DEPRESSION

This study tested two types of short digital messages to see if they could encourage COVID-19 vaccination in adults with anxiety or depression. Over 1,400 undervaccinated participants received either standard public health messages, messages designed to build resistance to misinf…

This study tested a 12-month program where nurses provided phone-based support to patients with depression and opioid use. 805 adults were randomly assigned to either receive the nurse support or continue with usual care. The goal was to see if this team-based approach could impr…

This study tested a program called ENHANCE to help people with two or more long-term health problems like HIV, high blood pressure, diabetes, asthma, or depression. Over 1,800 adults aged 40 and older took part. Some clinics used a special decision-support tool and home visits fr…

This study tested whether painting metal roofs with a special reflective coating (cool roofs) can lower indoor temperatures and improve health in Niue. 288 adults living in single-story homes with metal roofs took part. Researchers measured heart rate, blood sugar, depression, an…

This study tested two programs to help nurses who are at risk for suicide. One program screens nurses online to find those who need help, and the other teaches skills to manage stress and improve mood. About 849 nurses took part to see if these programs reduce suicidal thoughts a…

This study tested whether remote problem-solving sessions delivered by text or video call could help young people aged 18-29 living with HIV stay engaged in care, improve mental health, and reduce substance use. Fifty participants received the intervention over 4 months and were …

This study tested a smartphone app called iGAME that uses game-like features to encourage healthy lifestyle changes in people with low back pain, cancer, or depression. The goal was to see if the app could help them become more active and sit less. 48 adults took part, and the ap…

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 living with HIV and depression. The goal was to see if the program is feasible and acceptable, and whether it can reduce depression symptoms and improve engagement in HIV care. The study c…

This study tested a program to help adults with chronic pain, anxiety, and depression who were taking long-term opioids. The program added a pharmacist, a social worker, and a community health worker to the care team to support safer opioid use. The goal was to reduce high-dose p…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 adolescents aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. The goal was to…

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) for older adults from minority groups who have depression, anxiety, or physical limitations. The program combines mental health support with physical exercises to help prevent disability. Researcher…

This study looked at whether a structured physical activity program, along with health education materials, could help prevent colon cancer from returning in people who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. A total of 889 participants were…

This study tested a program called THRIVE for 75 hospitalized adults with HIV who were not regularly seeing a doctor. The program provided support to help them attend follow-up appointments after leaving the hospital. The goal was to improve viral load control and reduce anxiety …

This study tested a new clinic program to help people living with HIV. Over 10,000 patients used tablets to privately screen for substance use, depression, and anxiety during routine visits. Those who screened positive could then talk with an on-site specialist for counseling and…

This study tested whether a French translation of the HSCL25 questionnaire can help general practitioners accurately diagnose depression. Over 1,100 adults visiting their primary care doctor took part. The goal was to give doctors a simple, reliable tool to identify depression wh…

This study looked at whether an electronic self-report screening system (eScreening) helps VA clinics detect depression, PTSD, alcohol problems, and suicide risk more quickly and more often in newly enrolled veterans. Researchers compared screening rates and referral times before…

This study tested whether a 12-week healthy lifestyle program could prevent major depression in older adults (60+) who recently lost a spouse. Participants tracked their sleep, meals, and physical activity with digital tools and received motivational coaching. The goal was to see…

This study followed 217 children who were part of an earlier program for anxiety and depression. Researchers wanted to see if the program still helped 5 years later by reducing symptoms and preventing new diagnoses. The children, now teenagers, were assessed using questionnaires …

This study tested two different online education programs to see which one better prevents stress-related problems like PTSD, depression, and burnout in paramedics working during the COVID-19 pandemic in Singapore. 63 paramedics took part, completing 6 weekly online modules and a…

This study tested a program called SSAGE that works with the whole family—including brothers—to prevent mental health problems in teenage girls who were forced to leave their homes. The program was designed for girls and their families who recently moved to Colombia from Venezuel…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids or other substances. About 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress…

This study tested a 10-week program called Protecting Families for depressed parents and their pre-teen children. The goal was to see if the program could help prevent depression in the kids. 42 families took part, and the study compared the program to parent training alone, look…

This study looked at whether taking daily vitamin D or fish oil supplements could prevent depression in over 18,000 healthy adults. Participants had no major depression history and took supplements or placebos for about 5 years. The results showed that neither vitamin D nor fish …

This study tested a program designed to boost positive emotions in children aged 8 to 12 whose mothers have a history of depression and anhedonia (loss of interest or pleasure). The goal was to see if the program could change how their brains respond to rewards, potentially preve…

This study tested a smartphone app that uses cognitive behavioral therapy to help people with mild-to-moderate depression. 315 adults used either the active app or a placebo version for 8 weeks. The goal was to see if the app could reduce depression symptoms and improve daily fun…

This study looked at whether live music experiences could help people with depression feel better. Researchers worked with 84 participants aged 8 to 70 who had depression or were at risk for it. They measured changes in mood, resilience, and quality of life after group or individ…

This study tested a personalized form of transcranial magnetic stimulation (TMS) to treat emotional blunting—feeling numb or flat—in people with depression. 80 adults received brain stimulation tailored to their own brain scans. The goal was to see if this approach could improve …

This study tested a compassion meditation program for 142 Veterans with chronic pain and either depression or PTSD. Participants learned meditation techniques to reduce suffering and improve well-being. The goal was to see if this mind-body approach could lessen pain's impact on …

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers measured changes in depression scores and also used brain s…

This study tested a new way to treat depression using transcranial magnetic stimulation (TMS). Instead of delivering pulses at random times, the researchers timed the pulses to match the brain's natural alpha rhythm. They wanted to see if this synchronized approach would work bet…

This study tested whether a mobile app-based education program could improve depression, social adaptation, and recovery quality in 45 adults with a tracheostomy. Participants used the app to learn about their condition and care. The study measured changes in mood, social functio…

This study tested whether training traditional birth attendants (local midwives) to provide mental health support can reduce depression in pregnant women in rural Kenya, where mental health specialists are scarce. The study involved 220 pregnant women with depression. The goal wa…

This study looked at whether a special type of hot yoga (hyperthermic yoga) can help adults with mild to moderate depression. 80 people were randomly assigned to either do the yoga twice a week for 8 weeks or be placed on a waitlist. The goal was to see if the yoga was acceptable…

This study tested a 24-week remote self-management program called TEAM-Red for depressed young African American women (ages 18-49) who also have risk factors for high blood pressure. 83 women participated, with half receiving the program and half on a waitlist. The goal was to se…

This study tested a program called Mood Lifters for college students struggling with depression, anxiety, or stress. The program uses peer-led group meetings to help students feel better without needing expensive one-on-one therapy. 125 undergraduate students took part to see if …

This study tested a 3-week program that helps cancer patients identify and use their personal strengths to cope better with their illness. 32 adults with different types of cancer took part. The program included a card-sorting session, a personalized report, and weekly phone call…

This study tested an 8-week mindfulness-based stress reduction program for parents of children with autism. 96 parents took part to see if the program could lower their levels of depression, anxiety, stress, and hopelessness. The goal was to improve parents' emotional well-being …

This study tested a combination of two talking therapies—behavioral activation and emotion-focused interventions—for adults with depression. Seven participants completed the treatment, and researchers measured changes in depressive symptoms, emotion regulation, and quality of lif…

This study tested an 8-week text messaging program for young adults aged 18-25 with depression or anxiety who were not interested in or couldn't access in-person therapy. Participants received personalized or standard text messages, or weekly links to mental health info. The goal…

This study looked at whether adding the drug duloxetine to a supervised aerobic exercise program could help older adults with both knee osteoarthritis and depression. All 43 participants received the combined treatment to see if it was feasible and if it improved pain and mood. T…

This study looked at whether two types of psychological therapy could help people with relapsing-remitting multiple sclerosis who also have anxiety, depression, or thinking problems. 140 people took part and were randomly assigned to cognitive behavioral therapy, relaxation thera…

This study tested whether adding ketamine to the antidepressant milnacipran helps reduce depression in people with severe, progressive diseases (like advanced cancer). 42 hospitalized patients in palliative care received either ketamine plus milnacipran or a placebo plus milnacip…

This study tested if a non-invasive brain stimulation technique called tDCS can reduce depression symptoms. 198 adults with mild to moderate depression used a home-based device. The goal was to see if this gentle electrical stimulation could improve mood and daily function.

This study tested a digital mental health app for young adults (ages 18-25) who self-injure and are not in therapy. 90 participants were split into three groups: a self-guided app, the app with coaching, or an active control with educational content. The goal was to see if the ap…

This study tested three remote programs to help people with depression and substance use caused by COVID-19 stress. 113 adults from Cambridge Health Alliance took part. They either joined an 8-week online mindfulness class, an online therapy program, or received standard remote m…

This study tested whether adding whole-body hyperthermia (a treatment that safely raises body temperature) to standard cognitive behavioral therapy (CBT) could help adults with major depression. Thirty participants received either real or sham heat sessions alongside weekly thera…

This study tested a program that combines counseling and medication adjustments to reduce depression and anxiety in adults aged 60 and older who were scheduled for hip or knee replacement surgery. 116 participants were split into two groups: one received the program plus usual ca…

This study tested whether spending time in nature can help reduce anxiety and depression symptoms in teenagers. Researchers worked with 60 adolescents who did not have a psychiatric diagnosis and were not receiving therapy. The teens took part in a nature-based program, and their…

This study tested whether a brief behavioral therapy called Acceptance and Commitment Therapy (ACT) can help at-risk veterans avoid persistent pain and disability after total knee replacement. 402 veterans scheduled for knee surgery were randomly assigned to receive either ACT or…

This study tested whether a sleep improvement program (CBT-I) could reduce depression and anxiety symptoms in 51 adults with sleep problems and mood issues. Participants received six sessions of CBT-I over eight weeks. Researchers used brain scans to see if better sleep changed h…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills and daily functioning in 62 adults with stable mood disorders (like depression or bipolar disorder) or psychosis spectrum disorders (like schizophrenia). Participants used VR to…

This study tested whether "Tertulias" — culturally tailored peer support groups — could reduce depression and increase resilience in Mexican immigrant women. 241 women in Albuquerque took part. The program aimed to ease social isolation and improve mental health through regular g…

This study tested special glasses that control how much blue light reaches your eyes, aiming to improve sleep and depression symptoms. 96 adults in Ontario who had mild depression or sleep issues and spent less than 2 hours outdoors daily took part. Researchers measured changes i…

This study tested whether special LED lights that mimic sunlight, installed in hospital rooms, could help people with major depression. Fifteen patients took part, with some getting the dynamic light and others standard light. The goal was to see if the setup was practical and co…

This study tested a short talking therapy called CALM for people with advanced cancer in Korea. The goal was to see if it was practical and could help reduce depression and distress. 90 patients took part, and the therapy focused on helping them cope with their feelings and fears…

This study tested a 45-minute chat with an AI bot that teaches a 'growth mindset' — the idea that you can get better with effort. About 383 students in grades 6-8 in India took part. The goal was to see if the chatbot could lower symptoms of anxiety and depression. Results may sh…

This study tested a digital neurotherapy (brain-training) program in 36 adults who were either cancer survivors or on dialysis for kidney failure. The goal was to see if the program could help with depression, thinking skills, and quality of life. Participants completed surveys a…

This small study tested whether cannabis oil can improve sleep in people with major depression and insomnia. 14 adults took either cannabis oil or a placebo to see if it helped them fall asleep faster and sleep better. The goal was to see if a larger study is possible and if diff…

This study tested whether a therapy delivered by phone and home visits, which combines treatment for depression with physical rehabilitation, is practical and helpful for people who survived acute respiratory failure in the ICU. Fifty-two adults who lived at home before their hos…

This study looked at whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help university students in Malaysia feel better. Thirty-two students with mild to moderate anxiety, depression, or stress took part. Some received six weekly online ACT session…

This study tested a videogame called 'ACTing Minds' designed to improve mental health in adults with mild to moderate depression, anxiety, or stress. 302 participants played either the ACT-based game or a neutral game for one session. Researchers measured changes in psychological…

This study tested a program called PRISM (Promoting Resilience in Stress Management) to see if it could help young adults aged 18-39 with cancer or desmoid tumors manage anxiety and depression. The program teaches coping skills through sessions and a phone app. The main goal was …

This study tested a non-invasive brain stimulation technique called iTBS for treating depression. 73 adults with moderate depression received either real or fake (sham) stimulation daily for two weeks. Researchers measured changes in mood, thinking skills, and brain scans to see …

This study tested a new, non-invasive treatment for major depression called transcranial photobiomodulation (tPBM), which uses near-infrared light on the forehead. 50 adults with depression received either real or sham light therapy three times a week for six weeks. The goal was …

This study looked at whether teaching children aged 9 to 12 specific coping skills—like rethinking a situation, taking a mental break, or relaxing—can lower their risk for anxiety and depression after their parents separate or divorce. Researchers tested three digital tools in 14…

This study looked at whether a home-based exercise program could help reduce anxiety and depression in people undergoing hemodialysis. 54 adults on dialysis were split into two groups: one did home exercises for 6 months, the other did not. Researchers measured changes in depress…

This study tested two mental health tools—a smartphone app (Wysa) and a printed guide—for adults with long-term back or neck pain. Thirty patients gave feedback through interviews and surveys over one month. The goal was to see if these tools could help reduce anxiety and depress…

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who have lost the ability to feel pleasure (anhedonia). 85 adults with depression and significant anhedonia took pramipexole or a placebo alongside their usual antidepressa…

This study tested a painless brain stimulation treatment called tDCS in 38 veterans with chronic pain, PTSD, and depression. The treatment uses low-level electrical currents to calm brain areas linked to pain and stress. Researchers wanted to see if adding tDCS to standard therap…

This study tested a program where older Black caregivers, their loved ones with dementia, and a support person walk together while looking at old neighborhood photos on a tablet. The goal was to see if this combination of physical activity and social reminiscing could improve car…

This study tested a brain stimulation technique called theta burst stimulation (TBS) to see if it could reduce depression symptoms in 21 adults with current depressive disorder. Some participants also received training to boost positive emotions. The main goal was to measure chan…

This study looked at whether nurses could reduce their own stress, anxiety, and burnout by pressing on specific points on their hand and wrist (acupressure) twice a day for two weeks. 160 nurses from a hospital in Taiwan took part. The results suggest that this simple self-care t…

This study tested two types of online therapy for anxiety and depression in 2477 adults. Participants received either 8 or 16 weeks of treatment, with or without a support forum. The goal was to see which approach works best to ease symptoms and improve quality of life.

This study tested whether a brief online mindfulness program could reduce stress, anxiety, and depression in Indonesian university students. Over 400 students participated. The program aimed to help students manage emotional distress by teaching mindfulness techniques, with a foc…

This study tested a therapy called Managing Anxiety from Cancer (MAC) to see if it could reduce anxiety in people aged 65 and older with cancer, and their caregivers. 26 patients and their caregivers took part. The therapy uses a proven plan to help manage anxiety, and includes t…

This study looked at whether coloring mandalas (circular patterns) can help adults hospitalized for depression and anxiety feel better. Fifty-one patients took part, and researchers measured changes in their mood, stress, and quality of life. The goal was to see if this simple, l…

This study tested whether a smartphone-based program called Circadian Reinforcement Therapy (CRT) could help people with major depression recover faster and avoid relapse after leaving a psychiatric hospital. The program focused on keeping a regular sleep-wake cycle and daytime a…

This study tested magnetic seizure therapy (MST) as a possible alternative to electroconvulsive therapy (ECT) for people with depression that hasn't improved with medication. About 239 adults with treatment-resistant depression received MST to see if it could relieve symptoms whi…

This small study tested a non-invasive brain stimulation technique called iTBS in 14 adults who have both hoarding disorder and depression. The goal was to see if it could improve depression symptoms, and also whether it might help with hoarding behaviors and brain function. Rese…

This study tested a 9-week digital mindfulness program for teens aged 12-17 with anxiety or depression. Half of the parents also took the program to see if their involvement helped more. The goal was to reduce symptoms and improve well-being.

This study tested whether an online therapy program (internet-based cognitive behavioral therapy) could help older adults with depression. 84 people took part, and researchers tracked their symptoms for up to two years. The goal was to see if this convenient, at-home approach cou…

This study tested a mobile app designed to help people with glaucoma manage feelings of distress, anxiety, and depression. Researchers worked with 28 patients and health experts to refine the app, then checked if it was practical and well-liked. The goal was to see if this approa…

This study looked at whether a mindfulness-based program could improve mental health for Gen Z nursing students during their clinical training. 39 students were split into two groups: one received mindfulness training, the other got usual support. Researchers measured anxiety, de…

This study tested whether video-based therapy (telepsychology) can help people with spinal cord injury who feel depressed. 75 adults with a recent spinal cord injury and mild to moderate depression received cognitive behavior therapy over iPad FaceTime. The goal was to reduce dep…

This study tested a program called IPPI for 108 nursing home residents with dementia and depression. Care partners offered two short, personalized activities each week for six months. The goal was to see if this approach could improve mood and reduce distressing behaviors. The st…

This study tested whether daily text messages that adapt to a person's preferences can help reduce depression symptoms. 100 adults with moderate to severe depression received either personalized messages, standard messages, or just educational links for 8 weeks. The goal was to s…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to help older adults feel less depressed and anxious before and after heart surgery. 105 people aged 60 and older took part. The goal was to see if this program works better t…

This study tested an online workshop for 109 family caregivers of people with dementia. The workshop taught caregiving skills and ways to manage stress and difficult emotions. The goal was to see if the workshop was feasible and helpful for caregivers, with the long-term aim of i…

This study tested a new drug called JS1-1-01 in 267 adults with moderate to severe depression. The goal was to see if it safely reduces depression symptoms better than a placebo. Researchers measured changes using standard depression rating scales.

This study tested a program called MOSAIC Plus for 15 pregnant women and mothers of young children who had experienced intimate partner violence and had symptoms of depression or PTSD. The program added counseling techniques to help reduce these symptoms and prevent further viole…

This study tested a voice-enabled AI coach called Lumen that teaches problem-solving skills to adults with mild-to-moderate depression or anxiety. 200 participants were randomly assigned to receive coaching from Lumen, a human coach, or a waitlist. The goal was to see if the AI c…

This study looked at whether a version of cognitive behavioral therapy (CBT) adapted for South Asian culture could help reduce depression and anxiety. About 146 Canadian adults of South Asian origin with mild to severe symptoms took part. Researchers worked with community members…

This study tested a new group therapy for depressed parents of children aged 6 to 10 with emotional or behavioral issues. The goal was to see if the therapy was practical and well-liked by parents. The results will help design a larger study to see if this approach can improve bo…

This study tested whether fecal microbiota transplantation (FMT) — giving healthy donor gut bacteria in a capsule — can improve sleep in people with chronic insomnia. 80 adults took either FMT capsules or placebo starch capsules. Researchers measured sleep quality using sleep stu…

This study tested whether qigong relaxation exercises can lower anxiety and depression levels in adults hospitalized for depression. Researchers randomly assigned 70 patients to either do qigong or not, and measured their symptoms using standard questionnaires. The goal was to se…

This study tested whether a non-invasive brain stimulation technique called rTMS can reduce pain, headaches, depression, and other symptoms in 204 veterans with Gulf War Illness. Participants received rTMS and reported their pain levels, mood, sleep quality, and daily function. T…

This study tested a virtual mindfulness program to help veterans with depression and difficulty adjusting to civilian life. 36 veterans took part. The goal was to see if the program could reduce depressive symptoms and improve community reintegration.

This study tested a problem-solving program delivered by phone and online for 210 Hispanic caregivers of veterans who had a stroke. The goal was to reduce caregiver depression and burden, and improve problem-solving skills and quality of life. Caregivers received culturally tailo…

This study looked at whether doing Zumba for 10 weeks could help lower anxiety and depression in healthy adults aged 40 to 65. Forty people were split into two groups: one did Zumba three times a week, and the other kept their normal routine. The researchers measured mood before …

This study tested a Danish collaborative care model for people with depression in general practice, involving a team of GPs, care managers, and mental health specialists. 389 participants were randomly assigned to either this new model or standard liaison-consultation. The goal w…

This study tested whether weekly social groups called VOICES Veterans Socials could help older veterans with depression feel less lonely and more supported. 18 veterans joined the groups and filled out questionnaires about their mood, social connections, and satisfaction. The goa…

This pilot study tested a 10-session behavioral activation program delivered via teletherapy to increase physical activity and reduce depressive symptoms in 65 adults aged 18-64 with moderate-to-severe depression. Participants used a smartphone and Fitbit to track activity. The s…

This study tested whether a meditation app called the Healthy Minds Program can reduce depression symptoms in adults. Over 1,100 people with mild to moderate depression used the app for 4 weeks, and their symptoms were compared to those who used a different app or were on a waiti…

This study looked at whether adding pramipexole (a drug used for Parkinson's) to regular depression treatment can safely reduce anhedonia (loss of interest or pleasure) over the long term. 55 adults who had already been in a short-term trial took the drug for up to a year. Resear…

This study looked at whether a structured exercise program—including walking, stretching, and light strength training—can improve physical function, mood, and quality of life in hospitalized adults aged 65 and older. 100 participants were split into an exercise group and a routin…

This study tested a non-invasive brain stimulation technique called iTBS, personalized for each person's brain scan, to treat major depression. 68 adults received either real or sham stimulation. The goal was to see if targeting a specific brain connection could improve mood and …

This study looked at whether a combination of behavioral counseling and medication adjustments could reduce anxiety and depression in adults aged 60 and older who were about to have surgery for cancer. About 105 participants were randomly assigned to receive this support or usual…

This study tested whether using an extended reality (XR) headset to do behavioral activation therapy could help people with major depressive disorder. 26 adults with depression tried either XR-based therapy or standard real-life therapy. The goal was to see if the XR approach was…

This study looked at 90 veterans with obesity who took GLP-1 medicines (semaglutide or tirzepatide) for six months. Researchers found that participants reported significant improvements in depression symptoms, eating disorder behaviors, and overall quality of life, including less…

This study tested an experimental daily pill called MAP4343 in 126 adults whose depression did not improve with standard antidepressants. The goal was to see if the drug could reduce depressive symptoms over 6 weeks. The trial was a Phase 2 study, meaning it was an early test of …

This study tested a new web app that uses cognitive behavioral therapy (CBT) to help with depression and anxiety. The app was designed to work across different cultures and languages for people in low- and middle-income countries. 50 adults who owned a smartphone or computer and …

This study tested whether a mobile app called JoyPop can help college students handle their emotions better and reduce stress, anxiety, and depression. About 160 students aged 18-25 used the app or received no intervention. The goal was to see if the app improves emotion regulati…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble readjusting to civilian life. The workshop taught practical skills like managing emotions, solving problems, and paying attention, without calling it therapy to make it more welcoming. The go…

This small study tested whether a digital wellness app using artificial intelligence and virtual reality could safely provide mental health support to adults with inflammatory bowel disease who also have mild anxiety or depression. Twenty-two participants used the app during a si…

This study tested whether using a hand fan for 10 minutes each day for six weeks could help people with COPD feel less short of breath and improve their mood. Fifty-six patients took part, with half using the fan and half receiving usual care. The results will show if this simple…

This study tested an internet-based mindfulness program for adults with depression. 116 participants were randomly assigned to either the mindfulness training or usual care. The goal was to see if the program could reduce depressive symptoms and improve well-being, and to underst…

This study looked at whether alternative treatments can reduce anxiety and depression in college students. 55 students were randomly assigned to try external qigong, mindfulness meditation, or psychoeducation. The goal was to see if these approaches improve symptoms and help stud…

This study looked at whether adding a smartphone app that teaches cognitive behavioral therapy (CBT) skills helps veterans with depression recover better than standard CBT alone. Fifteen veterans who served in Iraq or Afghanistan took part. The goal was to see if the app improved…

This study looked at whether combining mental health care with vocational rehabilitation helps people on sick leave due to anxiety or depression return to work sooner. Over 600 participants from Denmark were randomly assigned to receive stepped mental health care alone or integra…

This study tested a special counseling program to help people living with HIV quit smoking. The program focused on reducing anxiety and depression, which often make it harder to stop smoking. 131 smokers with HIV took part to see if this approach helped them quit and stay smoke-f…

This study tested a non-invasive treatment called neurofeedback in 157 teens who had attempted suicide. Participants learned to control their own brain activity in real time using an MRI scanner. The goal was to see if this training could reduce suicidal thoughts and improve emot…

This study tested a program called MindUP in 61 orphan boys aged 11-16 in Pakistan. The program teaches mindfulness and emotional skills to help reduce depression, anxiety, and stress. Researchers compared those who took the program with those who did not, measuring changes with …

This study tested whether omega-3 supplements (a healthy fat found in fish oil) can reduce stress, anxiety, and depression, and improve memory and sleep. 64 Saudi adults with high stress took either omega-3 or a placebo daily for three months. Results showed that those taking ome…

This study tested a one-day life skills workshop for 176 veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The goal was to help them cope better and reintegrate into civilian life. The workshop focused on practical ski…

This study tested a version of mindfulness-based cognitive therapy designed for older Black adults (age 50+) who have both chronic pain and depression. The goal was to see if this approach could improve quality of life and reduce pain interference. The study enrolled 12 participa…

This study tested a culturally adapted version of cognitive behavioral therapy (CA-CBT) for Chinese youth aged 12 to 21 in Ontario who have anxiety or depression. The goal was to make treatment more relevant and accessible. Researchers measured changes in symptoms and satisfactio…

This small study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with a history of depression. Sixteen people aged 60 and older with recurrent depression took part. The goal was to see…

This study tested a program called PRISM that teaches coping skills to teens and young adults (ages 12-24) with advanced cancer. The goal was to see if it could improve their quality of life and reduce anxiety and depression. 195 participants were randomly assigned to receive PRI…

This study tested a non-medication sleep program for 88 adults with depression, bipolar disorder, or ADHD who also had insomnia. Participants received either the sleep program or standard sleep hygiene advice. The goal was to see if the program could reduce sleep problems and imp…

This study looked at whether progressive muscle relaxation exercises (tensing and relaxing different muscle groups) can help nursing students with depression, anxiety, and stress. 104 students were split into two groups: one did the exercises for 4 weeks, the other did not. Resea…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression received either usual care (medication or therapy) or PIC plus usual care. PIC combines bright …

This study tested a new brain-training method called PRISM neurofeedback in 19 adults with major depression and anhedonia (loss of pleasure). Participants were randomly assigned to real or sham training to see if it safely improves mood and pleasure. The goal is to help doctors p…

This study tested a technology service to help care managers in obstetrics clinics better treat depression in pregnant women and new mothers. 75 English-speaking adults with moderate to severe depression who owned a smartphone took part. The goal was to see if the tech support im…

This study tested whether a collaborative care model, where doctors, nurses, and mental health specialists work together, helps adults with depression more than usual care. 325 Danish adults with depression took part. The goal was to see if this team approach reduces depression s…

This study adapted a behavioral activation treatment (BeatIt-2) to help minimally verbal autistic adults with depression. Nine participants and their caregivers took part. The goal was to see if the therapy was feasible and could reduce depressive symptoms using caregiver-reporte…

This study tested a simple web platform called Adhere.ly that helps therapists encourage clients to practice therapy skills between sessions (homework). 79 adults with anxiety or depression and their therapists took part. The goal was to see if using the tool improved symptoms an…

This study tested whether expressive writing—writing about your deepest thoughts and feelings—can reduce anxiety and depression in young adults. 160 participants wrote daily for 14 days, either to themselves, to a loved one, or just describing their day. The goal was to see which…

This study tested whether adding pizotifen (a migraine medication) to the standard antidepressant escitalopram works better than escitalopram alone for major depression. 88 newly diagnosed patients aged 14-70 took part. Researchers measured symptom changes using the PHQ-9 questio…

This study tested a program called ENCODE to help family caregivers of people with dementia who are in hospice. The program taught caregivers how to better manage pain and stress. 452 caregivers took part, and the study measured changes in their quality of life, anxiety, and depr…

This study tested whether combining mental health care with job support helps people on sick leave due to anxiety, depression, stress, or personality disorders return to work. 900 participants in Denmark received either the combined program or usual care. The main goal was to see…

This study tested a new, non-invasive treatment for people with depression, anxiety, bipolar disorder, or PTSD. It used low-intensity focused ultrasound to gently stimulate a brain region called the amygdala, which is involved in emotion. 29 adults received daily sessions for thr…

This study tested whether using a person's genetic information (DNA) to select antidepressant medication can improve depression and anxiety in cancer patients. 99 adults with cancer and mild to severe depression or anxiety were randomly assigned to either DNA-guided drug selectio…

This study tested a new online therapy program designed to support the mental health of transgender and gender-diverse adults in Romania. The program consisted of 16 video sessions focused on LGBTQ-affirming counseling to help reduce depression, anxiety, and behaviors linked to H…

This study tested whether regular supportive phone calls could improve mental health in older adults who receive meal services and may feel lonely or isolated. Over 670 participants aged 55+ either received 8 weeks of 'warm calls' from trained helpers or were in a comparison grou…

This study looked at 39 children with asthma to see if those with depression have different lung inflammation and respond better to a specific inhaler (ipratropium). The goal was to understand a new asthma type linked to depression. Results may help personalize asthma treatment f…

This study looked at whether a program called POST Facilitation helps older adults (65+, including those with dementia) get the medical care they prefer at the end of life. Researchers worked with 389 participants to see if their treatment matched their wishes. The goal was to re…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. 66 healthy adults and people with depression took either the drug or a placebo for 3 days. Researchers used memory tests and high-resolution MRI scans …

This study created and tested a mobile app called VetEd to help student veterans with mental health conditions like depression, PTSD, and anxiety do better in college. Researchers worked with 13 veterans to design the app and check if it was easy to use and helpful. The goal was …

This study tested whether community health workers (CHWs) could effectively screen for depression in 30 Black churches and help people get treatment. 505 adults with possible depression were split into two groups: one received a structured program (SBIRT) and the other got usual …

This study tested whether healthcare providers can help low-income parents file taxes and receive tax credits. 21 parents with young children were referred to a tax filing app. Researchers checked if this increased tax filing and improved parent and child health over time.

This study tested a program that helps low-income parents build strong parenting skills to prepare their children for school. It combined two proven methods: one where a specialist videotapes and coaches parents during doctor visits, and another offering home-based support for fa…

This pilot study looked at how well depression screening and treatment work for adolescents in primary care clinics in Mozambique. About 95 teens took part, with some clinics offering a type of talk therapy called interpersonal therapy and others offering usual care. The goal was…

This study looked at whether a simple brain scan can identify people who are vulnerable to depression, even if they feel fine. Researchers used a light-based imaging technique to measure brain activity in 90 people: those who had recovered from depression, those with a family his…

This study looked at how teenage girls' brains pay attention to negative images, which might help predict who is at risk for depression. Researchers used EEG to measure brain activity and tested a real-time neurofeedback training to shift attention away from negative distractions…

This study screened over 4,000 people to see if genetic testing could help doctors choose better medicines for depression, acute pain, or chronic pain. Participants were randomly assigned to get genetic-guided treatment right away or after six months. The goal was to learn whethe…

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared gene variations in 188 patients who either improved or did not improve after 3 to 6 weeks of treatment. The goal is to better unde…

This study looked at whether prosthetists (the specialists who fit artificial limbs) can screen for common health problems like depression, nerve damage, and poor blood flow during routine visits. 70 people with a leg amputation took part. Half got standard care, and the other ha…

This study looked at whether adding social support (like help with jobs and housing) to standard mental health treatment helps refugees with PTSD. 196 unemployed refugees took part. The goal was to see if working together with city services improves daily functioning and reduces …

This study tested a modified behavioral parent training program for parents of children with ADHD who also have their own ADHD or depression symptoms. The goal was to see if changes to the program help parents engage more and improve their parenting skills. Thirty-three parents t…

This study tested whether having families keep a hospital diary during their child's stay in the pediatric intensive care unit (PICU) could reduce anxiety, depression, and post-traumatic stress after discharge. Researchers followed 431 families in four Brazilian PICUs, checking t…

This study tested whether sending outreach messages (online, by mail, or by phone) could help more people from racial and ethnic minority groups start treatment for depression. About 309 adults with a new depression diagnosis took part. The goal was to see which communication met…

This study looked at whether a type of talk therapy called schema therapy can help people with depression that hasn't gotten better with standard treatments. Two patients received 30 therapy sessions over about a year. The goal was to see if this approach is practical and to lear…

This study checked if a depression questionnaire (Cardiac Depression Scale) works well in Turkish for people with heart disease. Researchers tested the long and short forms in 360 stable heart patients. The goal was to make sure the scale accurately detects depression in this gro…

This study looked at how healthy young adults (ages 18-35) suppress negative memories. Using brain wave recordings (EEG) and tasks involving emotional images, researchers aimed to understand the brain's natural ability to forget unpleasant experiences. The goal is to better under…

This study tested different training methods to help healthcare workers in Vietnam provide depression care. Over 1,300 patients and providers took part across three provinces. The goal was to see which training approach worked best for getting providers to adopt and deliver depre…

This study explored whether certain harmful gut bacteria are linked to anxiety, depression, and panic disorders. Researchers analyzed stool samples from 500 adults, including people with these conditions and healthy controls. The goal was to find patterns that could lead to new t…

This study aims to find biological markers in blood, urine, and saliva that could help explain why up to 40% of people with depression do not get better with standard antidepressants. Researchers will analyze samples from 50 adults with major depression who have not taken antidep…

This study tested a short program called Making Connections Intervention (MCI) to help Black teenagers with depression feel more connected to treatment in urban schools. Researchers worked with 29 students in grades 6-12 to see if the program improved their engagement, reduced sy…

This study tested a three-week program where healthy adults and people with depression or bipolar disorder did brain-training exercises in a room with low oxygen (like high altitude). The goal was to see if this combination improves memory, focus, and problem-solving. Researchers…

This study followed over 18,000 Taiwanese adults to see if a vegetarian diet is linked to lower rates of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers used health insurance records to trac…

This study tested whether online tools like YouTube videos, TikTok clips, and resource links could help LGBTQ+ youth (ages 14-19) with mild depression or anxiety feel more willing to seek professional help. 81 participants joined a private Discord server for 4 weeks, where they w…

This study looked at 136 women to see if the age they go through menopause is linked to anxiety and depression. It compared women with early menopause (before age 40) to those with natural menopause after 40. Researchers used standard questionnaires to measure anxiety levels duri…

This study tested whether therapists looking at patients' electronic messages (like texts and emails) during sessions could improve treatment for anxiety and depression. About 110 adults in ongoing therapy participated. The goal was to see if this approach boosts quality of life …

This study looked at why some people with depression feel better even when given a placebo (a fake treatment). Researchers studied 76 adults to find brain and body markers that predict who responds to placebos. The goal is to improve future depression treatments and make clinical…

This study looked at 120 adults to see if anxiety and depression are linked to a common tooth infection called apical periodontitis. Participants had dental exams and filled out questionnaires about their mental health. The goal was to better understand how emotional well-being a…

This study looked at anhedonia — the loss of interest or pleasure in activities — in 123 young people with depression. Participants underwent brain scans, blood tests, and behavioral tasks to measure symptoms. Some also tried treatments like brain stimulation (TMS), positive thin…

This study tested a program called Care Coordination After Preterm Birth (CCAPB) to help mothers who had a preterm baby. The goal was to see if the program was acceptable and could reduce stress, improve health care use, and address issues like smoking and depression. 67 mothers …

This study looks at whether forgiving medical debt helps people use health care more and feel better mentally. About 15,000 adults who owed medical debt took part. Some had their debt forgiven by a charity, and researchers compared their health and wellbeing to those who still ow…

This study tested a program where local health workers screened women affected by floods for anxiety and depression. The goal was to see if this approach is practical and helpful in a rural area of Pakistan. About 4,800 women took part, and the program included referrals for furt…

This study looked at how the brain's reward system helps improve mood in people with depression. Researchers used brain scans, magnetic stimulation, and medications to understand these signals. 120 adults with mild depression took part. The goal was to learn more, not to test a n…

This study looked at whether a short therapy program for depression could help prevent type 2 diabetes in teenage girls at high risk. Researchers tested a cognitive-behavioral therapy group against a health education group in 147 girls aged 12-17 with depressive symptoms and a fa…

This study looked at whether community health workers visiting pregnant women at home in rural South Africa can improve health for both mothers and children. About 1,490 women took part, with some areas getting the home-visit program and others not. The program aimed to help with…

This study looked at 112 adults with moderate or major depression to compare two common talk therapies: Cognitive Behavioral Therapy (CBT) and Emotion-Focused Therapy (EFT). Researchers wanted to see how each therapy helps reduce symptoms and understand what patients experience d…

This study followed 169 elderly patients (over 60) with depression who were treated at specialized clinics in Norway. Researchers checked on them after one and three years to see how their depression changed and whether they developed dementia. The goal was to learn about long-te…

This study looked at whether a personalized meal plan with more omega-3 fatty acids (found in fish) could help breast cancer survivors manage symptoms like fatigue, pain, depression, and sleep problems. Researchers worked with 98 women who had finished treatment for early-stage b…

This study looked at whether training staff with computer simulations (called participatory system dynamics) helps more veterans start and finish effective treatments for PTSD, depression, and opioid use disorder. About 720 staff from 24 VA health systems took part. The goal was …

This study looked at whether brain insulin resistance plays a role in depression during adolescence. Researchers used MRI scans to compare brain activity in 24 teens with and without depression after they received insulin or a placebo through a nasal spray. The goal was to unders…

This study looked at how low and high frequency magnetic brain stimulation (rTMS) changes brain waves in 30 healthy adults. Participants received both 1 Hz and 20 Hz stimulation in separate sessions, and their brain activity was measured with EEG before and after. The goal was to…

This study looked at 15 women aged 20-50 who experienced domestic physical violence and visited a social service center in the last two years. Researchers wanted to see if their ability to do daily activities and take part in social roles was connected to how satisfied they felt …

This study tested a new afterschool program where college mentors help middle school students connect their mood with their actions, especially physical activity. The goal was to see if this approach is feasible for teens with depression symptoms. 209 students from a low-resource…

This study measured levels of certain minerals in the blood of 100 women with fibromyalgia and compared them to healthy women. The goal was to see if these minerals are linked to disease severity, depression, or anxiety. The study was observational, meaning no treatment was given…

This study looked at over 7,500 Chinese patients aged 65 and older who had non-cardiac surgery. Researchers measured how many developed anxiety or depression symptoms afterward and what factors made it more likely. The goal was to better understand and identify at-risk patients, …

This study looked at whether depression makes it harder for people with multiple sclerosis (MS) to recognize emotions like anger, joy, or neutral expressions on faces. Researchers tested 38 participants, including MS patients and healthy controls, using facial expression tasks an…

This study followed 125 ICU patients who needed a breathing tube and sedation for at least 48 hours. Researchers checked for memory and thinking problems 4 months after leaving the ICU. They also looked at stress, depression, and other factors. The goal was to understand how comm…

This study looked at how inflammation changes the brain's reward system in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure loss of pleasure and motivation after an inflammatory challenge. The goal was to understand the link betwe…

This early-stage study tested the safety of a new drug called NH102 in 40 healthy adults. The goal was to see how the body handles the drug and if it causes side effects. This research does not treat depression but helps gather important safety information for future studies.

This study looked at how the brain's circuits relate to anxiety and depression. 167 adults with recent anxiety or depression symptoms (no diagnosis needed) had brain scans and cognitive tests. Some also received a 12-week course of medication or brain stimulation (rTMS) as an alt…

This study tested whether people with major depression who eat a lot of ultra-processed foods could cut back on them. Twenty adults tried a personalized diet change for a short time. The goal was to see if it was possible and acceptable, not to measure health effects. Results wil…

This study followed over 1,000 medical interns to see if a smartphone app could help improve their mood, sleep, and physical activity. Participants reported their daily mood and wore fitness trackers to record steps and sleep. The goal was to gather information, not to test a tre…

This study looked at 175 adults with both coronary heart disease and depression to understand which depression symptoms, like fatigue and loss of interest, are linked to worse heart health. Researchers measured depression severity and heart risk markers to find better targets for…

This study looked at how inflammation changes the way younger women experience reward, which may help explain why some people develop depression. Researchers gave 40 healthy women a mild inflammatory substance or a placebo and measured their responses to money and smiling faces. …

This study looked at how depression changes the way mothers interact with their babies and how that affects the child's thinking, emotions, and development. Researchers filmed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The go…