplements or placebo pills for over five years…

This study tested a simple, secure website called Adhere.ly, designed to help therapists give and track practice exercises (homework) to their clients between therapy sessions. It compared standard therapy for anxiety and depression to therapy that used this digital tool. The goa…

This study tested whether using a simple hand fan could help people with COPD feel less short of breath and improve their mood. 59 patients were split into two groups: one used a fan for 10 minutes daily for six weeks, while the other received standard care. Researchers measured …

This study tested whether using the JoyPop mobile app could help college students better manage their emotions and improve their mental wellbeing. 160 students aged 18-25 were randomly assigned to either use the app or receive no intervention. Researchers measured changes in emot…

This study tested whether weekly social groups could help older veterans struggling with depression, loneliness, and isolation. Nineteen veterans participated in community-based social gatherings led by trained facilitators. Researchers collected feedback and measured changes in …

This study tested a digital support service to help pregnant women and new mothers manage depression. 75 participants used a smartphone app for self-management and connected remotely with care managers. The goal was to see if this technology could help reduce depression symptoms …

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) could reduce depression symptoms. Twenty-one adults with depression received multiple TBS sessions over two weeks, and some also received training to boost positive emotions.…

This study tested whether an 8-week online therapy program could help reduce depression symptoms in adults aged 60 and older. Researchers compared 84 participants who either received the internet-based cognitive behavioral therapy immediately or were placed in a delayed treatment…

This study tested whether a non-invasive brain stimulation device, used at home, could help reduce symptoms of depression. Nearly 200 adults with mild to moderate depression used the device on themselves for six weeks. Researchers measured changes in depression, anxiety, and thin…

This study tested whether a daily oral medication called MAP4343 could help reduce symptoms in people with major depression who did not respond to at least two standard antidepressant treatments. For 6 weeks, 126 participants either received MAP4343 or a placebo pill, without kno…

This study tested whether education delivered through a mobile app could help people with a tracheostomy (a breathing tube in the neck). Researchers wanted to see if the app could reduce feelings of depression, help patients adapt socially, and improve their overall recovery. The…

This small pilot study tested whether combining a supervised aerobic exercise program with the antidepressant medication duloxetine could help older adults who have both painful knee osteoarthritis and depression. The goal was to see if this combined approach was practical to del…

This small, exploratory study tested a single session using a virtual reality app with an AI-powered guide to provide mental health support. It involved 22 adults with inflammatory bowel disease (IBD) who also had mild to moderate anxiety or depression. The main goal was to see i…

This study tested whether an 8-week text messaging program could help young adults (ages 18-25) with depression and anxiety who were not interested in traditional therapy. Researchers compared personalized text messages (adjusted by a computer based on user responses) against gen…

This study tested whether a combined mental and physical health program, delivered mostly by phone with a few home visits, is practical and helpful for people recovering from life support in the ICU. It involved 52 adult survivors who were experiencing depressive symptoms. The go…

This study tested whether a simple exercise program could help older adults feel better during a hospital stay. Researchers assigned 100 hospitalized patients aged 65 and older to either do daily exercises or receive standard care. The goal was to see if activities like walking a…

This study tested whether providing therapy through video calls on an iPad could effectively treat depression in people who recently had a spinal cord injury. It involved 75 adults in California who were within a year of their injury and had mild to moderate depression. The goal …

This Yale University study tested whether an 8-week program of computer brain games could help reduce depression and improve thinking skills and quality of life. The study involved 36 people with major illnesses, specifically cancer survivors and patients with end-stage kidney di…

This study tested whether a non-invasive brain stimulation technique could help people who have both hoarding disorder and depression. Researchers used a method called intermittent theta burst stimulation (iTBS) to target specific brain areas. The goal was to see if this treatmen…

This study tested whether a new type of glasses could help people with depression and poor sleep. The 'Lumos Glasses' use a special coating and tiny lights to deliver a specific type of light to the eyes, aiming to mimic the benefits of natural daylight. Researchers wanted to see…

This small, completed pilot study explored whether a cannabis-infused oil could help improve sleep for people with major depression who also have chronic insomnia. Fourteen participants were randomly assigned to receive either a placebo or one of two oil formulas with different C…

This study explored whether participating in live music experiences could help reduce symptoms of depression and build resilience. Researchers worked with 84 participants aged 8-70 who had depression or were prone to it. They measured changes in depression symptoms and resilience…

This study tested whether using a virtual reality (VR) headset could help people with depression get more out of a common talk therapy. Researchers compared standard therapy to therapy enhanced with VR activities. The main goal was to see if the VR approach was practical, accepta…

This study tested whether a simple program could be used in nursing homes to help residents with dementia. The program involved care staff doing two short, personalized activities each week with residents for six months. Researchers wanted to see if this was practical to do and i…

This study tested whether a simple self-acupressure technique could help nurses manage work-related stress, anxiety, and burnout. 160 nurses with signs of emotional distress were randomly assigned to either perform daily acupressure on their hands or continue their usual coping m…

This study tested if using a patient's genetic information (DNA) to guide the choice of antidepressant medication works better than standard doctor-led care for cancer patients. 99 adults with cancer and symptoms of depression or anxiety were randomly assigned to either get a DNA…

This study tested whether a simple, home-based exercise program could help reduce feelings of depression and anxiety in people undergoing long-term kidney dialysis. Over 50 patients were split into two groups: one followed a 6-month exercise plan, while the other received their u…

This study tested whether a compassion meditation program could help Veterans who have both chronic pain and conditions like PTSD or depression. Researchers compared the meditation program to a standard health education course to see which was better at reducing pain interference…

This study tested whether taking capsules containing healthy gut bacteria from a donor (fecal microbiota transplantation) could improve sleep for people with chronic insomnia. 80 participants were randomly given either the real treatment capsules or identical-looking placebo caps…

This study tested a new phone-based therapy program designed to help people with depression become more physically active. 65 adults with moderate to severe depression who exercised very little received 10 therapy sessions by phone or video. Researchers wanted to see if this appr…

This study tested whether a simple mandala coloring activity could help people hospitalized for depression and anxiety. Fifty-one adult patients participated in eight coloring sessions. Researchers measured changes in their stress, anxiety, depression levels, and overall quality …

This study developed and tested a web-based app designed to help people manage symptoms of depression and anxiety. It involved 50 adults in low and middle-income countries who had access to a smartphone or computer. The main goal was to see if the app was easy to use, acceptable …

This study tested whether a six-week online therapy program could help university students in Malaysia better manage their emotions, anxiety, and depression. Researchers compared a group receiving Acceptance and Commitment Therapy (ACT) to a group that did not receive therapy dur…

This study tested whether a voice-based artificial intelligence coach named Lumen could teach problem-solving skills as effectively as a human coach to help adults with mild-to-moderate depression and anxiety. 200 participants were randomly assigned to receive coaching from the A…

This study tested a modified parenting program designed to help parents who have ADHD or depression themselves. The goal was to see if these modifications helped parents connect with and stick to the training, which teaches skills to support a child with ADHD and friendship diffi…

This study tested whether a brief, interactive conversation with an AI chatbot could help improve mental health for young students in India. About 380 students in grades 6-8 used a 45-minute chatbot program designed to teach a 'growth mindset'—the belief that abilities can improv…

This study tested whether a gentle, non-invasive brain stimulation technique (tDCS) could boost the benefits of computerized brain training games for older adults with recurring depression. Sixteen participants aged 60+ with depression and memory complaints were randomly assigned…

This small, early-stage study tested a 6-month community support program for pregnant women and mothers of young children who have recently experienced intimate partner violence and show signs of depression or PTSD. The program pairs participants with trained mentor mothers who p…

This study tested whether a non-invasive brain stimulation technique could reduce symptoms of depression. 73 adults with moderate depression received either real or placebo magnetic stimulation to a specific brain area for two weeks. Researchers measured changes in depression, th…

This VA study tested a virtual mindfulness program called RECLAIM, designed to help post-9/11 Veterans struggling with depression and difficulty adjusting to civilian life. The small pilot study compared the mindfulness program to basic educational materials to see if it was prac…

This study tested a special phone-based therapy program designed to help manage anxiety in older adults with cancer and their primary family caregivers. It compared this therapy to usual care to see if it could better reduce anxiety and improve emotional well-being. The program w…

This study tested a program called Mood Lifters, where college students lead weekly group meetings to help their peers manage mental health. The goal was to see if this low-cost, peer-led approach could effectively reduce symptoms of depression and anxiety in undergraduate studen…

This study tested a support program designed to help Spanish-speaking caregivers of veterans who have had a stroke. The program involved eight phone sessions and online tools to teach problem-solving skills. Researchers wanted to see if it could reduce caregivers' feelings of dep…

This study tested whether a special talk therapy called CALM could work for advanced cancer patients in Korea. The therapy helps people cope with depression, anxiety, and fears about the future. Researchers wanted to see if patients found it helpful and could complete the session…

This study tested if a 9-week mindfulness app helped teens with anxiety or depression feel better. Researchers wanted to know if having a parent also learn mindfulness alongside their teen provided extra benefit. They compared teens who used the app alone to teens whose parent al…

This study tested a program called SHARP-CG, designed to support older Black caregivers of people with dementia. Small groups walked together three times a week for 16 weeks, using a tablet to view historical photos of their neighborhood as conversation starters. Researchers meas…

This study tested whether daily omega-3 fish oil supplements could help adults who feel highly stressed or anxious. For three months, 64 participants took either omega-3 capsules or a placebo pill, without knowing which one they received. The results suggest that those taking ome…

This study tested whether an 8-week program of supportive phone calls could improve mental health for older adults at risk of loneliness and depression. Researchers enrolled 671 adults aged 55+ who were receiving meal services from senior centers. Participants received weekly 'wa…

This study tested whether repeated ketamine infusions could safely reduce depression in people with Parkinson's disease. Fifty-one participants with both conditions received either ketamine or a placebo infusion. Researchers also used brain scans on some participants to understan…

This study tested whether a 4-week virtual reality (VR) brain training program could improve thinking skills and daily functioning in people with stable depression, bipolar disorder, or schizophrenia. 62 participants were randomly assigned to receive either the active VR cognitiv…

This study tested whether a combined program of talk therapy and careful medication review could help reduce feelings of depression and anxiety in adults aged 60 and older who were having major heart surgery. It compared this special program to the usual care patients receive. Re…

This Stanford study tested whether a proven sleep therapy could reduce symptoms of depression and anxiety. Researchers worked with 51 adults who had both poor sleep and elevated depression/anxiety. They used brain scans to see if the therapy, which teaches better sleep habits, ca…

This study tested whether an 8-week mindfulness program could help parents of children with autism. The program involved weekly group sessions with education and meditation practices. Researchers measured changes in parents' levels of depression, anxiety, stress, and hopelessness…

This small, completed pilot study explored whether it's practical and acceptable for people with depression to reduce how much ultra-processed food they eat. The study involved 20 adults with major depressive disorder who typically ate a lot of these foods. Researchers wanted to …

This study tested whether personalized meal plans encouraging more fish and less red meat could help women manage common symptoms after breast cancer treatment. Researchers worked with 98 women who had finished treatment 1-2 years prior and were experiencing fatigue, pain, depres…

This study tested whether practicing Qigong, a gentle mind-body exercise, could help reduce anxiety and depression in people hospitalized for depression. Researchers compared 70 patients who did Qigong exercises to those who did not. The goal was to see if this non-drug approach …

This study tested a new online therapy program designed to support transgender and gender-diverse people in Romania. The program aimed to reduce depression, anxiety, and behaviors linked to HIV risk through 16 weekly video sessions with a trained therapist. Researchers worked wit…

This study tested whether a single-day group workshop could help veterans dealing with the combined effects of mild brain injury, chronic pain, PTSD, depression, or anxiety. The workshop taught life skills to help manage distress and improve daily functioning, aiming to be more a…

This study tested a non-drug sleep program for adults with depression, bipolar disorder, or ADHD who also had significant sleep problems. The program combined talk therapy and sleep schedule adjustments. Researchers compared it to basic sleep education to see if it better improve…

This study tested whether a brief, 14-day online mindfulness training could help reduce stress, anxiety, and depression in Indonesian university students. Researchers enrolled 426 students and compared the mindfulness program to a psychoeducation course and a waitlist group. The …

This study tested a mobile app designed to help people with glaucoma manage the anxiety and depression that can come with their diagnosis. Researchers worked with 28 patients to develop and refine the app, which uses therapy techniques to teach coping skills. The goal was to see …

This study tested whether giving families a diary to write in during their child's pediatric intensive care unit (PICU) stay could improve mental health and satisfaction. Researchers in Brazil enrolled over 400 families of children in the ICU to see if the diary program reduced a…

This study tested whether training traditional birth attendants to provide basic mental health support could reduce depression in pregnant mothers in rural Kenya. It involved 220 mothers with depression who were between 16 and 26 weeks pregnant. The goal was to see if this access…

This study tested whether weekly Spanish-language peer support groups, called 'Tertulias,' could help reduce depression and feelings of isolation in Mexican immigrant women. Over 240 women participated, with some attending weekly gatherings for a year while others received check-…

This study tested a new mobile app called VetEd, designed to help student veterans who have mental health conditions like depression or PTSD. The app helps with study skills, managing stress, and finding campus and VA resources. Fifteen veterans tried the app for four weeks to se…

This study tested whether a simple relaxation technique could help nursing students feel less depressed, anxious, and stressed. Researchers divided 104 nursing students into two groups: one group practiced progressive muscle relaxation exercises for four weeks, while the other di…

This study tested a group workshop called STEP-Home, designed to help post-9/11 Veterans who were struggling to adjust after military service. The workshop taught practical skills for managing emotions, solving problems, and focusing attention to improve daily life and community …

This study tested whether three different non-medication approaches could help reduce anxiety and depression symptoms in college students. Fifty-five students were randomly assigned to try either external qigong (a gentle energy practice), mindfulness meditation, or an educationa…

This study tested whether two types of group talk therapy could help people with multiple sclerosis (MS) feel better and think more clearly. Researchers compared a cognitive behavioral therapy (CBT) program and a psychophysiological regulation therapy to standard care in 140 part…

This small study tested whether installing special LED lights in hospital rooms could help people with major depression. The lights were designed to change like natural sunlight throughout the day. Researchers wanted to see if patients found the lights comfortable and if they hel…

This study tested whether a single one-hour session of a specially designed therapy video game could improve mental health. Researchers compared the game, based on Acceptance and Commitment Therapy (ACT), to a regular neutral game in 302 adults with mild to moderate depression, a…

This study tested a non-drug treatment for veterans suffering from both chronic pain and PTSD. Researchers combined a painless brain stimulation device (tDCS) with a therapy program to see if it could reduce pain and mental health symptoms. They also collected blood and saliva sa…

This study tested if a simple writing exercise could help reduce feelings of anxiety and depression. For 14 days, young adults wrote about their deepest thoughts and feelings. Researchers compared whether writing as if talking to yourself or to a loved one worked better.

This study tested two different online therapy programs designed to help people with anxiety and/or depression. Researchers enrolled 2,477 participants to compare two therapy approaches, different treatment lengths (8 vs. 16 weeks), and whether having access to a moderated suppor…

This study tested whether a non-invasive brain stimulation treatment could reduce chronic pain, headaches, and depression in veterans with Gulf War Illness. Researchers enrolled 204 veterans who served in the 1990-1991 Gulf War and experienced significant daily pain. The treatmen…

This study tested whether a mindfulness training program called MindUP could help reduce feelings of depression, anxiety, and stress in orphaned teenage boys living in care institutions in Pakistan. The program involved structured group sessions teaching mindfulness and emotional…

This study tested an online workshop designed to help family caregivers of people with dementia. The 6-week program taught caregiving skills and stress management. Researchers enrolled 109 caregivers to see if the workshop was practical to run and acceptable to participants, with…

This study tested whether a 10-week Zumba exercise program could help reduce feelings of anxiety and depression. Forty healthy adults aged 40 to 65 were randomly assigned to either take Zumba classes three times a week or continue their normal routine. Researchers measured partic…

This study tested a program called PRISM, designed to help teens and young adults (ages 12-24) with advanced cancer. The program taught skills like stress management, goal-setting, and finding meaning to improve their quality of life and reduce anxiety and depression. Researchers…

This study tested whether structured outdoor activities in nature could help reduce symptoms of anxiety and depression in teenagers. Researchers worked with 60 adolescents, comparing those who received the nature therapy program to a group that did not. The goal was to see if spe…

This study tested whether taking heated yoga classes could help adults with mild to moderate depression feel better. Researchers enrolled 80 people to either participate in twice-weekly hot yoga sessions or wait for treatment while tracking their symptoms. The main goals were to …

This small pilot study tested a culturally adapted mindfulness therapy program for older Black adults living with both chronic pain and depression. The main goal was to see if the program was practical and acceptable to participants, and to gather initial information on whether i…

This study tested whether a 4-week meditation and well-being app called the Healthy Minds Program could help reduce symptoms of depression. Over 1,100 U.S. adults with elevated depression symptoms were randomly assigned to use the app, use a version without meditation, or wait to…

This study tested if sharing and discussing a patient's text messages, emails, and social media chats with their therapist could improve mental health treatment. 110 adults in therapy for anxiety or depression were randomly assigned to either have their electronic communications …

This study tested whether adding the drug ketamine to a standard antidepressant could help control depression symptoms faster in patients with serious, progressive illnesses who are receiving palliative care. It involved 42 hospitalized patients with moderate-to-severe depression…

This study aimed to understand how inflammation might affect feelings of pleasure and motivation in older adults, particularly those with anxiety. Researchers gave 40 participants aged 60-80 either a substance that causes temporary inflammation or a placebo, then measured their m…

This study tested whether having prosthetists screen for common hidden health problems during routine visits could improve care for people after a leg amputation. Seventy patients were randomly assigned to receive either standard care or standard care plus extra screenings for is…

This study aimed to understand if the brain's response to insulin is different in teens with depression. Researchers compared brain scans of 12 adolescents with depression to 12 healthy teens after giving them a nasal spray containing either insulin or a placebo. The goal was to …

This study aimed to find biological markers in the blood, urine, and other samples that could help explain why up to 40% of people with depression do not respond to standard antidepressant medications. Researchers enrolled 50 adults with major depression who were not taking medic…

This study aimed to understand how healthy young brains voluntarily suppress negative or unpleasant memories. Researchers used EEG brain scans and computer tasks to measure attention and brain activity while participants tried to block certain memories. The goal was to map the br…

This study aimed to find out if simple online tools could help LGBTQ+ youth get past barriers and seek mental health support. Researchers tested four different types of online content, like videos and links, with 81 teens and young adults in an anonymous Discord group. The goal w…

This study tested if doctors and nurses could help low-income parents by referring them to a free tax-filing app. Researchers wanted to see if this simple referral made it easier for families to get tax credits they qualify for, and if that money might improve parent and child we…

This study tested whether having a trained facilitator visit older adults at home to help complete a medical order form (called a POST form) improved the care they received. Researchers wanted to see if this help made the medical care people got at the end of their life better ma…

This study aimed to understand how temporary inflammation might affect the brain's reward system—how we anticipate and enjoy things—in women. Researchers gave 40 healthy, premenopausal women either a low-dose substance to trigger a brief inflammatory response or a placebo, then m…

This study aimed to see if following a vegetarian diet is linked to developing fewer chronic diseases over time. Researchers followed over 18,000 Taiwanese Buddhists, comparing health outcomes between vegetarians and non-vegetarians. They tracked participants' health records for …

This study aimed to understand how a mother's depression affects her interactions with her baby and the child's early development. Researchers observed and filmed 701 mothers (some depressed, some not) playing with their infants at home and in a lab when the babies were 5, 12, an…

This study aimed to figure out the best way to offer mental health help to people seeing an orthopedic doctor for long-term back or neck pain. Researchers asked 30 patients and their doctors about their needs and then had patients try a mental health app and a printed resource gu…

This study aimed to understand if a simple, non-invasive brain scan could detect patterns linked to a person's risk for depression. Researchers used a special light-based scanner (fNIRS) while 90 participants performed a word task. They compared brain activity in people who had r…

This study investigated how short-term steroid medication affects specific memory areas in the brain. Researchers gave healthy volunteers and some people with depression either hydrocortisone (a steroid) or a placebo for three days. They used detailed brain scans and memory tests…

This study aimed to see if measuring how a teen's brain pays attention to negative information could predict their future risk for depression. Researchers used EEG brain scans and a special feedback training session with 15 teenage girls who had no history of depression. The goal…

This study aimed to find out if a person's genes can predict how well they will respond to a common antidepressant. Researchers looked at a specific gene in 188 adults with major depression who were taking the medication escitalopram. They compared the genes of people who got bet…

This study tested whether using trained community health workers in Black churches could improve depression screening and help more people get treatment. Researchers compared a special program that included screening, brief counseling, and referrals against usual referral methods…

This study tested whether a community-based mental health program was practical and acceptable for women affected by severe flooding in Pakistan. It trained local female health workers to screen nearly 4,800 women for anxiety and depression and refer those who needed help to clin…

This study aimed to understand if the age when a woman goes through menopause is linked to her levels of anxiety and depression. Researchers compared 136 women who experienced natural menopause after age 40 with those who had early menopause (before 40). The goal was to gather in…

This study aimed to understand how a woman's ability to perform daily tasks and participate in social roles relates to her life satisfaction and depression levels after experiencing domestic physical violence. Researchers surveyed 15 women who had sought help from a social servic…

This study aimed to understand why depression doubles the risk of death in people with heart disease. Researchers measured heart health markers, sleep, and activity levels in 175 patients with both conditions to find links to persistent symptoms like fatigue and lack of pleasure.…

This study aimed to understand the connection between depression and the ability to recognize facial emotions in people with multiple sclerosis (MS). Researchers compared 38 participants, including MS patients and healthy controls, using emotion recognition tests, brain scans (MR…

This study aimed to understand how the brain's reward system influences responses to depression treatments. Researchers tested 120 adults with depression using non-invasive brain stimulation and two different medications to see how they affected brain activity during a reward tas…

This is a very early study to check the safety of a new drug called NH102, which is being developed to treat depression. It tested multiple dose levels in 40 healthy volunteers to see how their bodies reacted to and processed the drug. The main goal was to find out what side effe…

This study aimed to understand how being on a ventilator in intensive care affects patients' memory and emotional health months later. Researchers followed 125 patients who were sedated and on breathing machines, checking in with them at 2 and 4 months after leaving the hospital.…